Obtenção de sistemas multiparticulados de isoniazida revestidos com polímero de liberação entérica

Known for thousands of years, tuberculosis (TB) is the leading cause of mortality by a single infectious disease due to lack of patient adherence to available treatment regimens, the rising of multidrug resistant strains of TB (MDR-TB) and co-infection with HIV virus. Isoniazid and rifampicin are the most powerful bactericidal agents against M. tuberculosis. Because of that, this couple of drugs becomes unanimity in anti-TB treatment around the world. However, the rifampicin in acidic conditions in the stomach can be degraded rapidly, especially in the presence of isoniazid, which reduces the amount of available drug for absorption, as well as its bioavailability, contributing to the growing resistance to tuberculostatic drugs. Rifampicin is well absorbed in the stomach because of its high solubility between pH 1 and 2 and the gastric absorption of isoniazid is considered poor, therefore it is mostly intestinal. This work has as objective the development of gastro-resistant multiple-systems (granules and pellets) of isoniazid aiming to prevent the contact with rifampicin, with consequent degradation in acid stomach and modulate the release of isoniazid in the intestine. Granules of isoniazid were obtained by wet method using both alcoholic and aqueous solutions of PVP K-30 as aggregating and binder agent, at proportions of 5, 8 and 10%. The influence of the excipients (starch, cellulose or filler default) on the physical and technological properties of the granules was investigated. The pellets were produced by extrusionesferonization technique using isoniazid and microcrystalline cellulose MC 101 (at the proportion of 85:15) and aqueous solution of 1% Methocel as platelet. The pellets presented advantages over granular, such as: higher apparent density, smaller difference between apparent and compaction densities, smoother surface and, especially, smaller friability, and then were coated with an organic solution of Acrycoat L 100 ® in a fluidized bed. Different percentages of coating (15, 25 and 50%) were applied to the pellets which had their behavior evaluated in vitro by dissolution in acidic and basic medium. Rifampicin dissolution in the presence of uncoated and coated isoniazid pellets was evaluated too. The results indicate that the gastro resistance was only achieved with the greatest amount of coating and isoniazid is released successfully in basic step. The amount of rifampicin in the dissolution medium when the isoniazid pellets were not coated was lower than in the presence of enteric release pellets. Therefore, the polymer Acrycoat L 100 ® was efficient for coating with gastro-resistant function and can solve the problem of low bioavailability of rifampicin and help to reduce its dosage

Micropartículas poliméricas à base de xilana e Eudragit® S-100 contendo mesalazina visando à liberação cólon-específica

Colon-specific drug delivery systems have attracted increasing attention from the pharmaceutical industry due to their ability of treating intestinal bowel diseases (IBD), which represent a public health problem in several countries. In spite of being considered a quite effective molecule for the treatment of IBD, mesalazine (5-ASA) is rapidly absorbed in the upper gastrointestinal tract and its systemic absorption leads to risks of adverse effects. The aim of this work was to develop a microparticulate system based on xylan and Eudragit® S- 100 (ES100) for colon-specific delivery of 5-ASA and evaluate the interaction between the polymers present in the systems. Additionaly, the physicochemical and rheological properties of xylan were also evaluated. Initially, xylan was extracted from corn cobs and characterized regarding the yield and rheological properties. Afterwards, 10 formulations were prepared in different xylan and ES100 weight ratios by spray-drying the polymer solutions in 0.6N NaOH and phosphate buffer pH 7.4. In addition, 3 formulations consisting of xylan microcapsules were produced by interfacial cross-linking polymerization and coated by ES100 by means of spray-drying in different polymer weight ratios of xylan and ES100. The microparticles were characterized regarding yield, morphology, homogeneity, visual aspect, crystallinity and thermal behavior. The polymer interaction was investigated by infrared spectroscopy. The extracted xylan was presented as a very fine and yellowish powder, with mean particle size smaller than 40μm. Regarding the rheological properties of xylan, they demonstrated that this polymer has a poor flow, low density and high cohesiveness. The microparticles obtained were shown to be spherical and aggregates could not be observed. They were found to present amorphous structure and have a very high thermal stability. The yield varied according to the polymer ratios. Moreover, it was confirmed that the interaction between xylan and ES100 occurs only by means of physical aggregation

