A new Stata command for computing and graphing percentile shares

Percentile shares provide an intuitive and easy-to-understand way for analyzing income or wealth distributions. A celebrated example is the top income shares sported by the works of Thomas Piketty and colleagues. Moreover, series of percentile shares, defined as differences between Lorenz ordinates, can be used to visualize whole distributions or changes in distributions. In this talk, I present a new command called pshare that computes and graphs percentile shares (or changes in percentile shares) from individual level data. The command also provides confidence intervals and supports survey estimation.

MASP-1 Induced Clotting--The First Model of Prothrombin Activation by MASP-1.

Mannan-binding lectin-associated serine protease-1 (MASP-1), a protein of the complement lectin pathway, resembles thrombin in terms of structural features and substrate specificity. Due to its interplay with several coagulation factors, it has the ability to induce fibrin clot formation independent of the usual coagulation activation pathways. We have recently shown that MASP-1 activates prothrombin and identified arginine (R) 155, R271, and R393 as potential cleavage sites. FXa cleaves R320 instead of R393, and thrombin cleaves R155 and R284 in prothrombin. Here we have used three arginine-to-glutamine mutants of prothrombin, R271Q, R320Q, R393Q and the serine-to-alanine active site mutant S525A to investigate in detail the mechanism of MASP-1 mediated prothrombin activation. Prothrombin wildtype and mutants were digested with MASP-1 and the cleavage products were analysed by SDS-PAGE and N-terminal sequencing. A functional clotting assay was performed by thrombelastography. We have found that MASP-1 activates prothrombin via two simultaneous pathways, either cleaving at R271 or R393 first. Both pathways result in the formation of several active alternative thrombin species. Functional studies confirmed that both R393 and R320 are required for prothrombin activation by MASP-1, whereas R155 is not considered to be an important cleavage site in this process. In conclusion, we have described for the first time a detailed model of prothrombin activation by MASP-1.

Preprocedural High-Sensitivity Cardiac Troponin T and Clinical Outcomes in Patients With Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention.

BACKGROUND Cardiac troponin detected by new-generation, highly sensitive assays predicts clinical outcomes among patients with stable coronary artery disease (SCAD) treated medically. The prognostic value of baseline high-sensitivity cardiac troponin T (hs-cTnT) elevation in SCAD patients undergoing elective percutaneous coronary interventions is not well established. This study assessed the association of preprocedural levels of hs-cTnT with 1-year clinical outcomes among SCAD patients undergoing percutaneous coronary intervention. METHODS AND RESULTS Between 2010 and 2014, 6974 consecutive patients were prospectively enrolled in the Bern Percutaneous Coronary Interventions Registry. Among patients with SCAD (n=2029), 527 (26%) had elevated preprocedural hs-cTnT above the upper reference limit of 14 ng/L. The primary end point, mortality within 1 year, occurred in 20 patients (1.4%) with normal hs-cTnT versus 39 patients (7.7%) with elevated baseline hs-cTnT (P<0.001). Patients with elevated hs-cTnT had increased risks of all-cause (hazard ratio 5.73; 95% confidence intervals 3.34-9.83; P<0.001) and cardiac mortality (hazard ratio 4.68; 95% confidence interval 2.12-10.31; P<0.001). Preprocedural hs-TnT elevation remained an independent predictor of 1-year mortality after adjustment for relevant risk factors, including age, sex, and renal failure (adjusted hazard ratio 2.08; 95% confidence interval 1.10-3.92; P=0.024). A graded mortality risk was observed across higher tertiles of elevated preprocedural hs-cTnT, but not among patients with hs-cTnT below the upper reference limit. CONCLUSIONS Preprocedural elevation of hs-cTnT is observed in one fourth of SCAD patients undergoing elective percutaneous coronary intervention. Increased levels of preprocedural hs-cTnT are proportionally related to the risk of death and emerged as independent predictors of all-cause mortality within 1 year. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT02241291.

Erschaffung des Menschen [Illustration] : Relief

Lorenz Ghiberti

Opferung Isaks [Illustration]

Lorenz Ghiberti

Opferung Isaks [Illustration] : (Relief an den "Paradiesestüren" des Baptiseriums)

Lorenz Ghiberti

Die Segnung Jakobs [Illustration]

Lorenz Ghiberti

Die Waisen aus Kischenew auf der Reise

Lorenz Rathauser

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 811 - Verspätetes Antwortschreiben mit Mitteilungen zu gemeinsamen Freunden und Bekannten

u.a. angebliche Beleidigungen Schopenhauers gegenüber Lorenz Meyer; geplante Reise nach Frankreich;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 810 - Antwortschreiben auf die positiven Erlebnisse Schopenhauers in Wimbledon

u.a. Ritterliche Übungen Arthur Schopenhauers; französischer Chanson; Einladung nach Montpellier;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 815 - Mitteilungen über aktuelle Ereignisse

abgedruckt in: Schopenhauer-Jahrbuch 51 (1970), S 38-40

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 814 - Antwortschreiben aus England auf die Mitteilungen aus Wien

u.a. Reisebericht;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 812 - Erfahrungsbericht über naturwissenschaftliche Experimente

u.a. Verbrennungen als Folge eines Unfalls; Europareisen; Konfirmation; Fahrt nach Montpellier;

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 820 - Antwort auf die Klagen Schopenhauers

u.a. Probleme Schopenhauers mit den Eltern; Mord in Hamburg; Schottlandreise der Eltern;