Dialogos de la naturaleza del hombre, de su principiom, y su fin : en los quales se le da ... verdadero conocimiento assi de Iesu Christo ... como de si mismo /

Mode of access: Internet.

Altnordische saga-bibliothek,

Vol. 17-18 ed. by F. Jónsson, E. Mogk, and E. Olson.

Assessment of retail and wholesale market competition in the Illinois electric industry /

In this report, the Commission examines developments relevant to the competitiveness of the retail and wholesale markets. In the retail market, two key indicators of activity are examined: The first indicator is the rate of customer switching from bundled services to "delivery services." Customers taking delivery services are either purchasing power and energy from ARES or are purchasing power and energy from the host utility on an "unbundled" basis under the utility's delivery services tariffs. Currently, bundled power sales mainly consist of sales to customers under the Sec. 16-110 "Power Purchase Option" (PPO). The second indicator of retail activity presented in this report is the number of suppliers active in the State's nine service territories.

Undersøgelse af kongesagaens fremvæxt.

Vol. 2: Tillægshefte til Christiania videnskabs-selskabs Forhandlinger for 1875... I commission hos J. Dybwad.

Grazing values and management of black grama and tobosa grasslands and associated shrub ranges of the Southwest /

Includes bibliographical references (p. 54-56).

Phylogenetics, conservation, and historical biogeography of the West Indian members of the Adelieae (Euphorbiaceae)

The Caribbean Island Biodiversity Hotspot is the largest insular system of the New World and a priority for biodiversity conservation worldwide. The tribe Adeliae (Euphorbiaceae) has over 35 species endemic to this hotspot, representing one of the most extraordinary cases of speciation in the West Indies, involving taxa from Cuba, Hispaniola, Jamaica, and the Bahamas. These species form a monophyletic group and traditionally have been accommodated in two endemic genera: Lasiocroton and Leucocroton. A study based on: (1) scanning electron microscopy of pollen and trichomes, (2) macromorphology, and (3) molecular data, was conducted to reveal generic relationships within this group. Phylogenies were based on parsimony and Bayesian analyses of nucleotide sequences of the ITS regions of the nuclear ribosomal DNA and the non-coding chloroplast DNA spacers psbM-trnD and ycf6-pcbM. One species, Lasiocroton trelawniensis, was transferred from the tribe into the genus Bernardia. Of the remaining species, three major monophyletic assemblages were revealed, one was restricted to limestone ares of Hispaniola and was sister to a clade with two monophyletic genera, Lasiocroton and Leucocroton. Morphological, biogeographical, and ecological data provided additional support for each of these three monophyletic assemblages. The Hispaniolan taxa were accommodated in a new genus with four species: Garciadelia. Leucocroton includes the nickel hyperaccumulating species from serpentine soils of Cuba, while the rest of the species were placed in Lasiocroton, a genus restricted to limestone areas. The geographic history of the islands as well as the phylogenetic placement of the Leucocroton-alliance, allows the research to include the historical biogeography of the alliance across the islands of the Caribbean based on a dispersal-vicariance analysis. The alliance arose on Eastern Cuba and Hispaniola, with Lasiocroton and Leucocroton diverging on Eastern Cuba according to soil type. Within Leucocroton, the analysis shows two migrations across the serpentine soils of Cuba. Additional morphological, ecological, and phylogenetic analyses support four new species in Cuba (Lasiocroton gutierrezii) and Hispaniola ( Garciadelia abbottii, G. castilloae, and G. mejiae). ^

"Aqui se faz Gostoso”: uma etnografia do turismo em São Miguel do Gostoso (RN)

This study it is an ethnography on the process of the tourist coast area of São Miguel do Gostoso, whose origin is made from a village of traditional fishermen located on the northeast coast of Rio Grande do Norte. From the late 90s, there were the first initiatives that transformed São Miguel do Gostoso in one of the state's major tourist destinations. The municipality is promoted within the national and international tourism scene through the sun and beach tourism - whose object of consumption is the natural landscape - and sports tourism - which exploited element is the "natural" geographic location (in the continent curve) of municipality that provides winds considered ideal for the practice of “Kitesurfing “ and Windsurfing. From this context, this ethnography had as a theme the social changes promoted by the tourism process in place here addressed, taking into account the perceptions produced by the actors involved in this social net. In this qualitative research, I endeavored to me in the methodological use of ethnographic techniques - bibliographic and field research, participant observation, open and structured interviews recorded by recording and field notes and photographic record. I also made use of theoretical tools and methodology inherent in ciberetnografia when analyzing the blogs and websites of intermediaries and institutions linked to local tourism.

