Structured RNAs in the ENCODE selected regions of the human genome

Functional RNA structures play an important role both in the context of noncoding RNA transcripts as well as regulatory elements in mRNAs. Here we present a computational study to detect functional RNA structures within the ENCODE regions of the human genome. Since structural RNAs in general lack characteristic signals in primary sequence, comparative approaches evaluating evolutionary conservation of structures are most promising. We have used three recently introduced programs based on either phylogenetic–stochastic context-free grammar (EvoFold) or energy directed folding (RNAz and AlifoldZ), yielding several thousand candidate structures (corresponding to ∼2.7% of the ENCODE regions). EvoFold has its highest sensitivity in highly conserved and relatively AU-rich regions, while RNAz favors slightly GC-rich regions, resulting in a relatively small overlap between methods. Comparison with the GENCODE annotation points to functional RNAs in all genomic contexts, with a slightly increased density in 3′-UTRs. While we estimate a significant false discovery rate of ∼50%–70% many of the predictions can be further substantiated by additional criteria: 248 loci are predicted by both RNAz and EvoFold, and an additional 239 RNAz or EvoFold predictions are supported by the (more stringent) AlifoldZ algorithm. Five hundred seventy RNAz structure predictions fall into regions that show signs of selection pressure also on the sequence level (i.e., conserved elements). More than 700 predictions overlap with noncoding transcripts detected by oligonucleotide tiling arrays. One hundred seventy-five selected candidates were tested by RT-PCR in six tissues, and expression could be verified in 43 cases (24.6%).

Quantifying urban attractiveness from the distribution and density of digital footprints

In the past, sensors networks in cities have been limited to fixed sensors, embedded in particular locations, under centralised control. Today, new applications can leverage wireless devices and use them as sensors to create aggregated information. In this paper, we show that the emerging patterns unveiled through the analysis of large sets of aggregated digital footprints can provide novel insights into how people experience the city and into some of the drivers behind these emerging patterns. We particularly explore the capacity to quantify the evolution of the attractiveness of urban space with a case study of in the area of the New York City Waterfalls, a public art project of four man-made waterfalls rising from the New York Harbor. Methods to study the impact of an event of this nature are traditionally based on the collection of static information such as surveys and ticket-based people counts, which allow to generate estimates about visitors’ presence in specific areas over time. In contrast, our contribution makes use of the dynamic data that visitors generate, such as the density and distribution of aggregate phone calls and photos taken in different areas of interest and over time. Our analysis provides novel ways to quantify the impact of a public event on the distribution of visitors and on the evolution of the attractiveness of the points of interest in proximity. This information has potential uses for local authorities, researchers, as well as service providers such as mobile network operators.

Santé et styles de vie des adolescents âgés de 16 à 20 ans en Suisse (2002). SMASH 2002 : Swiss multicenter adolescent survey on health 2002

Le présent rapport décrit les grandes tendances qui se dégagent des résultats de l'Enquête SMASH 2002 et propose quelques hypothèses pour éclairer la compréhension et les enjeux de la situation actuelle ainsi que des pistes de réflexion pour l'avenir. Cette étude repose sur deux approches complémentaires de la santé: l'une donne la primauté aux aspects sociologiques des conduites de santé ("lifestyle"); l'autre, de nature épidémiologique, met l'accent sur la prévalence des comportements et procède à des analyses dans divers sous-groupes ou dans le temps. L'étude SMASH 2002 fournit une photographie de la situation des adolescents et de leur état de santé : besoins et comportements de santé, facteurs associés et évaluation des grands changements intervenus depuis une dizaine d'années. Ces données doivent permettre de réfléchir à une planification optimale des services de soins et des programmes de prévention et de promotion de la santé en faveur des adolescents. [extraits du résumé des auteurs]

