Synthesis and characterisation of imprinted polymeric receptor mimics

Molecularly imprinted polymers (MIPs) are crosslinked polymers containing bespoke functionalised cavities arising from the inclusion of template molecules in the polymerisation mixture and their later extraction. When the polymers are prepared functional polymerisable monomers are included which become part of the polymer matrix and serve to decorate the cavities with functionality appropriate to the template molecules. Overall, binding sites are created which have a memory for the template both in terms of shape and matching functionality. Fluorescent molecularly imprinted polymers have the benefit of a fluorophore in their cavities that may respond to the presence of bound test compound by a change in their fluorescence output. The work presented falls into three main areas. A series of fluorescent MIPs was prepared with a view to generating material capable of mimicking the binding characteristics of the metabolically important cytochrome isoform CYP2D6. The MIPs re-bound their templates and various cross-reactivities were encountered for test compound/drug recognition. One MIP in particular exhibited a rational discrimination amongst the related synthetic templates and was reasonably successful in recognising CYP2D6 substrates from the drug set tested. In order to give some insights into binding modes in MIPs, attempts were made to produce functional monomers containing two or more fluorophores that could be interrogated independently. A model compound was prepared which fitted the dual-fluorophore criteria and which will be the basis for future incorporation into MIPs. A further strand to this thesis is the deliberate incorporation of hydrophobic moieties into fluorescent functional monomers so that the resulting imprinted cavities might be biomimetic in their impersonation of enzyme active sites. Thus the imprinted cavities had specific hydrophobic regions as well as the usual polar functionality with which to interact with binding test compounds.

Refractometer based on fiber Bragg grating Fabry-Pérot cavity embedded with a narrow microchannel

We report on inscription of microchannels of different widths in optical fiber using femtosecond (fs) laser inscription assisted chemical etching and the narrowest channel has been created with a width down to only 1.2µm. Microchannels with 5µm and 35µm widths were fabricated together with Fabry-Pérot (FP) cavities formed by UV laser written fiber Bragg gratings (FBGs), creating high function and linear response refractometers. The device with a 5µm microchannel has exhibited a refractive index (RI) detection range up to 1.7, significantly higher than all fiber grating RI sensors. In addition, the microchannel FBG FP structures have been theoretically simulated showing excellent agreement with experimental measured characteristics.

Repetition rate multiplication by phase-only filtering with multi-cavity optical structures

We propose several all-pass spectrally-periodic optical structures composed of simple optical cavities for the implementation of repetition rate multipliers of periodic pulse train with uniform output train envelope by phase-only filtering, and analyze them in terms of robustness and accuracy.

Acousto-optic effect in microstructured polymer fiber bragg gratings : simulation and experimental overview

A fine control of the microstructured polymer fiber Bragg grating spectrum properties, such as maximum reflected power and 3-dB bandwidth, through acousto-optic modulation is presented. For simulation purposes, the device is modelled as a single structure, comprising a silica horn and a fiber Bragg grating. For similar sized structures a good correlation between the numerical results and the experimental data is obtained, allowing the strain field to be completely characterized along the whole structure. It is also shown that the microstructured polymer fiber Bragg grating requires less effort from the piezoelectric actuator to produce modification in the grating spectrum when compared with a silica fiber Bragg grating. This technique has potential to be applied on tunable optical filters and tunable cavities for photonic applications.

Proposed flat-topped pulses bursts generation using all-pass multi-cavity structures

We propose a simple lossless method for the generation of flat-topped intensity pulses bursts from a single utrashort pulse. We have found optimum solutions corresponding to different numbers of cavities and burst pulses, showing that the proposed all-pass structures of optical cavities, properly designed, can generate close to flat-topped pulse busts.

Actively modelocked dual-wavelength fibre laser with ultra-low inter-pulse-stream timing jitter

We demonstrate a novel dual-wavelength erbium-fiber laser that uses a single nonlinear-optical loop mirror modulator to simultaneously modelock two cavities with chirped fiber Bragg gratings as end mirrors. We show that this configuration produces synchronized soliton pulse trains with an ultra-low RMS inter-pulse-stream timing jitter of 620 fs enabling application to multiwavelength systems at data rates in excess of 130 Gb/s. © 1995 IEEE

Improved supercontinuum generation by dispersion tuning and dual wavelength pumping

Supercontinuum generation in ultra-long Raman fibre laser cavities is compared for a range of fibre dispersions in the anomalous and normal regimes. For normal dispersion improved performance and efficiency is achieved using dual wavelength pumping.

Switchable dual-wavelength Q-switched and mode-locked fiber lasers using a large-angle tilted fiber grating

We proposed and demonstrated pulsed fiber lasers Q-switched and mode-locked by using a large-angle tilted fiber grating, for the first time to our best knowledge. Owing to the unique polarization properties of the large-angle tilted fiber grating (LA-TFG), i.e. polarization-dependent loss and polarization-mode splitting, switchable dual-wavelength Q-switched and mode-locked pulses have been achieved with short and long cavities, respectively. For the mode-locking case, the laser was under the operation of nanosecond rectangular pulses, due to the peak-power clamping effect. With the increasing pump power, the durations of both single-and dual-wavelength rectangular pulses increase. It was also found that each filtered wavelength of the dual-wavelength rectangular pulse corresponds to an individual nanosecond rectangular pulse by employing a tunable bandpass filter.

Stochasticity and coherent structures in ultra-long mode-locked lasers

Ultra-long mode-locked lasers are known to be strongly influenced by nonlinear interactions in long cavities that results in noise-like stochastic pulses. Here, by using an advanced technique of real-time measurements of both temporal and spatial (over round-trips) intensity evolution, we reveal an existence of wide range of generation regimes. Different kinds of coherent structures including dark and grey solitons and rogue-like bright coherent structures are observed as well as interaction between them are revealed.

