Preconditioning 2D Integer Data for Fast Convex Hull Computations

In order to accelerate computing the convex hull on a set of n points, a heuristic procedure is often applied to reduce the number of points to a set of s points, s ≤ n, which also contains the same hull. We present an algorithm to precondition 2D data with integer coordinates bounded by a box of size p × q before building a 2D convex hull, with three distinct advantages. First, we prove that under the condition min(p, q) ≤ n the algorithm executes in time within O(n); second, no explicit sorting of data is required; and third, the reduced set of s points forms a simple polygonal chain and thus can be directly pipelined into an O(n) time convex hull algorithm. This paper empirically evaluates and quantifies the speed up gained by preconditioning a set of points by a method based on the proposed algorithm before using common convex hull algorithms to build the final hull. A speedup factor of at least four is consistently found from experiments on various datasets when the condition min(p, q) ≤ n holds; the smaller the ratio min(p, q)/n is in the dataset, the greater the speedup factor achieved.

Post-Transcriptional Regulation of BCL2 mRNA by the RNA-Binding Protein ZFP36L1 in Malignant B Cells

The human ZFP36 zinc finger protein family consists of ZFP36, ZFP36L1, and ZFP36L2. These proteins regulate various cellular processes, including cell apoptosis, by binding to adenine uridine rich elements in the 3′ untranslated regions of sets of target mRNAs to promote their degradation. The pro-apoptotic and other functions of ZFP36 family members have been implicated in the pathogenesis of lymphoid malignancies. To identify candidate mRNAs that are targeted in the pro-apoptotic response by ZFP36L1, we reverse-engineered a gene regulatory network for all three ZFP36 family members using the ‘maximum information coefficient’ (MIC) for target gene inference on a large microarray gene expression dataset representing cells of diverse histological origin. Of the three inferred ZFP36L1 mRNA targets that were identified, we focussed on experimental validation of mRNA for the pro-survival protein, BCL2, as a target for ZFP36L1. RNA electrophoretic mobility shift assay experiments revealed that ZFP36L1 interacted with the BCL2 adenine uridine rich element. In murine BCL1 leukemia cells stably transduced with a ZFP36L1 ShRNA lentiviral construct, BCL2 mRNA degradation was significantly delayed compared to control lentiviral expressing cells and ZFP36L1 knockdown in different cell types (BCL1, ACHN, Ramos), resulted in increased levels of BCL2 mRNA levels compared to control cells. 3′ untranslated region luciferase reporter assays in HEK293T cells showed that wild type but not zinc finger mutant ZFP36L1 protein was able to downregulate a BCL2 construct containing the BCL2 adenine uridine rich element and removal of the adenine uridine rich core from the BCL2 3′ untranslated region in the reporter construct significantly reduced the ability of ZFP36L1 to mediate this effect. Taken together, our data are consistent with ZFP36L1 interacting with and mediating degradation of BCL2 mRNA as an important target through which ZFP36L1 mediates its pro-apoptotic effects in malignant B-cells.

D. João de Magalhães e Avelar e a Fundação da Real Biblioteca Pública Municipal do Porto (1833)

D. João de Magalhães e Avelar (1754-1833) formou aquela que, ao tempo, era a maior biblioteca privada portuguesa. Com cerca de 36000 volumes, foi elogiada por personalidades nacionais e estrangeiras, por aliar à quantidade de volumes inúmeros e valiosíssimos manuscritos. Formada ao longo dos séculos XVIII e XIX, durante mais de 30 anos, originou, em 1833, o primeiro núcleo da actual Biblioteca Pública Municipal do Porto. Numa época em que possuir livros era sinónimo de prestígio social mas num período em que quase não havia tradição de bibliotecas públicas no nosso país, contrariamente ao que acontecia noutras realidades, a livraria privada de Avelar formou, com outras, a Real Biblioteca Pública da Cidade do Porto. Em 1833, aquando do primeiro aniversário da entrada do exército liberal no Porto, por decreto, criou-se a biblioteca portuense. Estabelecida na casa que servia de Hospício dos Religiosos de Santo António do Val da Piedade, à praça da Cordoaria, tinha como objectivo satisfazer a utilidade pública, estando aberta todos os dias, excepto domingos e feriados. Propriedade da cidade do Porto, ficava sujeita à administração da Câmara que se obrigava à sua guarda, manutenção, conservação, bem como à constante aquisição de espólio. Como veremos, tratou-se de um processo conflituoso mas o Porto obtinha, definitivamente, a sua biblioteca pública.

