Modelos de tratamento para adenocarcinomas de próstata tratados por radioterapia conformacional 3D

Radiotherapy is a branch of medical physics related to the treatment of malignant neoplasm, being an important instrument in the fight against cancer, when combined with the effort of a multidisciplinary team, composed of, physicians, physicists, nurses and technicians. Every year more than 3.5 million new cases of cancer are recorded in the world, being the prostate cancer responsible for approximately 25% of this amount (INCA and IARC, 2008). In this type of cancer, radiotherapy is a method indicated for treatement. The technological advance in this area over years has allowed a greater accuracy in the tumor location, more conformation of the radiation beam around the tumor, reducing the dose in healthy tissues and a consequent dose increase on treatment (Bedford et al., 1999). A radiotherapy planning, in which the physicist develops an important role, is composed of several steps, including choosing the best configuration of treatment beams. This choice has a close relationship with success of therapy and is critical to achieve the best distribution of dose inside the tumor and expose the least as possible the healthy tissue to radiation. In this work, two options for setting up camps in the first phase in a treatment of prostate cancer were simulated in computer planning: 4 fields orthogonal or “Box” with gantry angles in 00, 1800, 2700 e 90° and 4 fields angled or “X” (1350, 450, 3150 e 2250). The percentage of the rectal volume exposed to 40, 50, 60, 72 and 76 Gy should be limited to 60, 50, 25, 15 and 5% respectively (Greco et al., 2003). The femoral toxicity have limited dose by 70% of the total dose prescribed in a prostate treatment (Bedford et al., 1999). The planning of 27 patients with prostate adenocarcinoma submitted to 3D conformal radiotherapy were accompanied. As a result, it was assessed that the best TCP (tumor control probability)... (Complete abstract click electronic access below)

Dinâmica de rotação de exoplanetas tipo terrestre com perturbação de terceiro corpo

In this work we study some topics of Celestial Mechanics, namely the problem of rigid body rotation and “spin-orbit” resonances. Emphasis is placed on the problem formulation and applications to some exoplanets with physical parameters (e.g. mass and radius) compatible with a terrestrial type constitution (e.g. rock) belonging to multiple planetary systems. The approach is both analytical and numerical. The analytical part consists of: i) the deduction of the equation of motion for the rotation problem of a spherical body with no symmetry, disturbed by a central body; ii) modeling the same problem by including a third-body in the planet-star system; iii) formulation of the concept of “spin-orbit” resonance in which the orbital period of the planet is an integer multiple of the rotation’s period. Topics of dynamical systems (e.g. equilibrium points, chaos, surface sections, etc.) will be included at this stage. In the numerical part simulations are performed with numerical models developed in the previous analytical section. As a first step we consider the orbit of the planet not perturbed by a third-body in the star-planet system. In this case the eccentricity and orbital semi-major axis of the planet are constants. Here the technique of surface sections, widely used in dynamical systems are applied. Next, we consider the action of a third body, developing a more realistic model for planetary rotation. The results in both cases are compared. Since the technique of disturbed surface sections is no longer applicable, we quantitatively evaluate the evolution of the characteristic angles of rotation (e.g. physical libration) by studying the evolution of individual orbits in the dynamically important regions of phase space, the latter obtained in the undisturbed case

Caracterização de plasmas a partir do monômero digime através da espectrometria de massa: deposição polimérica

Pós-graduação em Engenharia Mecânica - FEG

Tetraethylortossilicate plasma thin film with hydrophilic and hydrophobic characteristics: Use on passive mixers

This work aims to obtain plasma thin film composites with hydrophobic/hydrophilic alternated regions, which are useful for the production of miniaturized mixers. These regions were acquired by two different strategies: either the codeposition of TEOS and HFE plasma thin films or the exposition of TEOS plasma films to ultraviolet radiation (UVA and UVC). These films were characterized by several chemical and physical techniques. The refractive indexes vary from 1.4 to 1.7; infrared and photoelectron spectroscopy detect Si-O-Si and CHn species. Silicone-like structures with high or low number of amorphous carbon microparticles and with fluorinated organic clusters were produced. Cluster dimensions were in the 1-5 mm range and they are made of graphite or COF (carbon/oxygen/fluorine) compounds. Scanning electron and optical microscopy showed rough surfaces. Water contact angles were 90º; however, for TEOS films that value changed after 6 hr of UVC exposure. Moreover, after UV exposure, organic polar compounds could be adsorbed in those films and water was not. The passive mixer performance was simulated using the FemLab 3.2® program and was tested with 20 nm thick films on a silicon wafer, showing the capacity of these films to be used in such devices.