Quando fé e gestão se encontram: compreendendo uma ONG de filosofia protestante sob as lentes da prática e do Sensemaking

We find in Brazil the reality of religious pluralism. From the end of XIX century until now, the religious scenario became more diversified in a process of acceptance and legitimation of different religions. In the same period, the Third Sector was largely developed up until its current form: complex, broad and plural as well. In this context, we find non profitable organizations that provide services under a religious phylosophy. One in particular, placed in Uberlândia-MG, protestant, has the fearures of a big company and is the largest one among the ones that provide social services and receive public funds in the city: Missão Luz. Thinking about the organization, some questions came to mind: is there a noticeable influence of the religious orientation on practices? How do managers understand and make sense of their practices? Adopting Chanlat’s (1996) concept of management mode, the perspective proposed by the Practice Based Studies (GHERARDI, 2013) and the sensemaking studies (WEICK, 1995), I developed a research that intended to understand Missão Luz’ management practices. Three sources of data were used – documents, shadowing and interviews – to understand, in the most complete way, organization’s management practices, using managers’ perspective. Results pointed to a noticeable relation between faith and management. Ten practices were identified among managers: council decisions, appreciation for excellence, respect for authority figures, giving second chances to employees, desire to be a reference, results quantification, search for professionalization, organization, formalization and standardization. The first five practices were heavily influenced by religious principles, and the five last were influenced by instrumental rationality, usually found in the Second Sector. It was noticed that faith was also related to those last practices, justifying them for their contribution for achieving excellence e consequent action of glorifying God. Practices are maintained e passed by the cultivation of the Mission’s DNA, an organization’s way of doing things, and by the belief of the role of the leader maintaining this DNA. Associated to practices, sensemaking moments were analyzed, situations where there order was disrupted and managers had to make sense e act on this understanding. These situations were divided in three themes: “fly the flag of the company”, changes in schools’ management and God’s purpose and sovereignty. The paper is finished with some suggestions for future researches.

Farmacocinética de oxitetraciclina en dosificación oral múltiple en cerdos. Análisis PK-PD

La oxitetraciclina, antibiótico de amplio uso en medicina veterinaria, pertenece al grupo de las tetraciclinas. Inhibe la síntesis de proteínas en la bacteria a nivel ribosomal. La oxitetraciclina presenta principalmente una acción bacteriostática frente a bacterias Gram-positivas y Gram-negativas, así como también frente a otros microorganismos tales como micoplasmas, espiroquetas, clamidias y rickettsias. Se clasifica en la actualidad de acuerdo con la cinética de muerte bacteriana como co-dependiente. En la bibliografía científica existen trabajos publicados de farmacocinética de oxitetraciclina en distintas especies animales, sin embargo hay escasos trabajos realizados en el cerdo. Dado que es necesario conocer la disposición de un fármaco en la especie animal estudiada para diseñar un adecuado régimen de dosificación, los objetivos del presente trabajo han sido: (i) describir el perfil farmacocinético de la oxitetraciclina tras administración oral única y múltiple en cerdos (Sus scrofa domestica) y (ii) realizar el análisis PK-PD para predecir la eficacia terapeútica del régimen de dosificación...

