Na 1 Nachlass Max Horkheimer, 578 - Korrespondenzen mit Friedrich (Frederick) Pollock (p. VI 33, 1-360)

1 Brief von Margot von Mendelssohn an Alice H. Maier, 31.12.1942; 1 Drucksache von Fortune [amerikanische Zeitschrift], Dezember 1942; 1 Brief von Frederick Pollock an Bay District Motors Co. (Santa Monica), 17.09.1942; 3 Briefe zwischen Robert M. MacIver und Frederick Pollock, 1943; 2 Briefe zwischen Frederick Pollock und David Rosenblum, 1943; 1 Brief von Robert S. Lynd an Frederick Pollock, 26.04.1943; 1 Brief von Sheed and Ward Inc. (New York) an Max Horkheimer, 08.02.1943; 1 Telegramm von Juliane Favez an Frederick Pollock, 06.02.1943; 1 Brief von Max Horkheimer an das Federal Bureau of Investigation (Los Angeles), 13.01.1943; 1 Brief von Hannah Tillich an Frederick Pollock, 11.01.1943;

Na 1 Nachlass Max Horkheimer, 579 - Korrespondenzen mit Friedrich (Frederick) Pollock (p. VI 33, 361-548)

3 Briefe zwischen Robert M. Mac Iver und Frederick Pollock, 1943; 1 Brief von dem Office of Strategic Services (Washington) an Frederick Pollock, 14.09.1943; 1 Brief von dem U. S. Government Printing Office (Washington) an Frederick Pollock, 01.09.1943; 1 Brief von Frederick Pollock an Franco Bruno Averardi, 19.07.1943; 1 Brief von Frederick Pollock an Leo Löwenthal, 15.07.1943; 1 Brief von Emil E. Mayer an F. Landauer, 28.05.1943; 2 Briefe zwischen Frederick Pollock und Erich Rosenberg, 1943; 1 Brief von Frederick Pollock an George Mintzer, 12.05.1943; 1 Brief von Iago Galdstone (Arzt) an Frederick Pollock, 10.05.1943; 1 Brief von Frederick Pollock an Theodor W. Adorno, 11.05.1943; 1 Brief von Frederick Pollock an den British Information Services (New York), 11.05.1943;

Ms. lat. oct. 33 - Logica

Vorbesitzer: Martinus Christianus

Ms. lat. qu. 33 - Geschichte des Papsttums. Schweiz, Neapel. Hugenotten.

Vorbesitzer: Johann Maximilian Zum Jungen

Tumor heterogeneity dictates sensitivity to gefitinib (Iressa(TM)/ZD1839) in solid tumor models

The epidermal growth factor receptor (EGFR) and its ligands are overexpressed in many human tumors, including bladder and pancreas, correlating with a more aggressive tumor phenotype and poor patient prognosis. We initiated the present study to characterize the heterogeneity of gefitinib responsiveness in a panel of human bladder and pancreatic cancer cell lines in order to identify the biological characteristics of EGFR-dependent proliferation that could be used to prospectively identify drug-sensitive tumors. A second objective was to elucidate how to best exploit these results by utilizing gefitinib in combination therapy. To these ends, we examined the effects of the EGFR antagonist gefitinib on proliferation and apoptosis in a panel of 18 human bladder cancer cell lines and 9 human pancreatic cancer cell lines. Our data confirmed the existence of marked heterogeneity in Iressa responsiveness with less than half of the cell lines displaying significant growth inhibition by clinically relevant concentrations of the drug. Gefitinib responsiveness was found to be p27 kip1 dependent as DNA synthesis was restored following exposure to p27siRNA. Unfortunately, Iressa responsiveness was not closely linked to surface EGFR or TGF-α expression in the bladder cancer cells, however, cellular TGF-α expression correlated directly with Iressa sensitivity in the pancreatic cancer cell lines. These findings provide the potential for prospectively identifying patients with drug-sensitive tumors. ^ Further studies aimed at exploiting gefitinib-mediated cell cycle effects led us to investigate if gefitinib-mediated TRAIL sensitization correlated with increased p27kip1 accumulation. We observed that increased TRAIL sensitivity following gefitinib exposure was not dependent on p27 kip1 expression. Additional studies initiated to examine the role(s) of Akt and Erk signaling demonstrated that exposure to PI3K or MEK inhibitors significantly enhanced TRAIL-induced apoptosis at concentrations that block target phosphorylation. Furthermore, combinations of TRAIL and the PI3K or MEK inhibitors increased procaspase-8 processing above levels observed with TRAIL alone, indicating that the effects were exerted at the level of caspase-8 activation, considered the earliest step in the TRAIL pathway. ^

