Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization

Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions.

Identifying clones in functional programs for refactoring

Clone detection is well established for imperative programs. It works mostly on the statement level and therefore is ill-suited for func- tional programs, whose main constituents are expressions and types. In this paper we introduce clone detection for functional programs using a new intermediate program representation, dubbed Functional Control Tree. We extend clone detection to the identi cation of non-trivial func- tional program clones based on the recursion patterns from the so-called Bird-Meertens formalism

Criminal Liability of Organizations, Corporations, Legal Persons, and Similar Entities on Law of Portuguese Cybercrime: A Brief Discussion on the Issue of Crimes of “False Information,” the “Damage on Other Programs or Computer Data,” the “Computer-Software Sabotage,” the “Illegitimate Access,” the “Unlawful Interception,” and “Illegitimate Reproduction of the Protected Program”

Abstract: in Portugal, and in much of the legal systems of Europe, «legal persons» are likely to be criminally responsibilities also for cybercrimes. Like for example the following crimes: «false information»; «damage on other programs or computer data»; «computer-software sabotage»; «illegitimate access»; «unlawful interception» and «illegitimate reproduction of protected program». However, in Portugal, have many exceptions. Exceptions to the «question of criminal liability» of «legal persons». Some «legal persons» can not be blamed for cybercrime. The legislature did not leave! These «legal persons» are v.g. the following («public entities»): legal persons under public law, which include the public business entities; entities utilities, regardless of ownership; or other legal persons exercising public powers. In other words, and again as an example, a Portuguese public university or a private concessionaire of a public service in Portugal, can not commit (in Portugal) any one of cybercrime pointed. Fair? Unfair. All laws should provide that all legal persons can commit cybercrimes. PS: resumo do artigo em inglês.

Slicing functional programs by calculation

Program slicing is a well known family of techniques used to identify code fragments which depend on or are depended upon specific program entities. They are particularly useful in the areas of reverse engineering, program understanding, testing and software maintenance. Most slicing methods, usually targeting either the imperative or the object oriented paradigms, are based on some sort of graph structure representing program dependencies. Slicing techniques amount, therefore, to (sophisticated) graph transversal algorithms. This paper proposes a completely different approach to the slicing problem for functional programs. Instead of extracting program information to build an underlying dependencies’ structure, we resort to standard program calculation strategies, based on the so-called Bird- Meertens formalism. The slicing criterion is specified either as a projection or a hiding function which, once composed with the original program, leads to the identification of the intended slice. Going through a number of examples, the paper suggests this approach may be an interesting, even if not completely general alternative to slicing functional programs

Antibacterial activity of Baccharis trimera (Less.) DC. (carqueja) against bacteria of medical interest

Baccharis trimera (Less.) (Asteraceae), popularly know as "carqueja", is a species commonly used in folk medicine for the treatment or prevention of diseases. In this context, the purpose of this work was to study the antibacterial activity of crude hydroalcoholic extract from Baccharis trimera against Gram-positive bacterial strains (Staphylococcus aureus ATCC 29213, Staphylococcus saprophyticus ATCC 15305, Staphylococcus epidermidis ATCC 12228, Enterococcus faecalis ATCC 19433) and Gram-negative bacteria (Escherichia coli EHEC ATCC 43895, Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniae ATCC 27736, Salmonella typhi ATCC 19430) of clinical interest. Antibacterial susceptibility was evaluated by broth microdilution assay following the CLSI (formerly the NCCLS) guidelines. The extract from B. trimera showed antibacterial activity against Gram-positive bacteria and the most interesting result was obtained against S. epidermidis that presented Minimal Inhibitory Concentration of 250μg/mL. These results indicate that B. trimera have bacterisostatic potential against Gram-positive bacterial strains of medical interest and could serve as a base for further studies on the use of isolated compounds from this species as future antimicrobials.

El cuadro de mando integral, el activity based costing y la activity based management: un estudio empírico de su integración

Este artículo tiene como objetivo analizar la complementariedad y la posibilidad de integración entre las herramientas de gestión Cuadro de Mando Integral (CMI), Activity Based Costing (ABC) y Activity Based management (ABM). Para la realización del estudio empírico hemos recurrido a los datos obtenidos mediante la aplicación de un cuestionario postal a 591 organizaciones públicas (ayuntamientos, hospitales, empresas municipales y empresas intermunicipales) y 549 organizaciones privadas (grandes empresas y pequeñas y medianas empresas) portuguesas, con una tasa de respuesta total del 31,3%. Los resultados obtenidos indican que, contrariamente al registrado en las organizaciones públicas, observamos que un número significativo de organizaciones privadas ya utilizaba los sistemas ABC/ABM antes del CMI y que los han integrado (total o parcialmente) o esperan integrar en el CMI.

