Novel pathogenic pathways in diabetic neuropathy.

Diabetic peripheral neuropathy (DPN) is a common complication affecting more than one third of diabetes mellitus (DM) patients. Although all cellular components participating in peripheral nerve function are exposed to and affected by the metabolic consequences of DM, nodal regions, areas of intense interactions between Schwann cells and axons, may be particularly sensitive to DM-induced alterations. Nodes are enriched in insulin receptors, glucose transporters, Na(+) and K(+) channels, and mitochondria, all implicated in the development and progression of DPN. Latest results particularly reinforce the idea that changes in ion-channel function and energy metabolism, both of which depend on axon-glia crosstalk, are among the important contributors to DPN. These insights provide a basis for new therapeutic approaches aimed at delaying or reversing DPN.

Pieces of Iowa’s Past, January 25, 2012

Pieces of Iowa’s Past, published by the Iowa State Capitol Tour Guides weekly during the legislative session, features historical facts about Iowa, the Capitol, and the early workings of state government. All historical publications are reproduced here with the actual spelling, punctuation, and grammar retained. January 25, 2012 THIS WEEK: HOUSE RESOLUTIONS PRESENTED ON JANUARY 8, 1866 BACKGROUND: Background: The 11th General Assembly convened January 8, 1866, and adjourned April 3, 1866—an 86-day session. There were 146 members in the legislature, 48 senators and 98 representatives. Iowa’s Governor was William Milo Stone, and the 1860 census showed Iowa’s population at 482,699. Robert Finkbine represented House district 26. It was Finkbine’ s second term. He was 37 and listed his occupation as “builder.” Robert Finkbine went on to become the Superintendent of Construction for the present day Capitol. House district 26 represented Johnson County in 1866. In 1878, Marion County became the constituency for House district 26. The representative in House district 26 in 1878 was William Milo Stone, previous governor and resident of Knoxville

Le brigadier Frédéric / par Erckmann-Chatrian ; illustrations par Th. Schuler ; [gravures par Pannemaker]

Collection : Contes et romans alsaciens

Maître Gaspard Fix ; suivi de L'éducation d'un féodal / par Erckmann-Chatrian ; illustrations par Th. Schuler ; gravures par Pannemaker

Collection : Contes et romans alsaciens

Une campagne en Kabylie : récit d'un chasseur d'Afrique ; Les années de collège de Maître Nablot ; Une veillée au village ; Le pâté de lapin / par Erckmann-Chatrian ; illustrés de 22 dessins par Théophiles Schuler ; gravures par Pannemaker

Collection : Contes et romans alsaciens

Limites des procédés d'investigation de la fonction érectile dans le cadre d'expertises médicolégales [Limits of the processes of investigation of the erectile function in forensic expertises].

Résumé La responsabilité d'un expert chargé d'apprécier la capacité érectile d'un prévenu est importante, car la peine infligée par le tribunal peut dépendre de ses conclusions. Sa tâche est en plus ardue car les procédés d'investigations de la fonction érectile ont tous des limites. Malgré toutes ces limites qui sont décrites dans cet article, l'expert peut aider à la recherche de la vérité comme les auteurs le démontrent. Summary The responsability of the expert in charge to appreciate the erectile capacity of an accused is considerable, as the sentence inflicted by the Tribunal could depend directly on his conclusions. His duty is harder as all the investigation procedures of the erectile functions have limits. Despite these limits, described in this article, the expert can help to discover the truth, as demonstrated by the authors.