873 resultados para Pitkänen, Risto


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The objective of this article is to review the scientific literature on airflow distribution systems and ventilation effectiveness to identify and assess the most suitable room air distribution methods for various spaces. In this study, different ventilation systems are classified according to specific requirements and assessment procedures. This study shows that eight ventilation methods have been employed in the built environment for different purposes and tasks. The investigation shows that numerous studies have been carried out on ventilation effectiveness but few studies have been done regarding other aspects of air distribution. Amongst existing types of ventilation systems, the performance of each ventilation methods varies from one case to another due to different usages of the ventilation system in a room and the different assessment indices used. This review shows that the assessment of ventilation effectiveness or efficiency should be determined according to each task of the ventilation system, such as removal of heat, removal of pollutant, supply fresh air to the breathing zone or protecting the occupant from cross infection. The analysis results form a basic framework regarding the application of airflow distribution for the benefit of designers, architects, engineers, installers and building owners.

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This study was conducted at three sites of different characteristics in Sao Paulo State Sao Paulo (SPA), Piracicaba (PRB) and Mate Atlantica Forest (MAT) PM(10), n-alkanes. pristane and phytane, PAHs, water-soluble ions and biomass burning tracers like levoglucosan and retene, were determined in quartz fiber filters. Samplings occurred on May 8th to August 8th, 2007 at the MAT site; on August 15th to 29th in 2007 and November 10th to 29th in 2008 at the PRB site and, March 13th to April 4th in 2007 and August 7th to 29th in 2008 at the SPA site Aliphatic compounds emitted biogenically were less abundant at the urban sites than at the forest site, and its distribution showed the influence of tropical vascular plants Air mass transport front biomass burning regions is likely to impact the sites with specific molecular markers The concentrations of all species were variable and dependent of seasonal changes In the most dry and polluted seasons, n-alkane and canon total concentrations were similar between the megacity and the biomass burning site PAHs and inorganic ion abundances were higher at Sao Paulo than Piracicaba, yet, the site influenced by biomass burning seems lobe the most impacted by the organic anion abundance in the atmosphere Pristane and phytane confirm the contamination by petroleum residues at urban sites, at the MAT site, biological activity and long range transport of pollutants might influence the levels of pristane (C) 2010 Elsevier B V All rights reserved

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Background In ROCKET AF, rivaroxaban was non-inferior to adjusted-dose warfarin in preventing stroke or systemic embolism among patients with atrial fibrillation (AF). We aimed to investigate whether the efficacy and safety of rivaroxaban compared with warfarin is consistent among the subgroups of patients with and without previous stroke or transient ischaemic attack (TIA). Methods In ROCKET AF, patients with AF who were at increased risk of stroke were randomly assigned (1:1) in a double-blind manner to rivaroxaban 20 mg daily or adjusted dose warfarin (international normalised ratio 2-0-3.0). Patients and investigators were masked to treatment allocation. Between Dec 18,2006, and June 17,2009,14 264 patients from 1178 centres in 45 countries were randomly assigned. The primary endpoint was the composite of stroke or non-CNS systemic embolism. In this substudy we assessed the interaction of the treatment effects of rivaroxaban and warfarin among patients with and without previous stroke or TIA. Efficacy analyses were by intention to treat and safety analyses were done in the on-treatment population. ROCKET AF is registered with ClinicalTrials.gov, number NCT00403767. Findings 7468 (52%) patients had a previous stroke (n=4907) or TIA (n=2561) and 6796 (48%) had no previous stroke or TIA. The number of events per 100 person-years for the primary endpoint in patients treated with rivaroxaban compared with warfarin was consistent among patients with previous stroke or TIA (2.79% rivaroxaban vs 2.96% warfarin; hazard ratio [HR] 0-94,95% CI 0.77-1.16) and those without (1.44% vs 1.88%; 0.77, 0.58-1-01; interaction p=0.23). The number of major and non-major clinically relevant bleeding events per 100 person-years in patients treated with rivaroxaban compared with warfarin was consistent among patients with previous stroke or TIA (13.31% rivaroxaban vs 13.87% warfarin; HR 0.96,95% CI 0.87-1-07) and those without (16.69% vs 15.19%; 1.10, 0.99-1.21; interaction p=0.08). Interpretation There was no evidence that the relative efficacy and safety of rivaroxaban compared with warfarin was different between patients who had a previous stroke or TIA and those who had no previous stroke or TIA. These results support the use of rivaroxaban as an alternative to warfarin for prevention of recurrent as well as initial stroke in patients with AF.

