Identification of the mRNA targets of tRNA-­specific regulation using genome-­wide simulation of translation

FUNDING Biotechnology and Biological Sciences Research Council (BBSRC) [BB/I020926/1 to I.S.]; BBSRC PhD studentship award [C103817D to I.S. and M.C.R.]; Scottish Universities Life Science Alliance PhD studentship award (to M.C.R. and I.S.]. Funding for open access charge: BBSRC. Conflict of interest statement. None declared.

Principales puntos de convergencia entre las escuelas hegemónicas de teoría económica y sociológica desde la Ilustración escocesa hasta nuestros días

This research aims to show the main points of convergence between hegemonic schools of economic and sociological theory from the Scottish Enlightenment until today. To this end, on the one hand, we set three basic families of economic thought (the mainstream, the Austrian school and Marxism); and, on the other, we divide the history of sociology in five major generations (pioneers, founders, institutionalizers, compilers and constructivist). Subsequently, we set five historical periods as reference to our respective chapters and compare, within each of them, the theoretical contributions from these two areas. Thus, in the first chapter, called "the liberal parenthesis", we consider the relationship between the classical school of economics and the pioneers and founders of sociology. In the second, entitled "the social question" we analyze, on the one hand, the theoretical consistency of both the neoclassical school, as Austrian, with the principles defended by the institutionalizers of sociology; and, on the other, the influence of Karl Marx, as founder of sociology and classical economist, in the work of Soviet revolutionary theorists. In chapter three, called the "new industrial state", we demonstrate the theoretical proximity between both Keynesianism and the Austrian school of economics, with the doctrine defended by the generation of compilers in sociology. The fourth chapter, entitled "second industrial divide", refers to the similarities between the theoretical contributions of the monetarist Chicago school and the Austrian school with sociological constructivism. Finally, chapter five, the "global market", shows that the two hegemonic schools in economics, "integrated model", and sociology, "analytical sociology", are composed of the same three schools of thought: the rational choice, the neo-institutionalism and network approach. Thus, we can conclude that, if we look at their respective areas of influence, during this historical period occurs an manifest agreement between the theoretical contributions from the economic and sociological fields.

Rock 314: A Novel

During this Capstone project, the author composed and revised the introductory chapters of the novel Rock 314. This Capstone is comprised of the first four of those chapters and also includes a reflective essay that explores the many influences and inspirations that led to its creation. Rock 314 is a story about a lonely young artist who is unexpectedly taken away from the world he knows and finds himself flung across the cosmos in search of his kidnapped grandfather. This novel uses humor as a literary device to satirize contemporary society. In addition to an explanation of influences and story conception, the essay includes all cognitive decisions and discoveries made by the author throughout the evolution of this project.

[Student essay on vice], 1770 September 1

One leaf containing a handwritten essay on the proposition that "all Sinners, whatever Hopes they may have of Happiness, will hereafter be unhappy & miserable." The essay begins with an epitaph from Agamemnon: A Tragedy by Scottish poet James Thomson: "Vice always leads, however fair at first, to Wilds of Woe." The verso is dated September 1st 1770.

[Excerpt from the poem "Winter"], undated

One leaf containing a handwritten copy of a section of the poem "Winter" by Scottish poet James Thomson (1700-1748). The excerpt begins "'Tis done! dread Winter spreads his latest Glooms," and ends, "And one unbounded Spring encircle all."

Manuscript copy of the book of Harvard, 1767

The pamphlet-sized manuscript includes "The Book of Harvard" signed "Joseph Cummings, scriptis, Janr 7th 1767," an untitled two-page essay beginning, "Wisdom is ye Crown of life" and ending "Draught of Knowledge, let us with a laudable ambition, strive to excel each other in an ardent pursuit of Learning, then shall we raise to ourselves a monument of honest fame, which shall perish only in ye general wreak of nature," and on the last page, "An Accrostick" beginning "Jangling & Discord are thy Souls delight" and spelling out JAMES MITCHEL VARNUM dated July 3, 1767 and signed "The 3d edition revised & improved by Gove & Fogg."

Manuscript copy of the book of Harvard, 1767

Handwritten copy of the Book of Harvard written on one large sheet of paper and signed Boston, January 10th, 1767.

Collection of humorous verses and sketches relating to Harvard College, 1769

Manuscript volume in various hands containing three general sections: satirical poems about Harvard tutors, a section of "last words & dying" speeches of Harvard tutors, and a copy of the Book of Harvard."