Controle de qualidade físico-químico e biodisponibilidade relativa em ratos de suspensões orais de naproxeno sódico obtidas de farmácias de manipulação na cidade do Natal RN

Compounded medicines have been reported by the ANVISA due to decreased of the therapeutic response or toxicity of these formulations. The aim of this work was to investigate the physicochemical quality control among naproxen sodium oral suspensions 25 mg/mL obtained from six compounding pharmacies (A, B, C, D, E and F) and the manufactured suspension (R). In the quality control test, the tests of pH, content, homogeneity, volume and physical and organoleptic characteristics were performed according to the Brazilian Pharmacopoeia. The analytical method for determination of naproxen in suspensions was validate. This method showed excellent precision, accuracy, linearity and specificity. In the content test the suspensions B, C and E showed lower value and the F suspension showed a high value of the content. The products C and E were disapproved in the description of the physical and organoleptic characteristics test. In the pH test, three suspensions were outside specifications (C, E and F). Only the products R, A and D showed satisfactory results in these tests and therefore they were approved for relative bioavailability test. The R, A and D suspensions were orally administered to Wistar rats and the blood samples were taken at time intervals of 10, 20, 40, 60 min, 3, 4, 6, 24 and 48 h. The plasma samples were immediately stored at 80 ºC until analysis of HPLC. The bioanalytical method validation showed specificity, linearity (R2 0.9987), precision, accuracy, good recovery and stability. The chromatographic conditions were: flow rate of 1.2 mL.min-1 with a mobile phase of acetonitrile : sodium phosphate buffer pH 4.0 (50:50, v/v) at 280 nm, using a C18 column. The confidence interval of 90% for the Cmax and AUCt ratio was within the range of 80 - 125% proposed by the FDA. Only one suspension, obtained from the compounding pharmacy D, was considered bioequivalent to the rate of absorption under the conditions proposed by this study. Thus, the results indicate the need for strict supervision from the relevant authorities to ensure the patient safety and the quality of compounded drugs by pharmacies

Changes in physical properties of extruded sour cassava starch and quinoa flour blend snacks

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Produção de snacks funcionais à base de farinha de soja e polvilho azedo

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Soil attributes and efficiency of sulfentrazone on control of purple nutsedge (Cyperus rotundus L.)

Herbicidas aplicados ao solo são submetidos à adsorção, lixiviação e degradação por processos físicos, químicos e biológicos, além da absorção pelas plantas. Todos esses processos são afetados pela classe dos solos onde foram aplicados e das condições climáticas reinantes logo após a aplicação, que afetarão a eficiência dos produtos no controle de plantas daninhas. Investigaram-se as influências dos atributos de solos e condições de cultivo na eficiência do herbicida sulfentrazone no controle da planta daninha tiririca (Cyperus rotundus L.). O Latossolo Vermelho-Amarelo Distrófico (LVAd), o Latossolo Vermelho (LVd - Distrófico; LVdf - Distroférrico; LVef - Eutroférrico) e o Nitossolo Vermelho Eutrófico (NVe) foram coletados sob duas condições de cultivo, visando obter solos com teores diferenciados de argila, óxido de ferro e matéria orgânica. As amostras dos solos foram submetidas à caracterização granulométrica, química e mineralógica e, em seguida, utilizadas no bioensaio de avaliação da eficiência do sulfentrazone (1,6 L p.c. ha-1) no controle da tiririca em condições de pré-emergência. O sulfentrazone apresentou comportamento diferenciado entre as classes de solos estudados e a sua eficiência diminuiu com o aumento do teor de óxido de ferro nos solos, na seguinte ordem: LVAd, LVd, NVe, LVef e LVdf, sendo que as variações nos teores de argila (240 a 640 g kg-1) e da matéria orgânica (12 a 78 g kg-1) dos solos não interferiram na eficiência do sulfentrazone.

