889 resultados para Derricks, Leon
Resumo:
geh. ... von Leon Scheinhaus
Resumo:
auf Veranlassung des Grafen Kutaisoff verf. von [Simeon Leon von] Schwabacher
Resumo:
Regulatory T cells (Tregs), which are characterized by expression of the transcription factor Foxp3, are a dynamic and heterogeneous population of cells that control immune responses and prevent autoimmunity. We recently identified a subset of Tregs in murine skin with properties typical of memory cells and defined this population as memory Tregs (mTregs). Due to the importance of these cells in regulating tissue inflammation in mice, we analyzed this cell population in humans and found that almost all Tregs in normal skin had an activated memory phenotype. Compared with mTregs in peripheral blood, cutaneous mTregs had unique cell surface marker expression and cytokine production. In normal human skin, mTregs preferentially localized to hair follicles and were more abundant in skin with high hair density. Sequence comparison of TCRs from conventional memory T helper cells and mTregs isolated from skin revealed little homology between the two cell populations, suggesting that they recognize different antigens. Under steady-state conditions, mTregs were nonmigratory and relatively unresponsive; however, in inflamed skin from psoriasis patients, mTregs expanded, were highly proliferative, and produced low levels of IL-17. Taken together, these results identify a subset of Tregs that stably resides in human skin and suggest that these cells are qualitatively defective in inflammatory skin disease.
Resumo:
von Leon Wasilewski
Resumo:
L. Chasanowitsch
Resumo:
von Gottlieb v. Leon
Resumo:
von Leon Kellner. Hrsg. vom Jüd.-nat. Akadem. Verein 'Emunah', Czernowitz
Resumo:
hrsg. von Leon Kellner
Resumo:
hrsg. v. jüd.-nat. akad. Verein "Emunah" Czernowitz. Mit einem Vorworte v. Leon Kellner
Resumo:
by Ahad Haam [d. i. Asher Ginzberg]. Transl. from the Hebrew by Leon Simon
Resumo:
by P. Horowitz. With a foreword by Leon Simon
Resumo:
by Leon Simon. With an introd. by Alfred E. Zimmern
Resumo:
OBJECTIVE To provide guidance on standards for reporting studies of diagnostic test accuracy for dementia disorders. METHODS An international consensus process on reporting standards in dementia and cognitive impairment (STARDdem) was established, focusing on studies presenting data from which sensitivity and specificity were reported or could be derived. A working group led the initiative through 4 rounds of consensus work, using a modified Delphi process and culminating in a face-to-face consensus meeting in October 2012. The aim of this process was to agree on how best to supplement the generic standards of the STARD statement to enhance their utility and encourage their use in dementia research. RESULTS More than 200 comments were received during the wider consultation rounds. The areas at most risk of inadequate reporting were identified and a set of dementia-specific recommendations to supplement the STARD guidance were developed, including better reporting of patient selection, the reference standard used, avoidance of circularity, and reporting of test-retest reliability. CONCLUSION STARDdem is an implementation of the STARD statement in which the original checklist is elaborated and supplemented with guidance pertinent to studies of cognitive disorders. Its adoption is expected to increase transparency, enable more effective evaluation of diagnostic tests in Alzheimer disease and dementia, contribute to greater adherence to methodologic standards, and advance the development of Alzheimer biomarkers.
Resumo:
Leon da Modena. Übers. von Bath-Hillel
Resumo:
von Leon Kellner