Dynamic Analysis and Pattern Visualization of Forest Fires

This paper analyses forest fires in the perspective of dynamical systems. Forest fires exhibit complex correlations in size, space and time, revealing features often present in complex systems, such as the absence of a characteristic length-scale, or the emergence of long range correlations and persistent memory. This study addresses a public domain forest fires catalogue, containing information of events for Portugal, during the period from 1980 up to 2012. The data is analysed in an annual basis, modelling the occurrences as sequences of Dirac impulses with amplitude proportional to the burnt area. First, we consider mutual information to correlate annual patterns. We use visualization trees, generated by hierarchical clustering algorithms, in order to compare and to extract relationships among the data. Second, we adopt the Multidimensional Scaling (MDS) visualization tool. MDS generates maps where each object corresponds to a point. Objects that are perceived to be similar to each other are placed on the map forming clusters. The results are analysed in order to extract relationships among the data and to identify forest fire patterns.

A biblioteca pública e a literacia da informação: estudo de caso de uma biblioteca da região Centro de Portugal

O objetivo desta dissertação é perceber o papel do profissional de biblioteca pública na promoção da literacia da informação, através do estudo de uma biblioteca municipal do NUTS II Região Centro, a Biblioteca Municipal António Botto. Para isso segue-se uma metodologia do estudo de caso, recolhendo-se à observação de páginas de internet, entrevistas semiestruturadas e análise de documentação para recolha de dados. No primeiro capítulo será feita uma revisão da literatura abordando o conceito de literacia da informação, o papel das bibliotecas públicas em relação a essa questão e a problematização da situação portuguesa. No segundo capítulo será explicada a metodologia usada. No terceiro capítulo será caracterizada a Biblioteca António Botto, através do concelho em que está situada, da sua história e das suas características. No quarto capítulo será feita uma análise interpretativa das suas atividades de promoção de literacia da informação, com destaque para a criação e gestão do Tutorial e do Espaço Criança, disponíveis na sua página da internet. Conclui-se que o profissional da informação desempenha um importante papel no incentivo à literacia da informação, desde que tenha ao seu dispor condições para alcançar esses objetivos.

Bibliotecas públicas, responsabilidade social e cidadania

Este trabalho de investigação visa estudar e compreender a responsabilidade social de três bibliotecas públicas da margem sul do Tejo, analisando de que forma estas contribuem para o desenvolvimento de cidadãos civicamente mais ativos. Neste sentido, determina-se que modelo de responsabilidade social aplicam, que meios utilizam para incentivar o envolvimento cívico e que parcerias estabelecem. O método de recolha de dados utilizado foi a entrevista, tendo esta sido realizada aos responsáveis de cada bibliotecas em análise. Os resultados evidenciam que não existe uma política formal de responsabilidade social, mas sim ações que se assemelham a modelos práticos de RS que se classificam nas Teorias Integrativas. Relativamente às iniciativas desenvolvidas pelas bibliotecas públicas para a promoção da cidadania, estas vão de encontro ao Manifesto da IFLA/UNESCO para as Bibliotecas Públicas, podendo dizer-se que as suas ações se encontram confinadas à responsabilidade legal da organização. As bibliotecas identificam os seus stakeholders, mas é necessário que estes possuam um papel mais ativo no desenvolvimento de iniciativas que respondam às suas expetativas e necessidades. Efetuam-se cinco recomendações para melhorar o desempenho das bibliotecas públicas no domínio da responsabilidade social e da cidadania: implementar políticas de responsabilidade social; respeitar os interesses dos stakeholders; apostar na formação em responsabilidade social; investir na aprendizagem ao longo da vida; e inovar, no sentido de desenvolver atividades que vão além do cumprimento do Manifesto da IFLA/UNESCO para as Bibliotecas Públicas.

Niagara Region Newspaper Collection, 1811-1998 [non-inclusive]

Selected issues of historical newspapers of local interest, with dates starting from the mid-1800's, originally in the collections of the St. Catharines Public Library, the St. Catharines Historical Museum, and Brock University Library until they were microfilmed at which time they were transferred to Brock University Archives. The collection includes newspapers from various communities in the Niagara Region. The inventory includes the title of the newspaper and the issues available. Complete runs for each newspaper are virtually non extent.