A competência técnica em informática de alunos de enfermagem

Os enfermeiros na era da informação precisam desenvolver seus conhecimentos e habilidades para que se tornem competentes nessa área. O objetivo deste estudo foi verificar o conhecimento dos alunos matriculados no primeiro e no oitavo semestres do curso de graduação em enfermagem dos anos de 2008 e 2007, respectivamente, no que se refere à utilização de recursos da informática. Trata-se de uma pesquisa não experimental do tipo estudo survey descritivo exploratório usado para a coleta dos dados em um questionário baseado em um conjunto de competências em informática. Os resultados mostraram o baixo índice de conhecimentos em informática dos alunos que estão ingressando no curso de graduação. Contudo, na comparação dos aplicativos que os alunos têm maior dificuldade, entre os dois períodos avaliados, a maior porcentagem foi de alunos do oitavo semestre, demonstrando a necessidade da introdução do uso do computador na formação desses novos profissionais para sua posterior adaptação ao mercado de trabalho.

“Ficino i els dimonis del geni”

La configuració del concepte de geni al Renaixement suposa una de les principals aportacions a la psicologia de l’artista, un procés que ha estat considerat com a dispositiu per la noció moderna del geni. En el seu tractat mèdico-astrològic De vita (1489), Ficino va definir els dispositius d’aquesta idea través d’una tríade que vinculava Saturn amb la malenconia i el furor diví. La hipòtesi que guia el treball és que, si bé aquests conceptes van obrar una forta influència en la posterior definició de la genialitat, Ficino seguia considerant el geni en la seva definició clàssica, això és, com un dimoni custodi de l’home. Ara bé, Ficino no va intentar una mera paràfrasi de la doctrina del genii o el daemon, sinó que sumant-l’hi les seves concepcions entorn la màgia i l’astrologia, va desenvolupar una teoria pròpia respecte a la naturalesa del geni personal, abordant la necessitat de l’home de conèixer el seu dimoni per actuar sobre les seves limitacions i explotar-ne les virtuts. Per aquest motiu, en aquest treball es parlarà dels dimonis del geni, en quant en l’explotació del daemon atorgat en la genitura intervenien, segons Ficino, els dimonis adquirits amb els artificis de la màgia natural o a través de la professió. Així doncs, l’objectiu general del treball és definir els diferents dimonis implicats en la concepció del geni en Ficino i les seves conseqüències en la psicologia de l’artista i l’art.

Recessive multiple epiphyseal dysplasia (rMED) with homozygosity for C653S mutation in the DTDST gene - phenotype, molecular diagnosis and surgical treatment of habitual dislocation of multilayered patella: case report.

BACKGROUND: Multiple epiphyseal dysplasia (MED) is one of the more common generalised skeletal dysplasias. Due to its clinical heterogeneity diagnosis may be difficult. Mutations of at least six separate genes can cause MED. Joint deformities, joint pain and gait disorders are common symptoms. CASE PRESENTATION: We report on a 27-year-old male patient suffering from clinical symptoms of autosomal recessive MED with habitual dislocation of a multilayered patella on both sides, on the surgical treatment and on short-term clinical outcome. Clinical findings were: bilateral hip and knee pain, instability of femorotibial and patellofemoral joints with habitual patella dislocation on both sides, contractures of hip, elbow and second metacarpophalangeal joints. Main radiographic findings were: bilateral dislocated multilayered patella, dysplastic medial tibial plateaus, deformity of both femoral heads and osteoarthritis of the hip joints, and deformity of both radial heads. In the molecular genetic analysis, the DTDST mutation g.1984T > A (p.C653S) was found at the homozygote state. Carrier status was confirmed in the DNA of the patient's parents. The mutation could be considered to be the reason for the patient's disease. Surgical treatment of habitual patella dislocation with medialisation of the tibial tuberosity led to an excellent clinical outcome. CONCLUSIONS: The knowledge of different phenotypes of skeletal dysplasias helps to select genes for genetic analysis. Compared to other DTDST mutations, this is a rather mild phenotype. Molecular diagnosis is important for genetic counselling and for an accurate prognosis. Even in case of a multilayered patella in MED, habitual patella dislocation could be managed successfully by medialisation of the tibial tuberosity.

