984 resultados para Filmes moleculares auto-organizados


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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Neste trabalho, que está baseado nos princípios da Análise do Discurso francesa, seguindo especialmente o pensamento de Maingueneau, analisamos a relação que há entre o discurso de auto-ajuda e os provérbios, o que nos permitiu verificar que o discurso em questão pode ser considerado como um caso de captação do gênero proverbial.

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Neste trabalho, baseado nos princípios da Análise do Discurso francesa, seguindo especialmente o pensamento de Maingueneau (1998), analisamos a modalidade na literatura de auto-ajuda, o que nos permitiu verificar que a manifestação da certeza é um dos traços semânticos desse discurso.

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Pós-graduação em Biologia Geral e Aplicada - IBB

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Pós-graduação em Ciências Farmacêuticas - FCFAR

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Dermatosparaxis in animals is an autosomal recessive disorder of the connective-tissue clinically characterized by skin fragility and hiperextensibility. The disease in White Dorper sheep is caused by mutation (c.421G>T) in the ADAM metalloproteinase with thrombospondin type 1 motif, 2 (ADAMTS2) gene. This study describes the dermatological, histological and the molecular findings of the dermatosparaxis in White Dorper sheep from a herd located in the center-west of São Paulo State. The herd consisted of one ram, four ewe and their lambs. In this herd two lambs had clinical signs consistent with dermatosparaxis. Histopathological evaluation of the affected skin of these two animals also revealed consistent findings with dermatosparaxis, characterized by dysplasia of the collagen, which were arranged in small and fragmented collagen bundles and with foci of degeneration of collagen. Prominent cutaneous appendages and severe hemorrhagic focus in dermis region associated with mild neutrophilic infiltrate in the deep dermis. PCR using DNA blood and specific primers to amplify the mutation region c.421G>T was optimized in order to perform molecular diagnosis of the disease. The direct sequencing of the PCR products proved that the two clinically affected animals had the mutation responsible for dermatosparaxis, previously described for this breed and allowed the definitive diagnosis of the disease. This is the first report of the dermatosparaxis in White Dorper sheep in Brazil and the methodology used to confirm the diagnosis could be used in future studies to assess the prevalence of this mutation in Brazil, allowing the adoption of measures to prevent the spread of this mutation in the Brazilian White Dorper herd.

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This paper investigated the influence of the amount of superplasticizer and mineral adding - silica fume and basaltic filer - in plastic shrinkage and cracking of self-compacting concrete (SCC) mortars. Initially analysis was performed of the rheological behavior of cement paste and mortars phases of the compositions of SCC. Then the deformations of mortars were measured by the effect of shrinkage and evaluation of cracking. On plastic shrinkage and cracking, the composition with silica fume showed superior results, independent of wind and superplasticizer content, relative to the composition with addition of basalt filler. However, the composition with silica fume showed superior results only in the tests with imposed ventilation at vertical plastic deformation. The rheological behavior affected directly the plastic shrinkage and cracking at early ages, fact confirmed by the analysis of capillary pressures of mortars tested.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)