Aplicação de nanopartículas de quitosana com potencial de adjuvante na produção de soro contra o venneno do escorpião Tityus serrulatus

In Brazil, several species of scorpions are known to cause accidents which can lead to death, which are mainly belonging to the genus Tityus. The scorpion Tityus serrulatus is the main responsible for more severe cases. Anti-scorpion serums are routinely produced by various institutions, despite their effectiveness, quality and action depends on how quickly treatment is started. Studies have been developed in the search for appropriate technologies to encapsulate and release recombinant or natives proteins capable of inducing antibody production. In this context, chitosan copolymer which can be obtained from the partial deacetylation of chitin or in some microorganisms and it is biocompatible and biodegradable has been widely used for this purpose. This study aimed to search for a system release from chitosan nanoparticles for peptide / protein of the venom of the scorpion T. serrulatus, able to provide a new model of immunization in animals, in order to obtain a potential novel polyclonal serum, anti-venom T. serrulatus. The chitosan nanoparticles were prepared by ionic gelation with polyanion tripolyphosphate (TPP). After standardizing the concentrations of TPP and chitosan was evaluated the efficiency of incorporation of bovine serum albumin (BSA) and scorpion venom, showed particle size compatible with the intended purpose. The particles showed adequate size around 200nm. The crosslinking was confirmed by absorption spectroscopy in the infrared. After verified the high encapsulation efficiency (EE) for acid bicinconínico method (BCA) protein assay and the particle size distribution, the success of the technique was proven and the potential for in vivo application of nanoparticles. The experimental animals were vaccinated and the antibodies measured by ELISA

Contribuições sobre estudos térmicos (TG/DTG, DTA, DSC e DSC-Fotovisual) da rifampicina e seus principais produtos de degradação

Since its synthesis over 48 years rifampicin has been extensively studied. The literature reports the characterization of thermal events for rifampicin in nitrogen atmosphere, however, no characterization in synthetic air atmosphere. This paper aims to contribute to the thermal study of rifampicin through thermal (TG / DTG, DTA, DSC and DSC - FOTOVISUAL ) and non-thermal (HPLC, XRPD , IR - FTIR , PCA) and its main degradation products ( rifampicin quinone , rifampicin N-oxide 3- formylrifamicin). Rifampicin study was characterized as polymorph form II from techniques DSC, IR and XRPD. TG curves for rifampicin in synthetic air atmosphere showed higher thermal stability than those in N2, when analyzed Ti and Ea. There was characterized as overlapping events melting and recrystallization under N2 with weight loss in the TG curve, suggesting concomitant decomposition. Images DSCFotovisual showed no fusion event and showed darkening of the sample during analysis. The DTA curve in synthetic air atmosphere was visually different from DTA and DSC curves under N2, suggesting the absence of recrystallization and melting or presence only decomposition. The IV - FTIR analysis along with PCA analysis and HPLC and thermal data suggest that rifampicin for their fusion is concomitant decomposition of the sample in N2 and fusion events and recrystallization do not occur in synthetic air atmosphere. Decomposition products studied in an air atmosphere showed no melting event and presented simultaneously to the decomposition initiation of heating after process loss of water and / or solvent, varying the Ti initiating events. The Coats - Redfern , Madsudhanan , Van Krevelen and Herwitz - Mertzger kinetic parameters for samples , through the methods of OZAWA , in an atmosphere of synthetic air and / or N2 rifampicin proved more stable than its degradation products . The kinetic data showed good correlation between the different models employed. In this way we contribute to obtaining information that may assist studies of pharmaceutical compatibility and stability of substances

Acúmulo de matéria seca e macronutrientes por plantas de Merremia aegyptia

Um experimento em casa de vegetação foi conduzido entre janeiro e junho de 2008, na FCAV/UNESP, Brasil, objetivando estudar a produção de massa seca, a marcha de absorção e o acúmulo de macronutrientes por Merremia aegyptia, uma importante planta daninha em culturas anuais e perenes no Brasil. As plantas foram cultivadas em vasos de 7 L com substrato de areia, que foram irrigados diariamente com solução nutritiva de Hoagland & Arnon. Os tratamentos corresponderam às épocas de avaliação, em intervalos de 14 dias, iniciando-se 21 dias após a emergência (DAE). em cada avaliação, as plantas de quatro vasos foram analisadas quanto à produção de massa seca e ao conteúdo de macronutrientes. M. aegyptia apresentou pequeno acúmulo de massa seca e de macronutrientes no início da fase experimental, os quais foram intensificados após 49 DAE. As folhas foram as principais estruturas acumuladoras de massa seca na primeira metade do ciclo de M. aegyptia, enquanto os caules o foram na segunda metade. N e K foram os macronutrientes mais acumulados em plantas de M. aegyptia. O período de máximo acúmulo teórico de massa seca e macronutrientes por M. aegyptia ocorreu entre 146 e 160 DAE.