Efeito de protocolos de jateamento na resistência à flexão e transformação de fase cristalina em cerâmicas de Y-TZP

Pós-graduação em Odontologia Restauradora - ICT

Projeto mecânico de um modelo para túnel de vento e validação de seus componentes à partir de simulações em software de elementos finitos

The objective of this study was to develop a model that allows testing in the wind tunnel at high angles of attack and validates its most critical components by analyzing the results of simulations in finite element software. During the project this structure suffered major loads identified during the flight conditions and, from these, we calculated the stresses in critical regions defined as the parts of the model that have higher failure probabilities. All aspects associated with Load methods, mesh refining and stress analysis were taken into account in this approach. The selection of the analysis software was based on project needs, seeking greater ease of modeling and simulation. We opted for the software ANSYS® since the entire project is being developed in CAD platforms enabling a friendly integration between software's modeling and analysis

Orientação espacial em pessoas com deficiência visual: um estudo de triangulação por meio de monitoramento remoto

This study was conducted to investigate how visually impaired people perform distance estimation tasks by movement and navigation during deprivation of effective perceptual and proprioceptive information. For that they performed the task of walking three distances, being the first and second of 100 meters and the third of 140 meters (triangulation) from a point of origin in open field on a inverted L shaped trajectory and then returning to the origin. The first and second tasks were driven by means of a guide with GPS adapted to the study coordinates, and the third one was freeform with three sessions, the first without perceptual and proprioceptive restrictions, the second without auditory perception, and the third in a wheelchair, without proprioception. The objective of this study was to indicate the differences in distance reproduction in relation to accuracy and investigate the spatial representation of participants in a navigation task, in which there is active movement, but no effective perceptual and proprioceptive information. Results showed that the average participants underestimated distances producing average angles close to the value of 45°. And by means of the "t" students test no significant differences between subjects can be pointed out. To achieve these results we used remote monitoring by GPS and software TrackMaker.

Longitudinal study on skeletal changes during and after bionator therapy using metallic implants

Aim: To demonstrate the magnitude and direction of skeletal changes in the maxilla and mandible during and after the use of bionator, as well as their rotations. Methods: Partial superimposition on the maxilla and mandible on the metallic implants and total superimposition on the cranial base were performed at three periods, T1 before bionator therapy, T2 after bionator therapy, and T3 5.68 years after T2. Results: There was total clockwise maxillary rotation and counterclockwise mandibular rotation, in the North American technique, throughout the study period, as well as extensive remodeling on the condylar region, especially in vertical direction and on the gonial region in horizontal direction. Conclusions: The total maxillary rotation seemed to be significantly affected by therapy than the mandible. There was a clear change in the direction of condylar remodeling compared to the period of bionator therapy and posterior bionator therapy. Considering the entire study period, it was observed that intra-matrix rotation of the maxilla and mandible masked their total rotation, causing minimum changes in the matrix rotation.

Avaliação das alterações dentárias e esqueléticas induzidas pelo uso do aparelho de Herbst no tratamento da classe II na dentadura mista: Revisão sistemática

Objective: evaluate the immediate dental and skeletal changes induced by the Herbst appliance on early treatment of Angle´s Class II malocclusion. Material and Method: several electronic databases such as Scopus, Pub Med, Medline, Cochrane Library, Lilacs and Scielo were searched. The abstracts that fullfilled the selection criteria were selected and those that did not provide enough information about these criteria were selected but the final decision of including them or not on the research, was taken after the complete reading of the article. The selection criteria were: clinical studies with Class II individuals, both male and female, with initial age of 7 to 10 years, treated with the Herbst appliance that analysed the dental and/or skeletal changes evaluated on lateral cephalometric radiographs; researches where the treatment performed did not involve extractions or surgical interventions; studies that included patients without syndromes or health concerns and articles published in English or Portuguese. Results and Conclusions: five articles were selected. The articles showed that significant changes happened in the mandibular sagittal lenght, on facial convexity angle, on maxillo-mandibular relationship, on retroclination of the upper incisors and on distal movement of the upper molars, on proclination of the lower incisors and on extrusion of the lower molars. The appliance exerted a limited effect on the anterior relocation of the maxillary complex and on facial heights. However, more studies about the performance of the Herbst appliance on early treatment of Class II are needed.

Influência da clorexidina na capacidade de umectabilidade da dentina hígida e afetada por cárie por um sistema adesivo

To evaluate the effect of chlorhexidine (CHX) on the wettability of sound and caries affected dentin by a simplified adhesive system. Material and Methods: Flat coronal dentin surfaces were produced on 60 sound molars, 30 of which were artificially decayed. The teeth were divided randomly into 3 groups (n = 10) with smear layer (SL), without SL impregnated with water and without SL impregnated with chlorhexidine. The SL removal was performed by phosphoric acid etching for 15 s. 20 uL of distilled water or 2% chlorhexidine digluconate were applied on the demineralized dentin for 60 s. Then, a drop of Single Bond 2 was deposited on each surface. Contact angles between dentin surface and adhesive was measured by means of a goniometer and data were submitted to ANOVA and Tukey tests (α = 0.05). Results: Higher contact angles were obtained on sound versus caries affected dentin (p <0.05), regardeless of the surface treatment. For both substrates, contact angles statistically higher were obtained for dentin covered with SL (P <0.05). The SL removal resulted in significant reduction of the angles (P <0.05) and no difference was found among angles produced on demineralized dentin impregnated with water or chlorhexidine (p> 0.05). Conclusion: Caries affected dentin wettability was higher than sound dentin and that characteristic was not influenced by chlorhexidine application.

