Planiglobii Terrestris mappa vniversalis, utrumq[ue] Hemisphaerium Orient et Occidentale repraesentans ex. IV. mappis generalibus Hasianis composita et adjectis ceteris hemisphaeriis designata a G. M. Lowizio.

Pallonpuoliskot halkaisijaltaan n. 26 cm.

Sinus Finnici delineatio geographica ex quam plurimis subsidiis novissimis stereographice tradita per d.m Tobiam Maijerum, professorem matheseos Goettingensem.

[N. 1:1000000].

Evropa ad magnae Europae Gerardi Mercatoris p. imitationem, Rumoldi Mercatoris f. cura edita, seruato tamen initio longitudinis ex ratione magnetis, quod pater in magna sua vniuersali posuit.

Mittakaavaa ei määritelty ;

Tabvla Rvssiae ex autographo, quod delineandum curavit Foedor filius tzaris Boris desumta; et ad fluvios Dwinam, Zuchanam, aliaque loca, quantum ex tabulis et notitiis ad nos delatis fieri potuit, amplificata: ac magno domino, tzari , et magno duci Michäeli Foedorowits omnium Russorum, autcratori Wolodimeriae, Moscoviae et Novogardia. Tzari Cazaniae, tzari Astracaniae, tzari Siberiae, domino Plescoviae magno duci Smolenscoviae, Otweriae, Iugoriae, Permiae, Wiatkiae, Bulgariae etc: domino regionum Iveriae Kartalinie et Groesiniae tzari etc: dedicata ab Hesselo Gerardo M.DC.XIIII.

[N. 1:9000000].

Tabula Russiae ex autographo, quod delineandum curavit Foedor filius tzaris Boris desumta et ad fluvios Dwinam Zuchanaw aliaque loca quandum ex tabulis et notitÿs ad nos delatis fieri potuit amplificaca alias dicta Moscovia.

[N. 1:10000000].

Paullinia cupana Mart var. sorbilis, guaraná, reduces cell proliferation and increases apoptosis of B16/F10 melanoma lung metastases in mice

We showed that guaraná (Paullinia cupana Mart var. sorbilis) had a chemopreventive effect on mouse hepatocarcinogenesis and reduced diethylnitrosamine-induced DNA damage. In the present experiment, we evaluated the effects of guaraná in an experimental metastasis model. Cultured B16/F10 melanoma cells (5 x 10(5) cells/animal) were injected into the tail vein of mice on the 7th day of guaraná treatment (2.0 mg P. cupana/g body weight, per gavage) and the animals were treated with guaraná daily up to 14 days until euthanasia (total treatment time: 21 days). Lung sections were obtained for morphometric analysis, apoptotic bodies were counted to calculate the apoptotic index and proliferating cell nuclear antigen-positive cells were counted to determine the proliferation index. Guaraná-treated (GUA) animals presented a 68.6% reduction in tumor burden area compared to control (CO) animals which were not treated with guaraná (CO: 0.84 ± 0.26, N = 6; GUA: 0.27 ± 0.24, N = 6; P = 0.0043), a 57.9% reduction in tumor proliferation index (CO: 23.75 ± 20.54, N = 6; GUA: 9.99 ± 3.93, N = 6; P = 0.026) and a 4.85-fold increase in apoptotic index (CO: 66.95 ± 22.95, N = 6; GUA: 324.37 ± 266.74 AB/mm², N = 6; P = 0.0152). In this mouse model, guaraná treatment decreased proliferation and increased apoptosis of tumor cells, consequently reducing the tumor burden area. We are currently investigating the molecular pathways of the effects of guaraná in cultured melanoma cells, regarding principally the cell cycle inhibitors and cyclins.

De lapsu generis humani in quantum ex lumine naturae constat

Invokaatio: D.F.G.

De methodo existentiam Dei ex ordine naturae demonstrandi

Invokaatio: Deus benedicat.

De angelis imperiorum, ex Dan. X. 13, 20

Variantti A.

Theoremata nonnulla miscellanea ex amplissimo philosophiae agro collecta

Invokaatio: I.N.S.S.T.

Ex philologia sacra depromtae

Invokaatio: D.D.

De mysteriis naturae articuli, ex determinata maxime philosophiae notione concepti

Dedikaatio: Ernestus Johannes Creutz.

Methodus inveniendi tempus verum ex observatis aequalibus diversarum stellarum altitudinibus 2

Arkit: A-B4.

Water extracts of cabbage and kale inhibit ex vivo H2O2-induced DNA damage but not rat hepatocarcinogenesis

The chemopreventive potential of water extracts of the Brassica vegetables cabbage and kale was evaluated by administering their aqueous extracts in drinking water ad libitum to Wistar rats submitted to Ito’s hepatocarcinogenesis model (CB group and K group, respectively - 14 rats per group). Animals submitted to this same model and treated with water were used as controls (W group - 15 rats). Treatment with the vegetable extracts did not inhibit (P > 0.05) placental glutathione S-transferase-positive preneoplastic lesions (PNL). The number of apoptotic bodies did not differ (P > 0.05) among the experimental groups. Ex vivo hydrogen peroxide treatment of rat livers resulted in lower (P < 0.05) DNA strand breakage in cabbage- (107.6 ± 7.8 µm) and kale- (110.8 ± 10.0 µm) treated animals compared with control (120.9 ± 12.7 µm), as evaluated by the single cell gel (comet) assay. Treatment with cabbage (2 ± 0.3 µg/g) or kale (4 ± 0.2 µg/g) resulted in increased (P < 0.05) hepatic lutein concentration compared with control (0.5 ± 0.07 µg/g). Despite the absence of inhibitory effects of cabbage and kale aqueous extracts on PNL, these Brassica vegetables presented protection against DNA damage, an effect possibly related to increased hepatic lutein concentrations. However, it must be pointed out that the cause-effect relationship between lutein levels and protection is hypothetical and remains to be demonstrated.

In quâ homo christianus rudi penicillo describitur ex Actis apostolorum cap. XI. versu 26

Invokaatio: Syn tō theō trismegistō.