Estudo reológico de sistemas gelatina/colágeno/amido para obtenção de géis e aplicação dietéticas de gelatina

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo da influência da proporção de um mix leite/popa da marcacujá na produção de pó obtido por três diferentes tipos de secagem

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

O projeto de educação Ambiental Aprendendo com a Natureza como ponto de partida para uma ação formativa de professores do Ensino Fundamental

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A natureza comportamental da mente: behaviorismo radical e filosofia da mente

Pós-graduação em Filosofia - FFC

Estudo de fatores genéticos e de ambiente para reatividade na raça Nelore

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Caracterização química, física e térmica de pellets de madeira produzidos no Brasil

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Regeneração natural de um fragmento de cerrado degradado com a formação de pastagens de braquiária (Urochloa decumbens (Stapf) R. D. Webster)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A virtual contradiction between international migration and human rights

Abstract If there is a geographical area that will be particularly affected by the tragedy of September 11, that will be the international borders of the United States. It is understandable that a country that enters in a state of war after been attacked with enormous losses, reacts by closing its international borders. Such immediate reaction has now been substituted by a more strict control over everything that crosses the border but, a fact remains, the border life is not going to be what it used to before September 11. In the short run, everything that crosses the border has slowed down by new controls. In the long run many things will return to what it was before that Tuesday, but for a long while, life at the border will not be the same. An intense interaction of more than twelve million people from the two sides of the U.S.-Mexico border have made us live in many instances as if the border does not exist. This is the case among many of us in the way we practice our family life. For the planning of weddings, birthdays, reunions, ceremonies, the border is more virtual than real. This is reversed as we get more serious in what it means to the space where institutions, the laws and the governments reminds us that there is a line that marks the beginning and the end of two different nations.

Rastreabilidade da farinha de vísceras de aves em codornas submetidas a longo período de criação utilizando a técnica dos isótopos estáveis 'delta' 'intpot. 13 c' e 'delta' 'intpot. 15 N'

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Refuncionalização de Brownfields: estudo de caso na zona leste de São Paulo-SP

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo de correlação entre as provas bioquímicas de função hepática, no diagnóstico de hepatite aguda pelo vírus da hepatite A em crianças

Pós-graduação em Pediatria - FMB

Reforma do Estado e transformação das elites econômicas e políticas de São Paulo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Bagaço de cana-de-açúcar hidrolisado para coelhos em crescimento

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Brincar e desenvolvimento: um estudo sobre as concepções de professores de educação infantil

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Inovação do método MIA-QSAR: aplicação para doenças tropicais negligenciadas

Multivariate image analysis applied to the quantitative structure-activity relationships (MIA-QSAR) is a 2D QSAR technique that has been presenting promising outcomes for the development of new drug candidates, due to its simplicity, rapidity and low cost. In this way, the present study aims at introducing, consolidating and improving the new dimensions named aug-MIA-QSAR and aug-MIA-QSARcolor, as well as applying them to the study of neglected diseases, in order to obtain new drug targets using chemico-biological interpretation of the MIA molecular descriptors. Four compound data sets with experimental bioactivities against Chagas disease, malaria, dengue and schistosomiasis were evaluated using three approaches: MIA-QSARt, aug-MIA-QSAR and aug-MIA-QSARcolor. In general, representations of atoms as spheres with different colors and sizes proportional to the corresponding van der Waals radii (aug-MIA approaches) improved the predictive ability and interpretability in all data sets. The use of colors proportional to the Pauling´s electronegativity showed that MIA descriptors are capable of identifying periodic properties relevant for the studied activity. Finally, solid colors instead of spotlighted atoms allowed a correct identification of atoms by means of pixel values in the studies for malaria, dengue and schistosomiasis, which were, subsequently, useful for the chemical interpretation related to the bioactivity. It can be inferred that semicarbazones and thiosemicarbazones derivative with a tri-substituted ring in R1 group and a trifluoro methyl group in the R 3 position instead of a chlorine antitripanossoma resulted in higher activity. The antimalarial activity of quinolon-4(1H)imines can be improved if: 1) R1 and R2 are electron donor groups, 2) R3 has long aminoalkyl chains, and 3) R4 possesses substituents with big atomic volume. In the study for dengue, it was found that tetrapeptides with unbranched small size amino acids in the A1 and A4 positions can increase the substrate affinity (Km) to the NS3 protein, and when in A1 and A2 positions, the substrate cleavage rate (kcat). On the other hand, acidic amino acids in the A2 and A4 positions were found to be related with low substrate affinity to the NS3 protein and when present in A1, with low substrate cleavage rate. Finally, the presence of metoxy substituents in R1 (or R2) and R5 in the neolignan backbone can favor their antischistosomal activity.