The late roman pottery imports in the East of Hispania Tarraconensis

Recent studies provided new data about late Roman imports (ARS, amphorae, lamps) in the coast of Hispania Tarraconensis. Concerning urban contexts (the ancient towns of Barcino, Tarraco and others) and rural settlements, the data allow us to identify the imports and the economic trends of the region from the 4th to the late 6th /early 7th centuries. We hope this paper to be an interpretative work of synthesis about the economic relationship between town and country in Catalonia and Northern Comunidad Valenciana in the Late Antiquity.

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies

A series of 1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridines differently substituted at positions 1, 5, and 9 have been designed from the pyrano[3,2-c]quinoline derivative 1, a weak inhibitor of acetylcholinesterase (AChE) with predicted ability to bind to the AChE peripheral anionic site (PAS), at the entrance of the catalytic gorge. Fourteen novel benzonaphthyridines have been synthesized through synthetic sequences involving as the key step a multicomponent Povarov reaction between an aldehyde, an aniline and an enamine or an enamide as the activated alkene. The novel compounds have been tested against Electrophorus electricus AChE (EeAChE), human recombinant AChE (hAChE), and human serum butyrylcholinesterase (hBChE), and their brain penetration has been assessed using the PAMPA-BBB assay. Also, the mechanism of AChE inhibition of the most potent compounds has been thoroughly studied by kinetic studies, a propidium displacement assay, and molecular modelling. We have found that a seemingly small structural change such as a double O → NH bioisosteric replacement from the hit 1 to 16a results in a dramatic increase of EeAChE and hAChE inhibitory activities (>217- and >154-fold, respectively), and in a notable increase in hBChE inhibitory activity (> 11-fold), as well. An optimized binding at the PAS besides additional interactions with AChE midgorge residues seem to account for the high hAChE inhibitory potency of 16a (IC50 = 65 nM), which emerges as an interesting anti-Alzheimer lead compound with potent dual AChE and BChE inhibitory activities.

pH Sensitive surfactants from lysine: assessment of their cytotoxicity and environmental behavior

The toxicity and environmental behavior of new pH-sensitive surfactants from lysine are presented. Three different chemical structures are studied: surfactants with one amino acid and one alkyl chain, surfactants with two amino acids on the polar head and one alkyl chain, and gemini surfactants. The pH sensitivity of these compounds can be tuned by modifying their chemical structures. Cytotoxicity has been evaluated using erythrocytes and fibroblast cells. The toxic effects against these cells depend on the hydrophobicity of the molecules as well as their cationic charge density. The effect of hydrophobicity and cationic charge density on toxicity is different for each type of cells. For erythrocytes, the toxicity increases as hydrophobicity and charge density increases. Nevertheless, for fibroblasts cationic charge density affects cytotoxicity in the opposite way: the higher charge density, the lower the toxicity. The effect of the pH on hemolysis has been evaluated in detail. The aquatic toxicity was established using Daphnia magna. All surfactants yielded EC50 values considerably higher than that reported for cationic surfactants based on quaternary ammonium groups. Finally, their biodegradability was evaluated using the CO2 headspace test (ISO 14593). These lysine derivatives showed high levels of biodegradation under aerobic conditions and can be classified as"readily biodegradable compounds".

1,2,3,4-Tetrahydrobenzo[h][1,6]naphthyridines as a new family of potent peripheral-to-midgorge-site inhibitors of acetylcholinesterase: synthesis, pharmacological evaluation and mechanistic studies

A series of 1,2,3,4-tetrahydrobenzo[h][1,6]naphthyridines differently substituted at positions 1, 5, and 9 have been designed from the pyrano[3,2-c]quinoline derivative 1, a weak inhibitor of acetylcholinesterase (AChE) with predicted ability to bind to the AChE peripheral anionic site (PAS), at the entrance of the catalytic gorge. Fourteen novel benzonaphthyridines have been synthesized through synthetic sequences involving as the key step a multicomponent Povarov reaction between an aldehyde, an aniline and an enamine or an enamide as the activated alkene. The novel compounds have been tested against Electrophorus electricus AChE (EeAChE), human recombinant AChE (hAChE), and human serum butyrylcholinesterase (hBChE), and their brain penetration has been assessed using the PAMPA-BBB assay. Also, the mechanism of AChE inhibition of the most potent compounds has been thoroughly studied by kinetic studies, a propidium displacement assay, and molecular modelling. We have found that a seemingly small structural change such as a double O → NH bioisosteric replacement from the hit 1 to 16a results in a dramatic increase of EeAChE and hAChE inhibitory activities (>217- and >154-fold, respectively), and in a notable increase in hBChE inhibitory activity (> 11-fold), as well. An optimized binding at the PAS besides additional interactions with AChE midgorge residues seem to account for the high hAChE inhibitory potency of 16a (IC50 = 65 nM), which emerges as an interesting anti-Alzheimer lead compound with potent dual AChE and BChE inhibitory activities.