Production and photosynthetic activity of Mimosa Verde and Mimosa Roxa lettuce in two farming systems

Lettuce (Lactuca sativa L.) is the most commonly consumed leaf vegetable in the Brazilian diet, and it is a good source of vitamins and minerals. It is widely grown in the conventional farming system. However, the hydroponic farming system has been gaining importance in the market, wining confidence from consumers, who are becoming increasingly more demanding on food quality. The objective of this study was to evaluate the performance of two lettuce cultivars on hydroponic and conventional farming systems for the production of fresh mass (FM) and dry mass (DM), photosynthesis, contents of chlorophyll and anthocyanin. The following two experiments were carried out: hydroponics farming (HF) and conventional farming (CF), performed in protect and unprotect environments, respectively, in Florianópolis, SC. Mimosa Verde cultivar (MV) showed greater fresh mass than Mimosa Roxa (MR), in both farming systems and the two cultivars presented better performance in the hydroponic system (287.7 g MV and 139.1 g MR) than the conventional system (129.7 g MV and 111.8 g MR). Mimosa Verde cultivar presented lower average contents of total chlorophyll (7.7 mg g-¹ FM) than Mimosa Roxa (11.8 mg g-¹FM), and both cultivars displayed higher means for this variable in the hydroponic farming system. Mimosa Roxa presented higher contents of anthocyanin in the conventional system (88.24 mg g-¹ FM) than the ones in the hydroponic system (36.89 mg g-¹ FM). The best results for CO2 net assimilation rate regarded to photosyntheticaly active photon flux density were found in the hydroponic system, for both lettuce cultivars. Variation in the contents of chlorophyll were also found. Those variations were higher in the protected system than in the hydroponic system and contents of anthocyanin were higher in the conventional system.

Designing competitive international compensation programs

Over the past 25 years, expatriate managers have voiced increased disenchantment with their compensation packages whíle abroad. This paper takes a prescriptive approach, outlíning severa I elements of a successful human resources strategy and stressing key ingredients of effective international compensation programs. Particular ettention is given to the adherence of cultural values and distrlbutive justice when working across nations and cultures.

The undergraduate level (1st study cycle) as a fundamental platform/standard for the development of Urban and Regional Planning in higher education programs

LUDA is a research project of Key Action 4 "City of Tomorrow & Cultural Heritage" of the programme "Energy, Environment and Sustainable Development" within the Fifth Framework Programme of the European Commission

Estresse e desordem temporomandibular (DTM) : incidência e relação em docentes de nível

