Immune response of horses to vaccination with the recombinant Hc domain of botulinum neurotoxin types C and D

Botulinum neurotoxins, predominantly serotypes C and D, cause equine botulism through forage poisoning. The C-terminal part of the heavy chain of botulinum neurotoxin types C and D (HcBoNT/C and D) was expressed in Escherichia coli and evaluated as a recombinant mono- and bivalent vaccine in twelve horses in comparison to a commercially available toxoid vaccine. A three-dose subcutaneous immunization of adult horses elicited robust serum antibody response in an ELISA using the immunogen as a capture antigen. Immune sera showed dose-dependent high potency in neutralizing specifically the active BoNT/C and D in the mouse protection assay. The aluminium hydroxide based mono- and bivalent recombinant HcBoNT/C and D vaccines were characterized by good compatibility and the ability to elicit protective antibody titers similar or superior to the commercially available toxoid vaccine.

Qineat-emet (Wahrheitseifer) oder: offener Brief an A. Hochmuth als apologetische Entgegung auf seinen in der "Neuzeit" Nr. 18 a. c. gegen d. Werk Pi Senajim geschleuderten Angriff

von Kálmán Weiss

Catalogue d'une collection Anconienne dont la plus grande partie dérive de la bibliothèque appartenant aux célèbres C. J. D. Azulai et son fils Rafael

mise en vente par Samuel Schönblum

Prospectus of the Library of Ephraim Deinard at New Orleans, Louisiana : also a list of Jewish antiquities, depicting the "history of religion", on exhibition at the Smithsonian Institution at Washington, D. C., and at New Orleans, Louisiana

Devir Efrayim

Chemistry of pyrrocorphins: methylative opening of the macrocycle between rings A and D, a side reaction in the peripheral C-methylation of a 20-methyl-pyrrocorphinate

One of the minor products from the previously described peripheral -methylation of a magnesium()-20-methyl--pyrrocorphinate is a C-19-methylated 19,20-seco-corphinoid derivative which, on complexation with nickel() acetate, recyclizes to a nickel()-tetradehydro-corrinate.

Allerunterthänigst-gründliche Gegen-Information Und Exceptiones Sub- & Obreptionis : An Die Römis. Kayserl. ... Majestät ... Auff das am 12. May nup. und 19. currentis mensis erlassene Kayserl. Rescript, Juncta Petitione Humillima Pro Clementissima cassatione ejusdem ... ; In Sachen Judenschafft zu Franckfurth am Mayn Contrà Den Magistrat daselbsten ; Bey höchst-preyßlichen Reichs-Hof-Rath Den 23. Julii 1714 übergeben ; Mit Beylagen A, B, C & D ; Das Bau-Weesen betreffend

Burgerschafftl. Abgeordneter [Johann Dieterich Notebohm ; Joachim Hoppe] [[Elektronische Ressource]]