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Matrix metalloproteinases (MMPs, including the membrane-type MMPs (MT-MMPs)), a disintegrin and metalloproteinase (ADAM), and ADAM with thrombospondin motifs belong to the metzincins, a subclass of metalloproteinases that contain a Met residue and a Zn(2+) ion at the catalytic site necessary for enzymatic reaction. MMP proteolytic activity is mainly controlled by their natural tissue inhibitors of metalloproteinase (TIMP). A number of synthetic inhibitors have been developed to control deleterious MMP activity. The roles of MMPs and some of their ECM substrates in CNS physiology and pathology are covered by other chapters of the present volume and will thus not be addressed in depth. This chapter will focus (i) on the endogenous MMP inhibitors in the CNS, (ii) on MMP and TIMP regulations in three large classes of neuropathologic processes (inflammatory, neurodegenerative, and infectious), and (iii) on synthetic inhibitors of MMPs and the perspective of their use in different brain diseases.

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In this paper, we propose a new method for stitching multiple fluoroscopic images taken by a C-arm instrument. We employ an X-ray radiolucent ruler with numbered graduations while acquiring the images, and the image stitching is based on detecting and matching ruler parts in the images to the corresponding parts of a virtual ruler. To achieve this goal, we first detect the regular spaced graduations on the ruler and the numbers. After graduation labeling, for each image, we have the location and the associated number for every graduation on the ruler. Then, we initialize the panoramic X-ray image with the virtual ruler, and we “paste” each image by aligning the detected ruler part on the original image, to the corresponding part of the virtual ruler on the panoramic image. Our method is based on ruler matching but without the requirement of matching similar feature points in pairwise images, and thus, we do not necessarily require overlap between the images. We tested our method on eight different datasets of X-ray images, including long bones and a complete spine. Qualitative and quantitative experiments show that our method achieves good results.

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We measured condensation particle (CP) concentrations and particle size distributions at the coastal Antarctic station Neumayer (70°39'S, 8°15'W) during two summer campaigns (from 20 January to 26 March 2012 and 1 February to 30 April 2014) and during polar night between 12 August and 27 September 2014 in the particle diameter (Dp) range from 2.94 nm to 60.4 nm (2012) and from 6.26 nm to 212.9 nm (2014). During both summer campaigns we identified all in all 44 new particle formation (NPF) events. From 10 NPF events, particle growth rates could be determined to be around 0.90±0.46 nm/h (mean ± std; range: 0.4 nm/h to 1.9 nm/h). With the exception of one case, particle growth was generally restricted to the nucleation mode (Dp < 25 nm) and the duration of NPF events was typically around 6.0±1.5 h (mean ± std; range: 4 h to 9 h). Thus in the main, particles did not grow up to sizes required for acting as cloud condensation nuclei. NPF during summer usually occurred in the afternoon in coherence with local photochemistry. During winter, two NPF events could be detected, though showing no ascertainable particle growth. A simple estimation indicated that apart from sulfuric acid, the derived growth rates required other low volatile precursor vapours.

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The purpose of this study was to compare a number of state-of-the-art methods in airborne laser scan- ning (ALS) remote sensing with regards to their capacity to describe tree size inequality and other indi- cators related to forest structure. The indicators chosen were based on the analysis of the Lorenz curve: Gini coefficient ( GC ), Lorenz asymmetry ( LA ), the proportions of basal area ( BALM ) and stem density ( NSLM ) stocked above the mean quadratic diameter. Each method belonged to one of these estimation strategies: (A) estimating indicators directly; (B) estimating the whole Lorenz curve; or (C) estimating a complete tree list. Across these strategies, the most popular statistical methods for area-based approach (ABA) were used: regression, random forest (RF), and nearest neighbour imputation. The latter included distance metrics based on either RF (NN–RF) or most similar neighbour (MSN). In the case of tree list esti- mation, methods based on individual tree detection (ITD) and semi-ITD, both combined with MSN impu- tation, were also studied. The most accurate method was direct estimation by best subset regression, which obtained the lowest cross-validated coefficients of variation of their root mean squared error CV(RMSE) for most indicators: GC (16.80%), LA (8.76%), BALM (8.80%) and NSLM (14.60%). Similar figures [CV(RMSE) 16.09%, 10.49%, 10.93% and 14.07%, respectively] were obtained by MSN imputation of tree lists by ABA, a method that also showed a number of additional advantages, such as better distributing the residual variance along the predictive range. In light of our results, ITD approaches may be clearly inferior to ABA with regards to describing the structural properties related to tree size inequality in for- ested areas.

