Noisy Oncology: applications of bounded noise transitions in modelling tumor growth

I tumori macroscopici e microscopici, dopo la loro prima fase di crescita, sono composti da un numero medio elevato di cellule. Così, in assenza di perturbazioni esterne, la loro crescita e i punti di equilibrio possono essere descritti da equazioni differenziali. Tuttavia, il tumore interagisce fortemente col macroambiente che lo circonda e di conseguenza una descrizione del tutto deterministica risulta a volte inappropriata. In questo caso si può considerare l'interazione con fluttuazioni statistiche, causate da disturbi esterni, utilizzando le equazioni differenziali stocastiche (SDE). Questo è vero in modo particolare quando si cerca di modellizzare tumori altamente immunogenici che interagiscono con il sistema immunitario, in quanto la complessità di questa interazione risulta in fenomeni di multistabilità. Così, il rumore può provocare disturbi e indurre transizioni di stato (Noise-Induced-Transitions). E' importante notare che una NIT può avere implicazioni profonde sulla vita di un paziente, dal momento che una transizione da uno stato di equilibrio piccolo, nelle dimensioni del tumore, ad uno stato di equilibrio macroscopico, nella maggior parte dei casi significa il passaggio dalla vita alla morte. Generalmente l'approccio standard è quello di modellizzare le fluttuazioni stocastiche dei parametri per mezzo di rumore gaussiano bianco o colorato. In alcuni casi però questa procedura è altamente inadeguata, a causa della illimitatezza intrinseca dei rumori gaussiani che può portare a gravi incongruenze biologiche: pertanto devono essere utilizzati dei rumori "limitati", che, tuttavia, sono molto meno studiati di quelli gaussiani. Inoltre, l'insorgenza di NIT dipende dal tipo di rumore scelto, che rivela un nuovo livello di complessità in biologia. Lo scopo di questa tesi è quello di studiare le applicazioni di due tipi diversi di "rumori limitati" nelle transizioni indotte in due casi: interazione tra tumore e sistema immunitario e chemioterapia dei tumori. Nel primo caso, abbiamo anche introdotto un nuovo modello matematico di terapia, che estende, in modo nuovo, il noto modello di Norton-Simon.

Development of human visual system analysis for the implementation of a new instrument for flicker measurement

Flicker is a power quality phenomenon that applies to cycle instability of light intensity resulting from supply voltage fluctuation, which, in turn can be caused by disturbances introduced during power generation, transmission or distribution. The standard EN 61000-4-15 which has been recently adopted also by the IEEE as IEEE Standard 1453 relies on the analysis of the supply voltage which is processed according to a suitable model of the lamp – human eye – brain chain. As for the lamp, an incandescent 60 W, 230 V, 50 Hz source is assumed. As far as the human eye – brain model is concerned, it is represented by the so-called flicker curve. Such a curve was determined several years ago by statistically analyzing the results of tests where people were subjected to flicker with different combinations of magnitude and frequency. The limitations of this standard approach to flicker evaluation are essentially two. First, the provided index of annoyance Pst can be related to an actual tiredness of the human visual system only if such an incandescent lamp is used. Moreover, the implemented response to flicker is “subjective” given that it relies on the people answers about their feelings. In the last 15 years, many scientific contributions have tackled these issues by investigating the possibility to develop a novel model of the eye-brain response to flicker and overcome the strict dependence of the standard on the kind of the light source. In this light of fact, this thesis is aimed at presenting an important contribution for a new Flickermeter. An improved visual system model using a physiological parameter that is the mean value of the pupil diameter, has been presented, thus allowing to get a more “objective” representation of the response to flicker. The system used to both generate flicker and measure the pupil diameter has been illustrated along with all the results of several experiments performed on the volunteers. The intent has been to demonstrate that the measurement of that geometrical parameter can give reliable information about the feeling of the human visual system to light flicker.

Misure di rumore flicker e affidabilita nei dispositivi mosfet di potenza

L'attività di tesi consiste sia nella calibrazione di un banco di misura per analisi di rumore a basse frequenze nei dispositivi MOSFET di potenza, sia nella valutazione dei relativi e successivi dati sperimentali (con particolare attenzione anche ai processi di stress e recupero applicati ai dispositivi).

