Identificação de SNPs para uma anomalia de desenvolvimento em E. grandis e seus efeitos na estrutura proteica e interatoma

Pós-graduação em Ciências Biológicas (Genética) - IBB

Sistemas precursores de cristais líquidos mucoadesivos para administração bucal de curcumina no tratamento do câncer bucal

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Métodos geoelétricos aplicados ao diagnóstico ambiental subsuperficial do Cemitério Municipal de Rio Claro, SP

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Uso de implantes zigomáticos na fixação de próteses bucomaxilofaciais

The maxillofacial prosthetic rehabilitation aims of individuals with craniofacial deformities resulting from trauma, congenital malformations or tumors. Many researches have been done to improve the stability and retention of dentures in patients. With the advent of osseointegration, the maxillofacial prosthesis suffered a major advance making possible the realization of prosthetic works with stability, aesthetic quality and predictable results. This paper reviews the literature regarding the use of zygomatic implants in the fixation of maxillofacial prostheses.

Prótese parcial removível obturadora: uma reabilitação oral que devolve o bem estar físico e mental

Maxillofacial deformities may cause awkward and embarrassing bearer. These patients present serious psychological, family and social issues becoming traumatized and complexed. These deformities can have congenital origin, malformations and developmental disorders, or can be caused by pathological mutilation such as necrotizing diseases and surgical oncology, or traumas such as traffic and work accidents.

Princípios de redução das fraturas panfaciais: revisão de literatura

Are called panfacial fractures when the upper, middle and lower facial thirds present fractures concurrently. In clinical practice, came to imply the involvement of two facial thirds. Panfacial fractures are usually accompanied by other systemic lesions that impair the patient's life and therefore require primary treatment. Almost invariably are associated with damage to soft tissues and severe losses of bone structures which may lead to severe facial deformations and malocclusions. The panfacial fractures treatment is complex because often there isn’t a stable bone structure to guide the reduction of various fractures. Several orders of treatment have been proposed, but they are variations of the two classical approaches "bottom to top and inside-out" and "top to bottom and out-inside". The aim of this paper is to discuss the principles of management and panfacial fractures treatment, emphasizing the sequence of fracture reduction and highlighting its indications, advantages and disadvantages, through literature review and reports of surgical clinic cases. We conclude that the exact sequence of fracture reduction is not as important as developing a treatment plan that allows accurate positioning of the fractured segments.

Case report: Cornelia de Lange Syndrome (CDLS)

The Cornélia of Lange´s syndrome is a genetic anomaly, described and published by Cornelia Catharina of Lange in 1933, however, their aspects were described previously by Winfried Robert Clemens Brechmann in 1916, that’s why it is also known as Brachmann of Lange’s syndrome. The most frequent clinical characteristics include typical face dismorfia, variable degree of mental delay, anomalies of the hands and feet, multiple malformations, retardation of the pre and postnatal physical development and microcephaly variable intellectual compromising. Some facial characteristics are peculiar and they are mixed with the inherited lines of their own family, the united brows, the long lashes, the small nose, the round face, the fine lips and lightly inverted. As oral manifestations they present micrognathia, dental crowding, periodontal disease, delayed dental eruption, enamel hypoplasia, erosion of the enamel and dentine caused by stomach acids of the gastroesophageal reflux and atresia of the dental arches. The purpose of this paper is to present a clinical report of a boy bearer of this syndrome assisted at CAOE - FOA - UNESP, emphasizing the importance of multiprofessional team for the diagnosis and treatment of this syndrome.

Giroversão dental: formação de imagem radiográfica virtual

Entre as diversas anomalias dentárias, a giroversão dental constitui uma anomalia de grande prevalência, na qual o dente realiza rotação em torno do seu próprio eixo. No exame radiográfico panorâmico é possível verificar a presença de giroversão, porém, quando a dinâmica de giro do eixo do equipamento não coincide com a curvatura da maxila e mandíbula, a imagem dos dentes apresenta-se girovertida ou com apinhamento dental. O presente trabalho teve por objetivo avaliar se as giroversões dentais presentes nas radiografias panorâmicas são verdadeiras ou apenas “virtuais”. Foram selecionadas 71 radiografias panorâmicas com imagens sugestivas de dentes girovertidos, de pacientes que também possuíam a documentação da cavidade bucal por fotografia e modelo de estudo. A média de idade dos pacientes avaliados foi 15 anos de idade. A imagem radiográfica panorâmica, fotografia e modelo de estudo foram avaliadas por um único examinador. Na avaliação das radiografias panorâmicas foram encontradas 246 dentes girovertidos. Porém, ao avaliar a fotografia e o modelo de estudo destes pacientes comprovou-se apenas 127 dentes com giroversão. Estes resultados indicam uma correspondência clinica/radiográfica de 51,4 %, ou seja, 48,6% das giroversões identificadas radiograficamente, eram “virtuais”. Pode-se concluir que o diagnóstico de giroversão dental utilizando a radiografia panorâmica deve ser confirmado pelo exame clínico para evitar diagnósticos falsos positivos.