Efeito do ângulo de trabalho do ultrassom e do jato de bicarbonato sobre as superfícies ranculares

The aim of this study was to evaluate the effect of the working angle variation of the magnetoestritive ultrasonic (MU) and air polishing devices (APD) on the roughness and wear of dental root. Fifty bovine incisive teeth were used in this study. The proximal surfaces of the teeth were divided in three regions: coronal, median, and an apical. The coronal region was treated with a manual scaler, the apical region was treated with APD or with a MU and the medium region was maintained untreated to serve as a control. The teeth were divided in 11 groups according to the treatment applied: MU-0º; MU-30º; MU-45º; MU-60º; MU-90º; AP-0º; AP-30º; AP-45º; AP-60º; AP-90º; MS: manual scaler. To the statistical analysis, data submitted to the Anova and Tukey's test (p < 0.05). The manual curette promotes less roughness and higher tooth wear in comparison with the both ultrasonic and air polishing devices (p < 0.05). The angles of 45º, 60º and 90º caused higher rate of tooth wear and roughness when the MU was used (p < 0.05), while the angle of 90° caused a higher tooth wear than the angle of 30° when the APD was used (p < 0.05). The working angle variation influenced the tooth wear and roughness promoted by MU, whereas when using APD, the working angle variation influenced only the tooth wear.

Effect of surface roughness on the hydrophobicity of a denture-base acrylic resin and Candida albicans colonization

Aim The aim of the present study was to evaluate the effect of surface roughness (roughness average [Ra] μm) on the hydrophobicity of a denture-base acrylic resin and the initial adherence and biofilm formation of Candida albicans (C. albicans). Methods Disk-shaped specimens were divided into six groups: Ra 0.05, Ra 0.2, Ra 0.4, Ra 0.8, Ra 1.5, and Ra 3.0. Water contact angles (WCA) were measured, and the specimens incubated with C. albicans for 90 min (initial adherence, n = 108) or 48 h (biofilm formation, n = 108). Adhered and biofilm cells were evaluated by c.f.u./mL and 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT), and the correlation between the two methods was evaluated. The surface of the specimens and cells (adhered and biofilm) were also analyzed by scanning electron microscopy (SEM). Results Groups Ra 0.05 and 3.0 exhibited the lowest (~75°) and the highest (~100°) WCA mean values, respectively. For both initial adherence and biofilm formation, no statistically-significant differences were observed among all groups, as determined by c.f.u./mL and XTT. A positive correlation between these two methods was found. SEM analysis showed the presence of scratches and valleys on the acrylic specimens and densely-packed yeast cells covering the entire surface. Conclusions Roughness significantly increased hydrophobicity (WCA), but had no effect on the number and metabolic activity of adherent and biofilm cells of C. albicans.

The effect of the angle of instrumentation of the piezoelectric ultrasonic scaler on root surfaces

To evaluate the influence of variations in the working angle of the piezoelectric ultrasonic scaler (PUS) on root surfaces. Material and methods Fifty-five uniradicular bovine teeth were used, of which 25 teeth were used for the analysis of the roughness and root wear, while the remaining 30 teeth were used for the analysis of morphology (MRS) and the attachment of blood components (ABC). The teeth were randomly divided into five groups according to the type of treatment (G1-G5: piezoelectric ultrasonic scaler; G6: manual curette) and to the PUS working angle applied (G1: 0°; G2: 30°; G3: 45°; G4: 60°; G5: 90°). For statistical analysis, the data describing the MRS and ABC were analysed by the Kruskal–Wallis and Dunn's tests, and the data describing the roughness and tooth wear were analysed by anova and Tukey's tests at the significance level of 5%. Results Manual curette (MC) promoted a smoother root surface than the application of the PUS. The PUS used at the angles of 30° and 45° resulted in a high level of ABC that was comparable to that obtained by MC. Additionally, the group in which the PUS was applied at an angle of 45° exhibited less tooth wear than the other groups. Conclusions Changes in the working angle of the PUS influenced the characteristics of root surfaces after instrumentation.

Influence of the rotary and/or oscillatory reciprocating systems in the morphological changes of narrow and curved molar root canals anatomy

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Dental and skeletal components of Class II open bite treatment with a modified Thurow appliance

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)