Multiple trauma in a 5 years child with a longitudinal follow up

Dental-alveolar trauma in the primary dentition associated with intra-cranial injuries is not common. This article reports the management of a complex trauma involving cranial trauma and multiple luxations and avulsions of primary teeth in a five-year old boy as a consequence of a horse kick. The treatment, including the hospital intervention and dentistry procedures, is described. The clinical outcomes are reported at a 5-year follow-up.

Extrações seriadas: protocolo e inplicações clínicas

A Ortodontia é uma especialidade da Odontologia que visa, entre seus diversos objetivos, proporcionar uma arcada dentária alinhada, estável e funcional. A discrepância dentoalveolar negativa em indivíduos na fase de dentição mista apresenta alta prevalência e requer a utilização de métodos de tratamento que proporcionem a obtenção de espaço. As extrações seriadas constituem uma solução adequada, mas frequentemente questionada quanto às indicações, contraindicações e sequência apropriada. Assim, o propósito deste artigo é apresentar uma discussão, embasada na literatura pertinente, dos principais fatores envolvidos com esse procedimento e ilustrar esta terapia por meio de um caso clínico.

Educação em saúde bucal na visão de acadêmicos de odontologia

Aim: To analyze dental students' view concerning Oral Health Education. Materials and Methods: The present research, using both qualitative and quantitative approaches, addresses aspects related to dental students' understanding of Oral Health Education, the value that they attach to this practice in the school environment, as well as the importance of their participation in these and other activities during their studies in dentistry. Results: Although dental students recognize the importance of Oral Health Education in the school environment,as well as the importance of their own participation within these activities, their perception of "Oral Health Education" is reductionist and focused primarily on the disease. Conclusion: It is well-known that these findings are reflections and consequences of an established context within a university education. It is therefore necessary that these professional educators perform an in-depth rethinking of the dental practice, in an attempt to develop methodologies based on Health Education in their own teaching practices.

The importance of a good relationship between patient/dentist based on the obtaining of an informed consenr to prevent lawsuits

The increased number of law suits in the Dentistry field constitutes an international trend. Patients well informed by the media and supported by the law sue their dentists, when they judge they were victim of bad practice. Professionals even with all discussion about this subject do not have the habit of prevent themselves. It is known that for a defensive practice the best way to avoid litigation is a good relationship with patient, based on dialog and on informed consent. This relation is very important, since patients who rely on their dentists rarely take them to justice. Hence, this article discusses the importance of this relation, as well as the obtaining of informed consent in order to prevent lawsuits.

Characterization of biomodified dentin matrices for potential preventive and reparative therapies

Biomodification of existing hard tissue structures, specifically tooth dentin, is an innovative approach proposed to improve the biomechanical and biochemical properties of tissue for potential preventive or reparative therapies. The objectives of the study were to systematically characterize dentin matrices biomodified by proanthocyanidin-rich grape seed extract (GSE) and glutaraldehyde (GD). Changes to the biochemistry and biomechanical properties were assessed by several assays to investigate the degree of interaction, biodegradation rates, proteoglycan interaction, and effect of collagen fibril orientation and environmental conditions on the tensile properties. The highest degree of agent–dentin interaction was observed with GSE, which exhibited the highest denaturation temperature, regardless of the agent concentration. Biodegradation rates decreased remarkably following biomodification of dentin matrices after 24 h collagenase digestion. A significant decrease in the proteoglycan content of GSE-treated samples was observed using a micro-assay for glycosaminoglycans and histological electron microscopy, while no changes were observed for GD and the control. The tensile strength properties of GD-biomodified dentin matrices were affected by dentin tubule orientation, most likely due to the orientation of the collagen fibrils. Higher and/or increased stability of the tensile properties of GD- and GSE-treated samples were observed following exposure to collagenase and 8 months water storage. Biomodification of dentin matrices using chemical agents not only affects the collagen biochemistry, but also involves interaction with proteoglycans. Tissue biomodifiers interact differently with dentin matrices and may provide the tissue with enhanced preventive and restorative/reparative abilities.

Condutas terapêuticas para caninos inclusos

Normally, the last teeth to erupt are the ones which remain impacted or semi-impacted, and that is the case of the canines. This study aimed to report a few options of treatment, aiming at esthetic and functional maintenance of the affected area before a impacted canine, discussing its indications, contraindications, advantages and disadvantages. This study also aims to emphasize the accessibility the patient would have in case his/her option were one of the approached ways of treatment. In order to identify the studies included or analyzed in this review, a detailed search strategy was performed for the database used: Pubmed, Bireme, Scielo, Cochrane, and Dentistry Oral Science up to 2011. We used non-erupted teeth, canine, and therapeutics as descriptors. The criteria of inclusion were clinical and review articles that approached the theme. Through this review, it was found that the surgeon dentist’s lack of technical and scientific knowledge and the financial impossibility of most population are some hindrances for the establishment of the right planning for the impacted canine.

