Modelo de plan estratégico para la gestión de inventarios para los repuestos John Deere de Ponce Yepes S.A.

En el presente trabajo se propone un modelo de plan estratégico, cuya aplicación se sugiere en la empresa Ponce Yepes S.A., con el objetivo de conseguir una eficiente y eficaz gestión de inventarios para la Línea de Repuestos John Deere. El estudio se ha dividido en tres capítulos, en los cuales se van estructurando progresivamente las diferentes etapas para el establecimiento del plan estratégico que se propone. El primer capítulo contiene un resumen teórico sobre la administración de inventarios, los conceptos, la clasificación y los modelos más difundidos. En el segundo capítulo se realiza el análisis de la situación actual de la empresa, enfocado a la Línea de Repuestos John Deere. Este capítulo incluye el análisis del entorno, el esquema de funcionamiento actual del sistema de inventarios, el análisis FODA, la determinación de los clientes internos y externos con sus correspondientes demandas, la elaboración y análisis de las matrices de evaluación de factores internos y externos, en forma individual y combinada; y, se presentan las listas de las estrategias a aplicarse. En el tercer capítulo se presenta la estructuración del plan estratégico, que está compuesto por la reformulación de la misión y visión, el establecimiento de objetivos globales para la gestión de repuestos John Deere, la formulación de las estrategias y políticas para alcanzar dichos objetivos y se concluye detallando el plan operativo, el cual incluye la matriz de aplicación del plan operativo, el cronograma de cumplimiento, el modelo de evaluación y seguimiento de dicho plan, y el flujo de caja del presupuesto de costos. Finalmente se presentan las conclusiones y recomendaciones resultantes del modelo de plan estratégico propuesto.

Nerve terminal GABAA receptors activate Ca2+/calmodulin-dependent signaling to inhibit voltage-gated Ca2+ influx and glutamate release

-Aminobutyric acid type A (GABAA) receptors, a family of Cl-permeable ion channels, mediate fast synaptic inhibition as postsynaptically enriched receptors for -aminobutyric acid at GABAergic synapses. Here we describe an alternative type of inhibition mediated byGABAA receptors present on neocortical glutamatergic nerve terminals and examine the underlying signaling mechanism(s). By monitoring the activity of the presynaptic CaM kinase II/synapsin I signaling pathway in isolated nerve terminals, we demonstrate that GABAA receptor activation correlated with an increase in basal intraterminal [Ca2]i. Interestingly, this activation of GABAA receptors resulted in a reduction of subsequent depolarization-evoked Ca2 influx, which thereby led to an inhibition of glutamate release. To investigate how the observed GABAA receptor-mediated modulation operates, we determined the sensitivity of this process to the Na-K-2Cl cotransporter 1 antagonist bumetanide, as well as substitution of Ca2 with Ba2, or Ca2/calmodulin inhibition by W7. All of these treatments abolished the modulation by GABAA receptors. Application of selective antagonists of voltage-gated Ca2 channels (VGCCs) revealed that the GABAA receptor-mediated modulation of glutamate release required the specific activity of L- and R-type VGCCs. Crucially, the inhibition of release by these receptors was abolished in terminals isolated from R-type VGCC knock-out mice. Together, our results indicate that a functional coupling between nerve terminal GABAA receptors and L- or R-type VGCCs is mediated by Ca2/calmodulin-dependent signaling. This mechanism provides a GABA-mediated control of glutamatergic synaptic activity by a direct inhibition of glutamate release.

Dr John Snow and an early investigation of groundwater contamination

John Snow was a physician but his studies of the way in which cholera is spread have long attracted the interest of hydrogeologists. From his investigation into the epidemiology of the cholera outbreak around the well in Broad Street, London, in 1854, Snow gained valuable evidence that cholera is spread by contamination of drinking water. Subsequent research by others showed that the well was contaminated by sewage. The study therefore represents one of the first, if not the first, study of an incident of groundwater contamination in Britain. Although he had no formal geological training, it is clear that Snow had a much better understanding of groundwater than many modern medical practitioners. At the time of the outbreak Snow was continuing his practice as a physician and anaesthetist. His casebooks for 1854 do not even mention cholera. Yet, nearly 150 years later, he is as well known for his work on cholera as for his pioneering work on anaesthesia, and his discoveries are still the subject of controversy.