Planeamento espacial marinho das áreas marinhas protegidas: o caso de estudo da ára protegida de gestão de recursos: Caloura - ilhéu de Vila Franca do Campo

Tese de Doutoramento, Ciências do Mar (Ecologia Marinha), 26 de Novembro de 2013, Universidade dos Açores.

Plano de marketing para a empresa: Salss - Importação e Comércio Lda

Trabalho de projeto apresentado à Escola Superior de Comunicação Social como parte dos requisitos para obtenção de grau de mestre em Publicidade e Marketing.

Estudo do comportamento térmico de edifícios de habitação segundo o RCCTE e o REH

Com a melhoria das condições de vida verificada nas últimas décadas em Portugal e no mundo, tem-se assistido a um importante desenvolvimento dos atributos funcionais dos edifícios, onde o conforto térmico assume um papel importante, é nesse sentido que a presente dissertação aborda a área do Desempenho Térmico de Edifícios, mais precisamente os do sector residencial. Esta dissertação dividiu-se em três grandes partes: inicialmente é feito um enquadramento teórico do tema, em seguida faz-se a apresentação das metodologias de cálculo e, por último, a apresentação do caso de estudo e análise dos resultados. Procura-se analisar a situação energética no sector residencial, dando particular ênfase às causas e medidas correctivas a aplicar para evitar o aumento do consumo de energia. Também são abordadas as metodologias presentes na Legislação Portuguesa em vigor, e nas novas propostas que espera-se que entrem em vigor a 1 de Dezembro de 2013. Sendo que o principal objectivo desta dissertação é o estudo da nova proposta legislativa e apresentar um documento que procure efectuar uma comparação detalhada entre o DL 80/2006, de 4 de Abril e o DL 118/20013, de 20 de Agosto e sobretudo referir quais as implicações ao nível das soluções construtivas adoptadas e da certificação energética. Após esta analise, é apresentado um caso de estudo que consiste num edifício de habitação unifamiliar que será alvo da aplicação destes dois documentos. Por último é apresentada uma análise dos resultados comparando a classe energética conseguida pelo edifício através das duas metodologias de cálculo.

Spectrum and Frequency of GJB2 Mutations in a Cohort of 264 Portuguese Nonsyndromic Sensorineural Hearing Loss Patients

OBJECTIVE: To assess the spectrum and prevalence of mutations in the GJB2 gene in Portuguese nonsyndromic sensorineural hearing loss (NSSHL) patients. DESIGN: Sequencing of the coding region, basal promoter, exon 1, and donor splice site of the GJB2 gene; screening for the presence of the two common GJB6 deletions. STUDY SAMPLE: A cohort of 264 Portuguese NSSHL patients. RESULTS: At least one out of 21 different GJB2 variants was identified in 80 (30.2%) of the 264 patients analysed. Two mutant alleles were found in 53 (20%) of these probands, of which 83% (44/53) harboured at least one c.35delG allele. Twenty-seven (10.2%) of the probands harboured only one mutant allele. Subsequent analysis revealed that the GJB6 deletion del(GJB6-D13S1854) was present in at least 7.4% (2/27) of the patients carrying only one mutant GJB2 allele. Overall, one in five (55/264) of the patients were diagnosed as having DFNB1-related NSSHL, of which the vast majority (53/55) harboured only GJB2 mutations. CONCLUSIONS: This study provides clear demonstration that mutations in the GJB2 gene are an important cause of NSSHL in Portugal, thus representing a valuable indicator as regards therapeutical and rehabilitation options, as well as genetic counseling of these patients and their families.

Can the Yield Spread predict economic growth? An assessment for European countries

Double Degree. A Work Project presented as part of the requirements for the Award of a Masters Degree in Economics from the NOVA- School of Business and Economics and a Masters Degree in Management from Louvain School of Management

A decision- theoretic model for M&A sale processes

A Work Project, presented as part of the requirements for the Award of a Masters Double Degree in Economics and International Business from the NOVA – School of Business and Economics and Insper Instituto de Ensino e Pesquisa

Exploiting the cointrgration between vix and CDS in a credit market timing model

We investigate the cointegration between VIX and CDS indices, and the possibility of exploiting it in an existing credit market timing investment model. We find cointegration over most of the sample period and the leadership of VIX over the CDS in the price discovery process. We present two methods for including cointegration into the model. Both strategies improve the in-sample and out-of-sample model performances, even though out-of-sample results are weaker. We find that in-sample better performances are explained by a stronger cointegration, concluding that in the presence of cointegration our strategies can be profitable in an investment model that considers transaction costs.

Genetic algorithm for shipping route estimation with long-range tracking data : automatic reconstruction of shipping routes based on the historical ship positions for maritime safety applications

Ship tracking systems allow Maritime Organizations that are concerned with the Safety at Sea to obtain information on the current location and route of merchant vessels. Thanks to Space technology in recent years the geographical coverage of the ship tracking platforms has increased significantly, from radar based near-shore traffic monitoring towards a worldwide picture of the maritime traffic situation. The long-range tracking systems currently in operations allow the storage of ship position data over many years: a valuable source of knowledge about the shipping routes between different ocean regions. The outcome of this Master project is a software prototype for the estimation of the most operated shipping route between any two geographical locations. The analysis is based on the historical ship positions acquired with long-range tracking systems. The proposed approach makes use of a Genetic Algorithm applied on a training set of relevant ship positions extracted from the long-term storage tracking database of the European Maritime Safety Agency (EMSA). The analysis of some representative shipping routes is presented and the quality of the results and their operational applications are assessed by a Maritime Safety expert.

Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.

The Fragile X mental retardation protein (FMRP) regulates neuronal RNA metabolism, and its absence or mutations leads to the Fragile X syndrome (FXS). The β-amyloid precursor protein (APP) is involved in Alzheimer's disease, plays a role in synapse formation, and is upregulated in intellectual disabilities. Here, we show that during mouse synaptogenesis and in human FXS fibroblasts, a dual dysregulation of APP and the α-secretase ADAM10 leads to the production of an excess of soluble APPα (sAPPα). In FXS, sAPPα signals through the metabotropic receptor that, activating the MAP kinase pathway, leads to synaptic and behavioral deficits. Modulation of ADAM10 activity in FXS reduces sAPPα levels, restoring translational control, synaptic morphology, and behavioral plasticity. Thus, proper control of ADAM10-mediated APP processing during a specific developmental postnatal stage is crucial for healthy spine formation and function(s). Downregulation of ADAM10 activity at synapses may be an effective strategy for ameliorating FXS phenotypes.

Horae ad usum romanum

F. 1-12v. Calendrier en français, à l’encre rouge et noire, où l’on remarque des formes dialectales picardes et plusieurs saints du Nord : « sainte Audegonde » (30 janvier) ; « le Candelier » (2 févr.) ; « ste Gertrude » (17 mars) ; « saint Quentin » (2 mai) ; « saint Ernoulx » [ep. Suessonensis] (16 août) ; « saint Bertin » (5 septembre) ; « saint Lambert » (17 septembre) ; « saint Franchois » (4 oct.) ; « saint Gillain » [mart. in Hannonia] (16 oct., Ghislain); « le jour st Estievene » (26 déc., rouge). Une deuxième main très cursive ajouté d’autres saints, dont « s. Amand » (6 févr.) ; « s. Waleri » (1er avril) ; « s. Fuscien » [mart. Ambianensis] (27 juin et 10 déc.) ; « s. Firmin » [mart. Ambianensis] (25 septembre) ; « s. Bavon » (1er oct.). F. 13v-17v. « ... hore sancte Crucis». F. 18v-22v. « ... hore de sancto Spiritu ».F. 23v-85. « ... hore beate marie virginis secundum usum romanum ». F. 86v-94v. Office de la Vierge, selon les temps de l’année. « ... officum beate Marie virginis quod dicitur per totum adventum ad vesperas ».F.95-115. « ... septem psalmi penitentiales cum suis litaniis et precibus ». A noter « ... sancte Lamberte... sancte Rumolde [ep. Mechlinensis]... sancte Fursee [ab. Latiniacensis] ... sancte Amande... sancte Vedaste, sancte Bavo... sancte Philiberte... santa Ursula... sancta Brigida... sancta Aldegondis, sancta Gertrudis... ».F.116v-152v. « ... vigilie mortuorum » office des morts à l’usage de Sarum-Normandie-Metz ; cf. K. Ottosen, Responsories..., p. 242 (116v-151). — « Octo versus beati Bernardi ». « Illumina oculos meos ne umquam obdormiam... » ; cf. Leroquais, Livres d’heures, I, XXX-XXXI (151-152v).F.153-158v. « Initium sancti evvangelii secundum Johannem... secundum Lucam... secundum Matheum... secundum Marcum ».F. 158v-166. Suffrages aux saints : « Memoria de santo Johanne Baptista... ; devota oratio... » ; — « ... de sancto Adriano » ; — « ... de sancto Sebastiano » ; — « ... de sancto Anthonio » ; — « ... de sancto Quintino » ; — « ... de sancto Nicholae » ; — « ... de sancto Andrea » ; — « ... de sancto Fiacro ».F.166v-174v. Prières à la Vierge. « ... devotissima oratio ad beatem virginem Mariam ». « O intemerata... O Johannes... » (éd. Wilmart, Auteurs spirituels, 488-490) (166v-169v). — « Alia oratio ad beatam virginem Mariam ». « Obsecro te.... » (éd. Leroquais, Livres d’heures, II, 346-347) (169v-174). Les deux prières sont rédigées à la forme masculine. — « Laus Marie virginis ». « Salve regina... » (Analecta Hymnica, L, 318-319, n° 245) (174-174v). F. 175-184v. Suffrages aux saintes : « ... de santa Barbara » ; — « ... de sancta Margareta » ; — « ... de sancta Katerina » ; — « ... de sancta Maria Magdelena » ; — « ... de sancta Appolonia » ; — « ... de sancta Venicie [Venice, forme dérivée de Véronique] » « Veni sponsa Christi... Versus. Diffusa est gratia... Oratio. Exaudi nos Deus ut sicut de beate Venicie festivitate gaudemus, ita pie devotionis erudiamur. Per.... » ; sur le culte de sainte Véronique/Venice, en particulier à Paris, voir Gr. A. RUNNALS, Le mystère de sainte Venice, Exeter, 1980 (Textes littéraires) (175-180v). — Prières diverses : « ... quinque gaudia de beata virgine Maria » « Gaude Virgo mater Christi... » (éd. Leroquais, Livres d’heures, I, XXVI-XXVII) (180v-182). — « Oratio devota ad Jesum Christum ». « Ave domine Jhesu Christe verbum patris » (éd. Wilmart, Auteurs spirituels, 412 [III]) (182-183). — « Oratio devota que dicitur ad elevationem Domini ». « Ave verum corpus Domini nostri... » (éd. Szövérffy, Die Annalen , II, 298-299) (183-184). — « Memore de saint Miquiel », en latin (184-184v).