La traduzione poetica del Cinquecento e le "Metamorfosi d'Ovidio" dell'Anguillara

La thèse est articulée en trois grandes sections, consacrées respectivement: (I) à la traduction poétique en Italie à partir des années 1540 jusqu'à la fin du XVIème siècle (II), à la réception des Métamorphoses d'Ovide à travers la réflexion théorique et les réécritures en italien (III), à la plus célèbre des versions italiennes du poème latin, celle de Giovanni Andrea dell'Anguillara (1507-1570 env.), parue à Venise en 1561. Le premier chapitre (La traduzione poetica nel Cinquecento) prend en considération plus d'une trentaine de traductions d'auteurs classiques parues en Italie entre 1540 et 1580. L'examen détaillé du péritexte qui accompagne les éditions (préfaces, commentaires, dédicaces) montre l'existence d'un riche débat autour de la traduction littéraire ainsi que la présence d'un public vaste et diversifié comme destinataire de ces oeuvres. Dans ce contexte, la traduction en langue vulgaire de l'oeuvre d'Ovide, et particulièrement des Métamorphoses, constitue un cas fort intéressant. Le deuxième chapitre (Aspetti della ricezione delle Metamorfosi nel Cinquecento) offre un ample aperçu sur la réception du poème latin à travers ses principales éditions, commentaires et interprétations. En s'appuyant sur les travaux de A. Moss et D. Javitch, ce chapitre (II. 2 Usi e funzioni delle Metamorfosi in ambito teorico e poetico) montre les contradictions existant dans les jugements sur les Métamorphoses au XVIème siècle, partagés entre l'admiration pour la virtuosité du poète latin et l'écho des préjugés moraux et stylistiques hérités de la critique ancienne. La poétique du Cinquecento en effet devait faire face à deux problèmes majeurs posés par le texte d'Ovide: au niveau structurel son caractère polycentrique et digressif, inconciliable avec le modèle épique virgilien chéri par le siècle; au niveau thématique la présence de récits de phénomènes jugés invraisemblables, comme notamment celui de la métamorphose. L'analyse des traductions des Métamorphoses en italien entre 1530 et 1570 prend en considération autant les réécritures partielles (dues aux poètes Luigi Alamanni, Bernardo Tasso, Girolamo Parabosco) que les versions intégrales du poème. Parmi ces dernières, une attention particulière a été réservée à l'adaptation du vénitien Ludovico Dolce, Le Trasformationi (1553), libre réécriture sur le modèle du Roland Furieux. La dernière partie du travail est entièrement consacrée à la célèbre version de Giovanni Andrea dell'Anguillara, poète et traducteur dans le cercle du cardinal Alessandro Farnese. Comme le démontre l'analyse comparée du texte italien et de l'original latin, cette «belle infidèle» (qui supplanta la version de Dolce et fut réimprimée maintes fois jusqu'au XIX siècle) doit son succès à son parfait équilibre entre fidélité à la structure du poème et une attitude très libre dans la narration, qui n'hésite pas à actualiser et «contaminer» le texte ovidien avec des auteurs modernes tels que l'Arioste ou Bandello. L'appendice comprend une bibliographie exhaustive des éditions de la traduction d'Anguillara parues au XVIème siècle.

La Traducció al català en el context de la Unió Europea

"Traducció jurídicoeconòmica d'una fragment del Tractat pel qual s'estableix una Constitució per a Europa, amb el propòsit d'establir una sèrie de directrius sòlides per a la traducció al català en el context de la Unió Europea, tot seguint les indicacions dels organismes catalans competents."

Ens falla la intuïció?

Aquest treball pretén analitzar l’ús dels procediments heurístics i els seus biaixos. Per això, hemrealitzat un estudi entre dues poblacions: 4rt d’Humanitats i 4rt d’ECO/ADE. Per dur a termeaquesta comparació hem realitzat una enquesta que pretenia detectar els biaixos. Amb elsresultats hem pogut comprovar que efectivament hi ha diferències significatives entre els dosgrups. Concretament, els estudiants d’ECO/ADE cometen menys biaixos.