Metodi operativi per la riduzione dell'impatto acustico delle operazioni aeroportuali: efficacia delle noise abatement procedures

Il rumore causato dagli aeromobili nelle varie operazioni aeroportuali è uno dei problemi più sentiti dalle popolazioni che risiedono nelle aree adiacenti gli aeroporti.Nonostante i progressi fatti dal punto di vista tecnologico, che hanno portato a una notevole riduzione del fenomeno, il continuo aumento della domanda di traffico aereo ha ridotto l’efficacia di queste migliorie tecniche, anche a causa di una scarsa pianificazione territoriale nel corso degli anni. Ci sono numerosi interventi possibili per ridurre l'inquinamento acustico, in questa tesi vengono analizzate in special modo le NAP e la loro applicazione al caso dell'aeroporto di Bologna.

An Integrated Transmission-Media Noise Calibration Software For Deep-Space Radio Science Experiments

The thesis describes the implementation of a calibration, format-translation and data conditioning software for radiometric tracking data of deep-space spacecraft. All of the available propagation-media noise rejection techniques available as features in the code are covered in their mathematical formulations, performance and software implementations. Some techniques are retrieved from literature and current state of the art, while other algorithms have been conceived ex novo. All of the three typical deep-space refractive environments (solar plasma, ionosphere, troposphere) are dealt with by employing specific subroutines. Specific attention has been reserved to the GNSS-based tropospheric path delay calibration subroutine, since it is the most bulky module of the software suite, in terms of both the sheer number of lines of code, and development time. The software is currently in its final stage of development and once completed will serve as a pre-processing stage for orbit determination codes. Calibration of transmission-media noise sources in radiometric observables proved to be an essential operation to be performed of radiometric data in order to meet the more and more demanding error budget requirements of modern deep-space missions. A completely autonomous and all-around propagation-media calibration software is a novelty in orbit determination, although standalone codes are currently employed by ESA and NASA. The described S/W is planned to be compatible with the current standards for tropospheric noise calibration used by both these agencies like the AMC, TSAC and ESA IFMS weather data, and it natively works with the Tracking Data Message file format (TDM) adopted by CCSDS as standard aimed to promote and simplify inter-agency collaboration.

Context-sensitive design in transportation infrastructure: relating tire/pavement noise with wearing course characteristics

A design can be defined as context-sensitive when it achieves effective technical and functional transportation solutions, while preserving and enhancing natural environments and minimizing impacts on local communities. Traffic noise is one of the most critical environmental impacts of transportation infrastructure and it affects both humans and ecosystems. Tire/pavement noise is caused by a set of interactions at the contact patch and it is the predominant source of road noise at the regular traffic speeds. Wearing course characteristics affect tire/pavement noise through various mechanisms. Furthermore, acoustic performance of road pavements varies over time and it is influenced by both aging and temperature. Three experimentations have been carried out to evaluate wearing course characteristics effects on tire/pavement noise. The first study involves the evaluation of skid resistance, surface texture and tire/pavement noise of an innovative application of multipurpose cold-laid microsurfacing. The second one involves the evaluation of the surface and acoustic characteristics of the different pavement sections of the test track of the Centre for Pavement and Transportation Technology (CPATT) at the University of Waterloo. In the third study, a set of highway sections have been selected in Southern Ontario with various types of pavements. Noise measurements were carried out by means of the Statistical Pass-by (SPB) method in the first case study, whereas in the second and in the third one, Close-proximity (CPX) and the On-Board Sound Intensity (OBSI) methods have been performed in parallel. Test results have contributed to understand the effects of pavement materials, temperature and aging on tire/pavement noise. Negligible correlation was found between surface texture and roughness with noise. As a general trend, aged and stiffer materials have shown to provide higher noise levels than newer and less stiff ones. Noise levels were also observed to be higher with temperature increase.

Noise mapping of highly trafficked roads of the province of Bologna according to D.Lgs. 194/2005

The European Community has stressed the importance of achieving a common understanding to deal with the environmental noise through community actions of the Member States. This implies the use of harmonized indicators and specific information regarding the values of indicators, the exceedance of limits and the number of people and dwellings exposed to noise. The D.Lgs. 149/2005 in compliance with the European Directive 2002/49/EC defines methodologies, noise indicators and types of outputs required. In this dissertation the work done for the noise mapping of highly trafficked roads of the Province of Bologna will be reported. The study accounts for the environmental noise generated by the road infrastructure outside the urban agglomeration of Bologna. Roads characterized by an annual traffic greater than three millions of vehicles will be considered. The process of data collection and validation will be reported, as long as the implementation of the calculation method in the software and the procedure to create and calibrate the calculation model. Results will be provided as required by the legislation, in forms of maps and tables. Moreover results regarding each road section accounted will be combined to gain a general understanding of the situation of the overall studied area. Although the understanding of the noise levels and the number of people exposed is paramount, it is not sufficient to develop strategies of noise abatement interventions. Thus a further step will be addressed: the creation of priority maps as the basis of action plans for organizing and prioritizing solutions for noise reduction and abatement. Noise reduction measures are reported in a qualitative way in the annex and constitute a preliminary research.

