Desenvolvimento reprodutivo de ratos machos expostos ao agente hipolipemiante rosuvastatina

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Estudo comparativo do genoma e do transcriptoma de Phyllosticta citricarpa (fase sexual Guignardia citricarpa) agente da Mancha Preta dos Citros e Phyllosticta capitalensis

Pós-graduação em Ciências Biológicas (Genética) - IBB

Efeitos da Isradipina (LOMIR). Agente inibidor de canais de cálcio, no processo de reparo em feridas de extração dental: estudo histológico em ratos

In order to make a histological evaluation of the dental alveolus wound healing in presence of the Isradipine (Lomir/Sandoz Pharma), the new calcium channels blockers, forthy-eight albino rats were utilized. These animals were divided in two groups. The animals of group I were considered as control; in group II, after the dental extractions the rats received intraperitonial injections of 2,5 mg/Kg of isradipine, administered a single dose. From each group of animals were sacrificed at 3, 7, 14 and 21 post-operative days. The pieces were fixed, descalcified and embedded in paraffin. The blocks thus obtained were cut at 6 micrometers thick and sections were stained with hematoxylin and eosin for morphological study. According to the results obtained i t was verified that the treated animals did not alter of wound healing after dental extractions

Modelo regulatório da liberação comercial de plantas geneticamente modificadas no Brasil: existe um consenso?

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Mancha de ramularia do algodoeiro: agente etiológico, produção de inóculo, resistência de genótipos e controle integrado

Pós-graduação em Agronomia (Proteção de Plantas) - FCA

Avaliação de uma nova composição de agente clareador sobre a microdureza do esmalte: associação do trimetafosfato de sódio e fluoreto de sódio ao peróxido de hidrogênio a 10%

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Características agronômicas e qualidade comercial de cultivares de milho pipoca em alta população

Agronomic characteristics and commercial quality of popcorn maize cultivars. In order to identify popcorn cultivars that constitute a viable alternative For popcorn producers, an experiment was conducted using a randomized blocks experimental design with Five genotypes (BRS Angela, Zelia, IAC 112, IAC 12 and IAC TC-01) and four repetitions, during the 2003/2004 crop. The experiment was carried out with 60 cm spacing between lilies and density of 75 thousand plants per hectare. During the experiment, agronomic and commercial characteristics were evaluated, under field and laboratory conditions. The variety BRS Angela featured increased yield, followed by simple hybrids IAC, with Zelia (triple hybrid) showing lower yield. The simple hybrid IAC 12 showed the lowest commercial quality of popcorn. Grain production was positively associated with the number of grains per car and with the weigh of 1,000 grains, and negatively with the level of N(total) in grain. The commercial quality was negatively influenced by the weigh of 1,000 grains.

Análise dialógica do discurso publicitário

From the questions raised by Bakhtin Circle, especially those intended to gender and dialogue, this work aims to study the relationships of meaning that are established between the statements present in commercial advertising discourse. For each sphere of production, circulation and reception of discourses, genres are appropriate, therefore, all discourse requires a different choice of language resources, which determines, among other things, the style of the message. The advertising genre, a genre characterized as complex, as it works, reframes and incorporates primary genres, has the central objective of building the next one idea being to buy something more frequent. This process occurs mainly through the use of persuasive speeches, compelling, authoritative, imperative and seduction. Our goal is to analyze an advertising piece, discussing how the resources used in advertising participate in the process of enunciation and persuasion and the manner in which the voices of others (previous authors, recipients hypothetical ) mingle with the voice of the subject's explicit enunciation. (Bakhtin, 2010, p. XXVII). Thus, based on Bakhtinian studies, we will think about the relation of the dialogical voices raised in question in advertising, and attend to the role of the other, with his active responsive understanding, how to be active and modifying agent

Aplicação de técnicas eletroforéticas em amostras de musculos de aves de interesse comercial e de Tilápias (Oreochromis niloticus)

