The Ped-APS registry: The antiphospholipid syndrome in childhood

In recent years, antiphospholipid syndrome (APS) has been increasingly recognised in various paediatric autoimmune and nonautoimmune diseases, but the relatively low prevalence and heterogeneity of APS in childhood made it very difficult to study in a systematic way. The project of an international registry of paediatric patients with APS (the Ped-APS Registry) was initiated in 2004 to foster and conduct multicentre, controlled studies with large number of paediatric APS patients. The Ped-APS Registry is organised as a collaborative project of the European Forum on Antiphospholipid Antibodies and Juvenile Systemic Lupus Erythematosus Working Group of the Paediatric Rheumatology European Society. Currently, it documents a standardised clinical, laboratory and therapeutic data of 133 children with antiphospholipid antibodies (aPL)-related thrombosis from 14 countries. The priority projects for future research of the Ped-APS Registry include prospective enrolment of new patients with aPL-related thrombosis, assessment of differences between the paediatric and adult APS, evaluation of proinflammatory genotype as a risk factor for APS manifestations in childhood and evaluation of patients with isolated nonthrombotic aPL-related manifestations. © The Author(s), 2009.

Regional odontodysplasia in early childhood: A clinical and histological study

Regional odontodysplasia (RO) is a rare disorder of dental development. The affected teeth are clinically hypoplastic and hypocalcified, presenting a ghost-like appearance radiographically. The aim of this work was to report a clinical case of a child with both primary and permanent dentition affected by RO. The conducted therapy was based on a conservative approach, which consisted of follow-up clinical evaluations of the anomalous teeth. However, the endodontic treatment of the primary incisors failed. Then, the chosen option for patient rehabilitation became extraction followed by removable of prosthesis confection. The extracted teeth were processed for histological analysis. In spite of the uncertain prognosis, but taking into account the psychological aspects of the patient, a conservative approach in an attempt to maintain those viable teeth in the oral cavity should be established.

Childhood trauma in substance use disorder and depression: An analysis by gender among a Brazilian clinical sample

Objective: In this study, we compared the frequency and intensity of childhood traumas in alcohol- or other drug-dependent patients, in patients with depression, and in a control group without psychiatric diagnoses. Methods: The study had a retrospective design of a clinical sample of men and women from the groups listed above. They were evaluated by the same standardized instrument: the Childhood Trauma Questionnaire.. Results: A higher frequency and intensity of emotional, physical, and sexual abuse were found in alcohol- and other drug-dependent patients than in patients with depression, who, in turn, presented significantly higher proportions than the control group. In all of the cases, the frequency was higher among women than men. Conclusion: Because of the high frequency and intensity of childhood traumas among alcohol- or other drug-dependent patients and depressed patients, the assessment of problems due to childhood traumas among these patients is essential to a better understanding of the etiology of those disorders and to their treatment. © 2010 Elsevier Ltd. All rights reserved.

Poverty, hunger and food security in Central America and Panama

Includes bibliography

Hunger and malnutrition in the countries of the Association of Caribbean States (ACS)

Includes bibliography

Chile: Interaction between the State and civil society in policies on childhood

Includes bibliography

Moderate physical activity from childhood contributes to metabolic health and reduces hepatic fat accumulation in adult rats

Background: Obesity, oxidative stress and inflammation, by triggering insulin resistance, may contribute to the accumulation of hepatic fat, and this accumulation by lipotoxicity can lead the organ to fail. Because obesity is growing at an alarming rate and, worryingly, in a precocious way, the present study aimed to investigate the effects of moderate physical training performed from childhood to adulthood on liver fat metabolism in rats. Methods. Twenty rats that were 28days old were divided into two groups: control (C) and trained (T). The C Group was kept in cages without exercise, and the T group was submitted to swimming exercise for 1hour/day, 5days/week from 28 to 90days of age (8weeks) at 80% of the anaerobic threshold determined by the lactate minimum test. At the end of the experiment, the body weight gain, insulin sensitivity (glucose disappearance rate during the insulin tolerance test), concentrations of free fatty acids (FFA) and triglycerides (TG) and hepatic lipogenic rate were analyzed. For the statistical analysis, the Student t-test was used with the level of significance preset at 5%. Results: The T group showed lower body weight gain, FFA concentrations, fat accumulation, hepatic lipogenic rate and insulin resistance. Conclusion: The regular practice of moderate physical exercise from childhood can contribute to the reduction of obesity and insulin resistance and help prevent the development of accumulation of hepatic fat in adulthood. © 2013de Moura et al; licensee BioMed Central Ltd.