Valutazione dell'efficacia delle "noise abatement procedures": il caso dell'aeroporto G. Marconi di Bologna

A partire dalle caratteristiche chiave dell’inquinamento acustico, lo scopo della tesi è stato quello di valutare quantitativamente l’entità del rumore aeronautico prodotto dall'aeroporto Marconi e di analizzare le soluzioni tecniche e gestionali disponibili per definire misure adeguate alle caratteristiche infrastrutturali e operative dello scalo e capaci di mitigare il disturbo subito dalla popolazione. Si è tenuto conto delle profonde modificazioni in atto nel mondo dell’aviazione, il quale, avendo come obiettivo quello di fornire un servizio di trasporto sempre più sostenibile, efficace, competitivo e omogeneo sul territorio europeo, sollecita profonde innovazioni nei requisiti funzionali e tecnici. Inizialmente l’attenzione è stata rivolta alla descrizione del rumore aeronautico e del contesto in cui è inserito, soffermandosi sul concetto di sostenibilità di un’infrastruttura di trasporto. Si è proseguito con un'analisi dettagliata della normativa vigente, italiana ed europea, al fine di affrontare gli aspetti legislativi del problema e di delineare le line guida per la valutazione del rumore. Segue uno studio, dal punto di vista tecnico e infrastrutturale, dell’evoluzione della navigazione aerea e del concetto innovativo di performance based navigation, focalizzando l’interesse sul curved approach, procedura di avvicinamento non convenzionale. L'attenzione è stata, poi, dedicata alla descrizione del caso di studio e alla presentazione della metodologia usata. Mediante il supporto dell’INM, sono state determinate le curve isofoniche, quantificando la popolazione esposta a specifici livelli di rumore aeronautico per lo scenario consuntivo dell’anno 2015. Infine, sono state eseguite simulazioni future, sulla base delle previsioni di crescita del volume di traffico aereo, per definire un limite massimo per lo sfruttamento del sistema ILS in testata 30 e per valutare il beneficio generato dall’introduzione del curved approach.

Aircraft noise, air pollution, and mortality from myocardial infarction

Objective: Myocardial infarction has been associated with both transportation noise and air pollution. We examined residential exposure to aircraft noise and mortality from myocardial infarction, taking air pollution into account. Methods: We analyzed the Swiss National Cohort, which includes geocoded information on residence. Exposure to aircraft noise and air pollution was determined based on geospatial noise and air-pollution (PM10) models and distance to major roads. We used Cox proportional hazard models, with age as the timescale. We compared the risk of death across categories of A-weighted sound pressure levels (dB(A)) and by duration of living in exposed corridors, adjusting for PM10 levels, distance to major roads, sex, education, and socioeconomic position of the municipality. Results: We analyzed 4.6 million persons older than 30 years who were followed from near the end of 2000 through December 2005, including 15,532 deaths from myocardial infarction (ICD-10 codes I 21, I 22). Mortality increased with increasing level and duration of aircraft noise. The adjusted hazard ratio comparing ≥60 dB(A) with <45 dB(A) was 1.3 (95% confidence interval = 0.96-1.7) overall, and 1.5 (1.0-2.2) in persons who had lived at the same place for at least 15 years. None of the other endpoints (mortality from all causes, all circulatory disease, cerebrovascular disease, stroke, and lung cancer) was associated with aircraft noise. Conclusion: Aircraft noise was associated with mortality from myocardial infarction, with a dose-response relationship for level and duration of exposure. The association does not appear to be explained by exposure to particulate matter air pollution, education, or socioeconomic status of the municipality.

Nonlinear three-dimensional noise filter with low-dose CT angiography: effect on the detection of small high-contrast objects in a phantom model

To study the effect of a nonlinear noise filter on the detection of simulated endoleaks in a phantom with 80- and 100-kVp multidetector computed tomographic (CT) angiography.