Central line sepsis in intensive care units : overview and update

Catheter-related infection remains a leading cause of nosocomial infections, particularly in intensive care units. It includes colonization of the device, skin exit-site infection and device- or catheter-related bloodstream infection. The latter represents the most frequent life-threatening associated complication of central venous catheter use and is associated with significant patient morbidity, mortality and extra hospital costs. The incidence of catheter-related bloodstream infection ranges from 2 to 14 episodes per 1000 catheter-days. On average, microbiologically-documented device-related bloodstream infections complicate from three to five per 100 central venous line uses, but they only represent the visible part of the iceberg and most clinical sepsis are nowadays considered to be catheter-related. We briefly review the pathophysiology of infection, highlighting the importance of the skin insertion site and of intravenous line hub as principal sources of colonization. Principles of therapy are reviewed. Several preventive approaches are also discussed, in particular the possible benefit of recently developed impregnated catheters. Finally, the potential positive impact of a multimodal global preventive strategy based on strict application of hygienic rules is presented.

1st Conference on Arts-Based and Artistic Research. Critical reflections on the intersection between art and research

[eng] Proceedings for the 1st Conference on Arts-Based and Artistic Research: Critical Reflections on the Intersection of Art and Research. University of Barcelona, January 31st - February 1st, 2013.

Consumer Advisory: Hold the Line on Annoying Robocalls How to respond to unwanted or illegal prerecorded robocalls October 2014

The Attorney General’s Consumer Protection Division receives hundreds of calls and consumer complaints every year. Follow these tips to avoid unexpected expense and disappointments. This record is about: Hold the Line on Annoying Robocalls How to respond to unwanted or illegal prerecorded robocalls

Brief alcohol intervention and alcohol assessment do not influence alcohol use in injured patients treated in the emergency department: a randomized controlled clinical trial.

AIMS: To evaluate the effectiveness of brief alcohol intervention (BAI) in reducing alcohol use among hazardous drinkers treated in the emergency department (ED) after an injury; in addition it tests whether assessment of alcohol use without BAI is sufficient to reduce hazardous drinking. DESIGN: Randomized controlled clinical trial with 12-month follow-up conducted between January 2003 and June 2005. SETTING: Urban academic emergency department (ED) of the Lausanne University Hospital, Lausanne, Switzerland. PARTICIPANTS: A total of 5136 consecutive patients attending ED after an injury completed a seven-item general and a three-item alcohol screen and 1472 (28.7%) were positive for hazardous drinking according to the National Institute on Alcohol Abuse and Addiction definition; of these 987 (67.1%) were randomized into a BAI group (n = 310) or a control group with screening and assessment (n = 342) or a control group with screening only (n = 335) and then a total of 770 patients (78.0%) completed the 12-month follow-up procedures. INTERVENTION: A single 10-15-minute session of standardized BAI conducted by a trained research assistant. MEASUREMENTS: Percentage of participants who have changed to low-risk drinking at follow-up. FINDINGS: Data obtained at 12 months indicated that similar proportions were low-risk drinkers in BAI versus control groups with and without assessment (35.6%, 34.0%, 37.0%, respectively, P = 0.71). Data also indicated similar reductions in drinking frequency, quantity, binge drinking frequency and Alcohol Use Disorders Identification Test (AUDIT) scores across groups. All groups reported similar numbers of days hospitalized and numbers of medical consults in the last 12 months. A model including age groups, gender, AUDIT and injury severity scores indicated that BAI had no influence on the main alcohol use outcome. CONCLUSIONS: This study provides the evidence that a 10-15-minute BAI does not decrease alcohol use and health resource utilization in hazardous drinkers treated in the ED, and demonstrates that commonly found decreases in hazardous alcohol use in control groups cannot be attributed to the baseline alcohol assessment.

Violencia doméstica: sexo y género en las teorías psicosociales sobre la violencia. Hacia otras propuestas de comprensión e intervención = Domestic violence: sex and gender in psychosocial theories about violence. New approach to it comprehension and intervention

En el artículo se presenta la violencia doméstica como violencia política de género masculino. Se señalan el individualismo, la naturalización y el sexismo en el tratamiento de la violencia y la agresión así como de la identidad, por parte de la psicología tradicional, como factores que dificultan las intervenciones en la violencia doméstica. Los prejuicios, valores y estrategias de la sociedad patriarcal continúan influyendo en ellas. Desde la psicología crítica feminista se propone: a) una comprensión de la subjetividad, la diferencia sexo-género y la violencia como construcciones sociales; b) intervenciones menos autoritarias y que no participen en la reproducción del orden social; c) la incorporación de las resistencias desarrolladas; d) un análisis basado en las relaciones de poder y las prácticas discursivas

Brief intervention on tobacco use among young adults - do they benefit from booster sessions?