Broadband tunable all-fiber polarization interference filter based on 45° tilted fiber gratings

We have theoretically and experimentally designed and demonstrated an all-fiber polarization interference filter (AFPIF), which is formed by a polarization-maintaining (PM) fiber cavity structure utilizing two 45° tilted fiber gratings (45°-TFGs) inscribed by UV laser on the PM fiber. Such a filter could generate modulated transmission of linear polarization status. It has been revealed that the modulation depth of the transmission depends on the coupling angle between the 45°-TFGs and the PM fiber cavity. When the two 45°-TFGs in PM fiber are oriented at 45° to the principal axis of the PM fiber cavity, the maximum modulation depth is achievable. Due to the thermal effect on birefringence of the PM fiber, the AFPIF can be tuned over a broad wavelength range just by simple thermal tuning of the cavity. The experiment results show that the temperature tuning sensitivity is proportional to the length ratio of the PM fiber cavity under heating. For 18 and 40 cm long cavities with 6 cm part under heating, the thermal tuning sensitivities are 0.616 and 0.31 nm/° C, respectively, which are almost two orders of magnitude higher than normal fiber Bragg gratings. © 1983-2012 IEEE.

Acousto-optic effect in microstructured polymer fiber bragg gratings:simulation and experimental overview

A fine control of the microstructured polymer fiber Bragg grating spectrum properties, such as maximum reflected power and 3-dB bandwidth, through acousto-optic modulation is presented. For simulation purposes, the device is modelled as a single structure, comprising a silica horn and a fiber Bragg grating. For similar sized structures a good correlation between the numerical results and the experimental data is obtained, allowing the strain field to be completely characterized along the whole structure. It is also shown that the microstructured polymer fiber Bragg grating requires less effort from the piezoelectric actuator to produce modification in the grating spectrum when compared with a silica fiber Bragg grating. This technique has potential to be applied on tunable optical filters and tunable cavities for photonic applications.

Vector solitons in harmonic mode-locked erbium-doped fiber lasers

We report experimental study of vector solitons for the fundamental and harmonic mode-locked operation in erbiumdoper fiber lasers with carbon nanotubes based saturable absorbers and anomalous dispersion cavities. We measure evolution of the output pulses polarization and demonstrate vector solitons with various polarization attractors, including locked polarization, periodic polarization switching, and polarization precession.

Polymer optical fibre sensors for endoscopic optoacoustic imaging

Opto-acoustic imaging (OAI) shows particular promise for in-vivo biomedical diagnostics. Its applications include cardiovascular, gastrointestinal and urogenital systems imaging. Opto-acoustic endoscopy (OAE) allows the imaging of body parts through cavities permitting entry. The critical parameter is the physical size of the device, allowing compatibility with current technology, while governing flexibility of the distal end of the endoscope based on the needs of the sensor. Polymer optical fibre (POF) presents a novel approach for endoscopic applications and has been positively discussed and compared in existing publications. A great advantage can be obtained for endoscopy due to a small size and array potential to provide discrete imaging speed improvements. Optical fibre exhibits numerous advantages over conventional piezo-electric transducers, such as immunity from electromagnetic interference and a higher resolution at small sizes. Furthermore, micro structured polymer optical fibres offer over 12 times the sensitivity of silica fibre. We present a polymer fibre Bragg grating ultrasound detector with a core diameter of 125 microns. We discuss the ultrasonic signals received and draw conclusions on the opportunities and challenges of applying this technology in biomedical applications.

New nonlinear regimes of pulse generation in mode- locked fiber lasers

Mode-locked fiber lasers provide convenient and reproducible experimental settings for the study of a variety of nonlinear dynamical processes. The complex interplay among the effects of gain/loss, dispersion and nonlinearity in a fiber cavity can be used to shape the pulses and manipulate and control the light dynamics and, hence, lead to different mode-locking regimes. Major steps forward in pulse energy and peak power performance of passively mode-locked fiber lasers have been made with the recent discovery of new nonlinear regimes of pulse generation, namely, dissipative solitons in all-normal-dispersion cavities and parabolic self-similar pulses (similaritons) in passive and active fibers. Despite substantial research in this field, qualitatively new phenomena are still being discovered. In this talk, we review recent progress in the research on nonlinear mechanisms of pulse generation in passively mode-locked fiber lasers. These include similariton mode-locking, a mode-locking regime featuring pulses with a triangular distribution of the intensity, and spectral compression arising from nonlinear pulse propagation. We also report on the possibility of achieving various regimes of advanced temporal waveform generation in a mode-locked fiber laser by inclusion of a spectral filter into the laser cavity.

Controlling the properties of microstructured plastic optical fiber Bragg gratings using acousto-optic excitation

A fine control of the mPOF Bragg grating spectrum properties, such as maximum reflected power and 3dB bandwidth, through acousto-optic modulation (AOM) using flexural regime is presented. A numerical comparison of the strain field along mPOFBG - AOM and the similar structure with SMFBG-AOM was presented, showing that the strain field amplitude is higher along the mPOFBG due to its smaller mechanical stiffness. The obtained results can be used in the development of fine-tuned optical filters using low voltage sources and low frequency regimes, to obtain tunable optical filters and to control the shape of the spectrum. Studies of the behavior in different gratings (such as phase shifted and long period gratings) for photonic applications, such as tunable notch filters or tunable cavities, are in progress. It can potentially be applied on tunable optical filters for POF transmission. © 2012 IEEE.