Expressão diferencial de microRNAs no câncer de próstata

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Pharmacological evaluation and preparation of nonsteroidal anti-inflammatory drugs containing an N-Acyl hydrazone subunit

A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a–e) were synthesized and characterized. Docking studies were performed that suggest that compounds 4a–e bind to cyclooxygenase (COX)-1 and COX-2 isoforms, but with higher affinity for COX-2. The compounds display similar anti-inflammatory activities in vivo, although compound 4c is the most effective compound for inhibiting rat paw edema, with a reduction in the extent of inflammation of 35.9% and 52.8% at 2 and 4 h, respectively. The anti-inflammatory activity of N-acyl hydrazone derivatives was inferior to their respective parent drugs, except for compound 4c after 5 h. Ulcerogenic studies revealed that compounds 4a–e are less gastrotoxic than the respective parent drug. Compounds 4b–e demonstrated mucosal damage comparable to celecoxib. The in vivo analgesic activities of the compounds are higher than the respective parent drug for compounds 4a–b and 4d–e. Compound 4a was more active than dipyrone in reducing acetic-acid-induced abdominal constrictions. Our results indicate that compounds 4a–e are anti-inflammatory and analgesic compounds with reduced gastrotoxicity compared to their respective parent non-steroidal anti-inflammatory drugs.

Síntese e avaliação farmacológica de pró-fármacos derivados do ácido micofenólico úteis na prevenção e no tratamento da rejeição de transplantes

Pós-graduação em Ciências Farmacêuticas - FCFAR

Estratégias para administração segura de antineoplásicos

Pós-graduação em Enfermagem - FMB

A influência da fadiga nos músculos eversores durante a entorse lateral do tornozelo

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

A produção do conhecimento na área do lazer: uma análise sobre as temáticas formação e atuação profissional nos Anais do Enarel de 1997 a 2006

The present study’s aim was to check the academic-scientific productions conveyed in the several versions of the National Meeting on Recreation and Leisure (Enarel) to find out what courses have been taken within the studies on leisure regarding professional education and performance. Through literature review, the study adopted a qualitative methodology and its method was an exploratory study of the period ranging from 1997 to 2006. One hundred and thirty six works (oral communications or free subjects) were analyzed in a quali-quantitative approach. Results show that 50% of the works were produced collectively; as to the institutions, 77.02% of them were linked to academic institutions; regarding methodology, it was found that 58% explicitly presented the kind of research performed, and the most used methods were the “comparative studies”, with 26.11%, followed by “case studies”, with 14.17%.

Raman Lidar monitors emissions from sugar cane fires in the State of São Paulo: a pilot-project integrating radar, sodar, aerosol and gas observations

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

The ultrastructural evaluation of digestive cells in the hepatopancreas of the Amazon River prawn, Macrobrachium amazonicum

The Amazon River prawn Macrobrachium amazonicum is endemic to tropical South America and is being intensively exploited by artisanal fisheries in Brazil. Limited information is available about the nutritional requirements of M. amazonicum, although the production of this species is now technically feasible. The digestive process in this species is still unclear and investigation into the digestive cells of its hepatopancreatic epithelium is required. Thus, the hepatopancreas from 15 specimens were fixed in Karnovsky Solution and processed for Transmission Electron Microscopy. Our results indicate that E cells are located at the distal portion of the hepatopancreatic tubule and are involved in mitotic activity. The cylindrical R cells are sparse and are only found in the proximal portion of the hepatopancreatic tubule. According to its ultrastructural characteristics, this cell is involved in pinocytosis. M cells are generally found near the R cells. The F cells are scattered throughout the length of the hepatopancreatic tubules, and B cells are observed mainly in the proximal and middle regions. F cells and B cells are likely related to, respectively, the synthesis of enzymes and the intracelular digestion. R- and M cells are probably related to material storage. Thus, these findings provide basic information on the cell types that perform protein digestion in M. amazonicum, and will be useful in further nutritional research. The identification and characterization of digestive cells is an important step towards understanding the digestive mechanisms.

The journey to sustainable universities: insights from a Brazilian experience

Universities play a key role in humanity’s search for sustainable development. This paper presents the results of preliminary studies on projects regarding campus sustainability, conducted at Universidade Estadual Paulista ‘Julio de Mesquita Filho’ – UNESP’s Bauru Campus, State of São Paulo. It recommends the constitution of a sustainability committee, with a public participation and social responsibility (PPSR) framework, and the implementation of a campus sustainability program. The study also describes how social responsibility and sustainability can bring UNESP/Bauru economic advantages.