Commonplace book of Clement Weeks

Commonplace book containing a transcription of the "The Book of Harvard," a satirical account of the Butter Rebellion of 1766 followed with supplementary text of "The Arguments in Defence of the Proceedings of the Scholars" and "The Confession that was made after all was done." The above occupies pp. 1-14; pp. 15-18 missing. Pages 19-23 hold excerpts from Edward Young's Conjectures on Original Composition. Pages 24-62 hold excerpts from Saint Augustine's Heresies. Finally pages 62-64 hold an excerpt of Druidical maxims from the introduction of the first volume of Paul Rapin de Thoyras' The History of England (1724).

Letter from James Winthrop to William Bentley, 1806 March 31

Two folio-sized leaves containing a one-page handwritten letter from Winthrop to Bentley discussing world geography and asking for news about the African expedition of Scottish explorer Mungo Park (1771-1806).

Plays and poetry : manuscript, [17--]

Plays and poems, chiefly satires, in support of American independence and patriotic causes.

Student lecture notes on anatomy and surgery, and medical notes, of Lyman Spalding, 1795

Contains notes taken by Harvard student Lyman Spalding (1775-1821) from lectures on anatomy and surgery delivered by Harvard Professor John Warren (1753-1815) in 1795, as well a section entitled “Medical Observations,” which includes entries on “Vernal Debility,” or diseases occurring in the spring, and lung function. It is unclear if these are Spalding’s own writings or transcriptions from a published work. There is also text transcribed from “Elementa Medicinae,” published in 1780 by Scottish physician John Brown.

Student notes from medical lectures by Benjamin Rush, undated

The volumes contain student notes on a course of medical lectures given by Dr. Benjamin Rush (1746-1813) while he was Professor of the Institutes of Medicine and Clinical Practice at the University of Pennsylvania Medical School, likely in circa 1800-1813. The notes indicate Rush often referenced the works or teachings of contemporaries such as Scottish physicians William Cullen, John Brown, John Gregory, and Robert Whytt, and Dutch physician Herman Boerhaave. He frequently included anecdotes and case histories of his own patients, as well as those of other doctors, to illustrate his lecture topics. He also advised students to take notes on the lectures after they ended to allow them to focus on what they were hearing. Volume 1 includes notes on: physician conduct during visits to patients; human and animal physiology; voice and speech; the nervous system; the five senses; and faculties of the mind. Volume 2 includes notes on: food, the sources of appetite and thirst, and digestion; the lymphatic system; secretions; excretions; theories of nutrition; differences in the minds and bodies of women and men; reproduction; pathology; a table outlining the stages of disease production; “disease and the origin of moral and natural evil”; contagions; the role of food, drink, and clothing in producing disease; worms; hereditary diseases; predisposition to diseases; proximate causes of diseases; and pulmonary conditions. Volume 3 includes notes on: the pulse; therapeutics, such as emetics, sedatives, and digitalis, and treatment of various illnesses like pulmonary consumption, kidney disease, palsy, and rheumatism; diagnosis and prognosis of fever; treatment of intermitting fever; and epidemics including plague, smallpox, and yellow fever, with an emphasis on the yellow fever outbreaks in Philadelphia in 1793 and 1797.

Flashlight Europe N°2–September 2014: Is It Better To Be Alone Than Lonely Together? Scotland Is Voting On Whether Or Not To Become Independent

On 18 September 2014 the Scots are voting on whether or not to sever their ties with the UK. And the pro-independence camp is catching up fast. A survey conducted at the beginning of the month revealed that for the first time 51 percent of the Scottish electorate say that they will be casting a Yes vote, i.e. that they are in favour of independence. The outcome is now in the hands of the undecided voters, who are currently being heavily courted by the various parties. If the Scots vote in favour of independence, it is bound to cast doubt on the future of the government of David Cameron, the Conservative Party leader. Who is fighting on which side? What are the arguments? And what will happen if the Scots decide to opt out of the United Kingdom? Here are some of the things that are a distinct possibility.

Scotland and the EU: What impact of the potential in-out UK referendum on the independence debate?1 EPC Discussion Paper, 4 September 2014

Fabian Zuleeg explores the likelihood of Scottish Independence, and its potential impact on the EU–UK relations. As the Scottish independence vote is inextricably bound to the potential UK in-out referendum (and thus a potential exit of the UK from the EU), there are some potential feedback loops to the independence debate which are set to be relevant regardless of whether Scotland becomes independent or not.