925 resultados para High temperature liquid chromatography


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"Materials Central, Contract no. AF 33(616)-6552, Project no. 7381."

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"This report was prepared by the Research and Development Department of the New Departure Division, General Motors Corporation in Bristol, Connecticut."

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Mode of access: Internet.

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"Materials Laboratory, Contract number AF 61(514)-1144, Project no. 7351."

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"Project No. 1426. Task No. 142612."

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"December 1991."

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Prepared by Massachusetts Institute of Technology, Laboratory for Insulation Research, under USAF Contract F33615-67C-1612.

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Bibliography: pt. 1, p. 37-38.

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Caption title.

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The study was a comparison of bioassay and HPLC analysis of artesunate (ARTS) and dihydroartemisinin (DHA) in plasma. ARTS and DHA in plasma samples from patients treated with ARTS were quantified by HPLC and expressed as DHA. DHA-equivalents in the same plasma samples were measured using a standardised parasite culture technique. DHA concentrations estimated by both methods were highly correlated (bioassay = 0.96 x HPLC + 11.0; r(2) = 0.92). At high concentrations ( > 12 000 nmol/l) bioassay sometimes overestimated DHA. Bioassay of active drug in plasma correlates well with specific chemical analysis by HPLC. ARTS and DHA appear to account for the total antimalarial activity in plasma after ARTS administration. (C) 2003 Elsevier Science B.V. All rights reserved.