Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

U-BIOPRED is a European Union consortium of 20 academic institutions, 11 pharmaceutical companies and six patient organisations with the objective of improving the understanding of asthma disease mechanisms using a systems biology approach.This cross-sectional assessment of adults with severe asthma, mild/moderate asthma and healthy controls from 11 European countries consisted of analyses of patient-reported outcomes, lung function, blood and airway inflammatory measurements.Patients with severe asthma (nonsmokers, n=311; smokers/ex-smokers, n=110) had more symptoms and exacerbations compared to patients with mild/moderate disease (n=88) (2.5 exacerbations versus 0.4 in the preceding 12 months; p<0.001), with worse quality of life, and higher levels of anxiety and depression. They also had a higher incidence of nasal polyps and gastro-oesophageal reflux with lower lung function. Sputum eosinophil count was higher in severe asthma compared to mild/moderate asthma (median count 2.99% versus 1.05%; p=0.004) despite treatment with higher doses of inhaled and/or oral corticosteroids.Consistent with other severe asthma cohorts, U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment. It is well suited to identify asthma phenotypes using the array of "omic" datasets that are at the core of this systems medicine approach.

Dr. A. Kaminka [Illustration] : Sekretär der A. I. U. in Wien

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J. M. Bielefeld [Illustration] : der Senior der deutschen Conferenz-Gemeinschaft der A. J. U.

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Frau Rabb. Dr. Seligmann, Frankfurt a. M. [Illustration] : Leiterin der Zentral-Auskunftstelle des Frauen-Verbandes der U. O. B. B.-Logen

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Frau Minna Schwarz [Illustration] : Vorsitzende des Frauen-Vereins der Berliner Logen und II. Vorsitzende des Verbandes der Frauen-Vereine der U. O. B. B.-Logen

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Frau Rabb. Dr. Ernestine Eschelbacher [Illustration] : Vorsitzende des Verbandes der Frauen-Vereine der U. O. B. B.-Logen

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Frau Martha Schlesinger, Frankfurt a. M. [Illustration] : Leiterin der Zentral-Auskunftstelle des Frauen-Verbandes der U. O. B. B.-Logen

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U. Ginzberg (Achad Ha'am) [Illustration] : hervorragender hebräischer Publizist

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The Aggregate Demand for Private Health Insurance Coverage in the U.S.

This paper estimates the aggregate demand for private health insurance coverage in the U.S. using an error-correction model and by recognizing that people are without private health insurance for voluntary, structural, frictional, and cyclical reasons and because of public alternatives. Insurance coverage is measured both by the percentage of the population enrolled in private health insurance plans and the completeness of the insurance coverage. Annual data for the period 1966-1999 are used and both short and long run price and income elasticities of demand are estimated. The empirical findings indicate that both private insurance enrollment and completeness are relatively inelastic with respect to changes in price and income in the short and long run. Moreover, private health insurance enrollment is found to be inversely related to the poverty rate, particularly in the short-run. Finally, our results suggest that an increase in the number cyclically uninsured generates less of a welfare loss than an increase in the structurally uninsured.

Stanislaus Steiger [u.a.] [Illustration] : (Porträtzeichnung)

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Aus dem Pantheon des alten Friedhofes in Lemberg [Illustration] : Grab des David Lida, ... [u.a.]

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Josef Saul ha-Levi Nathansohn [u.a.] [Illustration] : An Salomo Kluger ...

Josef Saul ha-Levi Nathansohn

Druckerzeichen des Marco Giustani aus Israel (Isserlein) Aschkenasi [Illustration] : P'sakim u-k'thawim, Venedig 1546, Soncino Blätter

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Diagramm [Illustration] : zum Artikel "Anthopologische Untersuchungen über die russisch-polnischen Juden ..." von Dr. Elkind, S. 65 u. ff.

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Abraham Bar Samuel Ha-Levi Ibn Chisdai Ha-Nasi : sein Leben und seine Schriften, insbesondere das Sēfer ben ham-melek we-han-nāzîr, Vergleichung des hebr., arab. u. griech. Textes

München, Univ., Diss., 1889