Acúmulo de massa seca e de macronutrientes por plantas de Glycine max e Solanum americanum

A soja é uma das principais culturas agrícolas do Brasil, sendo a sua produtividade muito influenciada pela competição exercida pelas plantas daninhas. Foram realizados dois experimentos em casa de vegetação, em Jaboticabal, SP, objetivando determinar o acúmulo de massa seca, assim como a distribuição e o acúmulo de macronutrientes em plantas de soja, no período de outubro de 2000 a fevereiro de 2001, e de Solanum americanum, no período de janeiro a maio de 1995. As plantas cresceram em vasos com capacidade de 7 litros, preenchidos com areia de rio lavada e peneirada; elas foram irrigadas diariamente com solução nutritiva. Os tratamentos foram representados pelas épocas de amostragem, realizada a intervalos de 14 dias, iniciando-se 21 dias após a emergência (DAE), até 161 DAE para S. americanum e 119 DAE para soja cv. BR-16 (precoce). O ponto de máximo acúmulo teórico de massa seca deu-se aos 104 DAE para a soja (35,0 g por planta) e 143 DAE para S. americanum (179,62 g por planta). da emergência até 49 e 63 DAE, as folhas apresentaram maior participação no acúmulo de massa seca para soja e S. americanum, respectivamente. Após esses períodos, verificou-se, em ambas as espécies, inversão na representatividade das folhas por caules para a espécie daninha e por caules e, posteriormente, por estruturas reprodutivas, para a cultura. A taxa de absorção diária dos macronutrientes atingiu maiores valores entre 69 e 87 DAE para a soja e entre 105 e 119 DAE para a planta daninha. Considerando a média dos valores de pontos de inflexão observados para a cultura da soja, tem-se que aos 75 DAE uma planta de soja acumula teoricamente 23,9 g de massa seca, 564,4 mg de N, 7,1 mg de P, 490,8 mg de K, 487,0 mg de Ca, 156,6 mg de Mg e 36,0 mg de S. Para o mesmo período, uma planta de S. americanum acumula teoricamente 33,75 g de massa seca, 875,96 mg de N, 88,46 mg de P, 983,54 mg de K, 647,60 mg de Ca, 100,93 mg de Mg e 42,15 mg de S.

Efeito de níveis crescentes de calagem no crescimento e estado nutricional de fedegoso

A distribuição e desenvolvimento de plantas, a exemplo daquelas que infestam as áreas agrícolas, é influenciada por diversos fatores, a como aqueles ligados às caraterísticas do solo, naturais ou impostas pelo homem. Assim, o presente trabalho de pesquisa foi desenvolvido em condições de casa-de-vegetação com o objetivo de estudar o efeito de níveis crescentes de calagem no crescimento e estado nutricional de Senna obtusifolia, planta daninha comum em ecossistemas agrícolas. O delineamento experimental adotado foi o inteiramente casualizado, com seis tratamentos e quatro repetições. Os tratamentos constituíram-se em quantidades de calcário dolomítico calcinado com 38% de CaO e 20% de MgO, com um poder de neutralização total (PRNT) de 104%: 0, 2, 4, 6, 8 e 10 t/ha. As parcelas experimentais constituíram-se de recipientes de plástico com capacidade de 5 litros, preenchidos com terra coletada na camada arável de um latossolo vermelho escuro distrófico, A moderado, textura média. Após um período de crescimento de 56 dias as plantas foram coletadas e separadas em seus componentes vegetativos, sendo colocados a secar em estufa de circulação forçada de ar (70ºC por 72 horas) para determinação do peso seco. O material foi pesado e moído e analisado a nível de composição de nutrientes. Os resultados mostraram efeitos negativos dos níveis crescentes de calcário, sobre o crescimento das plantas de S. obtusifolia, evidenciando-se decréscimos nos valores da matéria seca acumulada a partir da dose de 4 t/ha de calcário (pH 5,8), com efeitos mais marcantes nas raízes. A aplicação de doses crescentes de calcário promoveu um aumento progressivo nos teores de Ca e Mg no solo, o que talvez possa ter estimulado a competição entre cátions, reduzindo a absorção do K. Os elementos N e P foram os mais absorvidos pela planta.