Farmacocinética y depleción de residuos de tilosina en truchas ("Oncorhynchus Mykiss")

La tilosina, antibiótico de amplio uso en medicina veterinaria, pertenece al grupo de los antibióticos macrólidos. Actúa inhibiendo la síntesis de proteínas en la bacteria. La tilosina es una mezcla de cuatro fracciones Tilosina A, Tilosina B, Tilosina C y Tilosina D. La Tilosina A es el componente mayoritario (normalmente constituye un 90% de la mezcla y nunca menos del 80%). La tilosina ha sido incluida en el Anexo I del Reglamento No 37/2010 de la Comisión para uso en todas las especies productoras de alimentos incluyendo peces, estableciéndose un Límite Máximo de Residuos (LMR). La tilosina presenta una acción esencialmente bacteriostática frente a bacterias Gram-positivas y algunas Gran-negativas, así como otros organismos como micoplasma, espiroquetas, clamidia y rickettsia. Presenta valores de concentración mínima inhibitoria (MIC) entre 0,2 y 1 μg/ml frente a varias bacterias y micoplasmas patógenos susceptibles. En la literatura existen trabajos publicados de farmacocinética de tilosina en ganado bovino, caprino, ovino, perros y aves, en los que tras administración intramuscular la tilosina se distribuye ampliamente a tejidos y presenta una alta biodisponilbilidad. Sin embargo, no existen estudios realizados en peces. Dado que es necesario conocer la disposición de un fármaco en la especie estudiada para diseñar un adecuado régimen de dosificación, los objetivos del presente trabajo han sido: (i) describir el comportamiento cinético de la tilosina tras administración oral única y múltiple en trucha arcoriris (Oncorhynchus mykiss) y (ii) evaluar la depleción de tilosina A en tejido comestible (músculo + piel) tras administración oral múltiple...

Characterization of a Full-Length TTP Family Member Association with RNA Sequence Elements

Post-transcriptional regulation of cytoplasmic mRNAs is an efficient mechanism of regulating the amounts of active protein within a eukaryotic cell. RNA sequence elements located in the untranslated regions of mRNAs can influence transcript degradation or translation through associations with RNA-binding proteins. Tristetraprolin (TTP) is the best known member of a family of CCCH zinc finger proteins that targets adenosine-uridine rich element (ARE) binding sites in the 3’ untranslated regions (UTRs) of mRNAs, promoting transcript deadenylation through the recruitment of deadenylases. More specifically, TTP has been shown to bind AREs located in the 3’-UTRs of transcripts with known roles in the inflammatory response. The mRNA-binding region of the protein is the highly conserved CCCH tandem zinc finger (TZF) domain. The synthetic TTP TZF domain has been shown to bind with high affinity to the 13-mer sequence of UUUUAUUUAUUUU. However, the binding affinities of full-length TTP family members to the same sequence and its variants are unknown. Furthermore, the distance needed between two overlapping or neighboring UUAUUUAUU 9-mers for tandem binding events of a full-length TTP family member to a target transcript has not been explored. To address these questions, we recombinantly expressed and purified the full-length C. albicans TTP family member Zfs1. Using full-length Zfs1, tagged at the N-terminus with maltose binding protein (MBP), we determined the binding affinities of the protein to the optimal TTP binding sequence, UUAUUUAUU. Fluorescence anisotropy experiments determined that the binding affinities of MBP-Zfs1 to non-canonical AREs were influenced by ionic buffer strength, suggesting that transcript selectivity may be affected by intracellular conditions. Furthermore, electrophoretic mobility shift assays (EMSAs) revealed that separation of two core AUUUA sequences by two uridines is sufficient for tandem binding of MBP-Zfs1. Finally, we found evidence for tandem binding of MBP-Zfs1 to a 27-base RNA oligonucleotide containing only a single ARE-binding site, and showed that this was concentration and RNA length dependent; this phenomenon had not been seen previously. These data suggest that the association of the TTP TZF domain and the TZF domains of other species, to ARE-binding sites is highly conserved. Domains outside of the TZF domain may mediate transcript selectivity in changing cellular conditions, and promote protein-RNA interactions not associated with the ARE-binding TZF domain.

In summary, the evidence presented here suggests that Zfs1-mediated decay of mRNA targets may require additional interactions, in addition to ARE-TZF domain associations, to promote transcript destabilization and degradation. These studies further our understanding of post-transcriptional steps in gene regulation.