Geochemistry and mineralogy at DSDP Holes 61-462, 61-462A and 33-315A

Sedimentary rocks of Barremian through early Maestrichtian age recovered on Deep Sea Drilling Project Leg 61 had their principal source in the complex of igneous rocks with which they are interlayered in the Nauru Basin. Relict textures and primary sedimentary structures show these Cretaceous sediments to be of hyaloclastic origin, in part reworked and redeposited by slumps and currents. The dominant composition now is smectite, but locally iron, titanium, and manganese oxides, plagioclase, pyroxene, analcime, clinoptilolite, chalcedonic quartz, cristobalite, amphibole, nontronite, celadonite, and pyrite are also present. The mineral assemblages and the geochemistry reflect the original basaltic composition and its subsequent alteration by one or more processes of submarine weathering, authigenesis, hydrothermal circulation, and contact metamorphism. Hyaloclastitic sandstone, siltstone, and breccia within the sheet flows below 729 meters sub-bottom depth have Barremian fossils, thus establishing the age of the lower, or extrusive, complex of post-ridge-crest volcanism. Similar hyaloclastites between 564 and 729 meters are invaded by hypabyssal sills of the upper igneous complex, and fossil ages of Albian or Cenomanian set an older limit to the age of that second post-ridge-crest episode. Cenomanian to early Campanian sedimentary rocks between 490 and 564 meters have a substantial contribution of clays of submarine-weathered-basalt origin, as well as hydrothermal and pelagic components. The interval of reworked hyaloclastitic siltstone, sandstone, and breccias between 450 and 490 meters is of late Campanian and early Maestrichtian age. These sediments probably formed from glassy basalt that fragmented upon eruption nearby, when sills were being emplaced. In addition to pelagic elements, these Upper Cretaceous volcanogenic sediments include redeposited material of shallow-water origin, apparently derived from the Marshall Islands.

Los sospechosos colonos extranjeros de Misiones (1930-43). En: Estudios Regionales, v. 1, n° 1

El período político que se abre en septiembre de 1930 hasta el 4 de junio de 1943, es conocido por distintos nombres: "década infame", "fraude patriótico" o "restauración oligárquica". Lo cierto que todas estas denominaciones aluden a la conformación de los distintos sectores que usufructuaron el poder, a sus relaciones sociales y económicas y al método que eligieron para llegar a los cargos.

(Table DR1) Trace element contents in basalts from ODP Hole 33-317A

Numerous large igneous provinces formed in the Pacific Ocean during Early Cretaceous time, but their origins and relations are poorly understood. We present new geochronological and geochemical data on rocks from the Manihiki Plateau and compare these results to those for other Cretaceous Pacific plateaus. A dredged Manihiki basalt gives an 40Ar-39Ar age of 117.9+/-3.5 Ma (2 sigma), essentially contemporaneous with the Ontong Java Plateau ~2500 km to the west, and the possibly related Hikurangi Plateau ~3000 km to the south. Drilled Manihiki lavas are tholeiitic with incompatible trace element abundances similar to those of Ontong Java basalts. These lavas may result from high degrees of partial melting during the main eruptive phase of plateau formation. There are two categories of dredged lavas from the Danger Islands Troughs, which bisect the plateau. The first is alkalic lavas having strong enrichments in light rare earth and large-ion lithophile elements; these lavas may represent late-stage activity, as one sample yields an 40Ar-39Ar age of 99.5+/-0.7 Ma. The second category consists of tholeiitic basalts with U-shaped incompatible element patterns and unusually low abundances of several elements; these basalts record a mantle component not previously observed in Manihiki, Ontong Java, or Hikurangi lavas. Their trace element characteristics may result from extensive melting of depleted mantle wedge material mixed with small amounts of volcaniclastic sediment. We are unaware of comparable basalts elsewhere.