Clinical evaluation of the bicoronal flap in the treatament of facial fractures: retrospective study of 132 patients

The aim of the present study was to evaluate the postoperative complications of bicoronal flaps used to treat facial fractures. One hundred and thirty two patients that received bicoronal flaps for the treatment of upper and middle third facial fractures were called for clinical and radiographic examination. Minimum follow-up was 1 year and all patients had charts with adequate information about their perioperative care pertinent to the study. Results showed as complications hypoesthesia (17%), partial unilateral frontal motor deficit (11%), infection (3%), hypertrophic scars (3%), varying degrees of alopecia (18%), seroma or hematoma in the immediate postoperative period (5%). The flap provided wide surgical access to the upper and middle facial thirds with very few serious complications, most frequently allowing good aesthetic results.

Transmissão congênita em cabras reinfectadas com Toxoplasma gondii

This study evaluated the potential of congenital transmission in goats experimentally infected and reinfected with Toxoplasma gondii, in three gestational stages (initial, intermediate and final). Of the 25 non-pregnant females negative for T. gondii, 20 were orally inoculated with 2.5 x 103 T. gondii ME49 oocysts. Of these, 15 pregnant females chronically infected were reinoculated, via oral, with 2.5 x 103 T. gondii VEG oocysts. Five experimental groups were formed (n=5): I, II and III (reinoculations in the initial, intermediate and final gestational stage, respectively), IV (inoculation) and V (no inoculation). Clinical and serological exams (IgG IFAT [indirect immunofluorescence antibody test]) in different days of evaluation, and bioassay and PCR were performed in all goats. In the infected goats with T. gondii a peak of 40.2°C (IV) at nine, seroconversion (IgG≥64) at 21 and stabilization (IgG<1024) at 119 days postinoculation were observed. In the reinfected goats with T. gondii occurred an increase in IgG titers (≥1,024) at 28 (I), 7 (II) and 3 (III) days post-reinoculation. During kidding were observed only in the reinfected groups: dystocia, malformation body, stillbirth and weakness, and IgG anti-Toxoplasma were detected in all and in some offsprings of the reinfected and infected goats, respectively. Tissue parasitism by T. gondii was diagnosed by bioassay and PCR in infected and reinfected goats and in their offspring. The congenital toxoplasmosis was possible in goats chronically infected and reinfected with T. gondii. The primary infection with T. gondii did not protect the pregnant goats against congenital disease resulting from toxoplasmic reinfection, in different gestational stages (initial, intermediate and final).

O desenho-estória na atenção psicológica a crianças na fase pré-cirurgica

The hospitalization process generates stress and, for a child who has already experienced a surgery can suffer from threatening, anxiety and distress. This search examines the experiences of children indicated for different craniofacial surgery which in many cases require more than esthetic or reconstructive surgery. It is quantitative and qualitative study, descriptive and comparative. The sample is intentional and it is made up of ten children, five boys and five girls in the pre-surgical Hospital for Rehabilitation of Craniofacial Anomalies HRAC-USP, Bauru-SP. As a tool for data collection, the design-themed story and data are used from subsequent survey developed by Walter Trinca. The results indicate that the design-themed story is suitable for the identification of the kid's childhood experiences in helping to deal with the stressful situation. Some of the children reveal their feelings of anxiety and fear and manifest other defenses such as denial. In all cases it identifies emotional states of concern such as anxiety and fear, or also denial of those feelings. It was concluded by the need of creating more favorable conditions in order to identify and address childhood experiences compared to surgery in a hospital environment, proposing the designthemed story technique that reveals those experiences. It emphasizes the relevance of psychological intervention in the hospital environment, considering childhood fantasies and feelings that generate or intensify emotional states of anxiety, fear and distress in pre-surgical level.

Deteccão de complexos QRS em eletrocardiogramas baseada na decomposição em valores singulares em multirresolução

Pós-graduação em Engenharia Elétrica - FEIS

Prótese de palato em sujeitos com disfunção velofaríngea: expectativa e ansiedade

Cleft lip and palate (CLL) is a very common craniofacial anomaly. The cleft is usually corrected with surgery which may fail resulting in velopharyngeal dysfunction (VPD). The use of palatal prosthesis is an alternative treatment for correcting both, CLP and VPD. This study evaluated anxiety symptoms expectations of subjects of both genders, with velopharyngeal dysfunction, referred to palatal prosthesis program for VPD treatment. In this cross sectional and descriptive study 30 subjects with velopharyngeal dysfunction, aged 15 to 64 years old (mean age of 28) were interviewed at the Hospital for Rehabilitation of Craniofacial Anomalies (HRAC). All subjects referred to the palatal prosthesis program at HRAC in the year of 2005 were considered for participation in the study but only the first 30 candidates were included. A questionnaire addressing expectation elaborated by the researcher and the Beck Scale on anxiety were used. All subjects showed expectation regarding speech modification. Changes in professional and affective aspects of their lives after changes in speech were obtained with palatal prosthesis were the most reported expectations. Subjects’ age and gender influenced anxiety levels significantly which were minimum across subjects. High levels of expectation were more frequent than anxiety in the sample population.