¿A quién le importa Europa? La UE en las elecciones generales españolas de 2011

Este artículo versa sobre el papel de la Unión Europea (UE) en las elecciones generales en España. Emplea los siguientes materiales: la base de datos del Manifesto Project, los programas de los partidos que obtuvieron representación en los comicios de 2011, así como, también para 2011, la transcripción del único debate televisado y las cuentas en la red social twitter de los candidatos a la Presidencia del Gobierno del Partido Popular y del Partido Socialista. La metodología empleada es el análisis de contenido. Los datos confirman las expectativas derivadas de la teoría de la importancia (saliency theory). Los partidos españoles han desenfatizado los asuntos de la UE, incluso en 2011, cuando medidas impulsadas por el gobierno anterior, incluida una reforma constitucional, fruto de decisiones adoptadas a escala europea, motivaron la convocatoria anticipada de elecciones. La evolución del énfasis y posición sobre la UE de los partidos españoles contrasta con los cambios observados en estas variables en otros Estados miembros como Francia o Italia. Los hallazgos de esta investigación tienen implicaciones desde el punto de vista de la legitimidad democrática de la UE en España.

Misura UHF (Ultra High Frequency) delle scariche parziali nei sistemi isolati a gas: metodologie per la verifica della sensibilità di misura

Le apparecchiature di manovra tramite isolamento a gas (GIS) sono in funzione da più di 45 anni e hanno dimostrato un alto livello di affidabilità, con tassi di difetto molto bassi. Tuttavia, il riscontro pratico indica che alcuni dei guasti che si verificano durante il servizio sono legati a difetti del sistema di isolamento. Molti di questi difetti possono essere rilevati tramite diagnostica con scariche parziali (PD). Per la rilevazione PD, viene utilizzato il metodo UHF perché meno sensibile ai disturbi e quindi più facile da gestire in confronto al metodo convenzionale secondo IEC 60270. Un rapporto di Electra pubblicato nel 1999 dal CIGRE Task Force 15/33.03.05 descrive la procedura in due fasi per la verifica della sensibilità del sistema UHF in modo molto generale. Dopo 15 anni dalla sua applicazione, è diventata necessaria una descrizione più dettagliata, sia su misure necessarie al test di laboratorio (Passaggio 1) che sul test in loco (Passaggio 2).

Relación entre los estilos cognitivos dependencia e independencia de campo y la selección de etiquetas de yogur

Los consumidores tienen capacidades limitadas para evaluar toda la información que se incluye en etiquetas de alimentos, y generalmente difieren en el estilo cognitivo que determina las estrategias de procesamiento de información en situaciones de toma de decisión. El objetivo del presente trabajo fue evaluar la relación entre los estilos cognitivos dependencia e independencia de campo y la selección de etiquetas de yogur. Se trabajó con 133 participantes, quienes completaron una tarea de análisis conjunto de elección de etiquetas de yogur, diseñadas utilizando cuatro variables independientes de dos niveles cada una: contenido de grasa y azúcar, fondo gráfico de las etiquetas, sistema semáforo, y marca. Se presentaron 16 sets compuestos por dos etiquetas en una pantalla de computadora y se les pidió a los participantes que indicaran cuál preferirían consumir. Durante la tarea se registraron los movimientos oculares de los participantes. Al finalizar los participantes completaron el Test Grupal de Figuras Enmascaradas (GEFT). De acuerdo a las puntuaciones obtenidas se identificaron dos grupos de participantes: dependientes e independientes de campo. Los participantes independientes realizaron búsquedas de la información más profundas en las etiquetas que los dependientes. También se encontraron diferencias entre los grupos en la forma en que tomaron sus decisiones, atribuyendo los participantes independientes de campo mayor relevancia a la composición nutricional de los productos para tomar sus decisiones. Los resultados de este trabajo proporcionan evidencias preliminares sobre la influencia de los estilos cognitivos en la selección de alimentos.

Diseño mecánico de los elementos de transmisión de un aerogenerador de 1, 3 MW

Partiendo de la potencia que ha de generar se pretende realizar el diseño de los distintos elementos de transmisión de un aerogenerador con el fin de garantizar un funcionamiento óptimo del mismo.