Analytical relationship between family history and genetic and environmental risks, with application to female breast cancer

It is well established in genetic epidemiology that family history is an important indicator of familial aggregation of disease in a family. A strong genetic risk factor or an environmental risk factor with high familial correlation can result in a strong family history. In this paper, family history refers to the number of first-degree relatives affected with the disease. Cui and Hopper (Journal of Epidemiology and Biostatistics 2001; 6: 331-342) proposed an analytical relationship between family history and relevant genetic parameters. In this paper we expand the relationship to both genetic and environmental risk factors. We established a closed-form formula for family history as a function of genetic and environmental parameters which include genetic and environmental relative risks, genotype frequency, prevalence and familial correlation of the environmental risk factor. The relationship is illustrated by an example of female breast cancer in Australia. For genetic and environmental relative risks less than 10, most of the female breast cancer cases occur between the age of 40 and 60 years. A higher genetic or environmental relative risk will move the peak of the distribution to a younger age. A more common disease allele or more prevalent environmental risk factor will move the peak to an older age. For a proband with breast cancer, it is most likely (with probability ge80%) that none of her first-degree relatives is affected with the disease. To enable the probability of having a positive family history to reach 50%, the environmental relative risks must be extremely as high as 100, the familial correlation as high as 0.8 and the prevalence as low as 0.1. For genetic risk alone, even the relative risk is as high as 100, the probability of having a positive family history can only reach about 30%. This suggests that the environmental risk factor seems to play a more important role in determining a strong family history than the genetic risk factor.

Genetic and environmental influences on variation in balance performance among female twin pairs aged 21-82 years

Genetic and environmental influences on variation in balance performance were measured in 93 monozygous and 83 dizygous female twin pairs aged 21–82 years (mean age, 50.5 years) in Melbourne, Australia, between 1999 and 2003. The authors administered clinical (Lord's Balance Test and Step Test) and laboratory tests of static and dynamic balance from the Chattecx Balance System with and without distractor tasks. The authors conducted factor analysis and estimated genetic and environmental variance components and heritability (defined as additive genetic variance as a proportion of all variance, after adjustment for age) using a multivariate normal model with the statistical package FISHER. Three factors were identified and adjusted for age. Heritability was 46% (standard error (SE), 9) for the "sensory balance tests" factor and 30% (SE, 9) for the "static and dynamic perturbations" factor. For both factors, the remaining variance was attributed to unique environmental effects. There was no evidence that genetic factors influenced variation in the "dynamic weight shift tests" factor, with environmental effects shared by twins accounting for 38% (SE, 7) of variance. Neither genetic nor environmental proportions of variance differed significantly between twin subgroups by age (≤50/>50 years). An age-related decline in performance measures was found across the whole sample. These results imply that balance impairments may have a heritable element.

The future of football is female : a case of fan-tastic imaginings?

Consistent with FIFA president Sepp Blatter’s proclamation that the future of football is female, the Australian Football League (AFL) has instituted a range of initiatives in an attempt to present a ‘female friendly’ face and garner women’s support for the national game. Given the large number of women who follow the AFL, especially in comparison to other football codes nationally, it’s worth considering the motivations behind the AFL’s tactics. To what extent does what the AFL think women want correlate with women supporters’ experiences and realities of being a football fan? This paper presents findings from semi-structured and focus group interviews with female AFL fans to gauge their perceptions of being an Australian rules football supporter and its impact on their lived experiences and sense of self. The responses of women supporters are critically assessed in order to contemplate how women negotiate gender identity through their support of a male dominated sport. As well as offering insights into the role gender plays in leisure pursuits such as sport spectatorship, this paper considers how femininity and masculinity might be contested and/or remade through the practice of following football in the Australian context. By demonstrating the range and diversity of women’s experiences, this research has the capacity to generate alternative imaginings of fanship and sporting community beyond gender stereotypes.

‘My school has been quite pushy about the Oxbridge thing’ : voice and choice of higher education

Whilst government policies are now pushing teachers to listen to pupils, this concern is largely framed within the school improvement agenda. This is not the only arena where listening to pupils counts. This article examines the ways in which two young people, making a significant choice about which university to attend, felt unable to discuss their interests and concerns with their teachers. In one case, this resulted in a young woman doing less well in her examinations in order to avoid getting her first preference of Oxbridge, and securing her ‘real choice’ at another Russell Group university. The other was not invited by his school to apply to Oxbridge, despite a desire to go there which he felt unable to articulate at school. We suggest that, given the current concern over widening participation, these two cases provide hints that all is not well with school gate-keeping and career guidance procedures.

Female university students' perceptions of a sexual assault when victim and perpetrator gender are varied

This study examines the general impressions and blame attributions of Trinidadian university students in cases of sexual assault. Participants were 132 female students from the University of the West Indies, Faculty of Social Sciences. Each respondent read one of four sexual assault scenarios, in which victim and perpetrator gender were varied. Participants' impressions of the incident, opinions about each party's behaviour, blame attributions, attitudes about reporting the incident to the police, desired outcome, and their reasons for these were then assessed. Consistent with Burt's rape myth theory, the qualitative and quantitative results showed a tendency for participants to attribute an internal locus of control to female victims, and to blame them more than males. Although same sex events evoked significantly more emotional and disgust-related reactions, these reactions did not translate into different seriousness scores, or different ideas about whether the victim should report the incident to the police. Although respondents showed an ability to separate their initial reactions from their attitudes about the legal status of the event, many of the response patterns indicated gender role biases on the part of these future professionals.

Female sexual dysfunction

This thesis examined the aetiology of female sexual dysfunction (FSD) and a model to represent sexual function. Relationship factors were the main predictor of sexual function for women with FSD. A circular model of sexual response represented women's sexual experience for those with FSD and those who did not have FSD. In order to illustrate the role of family emotional involvement in children's development of psychological disorders the portfolio presents and explores four case studies.

Microscopic modifications of the female reproductive tissues of Mustelus antarcticus

The ovarian follicles and oviducal glands have structural organisations similar to other chondrichthyans. Sperm are stored in the oviducal gland of all maturing and mature animals throughout the year and throughout pregnancy. Microscopic features of the uterine epithelium suggest nutrients are supplied to developing embryos without placenta formation.

The female nude

This thesis argues that a sense of personal power, agency and self-worth can be regained through art practice and will cite examples of this process by artists and others who are outside the parameters of hegemony. The author's experience as a female artist is discussed within the context of historical and contemporary art practices that focus mainly on representations of the female nude, and therefore follows the notion that the personal is political.

Female-perpetrated child sexual abuse

Research has shown that female-perpetrated child sexual abuse is under-recognised. Three studies were undertaken concerning victims' experiences, professional perspectives and court sentencing transcripts. These studies found that victim impact was significant; professionals considered the phenomenon less serious than male sexual offending; and that female sexual offenders were dealt with less harshly than male offenders within the criminal justice system. The portfolio examines four case studies concerning adult females who have reported a history of child sexual abuse within the context of a dual-diagnosis counselling agency and investigates both psychological and behavioural difficulties revealed by each of the young women.

Victimological and cognitive scripting study of adult male and female rape

From this exploratory study it appears that the experience of adult rape has many similarities for men and women, but there are additional factors which may account for the adjustment differences and difficulties for and of men.

A study of performing techniques and interpretations of G.F. Handel's operatic and oratorio arias for contralto voice

A comprehension of the interpretations and performing techniques of Handel's works is sought in order to perform a program of his vocal works. Genres, 17th and 18th century performance practice, modern interpretation of the repertoire and the author's personal realisations are examined.