Regulation of Nuclear Factor κB (NF-κB) Transcriptional Activity via p65 Acetylation by the Chaperonin Containing TCP1 (CCT)

The NF-κB family member p65 is central to inflammation and immunity. The purpose of this study was to identify and characterize evolutionary conserved genes modulating p65 transcriptional activity. Using an RNAi screening approach, we identified chaperonin containing TCP1 subunit η (CCTη) as a regulator of Drosophila NF-κB proteins, Dorsal and Dorsal-related immunity factor (Dif). CCTη was also found to regulate NF-κB-driven transcription in mammalian cells, acting in a promoter-specific context, downstream of IκB kinase (IKK). CCTη knockdown repressed IκBα and CXCL2/MIP2 transcription during the early phase of NF-κB activation while impairing the termination of CCL5/RANTES and CXCL10/IP10 transcription. The latter effect was associated with increased DNA binding and reduced p65 acetylation, presumably by altering the activity of histone acetyltransferase CREB-binding protein (CBP). We identified p65 lysines (K) 122 and 123 as target residues mediating the CCTη-driven termination of NF-κB-dependent transcription. We propose that CCTη regulates NF-κB activity in a manner that resolves inflammation.

Die Breslauische Sing-Akademie in den ersten fünf und zwanzig Jahren ihres Bestehens /

25 year history of Breslauische Sing-Akademie with repertoire and rosters in appendices.

Die Sendung Semaels; Jüdische Tragödie in fünf Aufzügen.

Mode of access: Internet.

Kleine Kammermusik für fünf Bläser (Flöte, Oboe, Klarinette, Horn, Fagott) Op.24, Nr.2.

Mode of access: Internet.

Der Tulpenfrevel : ein Schauspiel in fünf Akten /

Mode of access: Internet.

The electrolytic recovery of uranium and vanadium from carbon leach liquors by means of ion exchange membranes /

"Date Declassified: September 23, 1955."

The electrolytic recovery of uranium from Vitro leach liquor by means of ion exchange membranes /

The investigation of the electrolytic precipitation of uranium from a sample of acid leach liquor in an ion exchange membrane cell has been conducted on leach liquor from the Vitro Co. This leach liquor can be treated by the above means to precipitate essentially all the uranium and simultaneously to produce additional acid which may be used for further leaching.

The electrolytic migration of uranium from acid leach liquors by means of ion exchange membranes /

"Date Declassified: September 23, 1955."

Der Pentateuch : oder, die fünf Bücher Mose's in corectem hebräischen Texte mit worttreuer Ubersetzung, vollständiger Erklärung, und erbaulichen und homiletisch benutzbaren Andeutungen /

At head of title: Torat Moshe (romanized)

Diseases of the spinal cord and its membranes, and the various forms of paralysis arrising therefrom,- chorea and tetanus /

Mode of access: Internet.

Anatomie générale de la peau et des membranes muqueuses /

Mode of access: Internet.

Traité d'anatomie générale : théorie de la structure embrassant, les substances organiques et les élements, les tissus, les membranes et les parenchymes /

Mode of access: Internet.

Agnes Bernauer; ein deutsches Trauerspiel in fünf Aufzügen.

Mode of access: Internet.

Jan der wunderbare : ein derbes Lustspiel in fünf Bildern /

Mode of access: Internet.

Palästina und seine Kultur in fünf Jahrtausen-den nach den neuesten Ausgrabungen und Forschungen Dargestellt ...

Mode of access: Internet.