The Mexican film industry and its participation in the global value chain

Includes bibliography

Role of nitric oxide in the remodelling of extracellular matrix in myxomatous mitral valve degeneration of dogs and pigs

Myxomatous mitral valve degeneration (MMVD) or endocardiosis is a heart valve disease that occurs in many mammalian species, especially in humans, dogs and pigs. Nitric oxide (NO) plays an important role in the MMVD development. NO can be indirectly evaluated by the nitric-oxide synthase (NOS) expression and by the histochemical reaction of nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d). The aim of this study was to evaluate NOS activity, by NADPH-d reaction, in the anterior leaflet of dogs with regular mitral valves and in those with MMVD, as well as in young swine and old females, comparing the reaction level with the degree of endocardiosis disease and also the histological alterations. Twelve mitral valves of dogs and 22 of swine were used for the research. All the valves were macroscopically analyzed for the occurrence or not of endocardiosis. They were fixed in a 4% paraformaldehyde, exposed to NADPH-d reaction, routinely processed and microscopically evaluated for the detection of mucopolysaccharides (MPS) deposition, collagen degeneration, fibrosis and level of endocardiosis. In dogs, relation was observed between higher intensity of the NADPH-d reaction, higher endocardiosis degree, MPS deposition as well as the collagen degeneration. No alteration in color was observed in pigs ́ valves during NADPH-d reaction. In conclusion, NO works in canine mitral valve remodeling extracellular matrix and plays an important role in endocardiosis disease. In swine, the lack of reaction reinforces the absence of macroscopical endocardiosis lesions, suggesting restrict NO action or major differences in the structures of swine valves.

Intensified peginterferon α-2a dosing increases sustained virologic response rates in heavy, high viral load hepatitis c genotype 1 patients with high low-density lipoprotein

BACKGROUND AND GOAL: Patients infected with hepatitis C virus (HCV) with elevated low-density lipoprotein (LDL) levels achieve higher sustained virologic response (SVR) rates after peginterferon (PegIFN)/ribavirin treatment versus patients with lower LDL. Our aim was to determine whether SVR rates in patients with low/elevated LDL can be improved by dose intensification. STUDY: In PROGRESS, genotype 1 patients with baseline HCV RNA≥400,000 IU/mL and body weight ≥85 kg were randomized to 48 weeks of 180 μg/wk PegIFN α-2a (40 kDa) plus ribavirin (A: 1200 mg/d; B: 1400/1600 mg/d) or 12 weeks of 360 μg/wk PegIFN α-2a followed by 36 weeks of 180 μg/wk, plus ribavirin (C: 1200 mg/d; D: 1400/1600 mg/d). This retrospective analysis assessed SVR rates among patients with low (<100 mg/dL) or elevated (≥100 mg/dL) LDL. Patients with high LDL (n=256) had higher baseline HCV RNA (5.86×10 IU/mL) versus patients with low LDL (n=262; 4.02×10 IU/mL; P=0.0003). RESULTS: Multiple logistic regression analysis identified a significant interaction between PegIFN α-2a dose and LDL levels on SVR (P=0.0193). The only treatment-related SVR predictor in the nested multiple logistic regression was PegIFN α-2a dose among patients with elevated LDL (P=0.0074); therefore, data from the standard (A+B) and induction (C+D) dose arms were pooled. Among patients with low LDL, SVR rates were 40% and 35% in the standard and induction-dose groups, respectively; SVR rates in patients with high LDL were 44% and 60% (P=0.014), respectively. CONCLUSIONS: Intensified dosing of PegIFN α-2a increases SVR rates in patients with elevated LDL even with the difficult-to-cure characteristics of genotype 1, high baseline viral load, and high body weight. Copyright © 2013 by Lippincott Williams & Wilkins.

Synthesis and characterization of 3-[(thiourea)-propyl]-functionalized silica gel and its application in adsorption and catalysis

The objective of this research was the preparation of a silica gel functionalized successively with 3-chloropropyltrimethoxysilane (SG-PrCl) and thiourea (SG-Pr-THIO), and its application in adsorption and catalysis. The materials were characterized by 13C and 29Si NMR, FTIR, scanning electron micrographs (SEM), analysis of nitrogen and elemental analysis. Aiming at its application in adsorption, the [3-(thiourea)-propyl] silica gel (SG-Pr-THIO) was tested as an adsorbent for transition-metal ions using a batchwise process. The organofunctionalized surface showed the ability to adsorb the metal ions Cd(ii), Cu(ii), Ni(ii), Pb(ii) and Co(ii) from water, ethanol and acetone. The adsorption isotherms were fitted by Langmuir, Freundlich, Temkin and Dubinin-Radushkevich (D-R) models. The kinetics of adsorption of metals were performed using three models such as pseudo-first order, pseudo-second order and Elovich. The Langmuir and pseudo-first order models were the most appropriate to describe the adsorption and kinetic data, respectively. With the purpose of application in catalysis, the SG-Pr-THIO was reacted with a Mo(ii) organometallic complex, forming the new material SG-Pr-THIO-Mo. Only a few works in the literature have reported this type of reaction, and none dealt with thiourea and Mo(ii) complexes. The new Mo-silica gel organometallic material was tested as catalyst in the epoxidation of cyclooctene and styrene. © 2013 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.