Assistência em saúde mental sustentada no modelo psicossocial: narrativas de familiares e pessoas com transtorno mental

Esta pesquisa foi realizada com o método da história oral temática e desenvolvida no ano de 2009, em Curitiba, com oito colaboradores pertencentes a três famílias que tinham um integrante com transtorno mental. O objetivo do estudo foi descrever a percepção de familiares e de portadores de transtorno mental sobre a assistência em saúde mental sustentada no modelo psicossocial. Os dados foram obtidos por meio de entrevista semiestruturada, analisados e apresentados de maneira descritiva. Os colaboradores consideraram os serviços extra-hospitalares, como o Centro de Atenção Psicossocial e os ambulatórios de saúde mental, estratégias inovadoras, e mencionaram o atendimento por equipe multiprofissional, a mediação de conflitos familiares e o princípio de territorialidade. Destacaram o acompanhamento do portador de transtorno mental pela Unidade Básica de Saúde e ressaltaram a importância das associações na rede de saúde mental. Atribuíram à inclusão da família no tratamento a melhora na relação familiar e a aceitação da doença.

On Certain Greedoid Polyhedra, Partially Indexable Scheduling Problems, and Extended Restless Bandit Allocation Indices

We present a polyhedral framework for establishing general structural properties on optimal solutions of stochastic scheduling problems, where multiple job classes vie for service resources: the existence of an optimal priority policy in a given family, characterized by a greedoid (whose feasible class subsets may receive higher priority), where optimal priorities are determined by class-ranking indices, under restricted linear performance objectives (partial indexability). This framework extends that of Bertsimas and Niño-Mora (1996), which explained the optimality of priority-index policies under all linear objectives (general indexability). We show that, if performance measures satisfy partial conservation laws (with respect to the greedoid), which extend previous generalized conservation laws, then the problem admits a strong LP relaxation over a so-called extended greedoid polytope, which has strong structural and algorithmic properties. We present an adaptive-greedy algorithm (which extends Klimov's) taking as input the linear objective coefficients, which (1) determines whether the optimal LP solution is achievable by a policy in the given family; and (2) if so, computes a set of class-ranking indices that characterize optimal priority policies in the family. In the special case of project scheduling, we show that, under additional conditions, the optimal indices can be computed separately for each project (index decomposition). We further apply the framework to the important restless bandit model (two-action Markov decision chains), obtaining new index policies, that extend Whittle's (1988), and simple sufficient conditions for their validity. These results highlight the power of polyhedral methods (the so-called achievable region approach) in dynamic and stochastic optimization.

Financing Constraints, Irreversibility, and Investment Dynamics

We develop a model of an industry with many heterogeneous firms that face both financing constraints and irreversibility constraints. The financing constraint implies that firms cannot borrow unless the debt is secured by collateral; the irreversibility constraint that they can only sell their fixed capital by selling their business. We use this model to examine the cyclical behavior of aggregate fixed investment, variable capital investment, and output in the presence of persistent idiosyncratic and aggregate shocks. Our model yields three main results. First, the effect of the irreversibility constraint on fixed capital investment is reinforced by the financing constraint. Second, the effect of the financing constraint on variable capital investment is reinforced by the irreversibility constraint. Finally, the interaction between the two constraints is key for explaining why input inventories and material deliveries of US manufacturing firms are so volatile and procyclical, and also why they are highly asymmetrical over the business cycle.

Social use of alcohol among adolescent offenders: a fundamental approach toward human needs

This study examined some basic health care approaches toward human needs, with a particular focus on nursing. We aimed to incorporate these approaches into the discussion of the mental health of adolescent offenders who consume alcohol. We discuss specific needs of the delinquent group, critique policies that prioritize coercion of adolescent offenders, and the role that nurses could play in the sphere of juvenile delinquency.