972 resultados para Leucemia mileóide aguda Genética
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Pós-graduação em Fisiopatologia em ClÃnica Médica - FMB
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Pós-graduação em Agronomia - FEIS
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The kindergarten has as main objective the development of the child from zero to five years in their physical, emotional, cognitive and social domains. This is also the goal of the Centers for Children Living from the Universidade Estadual Paulista (UNESP) that caters to children of teachers, technical and administrative staff and students. In this work we report some of the action of the Technical Commission of the CCIs with reflections on the construction of children's knowledge through observations of the CCIs in different campuses of Unesp, conducted through technical visits. As a theoretical contribution we adopt the Genetic Epistemology of Jean Piaget. Partial results show that, although there are efforts to understand and assist the process of constructing knowledge of children, many challenges remain to be overcome in the realization of an excellent service to children.
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Pós-graduação em Genética e Melhoramento Animal - FCAV
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Pós-graduação em Genética - IBILCE
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Pós-graduação em Microbiologia - IBILCE
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Pós-graduação em Medicina Veterinária - FCAV
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Pós-graduação em Ciências Biológicas (Genética) - IBB
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Currently individuals are affected by a routine busy and they don't have time for physical activity, highlighting the sedentary lifestyle, a risk factor for cardiovascular diseases. For this reason, it focuses too much on cardiovascular diseases and the importance of physical practice. With the largest divulgation and variety of physical activities, activities that were not as practiced became popular, as is the case of resistive exercise. Much is said of the influence of resistance exercise in physical strength, in muscle development and in the quest for a more defined body. However, studies have shown beneficial contributions of resistance exercise on the cardiovascular system. During the physical effort, some changes occur in the body in order to meet the increased demand for oxygen. Among them is the increase in heart rate (HR), which varies with the intensity of effort. Thus, this research sought to contribute with an analysis of the HR behavior before, during and after 3 sets of hypertrophy, as far for the flexor group of the elbow as to the extensor group. It was observed that, although the HR has increased in the course of the series, the variations of HR were not significant between the flexor group and extensor group of the elbow joint. Also were not significant the differences between the variations of the HR from the 1ª to the 2ª series between the flexor group and extensor group, as well as to the variations from the 2ª to the 3ª series
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The aim of this study was to analyse the genetic diversity and agronomic performance of a group of advanced and superior strains of soybean, derived from biparental, four-way and eight-way crosses, in order to identify future promising and superior combinations. The experiment was carried out in the experimental area of the Paulista State University, Julio de Mesquita Filho, Jaboticabal Campus, in the state of Sao Paulo, Brazil. The characteristics under evaluation were: number of days to flowering, plant height at flowering, number of days to maturity, plant height at maturity, height of the first pod, number of branches, number of pods per plant, agronomic value, lodging, one hundred seed weight and seed yield., The Mahalanobis distance and the relative contribution of each characteristic were used to calculate the phenotypic distances. Among the genotypes analysed, 19 strains displayed high productivity, being superior to the controls (V-max, CD 216, CD 219 and Conquista). The greatest distance found was between strains JAB 41 and JAB 17 (279.81), followed by JAB 40 and JAB 17 (261.38) and between JAB 40 and JAB 22 (255.46). There were six groups formed using the Ward method, indicating the presence of genetic variability among the tested strains. Increasing the number of parents had no effect on the increase in genetic diversity between the strains, and was not the factor responsible for the grouping or not of the genotypes under test.
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One of the greatest challenges for the agricultural system is to establish agricultural production combined with the conservation of genetic resources, mainly aiming to protect the Permanent Preservation Areas. In this context, mulungu ( Erythrina velutina Willd), among other native species, has been suffering with anthropogenic pressures in various ecosystems, causing reductions in its genetic basis. This work aims to identify ecological and genetic population parameters as indicators of sustainability in two natural populations of mulungu, located in riparian forest, in the state of Sergipe, and to assess the tendency to their sustainability, aiming genetic conservation of the species. The matrix of Pressure-State-Impact/Effect-Response (PEI/ER) was used with the selection of 13 indicators, from the use of RAPDmolecular markers and biochemical (enzymes) markers in populations, in order to present them as relevant information to measure progress as for sustainability and conservation ofmulungu. The studied populations presented low tendency to sustainability, requiring strategies to change this status.
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Benzodiazepines are one of the most frequently prescribed drugs due to their anxiolytic properties. The aim of this study was to evaluate the effects of diazepam on lipopolysaccharide-induced peritoneal acute inflammatory responses. Swiss mice were treated with diazepam in a single dose of 1 or 10 mg/kg- subcutaneously 1 h before an intraperitoneal injection of lipopolysaccharide or sterile saline solution. The mice were killed 16 h after and the cells were washed from the peritoneal cavity to determine the total number of cells and the mononuclear and polimorfonuclear subpopulations, as well as the TNF-alpha activity and percentage of spread macrophages. Our results showed that the diazepam treatment (1 and 10 mg/kg) induced a significant reduction in the LPS-induced macrophage stimulation and TNF-α activity. Diazepam (10 mg/kg) also reduced the inflammatory cellular migration when compared to the control. It can be concluded that the diazepam treatment in a single dose is able to influence the inflammatory cellular influx, macrophage stimulation and TNF-α activity in the acute inflammatory response in mice, having possible implications on the anti-infectious response efficiency.
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BACKGROUND AND OBJECTIVES: Vaginal birth delivery may result in acute and persistent perineal pain postpartum. This study evaluated the association between catastrophizing, a phenomenon of poor psychological adjustment to pain leading the individual to magnify the painful experience making it more intense, and the incidence and severity of perineal pain and its relationship to perineal trauma. METHOD: Cohort study conducted with pregnant women in labor. We used the pain catastrophizing scale during hospitalization and assessed the degree of perineal lesion and pain severity in the first 24 hours and after 8 weeks of delivery using a numerical pain scale. RESULTS: We evaluated 55 women, with acute pain reported by 69.1%, moderate/severe pain by 36.3%, and persistent pain by 14.5%. Catastrophizing mean score was 2.15 ± 1.24. Catastrophizing patients showed a 2.90 relative risk (RR) for perineal pain (95% CI: 1.08-7.75) and RR: 1.31 for developing persistent perineal pain (95% CI: 1.05-1.64). They also showed a RR: 2.2 for developing acute and severe perineal pain (95% CI: 1.11-4.33). CONCLUSIONS: The incidence of acute and persistent perineal pain after vaginal delivery is high. Catastrophizing pregnant women are at increased risk for developing acute and persistent perineal pain, as well as severe pain. Perineal trauma increased the risk of persistent perineal pain.
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Conselho Nacional de Desenvolvimento CientÃfico e Tecnológico (CNPq)
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Pós-graduação em Fisiopatologia em ClÃnica Médica - FMB