Acúmulo de massa seca e macronutrientes por plantas de Glycine max e Richardia brasiliensis

Foram realizados dois experimentos, em condições de casa de vegetação, no Departamento de Biologia Aplicada à Agropecuária da FCAV-UNESP de Jaboticabal, objetivando-se determinar o acúmulo de massa seca, assim como a distribuição e o acúmulo de macronutrientes durante os ciclos de vida de plantas de soja cultivar BR16, no período de outubro de 2000 a fevereiro de 2001, e de Richardia brasiliensis (poaia-branca), uma planta daninha de elevada importância para esta cultura no Brasil, especialmente em áreas de plantio direto, no período de outubro de 1998 a fevereiro de 1999. Os estudos foram realizados em delineamento experimental inteiramente casualizado, com quatro repetições. Quatro plantas cresceram em vasos com capacidade de sete litros, preenchidos com areia de rio lavada, peneirada e irrigada diariamente com solução nutritiva. Os tratamentos foram representados pelas épocas de amostragem, realizadas a intervalos de 14 dias, a saber: 22, 36, 50, 64, 78, 92, 106, 120, 134, 148, 162 e 176 dias após a emergência (DAE) das plantas de R. brasiliensis; e 21, 35, 49, 63, 77, 91, 105 e 119 DAE das plantas de soja cv. BR-16 (precoce). em ambas as plantas, as folhas tiveram a maior partição de biomassa durante sete semanas. Para este dado, a partição foi maior para as estruturas reprodutivas em soja e nos caules para a poaia-branca. O ponto de máximo acúmulo teórico de massa seca deu-se aos 104 DAE para a soja (36,6 g por planta) e aos 146 DAE para a poaia-branca (16,4 g por planta). da emergência até aos 50 DAE as folhas apresentaram maior participação no acúmulo de massa seca, nas duas espécies. Após 50 DAE notou-se, em ambas as espécies, uma inversão na representatividade das folhas por caules, para a espécie daninha, e por caules e posteriormente por estruturas reprodutivas, para a cultura. A taxa de absorção diária dos macronutrientes atingiu maiores valores entre 69 e 87 DAE para a soja e entre 106 a 111 DAE para a planta daninha. Levando em conta a média dos valores de pontos de inflexão observados para a cultura da soja, aos 78 DAE uma planta de soja acumula teoricamente 25,9 g de massa seca; 615,5 mg de N; 77,2 mg de P; 538,6 mg de K; 535,0 mg de Ca; 171,5 mg de Mg; e 39,5 mg de S. Para o mesmo período, uma planta de R. brasiliensis acumula teoricamente 3,7 g de massa seca; 50,8 mg de N; 3,2 mg de P; 104,4 mg de K; 127,8 mg de Ca; 18,8 mg de Mg; e 3,7 mg de S.

Estudo comparativo do acúmulo de massa seca e macronutrientes por plantas de milho var. BR-106 e Brachiaria plantaginea

Foram realizados dois experimentos, em casa de vegetação, no Departamento de Biologia Aplicada à Agropecuária da FCAV-UNESP de Jaboticabal, objetivando-se determinar o acúmulo de massa seca e a distribuição e acúmulo de macronutrientes em plantas de milho, no período de outubro de 2000 a fevereiro de 2001, e de capim-marmelada, no período de setembro de 2003 a fevereiro de 2004. Os estudos foram realizados em delineamento experimental inteiramente casualizado, com quatro repetições. As plantas cresceram em vasos com capacidade de sete litros - preenchidos com areia de rio lavada e peneirada - e foram irrigadas diariamente com solução nutritiva. Os tratamentos foram representados pelas épocas de amostragem realizadas a intervalos de 14 dias, a saber: 21, 35, 49, 63, 77, 91, 105, 119 e 133 dias após a emergência (DAE) das plantas de milho; e 21, 35, 49, 63, 77, 91, 105, 119, 133 e 147 DAE das plantas de capim-marmelada. O ponto de máximo acúmulo teórico de massa seca deu-se aos 122 DAE para o milho (143,8 g por planta) e aos 143 DAE para o capim-marmelada (23,9 g por planta). A taxa de absorção diária dos macronutrientes atingiu maiores valores entre 71 e 104 DAE para o milho e entre 96 e 111 DAE para a planta daninha. Levando-se em conta a média dos valores de pontos de inflexão observados na cultura do milho, aos 85 DAE uma planta de milho acumula, teoricamente, 83,0 g de massa seca; 788,9 mg de N; 137,5 mg de P; 1.385,6 mg de K; 551,8 mg de Ca; 217,9 mg de Mg; e 92,5 mg de S. Enquanto que, no mesmo período, uma planta de B. plantaginea acumula, teoricamente, 9,6 g de massa seca; 127,8 mg de N; 15,9 mg de P; 217,3 mg de K; 43,9 mg de Ca; 58,3 mg de Mg; e 15,8 mg de S.

