Composition and Activity against Oral Pathogens of the Essential Oil of Melampodium divaricatum (Rich.) DC.

The chemical composition of the essential oil isolated from the aerial parts of Melampodium divaricatum (Rich.) DC. (Asteraceae) was characterized by GC-FID and GC/MS analyses. (E)-Caryophyllene (56.0%), germacrene D (12.7%), and bicyclogermacrene (9.2%) were identified as the major oil components. The antimicrobial activity of the oil against seven standard strains of oral pathogens from the American Type Culture Collection (ATCC) was evaluated by determining minimum inhibitory concentrations (MICs) using the microdilution method. MIC Values below 100 mu g/ml were obtained against Streptococcus sobrinus (90 mu g/ml), Lactobacillus casei (30 mu g/ml), S. mutans (20 mu g/ml), and S. mitis (18 mu g/ml). In contrast, the MIC values of the major oil compound (E)-caryophyllene were higher than 400 mu g/ml against all pathogens, suggesting that the activity of the oil might depend on minor oil components and/or on synergistic effects. The M. divaricatum essential oil is a promising agent to include in anticariogenic oral rinse formulations for the control of oral pathogens.

Reducing supplementation frequency for Nellore beef steers grazing tropical pastures

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Produtividade da cana-de-açúcar e definição de zonas específicas de manejo do solo

The correct spatial intervention in the administration of the plantation, arising from specific areas of soil mapping, can increase your productivity as well as profitability and yields in agriculture. The spatial and Pearson's relationships between sugarcane attributes and chemical attributes of a Typic Tropustalf were studied in the growing season of 2010, in Suzanapolis, State of Sao Paulo, Brazil (20 degrees 27'33 '' S lat.; 51 degrees 08'05 '' W long.), in order to obtain the attributes that had the best sugarcane productivity relationship. To this end, a geostatistical grid containing 118 sample points was installed for soil and plant data collection in an area of 10.5 ha with the third crop cut. The productivity of sugarcane (PRO) represented the attribute of the plant, while the attributes of the soil were: K+, Ca+2, Mg+2 and organic matter at depths of 0-0.20 m and 0.20-0.40 m. Relationships were calculated between the PRO and the attributes of the soil. Semivariograms were adjusted for all attributes, obtaining the respective krigings and the cross-validations. It was also made the cokrigings between the PRO and the soil attributes. The levels of the soil organic matter, for their evident substantial correlations, Sperman's Rho and spatial, with the productivity of sugarcane, are indicators of two specific areas of soil management strongly associated with the productivity of sugarcane. In such zones this productivity varies between 75.8-94.7 t ha(-1) and 101.0-119.9 t ha(-1), when the levels of organic matter respectively are 12.7-14.5 g dm(-3) (0-0.20 m) and 11.8-12.8 g dm(-3) (0.20-0.40 m).

Deleterious effects of low level of vitamin E and high stocking density on the hematology response of pacus, during chronic inflammatory reaction

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Decreased rate of protein synthesis, caspase-3 activity, and ubiquitin-proteasome proteolysis in soleus muscles from growing rats fed a low-protein, high-carbohydrate diet

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Tradução comentada de Peregrinaciones de una alma triste de Juana Manuela Gorriti

Pós-graduação em Letras - FCLAS

O papel dos projetos sociais na vida de adolescentes em contextos potenciais de rico e processos de resiliência

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Chico Antonio n' A Barca Mário de Andrade e outros diálogos com a tradição musical popular

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Controlabilidade para sistemas de equações diferenciais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Estudo da distribuição e do potencial de metilação do mercúrio em solos e sedimentos de áreas a serem inundadas para aproveitamento hidrelétrico: Vinicius Marques Gomes. -

Pós-graduação em Química - IQ

Macrophage Cell Activation with Acute Apical Abscess Contents Determined by Interleukin-1 Beta and Tumor Necrosis Factor Alpha Production

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Clinicopathologic features and outcome of mycophenolate-induced colitis in renal transplant recipients

Reports on the clinical course of mycophenolic acid (MPA)-related colitis in kidney transplant recipients are scarce. This study aimed at assessing MPA-related colitis incidence, risk factors, and progression after kidney transplantation. All kidney transplant patients taking MPA who had colonic biopsies for persistent chronic diarrhea, between 2000 and 2012, at the Kidney Transplantation Unit of Botucatu Medical School Hospital, Brazil, were included. Cytomegalovirus (CMV) immunohistochemistry was performed in all biopsy specimens. Data on presenting symptoms, medications, immunosuppressive drugs, colonoscopic findings, and follow-up were obtained. Of 580 kidney transplant patients on MPA, 34 underwent colonoscopy. Colonoscopic findings were associated with MPA usage in 16 patients. The most frequent histologic patterns were non-specific colitis (31.3%), inflammatory bowel disease (IBD)-like colitis (25%), normal/near normal (18.8%), graft-versus-host disease-like (18.8%), and ischemia-like colitis (12.5%). All patients had persistent acute diarrhea and weight loss. Six of the 16 MPA-related diarrhea patients (37.5%) showed acute dehydration requiring hospitalization. Diarrhea resolved when MPA was switched to sirolimus (50%), discontinued (18.75%), switched to azathioprine (12.5%), or reduced by 50% (18.75%). No graft loss occurred. Four patients died during the study period. Late-onset MPA was more frequent, and no correlation with MPA dose or formulation was found.

Evaluation of Antimalarial Activity and Toxicity of a New Primaquine Prodrug

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Environmental factors influencing the distribution of three species within the genus Persephona Leach, 1817 (Crustacea, Decapoda, Leucosiidae) in two regions on the northern coast of Sao Paulo State, Brazil

Patterns of spatio-temporal distribution of Brachyura are determined by the interaction among life history traits, inter and intraspecific relationships, as well as by the variation of abiotic factors. This study aimed to characterize patterns of spatio-temporal distribution of Persephona lichtensteinii, Persephona mediterranea and Persephona punctata in two regions of the northern coast of Sao Paulo State, southeastern region of Brazil. Collections were done monthly from July 2001 to June 2003 in Caraguatatuba and Ubatuba, using a shrimp fishery boat equipped with double-rig nets. The patterns of species distribution were tested by means of redundancy analysis (RDA) and generalized linear mixed models (GLMM) in relation to the recorded environmental factors (BT: bottom temperature, BS: bottom salinity, OM: organic matter and granulometry (Phi)). The most influent environmental factor over the species distribution was the Phi, and the ascendant order of influence was P. lichtensteinii, P. punctata and P. mediterranea. The greater abundance of P. mediterranea showed a conservative pattern of distribution for the genus in the sampled region. The greater occurrence of P. punctata and P. lichtensteinii, in distinct transects than those occupied by P. mediterranea, seems to be a strategy to avoid competition among congeneric species, which is related to the substratum specificity.