A common polymorphism in the oxygen-dependent degradation (ODD) domain of hypoxia inducible factor-1alpha (HIF-1alpha) does not impair Pro-564 hydroxylation

The hypoxia-inducible factor (HIF) transcription complex, which is activated by low oxygen tension, controls a diverse range of cellular processes including angiogenesis and erythropoiesis. Under normoxic conditions, the alpha subunit of HIF is rapidly degraded in a manner dependent on hydroxylation of two conserved proline residues at positions 402 and 564 in HIF-1alpha in the oxygen-dependent degradation (ODD) domain. This allows subsequent recognition by the von Hippel-Lindau (VHL) tumor suppressor protein, which targets HIF for degradation by the ubiquitin-proteasome pathway. Under hypoxic conditions, prolyl hydroxylation of HIF is inhibited, allowing it to escape VHL-mediated degradation. The transcriptional regulation of the erythropoietin gene by HIF raises the possibility that HIF may play a role in disorders of erythropoiesis, such as idiopathic erythrocytosis (IE).

Northern Ireland:Democratizing for Development

This introductory article does three things. First, it indicates the general purpose of this special edition an d outlines the structure an d intention of the four main articles that follow. Secondly, it elaborates the arguments and theoretical discourse underpinning the articles, and thirdly, it locates these concerns and development initiatives not only in the specifiŽc regional context of Northern Ireland, but also in the wider framework of a new global econom y.

New Visions for Old Cities: The Role of Visioning in Planning

Many plans and strategies these days are underpinned by `visions'. This article examines the cultural and policy shift in planning in the UK toward more integrated and participative practice, and the potential role of visioning in this new climate. Reviewing examples of vision planning in the US, where the process has a longer lineage, it argues that these interventions suffer from a lack of evaluation of the effects of `visioning'. Yet this visioning approach has been adopted in certain cities and towns in Northern Ireland in recent years. This article assesses the impact of this approach in a detailed case study and finds the impact to have been modest.

Northern Ireland:The Development Context

This article provides a contextual framework for the new agenda for development, represented in the economic strategy known as Strategy 2010, and the regional spatial plan known as Shaping Our Future. These are considered in the following two articles. This article begins by setting a perspective on the political economy of Northern Ireland and follows with an outline of the spatial planning process. In conclusion, it raises the key challenges facing attempts to renew the region.

A methodological framework for studying policy coherence for development

The purpose of this article is to develop a methodological framework for analyzing Policy Coherence for Development (PCD). With this goal, we analyze different views of PCD in order to establish a comprehensive approach of Coherence adapted to globalization process. In this context, the article proposes a methodological framework based on four dimensions of analysis in CPD. In each dimen-sion, we set the areas and actors to investigate and we put forward research questions that could be use as a guide for a comprehensive approach to study PCD.

The (in)visible scar. Representation of the body in blogs by women with breast cancer

In this paper we analyze the representation of the body in blogs by women with breast cancer. Taking into account both texts and images, we study the representation of the body on the basis of the body problems proposed by Frank (1995): control, body-relatedness, other-relatedness and desire. In the blogs studied we find a desiring and dyadic body, which is understood as part of a network of affection and care. The diagnosis of cancer can generate both dissociation, when the body is experienced as a threat, and association, a wish to be connected to it. In relation to control, a clear will of predictability is observed but traces of assumption of contingency also appear.