Community Newspapers on Microfilm

Reel 1. E.J. Palmer's Grimsby illustrated; Merritton advance; The Evening review; Niagara Falls evening review; The academy; St. Catharines constitutional; St. Catharines daily news; St. Catharines daily standard; St. Catharines daily times; St. Catharines evening journal; St. Catharines evening star. -- Reel 2. St. Catharines evening star. -- Reel 3. St. Catharines evening star. -- Reel 4. St. Catharines evening star; St. Catharines gazette; St. Catharines journal; St. Catharines semi-weekly post; St. Catharines star journal; St. Catharines weekly news; St. Catharines weekly star; St. Catharines women's patriotic journal; St. Catharines women's standard; Welland Canadian farmer supplement; Welland Canadian farmer and grange record; Welland Canal works; Welland telegraph extra; Welland telegraph; Welland tribune and telegraph. -- Reel 5. Beamsville express; Vineland Jordan post; Grimsby independent; Haldimand advocate; Haldimand tribune; Niagara onghiara; Smithville pioneer; The Irish Canadian. -- Reel 7. St. Catharines daily times. -- Reel 8. St. Catharines daily times. -- Reel 9. St. Catharines daily times. -- Reel 10. The Monck reform press; Herald (Fonthill); Independent (Grimsby); Beamsville express; Post express (Lincoln); Jordan post (Vineland); The gleaner and Niagara newspaper; Niagara advance; Pelham herald; Port Colborne news; Farmers' journal and Welland Canal intelligencer; Welland tribune; Welland Tribune; Welland tribune and telegraph; Evening tribune (Welland Ship Canal, centenary issue).

Formation and differentiation of multiple mesenchymal lineages during lung development is regulated by {beta}-catenin signaling.

BACKGROUND: The role of ss-catenin signaling in mesodermal lineage formation and differentiation has been elusive. METHODOLOGY: To define the role of ss-catenin signaling in these processes, we used a Dermo1(Twist2)(Cre/+) line to target a floxed beta-catenin allele, throughout the embryonic mesenchyme. Strikingly, the Dermo1(Cre/+); beta-catenin(f/-) conditional Knock Out embryos largely phenocopy Pitx1(-/-)/Pitx2(-/-) double knockout embryos, suggesting that ss-catenin signaling in the mesenchyme depends mostly on the PITX family of transcription factors. We have dissected this relationship further in the developing lungs and find that mesenchymal deletion of beta-catenin differentially affects two major mesenchymal lineages. The amplification but not differentiation of Fgf10-expressing parabronchial smooth muscle progenitor cells is drastically reduced. In the angioblast-endothelial lineage, however, only differentiation into mature endothelial cells is impaired. CONCLUSION: Taken together these findings reveal a hierarchy of gene activity involving ss-catenin and PITX, as important regulators of mesenchymal cell proliferation and differentiation.

Les missions des bibliothèques publiques autonomes du point de vue des élus municipaux québécois

La légitimité d’une organisation est fondée sur sa mission, c’est-à-dire sur sa raison d’être. Des responsables des bibliothèques et de nombreux chercheurs craignent que la légitimité des bibliothèques publiques soit contestée dans la société de l’information. De plus, les textes officiels présentant les missions des bibliothèques publiques sont divers et les missions y sont délibérément non définies. Au Québec, où une grande majorité des bibliothèques publiques autonomes sont placées directement sous la tutelle des municipalités, les bibliothèques publiques doivent définir et légitimer leurs missions avec les élus municipaux. L’objectif principal de cette recherche est de comprendre, via les discours, le point de vue des élus municipaux québécois sur les missions des bibliothèques publiques autonomes, en comparaison avec les pratiques et les ressources des bibliothèques au plan local. Basé sur la théorie de la construction sociale de la réalité, un cadre conceptuel est proposé de manière à étudier non seulement les discours dans leur dimension textuelle, mais aussi à contextualiser ces discours et analyser l’écart entre ces discours et les pratiques des bibliothèques.La stratégie de recherche adoptée est une étude de cas multiples. L’objectif est de développer une analyse en profondeur de chaque cas et une analyse inter cas. Les douze cas (municipalités) ont été sélectionnés en fonction de deux critères de variation (la taille de la municipalité et le budget annuel alloué par la municipalité à la bibliothèque) et un critère discriminant (la distance par rapport à l’Université de Montréal). Des entrevues ont été menées auprès des élus municipaux présidant la commission ou le comité dont dépendent les bibliothèques publiques. Ces entrevues et les politiques culturelles ont fait l’objet d’une analyse de discours. Les entrevues auprès des responsables des bibliothèques et la documentation ont fait l’objet d’une analyse de contenu. Ces analyses ont permis la triangulation des méthodes et des sources de données.Les élus municipaux québécois, comme les professionnels, n’offrent pas un discours homogène sur les missions des bibliothèques publiques. Toutefois, un modèle de discours émerge. Il montre un discours « limité » par rapport à la littérature, dans lequel une image passive de la bibliothèque est présentée et dans lequel la tradition perdure malgré le contexte de la société de l’information. Mais l’analyse révèle aussi que les élus municipaux construisent leurs points de vue sur leurs propres convictions en tant qu’individus, sur leur rôle dans la gestion de la municipalité en tant qu’élus et sur l’image qu’ils ont des usagers des bibliothèques publiques. Enfin, l’analyse a révélé un axe de différenciation des points de vue selon que le discours s’appuie sur des valeurs fondamentales ou sur les usages (réels ou supposés) de la bibliothèque.

