Driving ability, mental illness and psychotropic medication in the elderly

Fitness to drive in elderly drivers is most commonly discussed with a focus on cognitive impairment. Therefore, this article is focussing on mental illness and the use of psychotropic drugs in elderly drivers, which can both interfere with fitness to drive. Based on a detailed literature review and on clinical judgement, we propose signposts and "red flags" to judge the individual risks. Health professionals dealing with elderly patients should in particular be aware of the dangers related to cumulative risks and need to inform the patients appropriately. For medico-legal reasons the information provided to patients must be written down in the medical record. Individual counselling is important as fitness to drive is a complex topic.

XIAP Restricts TNF- and RIP3-Dependent Cell Death and Inflammasome Activation

X-linked inhibitor of apoptosis protein (XIAP) has been identified as a potent regulator of innate immune responses, and loss-of-function mutations in XIAP cause the development of the X-linked lymphoproliferative syndrome type 2 (XLP-2) in humans. Using gene-targeted mice, we show that loss of XIAP or deletion of its RING domain lead to excessive cell death and IL-1β secretion from dendritic cells triggered by diverse Toll-like receptor stimuli. Aberrant IL-1β secretion is TNF dependent and requires RIP3 but is independent of cIAP1/cIAP2. The observed cell death also requires TNF and RIP3 but proceeds independently of caspase-1/caspase-11 or caspase-8 function. Loss of XIAP results in aberrantly elevated ubiquitylation of RIP1 outside of TNFR complex I. Virally infected Xiap−/− mice present with symptoms reminiscent of XLP-2. Our data show that XIAP controls RIP3-dependent cell death and IL-1β secretion in response to TNF, which might contribute to hyperinflammation in patients with XLP-2.

Die bürgerliche Stellung der Juden in Bayern : ein Memorandum

vorgelegt von [Lazar] Adler

Hillel und Schamai, oder die conservative Reform und der stabile Conservatismus : eine Friedensstimme an die Gemeinden Israels und ihre Führer

verf. und hrsg. von L. Adler

Descriptive catalogue of a collection of objects of Jewish ceremonial deposited in the US National Museum by Hadji Ephraim Benguiat

Smithsonian Institution ... By Cyrus Adler and I. M. Casanowicz

Das Judentum u. die Kritik : ein Sendschreiben an Herrn Dr. F.W. Ghillani

A. Adler

Emancipation und Religion der Juden oder das Judenthum und seine Gegner : ein Sendschreiben an Herrn Prof. Dr. Allioli ...

von [Lazar] Adler

Assimilation oder Nationaljudenthum?

Von S. Adler

Deutsches Lesebuch für israelitische Schulen : in 3 Abt.

hrsg. von L. Adler

Für und wider die jüdische Volksschule in Preußen

von S. Adler

Leitfaden für den israelitischen Religionsunterricht

von S. Adler

Die letzte Versammlung im alten und die erste Versammlung im neuen Gotteshause : zwei Vorträge vor und zur Einweihung der neuen Synagoge zu Wolfhagen am 28. Tischri 5620 (26. October 1859)

gehalten von L. Adler