Prevalence of deciduous tooth erosion in childhood

Objectives: The objective of this study was to estimate the prevalence of deciduous tooth erosion and to identify possible associations with sex, age and toothbrushing frequency in children aged 4-6 years. Methods: The sample was drawn from attendants (n = 7058) of 57 public preschools in a Brazilian city. Tooth wear index was used to evaluate erosion. Descriptive statistical analysis consisted of the calculation of the prevalence of dental erosion; chi-squared and Fisher's exact tests were performed to verify the association between dental erosion and sex, age and toothbrushing frequency. Results: Two thousand and seven hundred and fifty-nine preschool students were examined. Deciduous tooth erosion was observed in 0.6% of children and its incidence did not differ between sexes. The highest prevalence was observed in children aged 6 years (58.3%) and the most affected sextants were the fourth (22.86%) and sixth (20.00%), indicating that lingual and occlusal tooth surfaces were most frequently involved. The degree of involvement was classified as incipient in 54.29% of children and moderate in 45.71%. The significance level was set at 5%. No association was found between erosion and sex, age or toothbrushing frequency. Conclusions: The prevalence of deciduous tooth erosion was low in Brazilian children, and this disorder is not considered a public health problem in this part of the population. © 2013 John Wiley & Sons A/S.

Fatores associados à persistência da desnutrição em crianças acompanhadas pelo sistema de vigilância alimentar e nutricional de Piracicaba-SP

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Experimenting with a procedure for estimating childhood mortality from information about the previous birth

Includes bibliography

The cost of hunger: Social and economic impact of child undernutrition in the Plurinational State of Bolivia, Ecuador, Paraguay and Peru

The Economic Commission for Latin America and the Caribbean (ECLAC) jointly with the World Program of Food (WFP) and recognized experts of the region developed a methodology that, using secondary information, estimate the opportunity cost derived from undernutrition. This methodology has been successfully applied in Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama and the Dominican Republic, where the cost of undernutrition was estimated at 6.7 billion dollars in 2004. The present study covers four countries in South America: Bolivia, Ecuador, Paraguay and Peru. The results indicate that the cost of the malnutrition in these countries reached 4.3 billion dollars in 2005, which is equivalent to 3.3 per cent of the GDP of these countries. The results strongly point out that child undernutrition is not only a problem of health or an unacceptable situation ethically, but it is a national problem, given the enormous social costs and the loss of opportunities that it imposes on the national economy.

The cost of hunger: Social and economic impact of child undernutrition in Central America and the Dominican Republic

This document presents the results derived from the analyses of the cost of undernutrition in Costa Rica, El Salvador, Guatemala, Honduras, Nicaragua, Panama and the Dominican Republic. The study shows that not only are the effects reported valid for the countries of Central America and the Dominican Republic, but the resultant economic impact is also significant, representing between 1.7% and 11.4% of GDP. In this regard, productivity losses as a consequence of the higher death rate and the lower level of education account for 90% of the costs. Thus, in addition to the ethical imperative, eradicating undernutrition would yield benefits as well. Therefore, any programme that is effective in reducing the prevalence of this problem will have an impact on people's quality of life, and will also represent major savings for society. The greater the problem, the greater the challenge, but the greater the benefits as well, especially in terms of countries' production capacity.

Da lama à ficção: memórias e diálogos da fome nos interstícios narrativos de homens e caranguejos

Homens e caranguejos (1967), única narrativa ficcional de Josué Apolônio de Castro (1908-1973), a priori publicada em francês (1966), durante o forçoso exílio do autor em Paris, é sumariamente expressiva desde o prólogo que antecede a trama. Nomeando as páginas introdutórias deste romance como Prefácio um tanto gordo para um romance um tanto magro, Josué de Castro distende, ao retomar num tempo que já considerava anacrônico, o hábito pela escrita prefacial, a concepção de paratexto ampliada por Gerard Genette (1930), em Palimpsestes (1982). Apresentando a fome pelas recordações infantis que dela possui, o autor aguça no público-leitor a vontade de tatear, rente a seu olhar aparentemente ingênuo de criança e, de ficcionista de “primeira viagem”, o macrocosmo de memórias da fome que lhe serve como porto de partida para a criação de um microcosmo lúdico e faminto, pelo qual a imaginação e impossibilidade de re-apresentação total do vivido na linguagem, rearranjam a realidade da condição humana, reinventando-a pela articulação dramática dos elementos formais, sobretudo, tempo-espaço, narrador e personagem. A ficção se põe no ritmo fragmentado de aventuras e desventuras assumidas a partir dos intervalos da memória. Serão sumários nos estudos mnemônicos, as apreciações de Henri Bergson em Matéria e memória (1896), Jacques Le Goff em História e memória (1924) e Maurice Halbwachs, na publicação póstuma de A memória coletiva (1950), em face de serem fontes subsidiárias da aproximação entre os estudos da memória e a literatura. Lança-se mão da lembrança a fim de legendar os diálogos futuros entre o protagonista infantil, João Paulo, ávido pela liberdade sonhadora própria da criança, e as memórias de outros experientes personagens, nem tão esperançosos assim. Dá-se na narrativa o tom que oscila entre a transformação e a acomodação do eu e do outro, de espaços simbioticamente incertos e unidos por suas fomes. Fome que é, desde então, a personagem modeladora, que provoca o diálogo da presente pesquisa com o modo de apreensão que é dado por Angela Faria, na dissertação Homens e caranguejos: uma trama interdisciplinar. A literatura topofílica e telúrica (2008). Vislumbra-se no elemento famélico uma função que vai além da tematização social do subdesenvolvimento, como agente que apalpa com mãos-de-ferro o estrato formal e interno da obra.