Étude qualitative sur les attitudes des bibliothécaires québécois vis-à-vis la liberté intellectuelle et la censure

Reposant sur un devis qualitatif, la présente recherche vise à comprendre les attitudes des bibliothécaires québécois vis-à-vis la liberté intellectuelle et la censure dans le contexte des bibliothèques publiques. Les données ont été colligées par le biais d’entrevues semi-structurées menées auprès de 11 bibliothécaires, dont six directeurs, responsables en tout ou en partie du développement des collections ainsi que de la gestion des plaintes relatives à l’offre documentaire. Les témoignages recueillis ont fait l’objet d’une analyse thématique. À l’instar des études antérieures ayant porté sur le sujet, la présente recherche a permis de constater qu’il existait un écart entre les attitudes des participants vis-à-vis la liberté intellectuelle en tant que concept et la liberté intellectuelle en tant qu’activité. Tout en étant en faveur de la liberté d’expression, les bibliothécaires étaient en accord, sous certaines circonstances, de mesures restrictives. Plus que des défenseurs de la liberté intellectuelle, les bibliothécaires seraient ainsi des gardiens du consensus social, ayant sans cesse à (re)négocier la frontière entre les valeurs individuelles et sociétales. L’analyse des données a également permis de révéler que les bibliothécaires québécois seraient moins activement engagés que leurs collègues canadiens et américains dans la lutte pour la défense et la promotion de la liberté intellectuelle. Ce faible engagement serait notamment lié à une importante variable culturelle. L’absence de lobbies religieux et le développement tardif des bibliothèques publiques ont en effet été identifiés comme deux facteurs qui auraient une influence sur l’engagement des bibliothécaires québécois en faveur de la liberté intellectuelle.

Services aux adultes handicapés physiques : enquête auprès des bibliothèques publiques québécoises

Les services aux usagers des bibliothèques représentent un sujet fondamental en bibliothéconomie. Or, les usagers sont un groupe hétérogène à qui l’on doit offrir les mêmes services ou, à tout le moins, la possibilité d’obtenir des services répondant à leurs besoins en matière d’adaptation des lieux et des services. Malheureusement, les bibliothèques publiques ont parfois du mal à rendre un service adapté adéquat et les personnes concernées connaissent souvent mal les services dont elles pourraient bénéficier. Pourtant, les personnes handicapées font partie intégrante des usagers et leur présence augmente, notamment à cause du vieillissement de la population et d’une meilleure capacité d’établir des diagnostics. Notons que ces citoyens revendiquent de plus en plus leur autonomie et le fait de pouvoir profiter des mêmes services que le reste de la population. Ceci est d’autant plus vrai depuis l’apparition d’aides techniques et des outils technologiques tels les ordinateurs, les tablettes, les logiciels, etc. qui leur permettent de vivre leur vie à part entière. Aussi, les bibliothèques et leurs gestionnaires doivent impérativement s’assurer que l’accueil de ces usagers « comme les autres », mais aux besoins particuliers, sera assuré convenablement. Puisqu’il manque d’études concernant les services offerts aux personnes handicapées dans les bibliothèques publiques du Québec, nous avons décidé de procéder à une enquête, par le biais d’un questionnaire électronique administré aux employés de bibliothèques dont les fonctions sont de participer aux services aux usagers. Les réponses obtenues ont permis de dresser un portrait de la situation actuelle en matière de services aux personnes adultes handicapées dans les bibliothèques publiques québécoises et d’avancer certaines recommandations. Les résultats devraient aider les responsables de bibliothèques à déterminer où et comment concentrer leurs efforts pour rendre leurs établissements plus accueillants pour les personnes ayant des incapacités. Plus précisément, les objectifs de la recherche étaient les suivants : 1. Recenser les services offerts par les bibliothèques publiques québécoises aux usagers adultes handicapés. 2. Recenser les éléments d’accessibilité présents dans les infrastructures des bibliothèques publiques québécoises. 3. Évaluer l’impact de certaines caractéristiques des bibliothèques sur l’offre de services aux usagers adultes handicapés et les éléments reliés à l’accessibilité. 4. Comparer les résultats des enquêtes précédentes (Bibliothèque nationale du Canada 1976 ; Bergeron 1987) pour mettre en évidence les recommandations qui ont été appliquées et celles qui ne l’ont pas été.