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Top Row: Maura P. Boran, Michelle M. Bernier, Pamela S. Reed, Catherine G. Dollries, Dorinda K. Nance, Sheila M. Raftery, Sandra J. Toner, Nancy E. Naeckel, Jill M. Cornell, Amy C. Wikol, Valerie A. Quaderer, Debra A. Davis, Beth I. Craigie, Lynne L. Stallworth, Elizabeth Foote

Row 2: Jill A. Stockwell, Katherine A. Allen-Bridson, Elizabeth J. Henry, Yvonne M. Levernois, Kristen Ligness, Karen Riffel, Carol Hayes, Lori Follmer, Laura Risto, Lisa Crouch, Kelli J. Chandler, Debra L. Browning, Cassandra L. Milne, Venus M. Varner

Row 3: Tamara D. Haas, Betsy A. Mahlke, Linda D. Dillard, Rebecca A. Miller, Julie A. Hatch, Kimberly E. Kinning, Elizabeth A. Bole, Sharon Szetela

Row 4: Jill Y. Frye, C. Holly Trentacoste, Hristine S. Cavanaugh, Shari W. Goldstein

Row 5: Lisa A. Danto, Laura L. Greig, Kristen L. Jacobus, Mary E. Zukowski, Tracy L. Park, Alicia L. Hempstead

Row 6: Catherine A. Mehall, Leigh A. Baguley, Heide Milbrandt-Godke, Tina Vasher, Cindy L. Bishop, Jayne C. Grun

Row 7: Paula M. Daoust, Cindy T. Cassidy, Sally J. Williams, Theresa Harris, Cheryl E. Easley, Janice B. Lindberg, Rhetaugh G. Dumas, Sally A. Sample, Shake Ketefian, Lori S. Smith, Teresa L. O'Brien, Lauren A. Christoff, Susan R. Stein

Row 8: Amy L. Manley, Jennifer L. Elie, Linda L. Grabowski, Cheryl L. Pavlik, Dana S. Berry, Kriste L. Fedon, Lynn M. Shute, Kathleen J. Burns, Suzanne L. Farhat, Kathryn E. Grant, Catharina M. Ojert, Laurie A. Klemczak, Caroline E. Broida, Mary M. Heikkinen

Row 9: Shelley A. Howington, Rita A. Mclemore, Shirley A. Stratton, Laura A. Sweeney, Bonnie L. Woods, Mary D. Wheatley, Colleen M. Brown, Ilze E. Sturis, Karen A. Gilbert, Amy L. Mayne, Jennifer L. Borucki, Connie L. Passon, Caryn A. Spielman, Judy L. Buhler

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Little attention in literature so far has been given to the impact of feedback on organizational development and change. As well as the impact of feedback on the innovation power of organizations. The capacity of innovation of organizations however may be seen as a crucial capacity of organizations to survive in competitive markets. Prior studies towards the impacts of feedback have more often analyzed formal and informal feedback separately, other than analyzing them together in one study. This master thesis develops and explores a model to assess the possible impact of both formal and informal feedback on the capacity of innovation within organizations. The master thesis is the closing assignment of a Master Study Management at the Open Universiteit Nederland. The general question of the single-case study is: What is the impact of formal and informal feedback on the capacity of innovation of companies? The explored model in the study is a combination of the model of Lawson and Samson (2001) about the capacity of innovation and the framework model of Pitkänen and Lukka (2011) about formal and informal feedback. The single-case study is performed at Yellowbrick, a Dutch company which offers consumers an online parking service, suitable for the use on smartphones. The single-case study is performed twofold by semi-structured interviews and a survey. Although conclusions may not be generalized, because of the limitations of the study and the particularly small investigated group, some findings may be suitable for further investigation. In the study was found that feedback has an impact on the capacity of innovation. Formal feedback scored higher than informal feedback when asked about the impact on the capacity of innovation. The study also found multiple ‘new’ kinds of feedback used by organizations, other than the more ‘traditional’ forms of feedback, such as team meetings and bilateral meetings. Further on was analyzed that when employees find themselves more involved in the process of an innovation, they also seem to score the organization higher on the capacity of this innovation.