Associations between Intake of Folate, Methionine, and Vitamins B-12, B-6 and Prostate Cancer Risk in American Veterans.

Prostate cancer (PC) is the second leading cause of cancer death in men. Recent reports suggest that excess of nutrients involved in the one-carbon metabolism pathway increases PC risk; however, empirical data are lacking. Veteran American men (272 controls and 144 PC cases) who attended the Durham Veteran American Medical Center between 2004-2009 were enrolled into a case-control study. Intake of folate, vitamin B12, B6, and methionine were measured using a food frequency questionnaire. Regression models were used to evaluate the association among one-carbon cycle nutrients, MTHFR genetic variants, and prostate cancer. Higher dietary methionine intake was associated with PC risk (OR = 2.1; 95%CI 1.1-3.9) The risk was most pronounced in men with Gleason sum <7 (OR = 2.75; 95%CI 1.32- 5.73). The association of higher methionine intake and PC risk was only apparent in men who carried at least one MTHFR A1298C allele (OR = 6.7; 95%CI = 1.6-27.8), compared to MTHFR A1298A noncarrier men (OR = 0.9; 95%CI = 0.24-3.92) (p-interaction = 0.045). There was no evidence for associations between B vitamins (folate, B12, and B6) and PC risk. Our results suggest that carrying the MTHFR A1298C variants modifies the association between high methionine intake and PC risk. Larger studies are required to validate these findings.

Outcomes of metallic stents for malignant ureteral obstruction.

PURPOSE: Malignant ureteral obstruction often necessitates chronic urinary diversion and is associated with high rates of failure with traditional ureteral stents. We evaluated the outcomes of a metallic stent placed for malignant ureteral obstruction and determined the impact of risk factors previously associated with increased failure rates of traditional stents. MATERIALS AND METHODS: Patients undergoing placement of the metallic Resonance® stent for malignant ureteral obstruction at an academic referral center were identified retrospectively. Stent failure was defined as unplanned stent exchange or nephrostomy tube placement for signs or symptoms of recurrent ureteral obstruction (recurrent hydroureteronephrosis or increasing creatinine). Predictors of time to stent failure were assessed using Cox regression. RESULTS: A total of 37 stents were placed in 25 patients with malignant ureteral obstruction. Of these stents 12 (35%) were identified to fail. Progressive hydroureteronephrosis and increasing creatinine were the most common signs of stent failure. Three failed stents had migrated distally and no stents required removal for recurrent infection. Patients with evidence of prostate cancer invading the bladder at stent placement were found to have a significantly increased risk of failure (HR 6.50, 95% CI 1.45-29.20, p = 0.015). Notably symptomatic subcapsular hematomas were identified in 3 patients after metallic stent placement. CONCLUSIONS: Failure rates with a metallic stent are similar to those historically observed with traditional polyurethane based stents in malignant ureteral obstruction. The invasion of prostate cancer in the bladder significantly increases the risk of failure. Patients should be counseled and observed for subcapsular hematoma formation with this device.

Accuracy of proactive case finding for mental disorders by community informants in Nepal.

BACKGROUND: Accurate detection of persons in need of mental healthcare is crucial to reduce the treatment gap between psychiatric burden and service use in low- and middle-income (LAMI) countries. AIMS: To evaluate the accuracy of a community-based proactive case-finding strategy (Community Informant Detection Tool, CIDT), involving pictorial vignettes, designed to initiate pathways for mental health treatment in primary care settings. METHOD: Community informants using the CIDT identified screen positive (n = 110) and negative persons (n = 85). Participants were then administered the Composite International Diagnostic Interview (CIDI). RESULTS: The CIDT has a positive predictive value of 0.64 (0.68 for adults only) and a negative predictive value of 0.93 (0.91 for adults only). CONCLUSIONS: The CIDT has promising detection properties for psychiatric caseness. Further research should investigate its potential to increase demand for, and access to, mental health services.

Molecular dissociation of FHA-induced IL-10 and IL-12 secretion by human dendritic cells.

info:eu-repo/semantics/nonPublished

Role of the IL-10/IL-12 balance in the primary cellular immune response of infants to pertussis vaccines

info:eu-repo/semantics/nonPublished

Effects of different molecular forms of FHA on IL-10 and IL-12 secretions by human dendritic cells.

info:eu-repo/semantics/nonPublished

Con máquinas propias o con las del contratista : puntos de indiferencia a través de 12 años

p.235-240

Respuestas morfo fisiológicas en Aglaonema Commutatum ante cambios en la intensidad y calidad de la luz

p.113-126

Razonamiento inductivo de 12 alumnos de secundaria en la resolución de un problema matemático

En este trabajo se presenta el resultado obtenido del análisis de un proceso de razonamiento inductivo desarrollado por 12 estudiantes de secundaria en un contexto de resolución de problemas. Se plantea un problema, en el transcurso de una entrevista, que consiste en determinar el número máximo de regiones que se obtienen al trazar rectas sobre un plano. Durante la resolución del problema los estudiantes, y a través del dialogo con el entrevistador, han de explicar y justificar sus decisiones. Centrándonos en el trabajo de Pólya y en otras investigaciones previas relacionadas sobre este tema, se define un sistema de categorías mediante las cuales se organizan los datos para su análisis.

Cuestiones metodológicas en la investigación educativa

En este trabajo pretendemos sintetizar algunas cuestiones de método aplicables a la investigación educativa. Para ello reflexionamos sobre el método seguido para la realización de una amplia investigación de referencia, Vallecillos (1994), que pertenece al campo de la educación estadística. Es un ejemplo de lo que podemos llamar ‘método estadístico’ que puede aplicarse como ‘modelo’ en la investigación educativa en general. Se incluyen también, a modo de ejemplo de su funcionamiento, los resultados obtenidos en esa investigación sobre la comprensión de un concepto clave en los contrastes de hipótesis como el nivel de significación.

imátgenes 10, 11 y 12

Fue el último en poseerla quien, instantes antes de perderla para siempre y movido por una presunción ya del todo instintiva, bautizó la ciudad con el nombre de Memoria grafiando esa palabra en las fachadas de las avenidas. Presumió que en un futuro, muy lejano quizá pero alcanzable, y a pesar de los trazos ya inseguros de su escritura afectada, alguien podría leerla y recobrar la lucidez.

Bases para un planteamiento actual de la geometría en la enseñanza secundaria obligatoria (12-16)

Propuesta para un planteamiento de la Geometría en la Enseñanza Secundaria Obligatoria (12-16), siguiendo las directrices del Diseño Curricular Base.

[Recording review] William Herschel, Symphonies Nos. 2, 8, 12, 13, 14, 17

Tony Mann provides a review of the recording: William Herschel, Symphonies Nos. 2, 8, 12, 13, 14, 17, soloists, London Mozart Players / Matthias Bamert, Chandos 10048, 2003, (68 mins). [CD]