Reliure de : Poésies galliques, traduites sur l'anglois de M. Macpherson, par M. Le Tourneur

Numérisation partielle de reliure

Cobalamin deficiency resulting in a rare haematological disorder: a case report.

INTRODUCTION: We present the case of a patient with a cobalamin deficiency resulting in pancytopaenia, emphasizing the importance to define, diagnose and treat cobalamin deficiency. CASE PRESENTATION: A 52-year-old man from the Democratic Republic of Congo presented to the emergency department with shortness of breath and a sore tongue. Physical examination was unremarkable. His haemoglobin was low and the peripheral blood smear revealed pancytopaenia with a thrombotic microangiopathy. The findings were low cobalamin and folate levels, and high homocysteine and methylmalonate levels. Pernicious anaemia with chronic atrophic gastritis was confirmed by gastric biopsy and positive antiparietal cell and anti-intrinsic factor antibodies. Cobalamin with added folate was given. Six months later, the patient was asymptomatic. CONCLUSION: Cobalamin deficiency should always be ruled out in a patient with pancytopaenia. Our case report highlights a life-threatening cobalamin deficiency completely reversible after treatment.

Médaille décernée à Henri Labrouste, à l'école des Beaux-Arts, en 1823 / E. Gatteaux

Ancien possesseur : Labrouste, Henri (1801-1875)

SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools.

BACKGROUND: Qualitative frameworks, especially those based on the logical discrete formalism, are increasingly used to model regulatory and signalling networks. A major advantage of these frameworks is that they do not require precise quantitative data, and that they are well-suited for studies of large networks. While numerous groups have developed specific computational tools that provide original methods to analyse qualitative models, a standard format to exchange qualitative models has been missing. RESULTS: We present the Systems Biology Markup Language (SBML) Qualitative Models Package ("qual"), an extension of the SBML Level 3 standard designed for computer representation of qualitative models of biological networks. We demonstrate the interoperability of models via SBML qual through the analysis of a specific signalling network by three independent software tools. Furthermore, the collective effort to define the SBML qual format paved the way for the development of LogicalModel, an open-source model library, which will facilitate the adoption of the format as well as the collaborative development of algorithms to analyse qualitative models. CONCLUSIONS: SBML qual allows the exchange of qualitative models among a number of complementary software tools. SBML qual has the potential to promote collaborative work on the development of novel computational approaches, as well as on the specification and the analysis of comprehensive qualitative models of regulatory and signalling networks.

La chasse au fusil...

Mécénat texte imprimé : Cet ouvrage a été numérisé grâce à un don du Musée de la Chasse et de la Nature, Paris

[Illustrations de La tragique expédition de Lapérouse et Langle] / [Non identifié] ; Vicomte Paul Fleuriot de Langle, aut. du texte

Comprend : [Couverture : le char de Neptune. Bateaux de Lapérouse et de Langle. Carte des terres de Polynésie et d'Australie.] [Cote : 16 ° Ln27 85465/Microfilm R 122008] ; [Carte double avant la p.10 de l'Avant-propos :] Voyages de Lapérouse 1785-1788 (...). [Cote : 16 ° Ln27 85465/Microfilm R 122008] ; [pl. en reg. p.80 :] J.F. Galaup de Lapérouse (...). P.A. Fleuriot de Langle (...). [Cote : 16 ° Ln27 85465/Microfilm R 122008] ; [pl. en reg. p.81 :] Manoir de Rosvilio, près Callac (Côtes-du-Nord) demeure du Chevalier de Langle (...). [Cote : 16 ° Ln27 85465/Microfilm R 122008] ; [pl. en reg. p.96 :] Louis XVI donne ses instructions aux chefs de l'expédition (...). [Cote : 16 ° Ln27 85465/Microfilm R 122008] ; [pl. en reg. p.97 :] Insulaires et cyclopes de l'île de Paques (...). [Cote : 16 ° Ln27 85465/Microfilm R 122008] ; [pl. en reg. p.160 :] Mouillage des frégates françaises devant l'île de Mowee (...). [Cote : 16 ° Ln27 85465/Microfilm R 122008] ; [pl. en reg. p.161 :] Costume des habitants de la baie de Langle, manche de Tartarie (.. .). [Cote : 16 ° Ln27 85465/Microfilm R 122008] ; [pl. en reg. p.192 :] Massacre de MM. De Langle, de Lamanon et de dix autres membres des deux équipages, à Tutuila, Océanie (...). [Cote : 16 ° Ln27 85465/Microfilm R 122008] ; [pl. en reg. p.193 :] Mémorial élevé à Tutuila, en 1887, par les soisn de la Marine française, en souvenir du 11 décembre 1787 (...). [Cote : 16 ° Ln27 85465/Microfilm R 122008]