Re-engineering and Re-defining University Libraries in the context of modern Information and Communication Technologies: a study with special reference to the University Libraries in Kerala

Information and communication technologies are the tools that underpin the emerging “Knowledge Society”. Exchange of information or knowledge between people and through networks of people has always taken place. But the ICT has radically changed the magnitude of this exchange, and thus factors such as timeliness of information and information dissemination patterns have become more important than ever.Since information and knowledge are so vital for the all round human development, libraries and institutions that manage these resources are indeed invaluable. So, the Library and Information Centres have a key role in the acquisition, processing, preservation and dissemination of information and knowledge. ln the modern context, library is providing service based on different types of documents such as manuscripts, printed, digital, etc. At the same time, acquisition, access, process, service etc. of these resources have become complicated now than ever before. The lCT made instrumental to extend libraries beyond the physical walls of a building and providing assistance in navigating and analyzing tremendous amounts of knowledge with a variety of digital tools. Thus, modern libraries are increasingly being re-defined as places to get unrestricted access to information in many formats and from many sources.The research was conducted in the university libraries in Kerala State, India. lt was identified that even though the information resources are flooding world over and several technologies have emerged to manage the situation for providing effective services to its clientele, most of the university libraries in Kerala were unable to exploit these technologies at maximum level. Though the libraries have automated many of their functions, wide gap prevails between the possible services and provided services. There are many good examples world over in the application of lCTs in libraries for the maximization of services and many such libraries have adopted the principles of reengineering and re-defining as a management strategy. Hence this study was targeted to look into how effectively adopted the modern lCTs in our libraries for maximizing the efficiency of operations and services and whether the principles of re-engineering and- redefining can be applied towards this.Data‘ was collected from library users, viz; student as well as faculty users; library ,professionals and university librarians, using structured questionnaires. This has been .supplemented by-observation of working of the libraries, discussions and interviews with the different types of users and staff, review of literature, etc. Personal observation of the organization set up, management practices, functions, facilities, resources, utilization of information resources and facilities by the users, etc. of the university libraries in Kerala have been made. Statistical techniques like percentage, mean, weighted mean, standard deviation, correlation, trend analysis, etc. have been used to analyse data.All the libraries could exploit only a very few possibilities of modern lCTs and hence they could not achieve effective Universal Bibliographic Control and desired efficiency and effectiveness in services. Because of this, the users as well as professionals are dissatisfied. Functional effectiveness in acquisition, access and process of information resources in various formats, development and maintenance of OPAC and WebOPAC, digital document delivery to remote users, Web based clearing of library counter services and resources, development of full-text databases, digital libraries and institutional repositories, consortia based operations for e-journals and databases, user education and information literacy, professional development with stress on lCTs, network administration and website maintenance, marketing of information, etc. are major areas need special attention to improve the situation. Finance, knowledge level on ICTs among library staff, professional dynamism and leadership, vision and support of the administrators and policy makers, prevailing educational set up and social environment in the state, etc. are some of the major hurdles in reaping the maximum possibilities of lCTs by the university libraries in Kerala. The principles of Business Process Re-engineering are found suitable to effectively apply to re-structure and redefine the operations and service system of the libraries. Most of the conventional departments or divisions prevailing in the university libraries were functioning as watertight compartments and their existing management system was more rigid to adopt the principles of change management. Hence, a thorough re-structuring of the divisions was indicated. Consortia based activities and pooling and sharing of information resources was advocated to meet the varied needs of the users in the main campuses and off campuses of the universities, affiliated colleges and remote stations. A uniform staff policy similar to that prevailing in CSIR, DRDO, ISRO, etc. has been proposed by the study not only in the university libraries in kerala but for the entire country.Restructuring of Lis education,integrated and Planned development of school,college,research and public library systems,etc.were also justified for reaping maximum benefits of the modern ICTs.

Lumbar estrecho: experiencia de 10 años en la fundación santa fé de Bogotá

El canal lumbar estrecho de tipo degenerativo, es una enfermedad que se presenta en pacientes entre la quinta y la sexta década de vida; es la causa más común de cirugía lumbar después de los 65 años. Este trabajo busca determinar cuáles son los factores asociados a la presentación de eventos adversos o re-intervención en cirugía de canal lumbar estrecho en la Fundación Santa Fe de Bogotá en los años comprendidos entre 2003 y 2013. Métodos: se realizó un estudio de prevalencia de tipo analítico, en donde se analizaron 249 pacientes sometidos a intervención quirúrgica por cirugía de canal lumbar estrecho.