Análisis técnico-jurídico de la Ley de Emprendedores

Els temps canvien, i amb el temps, els negocis. L'entorn social, cultural i econòmic ha canviat durant els darrers anys i s’han desenvolupat grans oportunitats i difícils problemes. Molts dels països desenvolupats han sofert altes taxes d’atur i els individus han vist disminuïdes les seves qualitats de vida. Noves i a la vegada antigues opcions han sorgit per fer front a tots aquests canvis, una d’aquestes, l’autoocupació. Els emprenedors estan de moda, i qualsevol canvi social, implica un canvi legislatiu. El legislador espanyol ha trigat temps en desenvolupar mecanismes per protegir i promocionar als emprenedors. En primer lloc, aquesta investigació tracta d’entendre perquè Espanya és un dels països amb pitjors condicions per emprendre un negoci. En segon lloc, es pretén inspeccionar la Llei 14/2013 de recolzament als emprenedors i la seva internacionalització, aprovada els darrers mesos de l’any 2013, per veure si dóna solucions al problema anterior. En tercer lloc, per poder aconseguir aquesta difícil tasca, la investigació compara la legislació espanyola amb les necessitats reals dels emprenedors i amb les bones mesures implementades per altres països europeus. No hi ha dubte de que l’emprenedoria és una realitat, ara hem d’observar si les bones condicions per emprendre a Espanya també són una realitat.

Financiación autonómica y tributos cedidos: El impuesto de Sucesiones y Donaciones como instrumento de competencia fiscal

Aquest treball té com a objecte l'estudi del finançament de les CCAA posant l'accent en la figura del tribut cedit com a font de finançament de les mateixes. Més concretament es farà un estudi de la naturalesa de l'impost sobre successions i donacions com a tribut que tanca el marc de la imposició directa a Espanya i la seva repercussió en el sistema tributari actual. En primer lloc, s'estudia el sistema de finançament autonòmic. Posteriorment s'analitza l'impost de successions i donacions. Finalment, s'exposen algunes conclusions i reflexions sobre el sistema actual de finançament, així com la regulació del referit impost.

La influencia de la Constitución Española de 1812 en el constitucionalismo chileno del s. XIX. Un análisis comparado

Aquest treball presenta un anàlisi comparat de la Constitució espanyola de 1812 i les diverses constitucions xilenes del segle XIX. L’objectiu és determinar la influència d’una constitució vigent en ambdós territoris al desenvolupament constitucionalisme xilè posterior. L’estudi es realitza des de tres perspectives: institucional, estructural i literal.

Análisis bibliométrico sobre el Aprendizaje Basado en Problemas (ABP) en la educación superior a partir de la base de datos ERIC

[spa]El estudio bibliométrico descriptivo que sigue presenta tendencias de investigación sobre el aprendizaje basado en problemas entre 1974 y 2009. Se sirve de la base de datos ERIC y trabaja con una muestra de 1007 documentos. Se analizan los registros a tenor de cuatro variables: el año de publicación o realización, la titulación, el área de conocimiento y la tipología de investigación. En cuanto a la producción científica, pueden diferenciarse tres fases: la primera, de 1974 a 1989, supone el inicio de las publicaciones y muestra escasa relevancia estadística; la segunda, de crecimiento, durante la década de los 90 del pasado siglo; y la última, de maduración, desde el año 2000 hasta el año 2009. La distribución de los registros por sectores de conocimiento destaca Ciencias de la Salud, Ciencias Sociales y Enseñanzas Técnicas. Las titulaciones en las que más ha proliferado el ABP son Medicina, Económicas, Empresariales, Pedagogía, Formación del Profesorado y el conjunto de las ingenierías.

UOCsurveys

Aplicación para la creación de cuestionarios.

UOCsurveys : Aplicación web para la realización de cuestionarios

El trabajo final de carrera consiste en realizar el análisis, diseño e implementación de una aplicación web mediante la tecnología Java y la arquitectura J2EE. Se pretende desarrollar una aplicación web para la realización de cuestionarios.

Conservação de goiabas tratadas com emulsões de cera de carnaúba

A goiaba é um fruto muito perecível. Assim, objetivou-se avaliar os efeitos de ceras à base de carnaúba na conservação pós-colheita de goiabas Pedro Sato sob condição ambiente. Utilizaram-se cinco ceras comerciais: Citrosol AK (18%), Citrosol M (10%), Fruit wax (18 a 21%), Meghwax ECF-100 (30%) e Cleantex wax (18,5 a 20,5%), as quais foram aplicadas manualmente, na proporção de 0,15 a 0,20mL por fruta. Frutas sem aplicação de cera foram utilizadas como controle. O delineamento experimental foi inteiramente casualizado com 6 tratamentos, 4 repetições e 5 frutas por parcela. As goiabas foram caracterizadas imediatamente após a colheita e avaliadas aos 2, 4 e 6 dias após a aplicação dos tratamentos. As ceras exerceram pouca influência nos teores de sólidos solúveis totais, acidez total titulável e ácido ascórbico, porém, foram eficientes em retardar o amadurecimento, reduzir a perda de massa e a incidência de podridões. A cera Meghwax ECF-100 apresenta potencial para utilização em goiabas, porém há necessidade de ser avaliada em maior diluição, para evitar alterações indesejáveis.