Novas formas de encarceramento?: os jovens e o centro de ressocialização

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Formação inicial de professores de física: fatores limitantes e possibilidades de avanços

Pós-graduação em Educação para a Ciência - FC

Crítica e autocrítica da modernidade: crise civilizatória e utopia anticapitalista em Michael Löwy

Pós-graduação em Ciências Sociais - FCLAR

Análise econômica do uso de célula a combustível para acionamento de ônibus urbano

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A Biogeografia no núcleo de Rio Claro (SP): análise e avaliação das contribuições científicas no período de 1969-2004

Pós-graduação em Geografia - IGCE

Metáfora urbana: reminiscências do bairro do Ipiranga em registros de gravura

Pós-graduação em Artes - IA

A filosofia do direito no sistema filosófico hegeliano

The Hegelian philosophy is presented as a progress in relation to other philosophies and it offers to take in itself all the other demonstrations. Thereby, Hegel intends to carry out his philosophical effort towards the establishment of a philosophical system. It is a comprehension recognized and exposed by Hegel in his doctoral thesis, i.e., that philosophy only becomes possible as a system. In this sense, the treatment dispensed to each one of his works necessarily evokes a relationship with all other. An work taken in isolation gets the feeling that something else should be presented, however, every work written by Hegel also contemplates a relation with his other works. In this sense, the objective here is to considerate Hegel’s Philosophy of Law in his philosophical system seeking to explicit its specific place, as well as its transit among the works of the thinker as a whole. The Philosophy of Law finds its particular moment in the ambit of the objective spirit or during the subjective spirit’s effectuation. However, it is assumed here the perspective that the Philosophy of Law represents, as the objective spirit does, a moment of mediation as well as a there-being whereby the absolute spirit’s effectuation would happen. Furthermore, Hegel’s Philosophy represents the presentation of what he considers as extremely important in philosophy, that is precisely, the need to sublate the separation between man and the world. It is not enough for Hegel, the affirmation of the being and the thinking in itself, but it is required to confirm them in their being other that will be evinced being itself. Thus, Philosophy is given as a reconstruction or as the factual knowledge as a science ceasing to be so only love of learning. This means in other words that philosophy deals with the world, in the world and for the world being much more than a speech to the world to be the talk of the world itself. If philosophy is the owl of Minerva who always arrives late, she does it for the reasons of the other to be recognized.

Characterizing background heterogeneity in visual communication

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Intertextualidade entre Coraline e Alice's adventures in wonderland & Throught the looking-glass and what Alice found there

When writing Coraline, Neil Gaiman takes up some resources used by Lewis Carroll in his two major works, Alice's Adventures in Wonderland and Through the Looking-Glass and What Alice Found There, but still manages to write a unique novel, seemingly grim, filled with horror. In the 1960s, the theoretician Julia Kristeva conducted a study on the possible dialogue between the texts, concluding that every text contains parts of other texts, already written or that will be. Based on the theory of intertextuality she first proposed and which was subsequently discussed by several theoreticians, this paper aims to find points in the works in which this dialogue is present, as well as how Neil Gaiman appropriates these resources properly. It also tries to show elements where these points of intertextuality differ, proposing that this difference is because Gaiman resorted, directly, or indirectly, to insights drawn from the study of Freud’s psychoanalytic theory

Fragmento d'alma

Fragmento D' Alma is an artistic research that part of a poetic tale through an initial charge of dawn one fantastic universe where words have life and willingly. The work includes sculptural works in order to interpret through the use of allegory situations of the tale in the form of sculptural compositions considering one or more characters in the story. In the sculptural work, I tried figuring the relations tale as my interpretations and poetic, so I sought theoretical studies of allegory after noting my affinity with the theme to contribute to the relationship text and image set in my work. I also sought to understand the relationships that the text played with sculptural work, so the chances that I could address this through dialogue between text and image. The studies collected through surveys pointed allegory by João Adolfo Hansen, as well as in various artistic and visual references present in my repertoire, such as the Baroque sculpture of Bernini, the performances of Berna Reale and literature of Neil Gaiman, contributed in this research to the development of my creative process during the preparation of this research work of art, making the complexity of the relationship between textual production and poetic sculptural three-dimensional, also became a concern and an integral theme of my work and my reflections presented here. Therefore, I conclude based on my own experience in this work, the artistic research inspired allegory might contribute to the development of my creative process during the preparation of this artwork, besides assigning relations between textual production and poetic dimensional sculpture

O Trickster na escola: um estudo sobre a função educativa do mito

Pós-graduação em Educação Escolar - FCLAR