Junto ao Laboratório de Fracionamento de Proteínas, desenvolveu atividades aplicando técnicas eletroforéticas (gel de agarose, eletroforese nativa em gel de poliacrilamida) em amostras de músculos de aves de interesse comercial (frangos, perus e avestruzes), tendo como co-orientador o Prof. Paulo Tadeu Figueira da Faculdade de Medicina Veterinária, PUC/PR - Toledo, onde desenvolveu atividades de análise de géis de eletroforese. Aplicou as técnicas de eletroforeses citadas em amostras de músculos e soro sanguíneo (em andamento) de tilápias (Oreochromis niloticus), bem como desenvolveu atividades de análises computacionais (VDS – PHARMACIA) e estatísticas (ASSISTAT) nos dados obtidos, resultando na participação em 7 congressos com apresentação de trabalhos. Cursou a disciplina de Genética, como aluno especial, junto à turma de Licenciatura em Ciências Biológicas, num total de 8 créditos, sendo aprovado com média 7,2

Avaliação da qualidade de comprimidos de captopril 50 mg comercializados no Brasil

O captopril foi o primeiro agente desenvolvido para o tratamento da hipertensão, doença que acomete grande parte da população adulta mundial, a qual requer cuidados especiais quanto à farmacoterapia e ajuste de doses. Assim sendo, este trabalho tem como objetivo avaliar a qualidade de comprimidos de captopril 50 mg comercializados no Brasil através da realização da equivalência farmacêutica entre duas marcas de comprimidos não revestidos de captopril 50 mg (um genérico G e um similar S) em relação ao medicamento referência (R) Capoten® Bristol Myers Squibb 50 mg, utilizando os requisitos descritos na monografia individual do fármaco da Farmacopeia Brasileira e da Farmacopeia Americana. Medicamentos referência são produtos inovadores, cuja eficácia, segurança e qualidade foram comprovadas cientificamente; os chamados similares são os que contêm as mesmas substâncias ativas, mesma concentração, forma farmacêutica, via de administração, posologia e indicação terapêutica do medicamento de referência e são identificados por nome comercial ou por sua marca; os medicamentos genéricos são intercambiáveis com o produto referência e, geralmente, são produzido após a expiração ou renúncia da proteção patentária do mesmo, ele deve ser designado pela DCB (Denominação Comum Brasileira) ou, na ausência desta, pela DCI (Denominação Comum Internacional). Os dois medicamentos analisados, medicamento similar e medicamento genérico, apresentaram resultados satisfatórios quanto à determinação de peso médio, resistência mecânica e tempo de desintegração dos comprimidos, identificação, doseamento, limite de dissulfeto de captopril, uniformidade de doses unitárias, teste de dissolução e perfil de dissolução do fármaco, com relação ao seu medicamento referência correspondente, ou seja, estes são equivalentes farmacêuticos e apresentam qualidade... (Resumo completo, clicar acesso eletrônico abaixo)

Estudo fotodinâmico da clorofila a, azul de metileno e rosa bengala como agente inseticida contra Aedes aegypti

Photodynamic therapy, term introduced by von Tapeiner in 1900, can be defined as the administration of a non toxic drug, i.e., a dye, known as photosensitizer (FS), which subsequently will be illuminated with light of specific wavelength. PDT is based on the interaction among FS, oxygen and light, which through photochemical reactions cause cell death. The FS molecules must have a high probability to form the singlet state after the excitation, which can induce chemical changes in the neighborhood in two ways, called reactions type I and type II. The type II reaction is based on the exchange of energy to molecular oxygen, exciting it to its state of higher energy (singlet), which is highly reactive. The proposed mechanisms for cell death are linked to damage to the DNA, mitochondria and to the cytoplasmic membrane. Several pre‐clinical and clinical trials have been carried out and the PDT is already used in many countries for treatment mainly against certain types of cancer. The therapy also has been gaining strength in antimicrobial control, since the microorganisms have appeared increasingly resistant to current antibiotics. Another attempt to use the PDT is for the inactivation of macro‐organisms, such as micro‐crustaceans and mosquitoes. To this end I tested whether the photosensitizers methylene blue, rose Bengal and the chlorophyll a has insecticidal activity against the yellow fever and dengue vector mosquito, Aedes aegypti. Since these diseases have no effective treatments, its control is linked to the vector control, which has shown resistance to chemical pesticides used. Based on this, this work shows its importance, because it is a new type of mosquito control since all the photosensitizers used are low cost, do not generate toxic products at the concentrations used and showed good results in mortality. The best photosensitizer was rose Bengal... (Complete abstract click electronic access below)