Desenvolvimento, pobreza e meio ambiente no seridó potiguar: um estudo centrado nas micro-regiões do seridó oriental e ocidental

This research work intends to carry out a study focused on the dynamic between development, poverty reduction and conservation of natural resources. To consider this relationship to the region chosen was the micro-region of Eastern and Western Seridó in the state of Rio Grande do Norte. In recent years, several studies (Araújo, 2011; BASTOS, 2009) have pointed out that after a period of economic crisis in its tripodproductive, formed by the activities of farming, cotton farming, mining and faced in the eighties, this region of the State of Rio Grande do Norte, has not only shown signs of economic recovery but also improve their social indicators. On the other hand, studies of desertification as the view of the state of RN (produced in cooperation between the Government of RN and research institutions) and the Sustainable Development Plan of Seridó (ADES, 2000), indicate that there is an ongoing French process of degradation of natural resources that is capable of compromising the ability of sustaining such a system. To verify this reality and likely finding this relationship, this work is adopted for this study, the analysis of evolution of secondary data from official bodies such as the IBGE on HDI, per capita income and other social indicators between 2000 and 2009. Here is another time of the survey analysis of qualitative data collected from interviews with institutions of academic intervention in nature, researchers at the Federal University of Rio Grande do Norte (UFRN) State agencies that address the issue of the Middle Environment in Seridó: Institute for Sustainable Development of the NB (IDEMA) and the Brazilian Institute of Environment and the Amazon (IBAMA) and institutions of direct intervention in the region, as the Agency's Sustainable Development Seridó (adhesive) and the Joint Semi-Arid (ASA). After crossing data from quantitative and qualitative, it was found that the dynamics of the region's economic Seridó Potiguar partially answers the improvement of social indicators of poverty. Contribution by the State in this shared stock transfer income. Regarding the influence of productive restructuring in the region on issues of environment, it is noted that the ceramic tile industry, responsible for the absorption percentage of the population with limited ingress into the urban economy, given the low education, accounts for the increase of susceptibility to the ongoing process of desertification in North Seridó Rio Grande. We conclude finally that the guarantee of increased income, freedom and conservation of natural resources ensures primarily by changing the beliefs and values, especially on the part of the business sector, which use natural resources so predatory, aimed at maintaining their rates of return on investment. And concomitantly, the synchronization between technological change, through the use of new energy sources, and institutional change.

Informação fluida e conhecimento no ciberespaço : uma análise do Portal Infonet-SE

The internet is a transbordering and potentializing environment for the information, since it makes possible the sheering, distribution and interaction of the contents available in it. However, this information system may generate an opposing move when it produces an avalanche of superficial information which difficult the absorption criticism by the user. This modern-liquid society, which is characterized by short living fashionisms, creates a fluid subject on which its habits do not become concrete, since they are so temporary that they don t shape up. The information also reproduces the same scenario, since the user is inserted into a logic based on supplying information and so it is conditioned to consume, not absorb or transform them into knowledge, since the flow of content production does not allow it. It is in his context that the publishing of cultural expressions come to be questioned, since they follow a liquid society trend. This discussion will take on topics that approach diverse cultural expressions in Sergipe, such as cinema, theater, craftsmanship, events, memory spaces(museums, art galleries, memorials, files, libraries, history institutes, science academies), amongst others and will analyze the content production of the Infonet Portal, from the reports published during April, May and June of 2008, period considered to be of cultural turbulence in the state, due to the June Festivals (Saint john, Saint Joseph and Saint Peter). To do so, Zigmunt Bauman s, Pierre Levy s, Edgar Morin s and Dominique Wolton s ideas were discussed. Besides, were analyzed the characteristics of the internet and its applicability within the portal hereby discussed in order to perceive the way the information is produced in the cyber culture, a movement that allows memorization, potentialization, interaction , besides other criteria inherent to the cyberspace