Introduction Le tabac représente un risque majeur pour la santé de chacun, avec un lien direct établi entre le risque de développer des pathologies et la durée de sa consommation. Les jeunes sont donc des cibles primordiales pour la prévention du tabac ; les quelques recherches effectuées dans ce groupe d'âge ne sont pas encore parvenues à identifier des moyens efficaces afin d'éviter le début de la cigarette ou d'arrêter une consommation préexistante. Les buts de cette étude sont d'identifier les effets de l'intervention motivationnelle brève et de définir la nécessité d'un booster dans cette catégorie particulière de la population que sont les jeunes hommes de 19 ans. Méthodes Cette étude a été menée d'octobre 2008 à septembre 2009 au centre de recrutement de Lausanne, Vaud. Les individus étaient invités à participer à une intervention motivationnelle brève ciblant simultanément le tabac, l'alcool et le cannabis, sans screening préalable. Les 823 volontaires ont été assignés de manière randomisée entre les groupes cas et témoin, avec dans le groupe intervention une nouvelle randomisation attribuant un booster téléphonique trois mois plus tard à certains cas. Ce travail se fixe uniquement sur les résultats concernant le tabac, six mois après l'intervention. Les effets (statut de fumeur et de fumeur quotidien, nombre de cigarettes fumées en moyenne, dépendance à la cigarette selon les critères de Fagerström) étaient analysés sur la base d'un questionnaire écrit au baseline, puis d'un contact téléphonique au follow-up à six mois ; ils ont été analysés séparément pour différents groupes : l'entier des participants, les fumeurs et les fumeurs quotidiens. Résultats Les interventions motivationnelles brèves n'ont aucun effet significatif sur la consommation de tabac. Elles ont cependant une tendance bénéfique sur le fait d'être de fumeur et fumeur quotidien, sur le nombre de cigarettes consommées en moyenne et la dépendance selon Fagerström chez tous les participants, ainsi que dans les sous-groupes de fumeurs et fumeurs quotidiens. Les résultats des boosters ne sont pas significatifs et entraînent des effets mitigés selon les analyses effectuées et les groupes observés. Discussion Les interventions motivationnelles brèves n'ont pas d'effet significatif mais semblent avoir une tendance favorable à une diminution de la consommation de tabac. Les boosters ne paraissent pas avoir d'impact bénéfique mais ces conclusions sont à pondérer avec le fait qu'aucun des résultats obtenus n'est significatif. Des recherches plus systématiques sont nécessaires pour mieux comprendre ces résultats décevants : en ce qui concernent les interventions, les causes à envisager sont le fait d'utiliser des volontaires sans screening préalable, de cibler l'intervention sur de multiples substances pendant un temps relativement court ou encore la difficulté de cibler les jeunes vis-à-vis des risques liés à la cigarette ; quant aux boosters, une augmentation de fréquence ou de durée pourrait représenter une alternative, afin de rendre cette session complémentaire efficace.

On-line desorption of dried blood spot: A novel approach for the direct LC/MS analysis of micro-whole blood samples.

The aim of this work is to present a new concept, called on-line desorption of dried blood spots (on-line DBS), allowing the direct analysis of a dried blood spot coupled to liquid chromatography mass spectrometry device (LC/MS). The system is based on an inox cell which can receive a blood sample (10 microL) previously spotted on a filter paper. The cell is then integrated into LC/MS system where the analytes are desorbed out of the paper towards a column switching system ensuring the purification and separation of the compounds before their detection on a single quadrupole MS coupled to atmospheric pressure chemical ionisation (APCI) source. The described procedure implies that no pretreatment is necessary in spite the analysis is based on whole blood sample. To ensure the applicability of the concept, saquinavir, imipramine, and verapamil were chosen. Despite the use of a small sampling volume and a single quadrupole detector, on-line DBS allowed the analyses of these three compounds over their therapeutic concentrations from 50 to 500 ng/mL for imipramine and verapamil and from 100 to 1000 ng/mL for saquinavir. Moreover, the method showed good repeatability with relative standard deviation (RSD) lower than 15% based on two levels of concentration (low and high). Function responses were found to be linear over the therapeutic concentration for each compound and were used to determine the concentrations of real patient samples for saquinavir. Comparison of the founded values with those of a validated method used routinely in a reference laboratory showed a good correlation between the two methods. Moreover, good selectivity was observed ensuring that no endogenous or chemical components interfered with the quantitation of the analytes. This work demonstrates the feasibility and applicability of the on-line DBS procedure for bioanalysis.

The Lunch Line, Fall 2009

Newsletter produced by Department of Education, Bureau of Food and Nutrition

The Lunch Line, Spring 2010

Newsletter produced by Department of Education, Bureau of Food and Nutrition

The Lunch Line, Summer 2009

Newsletter produced by Department of Education, Bureau of Food and Nutrition

The Lunch Line, Winter 2009

Newsletter produced by Department of Education, Bureau of Food and Nutrition

The Lunch Line, Fall 2010

Newsletter produced by Department of Education, Bureau of Food and Nutrition

The Lunch Line, Spring 2011

Newsletter produced by Department of Education, Bureau of Food and Nutrition

The Lunch Line, Summer 2011

Newsletter produced by Department of Education, Bureau of Food and Nutrition