Crise do modelo do jornalismo comercial e emergência do jornalismo cidadão

Corporative media, represented by TV, radio, press and internet conglomerates, is responsible for the biggest portion of audience and public all over the world. The commercial media was built upon media concentration and monopoly strategies and this business aims society’s economic and political control. Unfortunately, they don’t represent the biggest portion of population’s interests and, because of that, corporative media faces a crisis moment while alternative means of communication rise from the initiative of professionals who are committed to society’s marginalized sectors. Radical media intends to express a variant vision about hegemonic policies, priorities and perspectives. Citizen journalism is one of radical media arms and this research proposition is to analyze the business model of commercial media in Brazil and in the world, its means of production, and compare them with citizen journalism methods. This work also intends to analyze radical media and how it is opposite to corporative media by studying Escola de Notícias, an educommunication project from São Paulo

Capacitação de agente comunitário de saúde em anemia falciforme

Introduction: This study is about the training of community health agents (CHA) in the municipality of Araraquara SP about the topic of sickle cell disease which this purpose is improving the knowledge and care provided by these professionals. Method: Educational intervention with CHA for training in sickle cell disease and using as indicator qualitative and quantitative, a questionnaire to assessment before and after the intervention process. Results: The process of training increased significantly the knowledge of CHA in sickle cell disease. In the questionnaire before, 30% of participants scored above 40 points, while after 97% achieved grades above 40 points. Moreover, it was possible to assessment the development of skills through the solution of a simulated case. Processes interventionist educational are great validity in the process of Pharmaceutical Care Conclusion: The Health Education for CHA may contribute to the improvement of care and treatment of patients with sickle cell disease through humanized health care

Síntese e caracterização de ferritas de manganês e zinco visando aplicação como agente de contraste em diagnóstico médico

This work aims to synthesize the manganese and zinc ferrite, by the polymeric precursor method, in order to obtain materials with appropriate characteristics for the application in medical diagnosis techniques. The manganese and zinc ferrite powders with the composition of Mn(1-x)ZnxFe2O4, where x=0,23, were prepared and calcined in air at different times and temperatures. The X-ray diffraction (XRD) data show that the sample calcined at 400°C crystallize as ferrite (monophase), but in an inverted spinel structure (high content of iron occupying manganese tetrahedral site and manganese occupying the iron octahedral site). The samples calcined at temperatures between 600°C and 900°C shows the secondary phase of hematite and the sample calcined at 1100oC shows to be monophase in ferrite with normal spinel structure. The monophase powders of ferrite showed a reduction in the surface area and an increasing in the pore size for higher calcination temperatures. The magnetic analysis show that the sample calcined at 400°C presents satisfactory magnetization at room temperature, however, it behaves as diamagnetic material at low temperatures (10K). The powder containing hematite, without the partial substitution of iron ions by manganese, showed to have low transition temperature, and consequently low magnetization at room temperature. The hematite, when partially substituted, provides materials with irregular magnetization at the saturation region. The powder calcined at 1100°C shows high magnetization either at room temperature or low temperature (10K)

Sistema de Acelerador Linear Comercial para Radioterapia

This paper presents a study about the operation of the major system’s components of a linear particle acclerator (Linac). It addresses the components mainly responsible for the formation of the beam, through the inclusion of several block diagrams showing the details of the structure. Among the systems discussed may be mentioned the system modulator, automatic frequency control, dosimetry and auxiliary systems. The main objective is the dissemination of basic technology applied in linear accelerators and create literature about this subject in national language. Despite the high complexity and large number of devices that comprise a linear accelerator, it has been developed an easy to understand text that adresses the most relevant issues to the operation of the linear accelerator from the point of view of electrical engineering