RESUMO: O trabalho docente exige dedicação em sala de aula e fora dela, pois o professor vê-se na missão de educador, formador de opiniões e de futuros profissionais no mercado de trabalho. Uma das patologias que pode ocorrer devido ao estresse gerado pela docência é o desenvolvimento de Desordens Temporomandibulares, que acarretará cefaleias, dores musculares na região cervical e facial e alterações posturais. Tivemos a pretensão de conduzir nossas reflexões sobre o estresse do docente para procurar responder às nossas inquietações. Para isso, formulamos o seguinte questionamento: qual a incidência e a relação entre o estresse e o desenvolvimento de Desordens Temporomandibulares no docente de nível superior? O objetivo geral desta investigação foi descrever e analisar a relação entre o estresse e a incidência de Desordem Temporomandibular (DTM) em docentes de nível superior da cidade de Palmas – Tocantins – Brasil. Para contemplar o objetivo geral, buscamos verificar a presença ou não de estresse e os principais sintomas de estresse nos docentes de Ensino Superior, identificando a fase do estresse em que os professores se encontravam e verificar a presença ou não de DTM e seus graus. Procuramos, ainda, avaliar a relação entre sexo e presença de estresse, estado civil e presença de estresse, o tempo de docência e a presença de estresse e a relação entre a carga horária em sala de aula e a carga horária total de trabalho e a presença de estresse, entre sexo e presença de DTM, estado civil e presença de DTM, o tempo de docência e a presença de DTM e a relação entre a carga horária em sala de aula e carga horária total de trabalho e a presença de DTM. A metodologia utilizada, para a realização deste trabalho, foi de caráter exploratório e descritivo com uma abordagem quantitativa dos dados obtidos. A pesquisa caracterizou-se num estudo de campo, fundamentada em um instrumento denominado “Inventário de Sintomas de Stress Lipp – ISSL” da autora Marilda Lipp (2005), versão para adulto, ao qual acrescentamos dados sociodemográficos (estado civil, tempo de docência, carga horária de sala de aula e de trabalho total). Recorremos, ainda, ao Questionário Índice de Helkimo para identificar a ocorrência de DTMs. A coleta dos dados foi realizada a partir de uma amostra de duzentos e trinta e três (233) docentes de Ensino Superior, com idade entre 23 e 74 anos. Com base na análise realizada, os resultados revelaram que a presença de sintomas de estresse se encontra em 106 (45,49%) docentes, com predomínio da fase de resistência. Verificamos que 127 (54,5%) docentes não apresentam estresse. A sintomatologia predominante são sintomas psicológicos. Vimos que o tempo de docência e a jornada de trabalho não contribuem como um valor preditivo da presença de estresse, bem como o estado civil, e verificamos que o sexo feminino apresentou mais sintomas de estresse. Ao analisarmos a presença ou não de DTM, vimos que os docentes apresentam sintomas de DTM em sua maioria, encontrada em 187 docentes (80,25%), com predomínio do grau de DTM leve. Vimos que o tempo de docência e a jornada de trabalho não contribuem como um valor significativo para a presença de DTM, mas que o sexo feminino apresentou mais sintomas de DTM, bem como os casados. Buscando responder ao problema norteador desta 6 investigação, vimos que, mesmo nos docentes sem presença de estresse, havia sintomas de DTM. Esses dados indicam que a profissão docente pode causar sobrecargas e gerar a DTM. Diante dessa amostra de docentes pesquisados, concluímos que os dados aqui apresentados sugerem uma ampliação do estudo. Considerando a relevância do papel desempenhado pelos docentes das Instituições de Ensino Superior na formação dos acadêmicos e em sua efetiva transformação em futuros profissionais, nossa contribuição para o conhecimento do processo de estresse e os graus de DTM na atividade docente proporcionará oportunidade aos profissionais das diversas áreas do conhecimento e, principalmente, aos docentes para despertarem para a elaboração de programas de combate, controle e prevenção do estresse e do desenvolvimento de DTMs, resultando, dessa forma, na conquista de uma vida mais saudável, tanto na área física quanto na área psicológica. ABSTRACT: Abstract The teacher’s job requires dedication in and out of the classroom for a teacher is in a education mission, he/she is an opinion maker and responsible for future professionals in the market. One of the pathologies that may take place due to the stress caused by this job is the Temporomandibular Joint Disorder (TMD) that will trigger cephaleas, muscle pain in the cervical and facial area and posture changes. The purpose of this paper is to conduct reflections about teachers’ stress trying to answer the following question: What is the incidence rate and correlation between stress and the occurrence of Temporomandibular Joint Disorder (DTM) in teachers of institutions of higher learning in the city of Palmas – Tocantis – Brazil. To fulfill the general purpose we tried to verify the presence or not of stress and the principal symptoms in teachers in universities and colleges, identifying the levels of stress that they were, and verifying the presence or not of TMD and its levels. We tried to evaluate the correlation between gender and the occurrence of stress, marital status and the presence of stress, career time and the presence of stress, and time working in classroom and the total time of work and the presence of stress. The methodology used to perform this was an exploratory and descriptive study with a quantitative approach of the data gathered. The research was characterized by a field study, fundamented by a tool called “Lipp Stress Symptom Inventory – ISSL” from the author Marilda Lipp (2005), adult version, which we also added social-demographic data (marital status, time teaching, hours working in the classroom, and total time of work). We also used the Helkimo Index Questionnaire to identify the occurrence of TMD’s. The data was collected from a sample of two hundred three (233) teachers of universities and colleges between 23 to 74 years of age. Based on the analysis performed, the results showed the presence of stress among 106 (45.49%) of the teachers, with the predominance of the resistance level. We observed that some 127 teachers (54.5%) did not show stress. The predominant symptomology were psychological ones. We observed that time of experience and the schedule do not influence as a predictive value for the stress presence, neither does the marital status and we also observed that the female gender showed more stress symptoms. When we analyzed the presence or not of TMD, we observed that most of the teachers showed symptoms of TMD, some 187 teachers (80.25%), with the predominance of first level TMD. We observed that the time as teacher and the schedule do not influence with an important value for the TMD presence, however the feminine gender as well as married teachers showed more symptoms of TMD. Trying to answer the most important issue of this study, we saw that even without the occurrence of stress the TMD was present showing that the profession can cause overwork and consequently TMD. With this sample of teachers studied we conclude that the found data suggest a wider research. Considering the role performed by teachers of universities and colleges in the development of students and future professionals, our contribution for the understanding of the stress development and TMD levels in the teaching activity will enable the opportunity for professionals of different areas of knowledge, and 8 principally for teachers, to awaken to the need to develop programs to fight, control, and prevent stress and the development of TMD, therefore resulting in a healthier life, both a physical as well as a psychological one.

Biting activity of Aedes scapularis (Rondani) and Haemagogus mosquitoes in Southern Brazil (Diptera: Culicidae)

The biting activity of a population of Aedes scapularis (Rondani), Haemagogus capricornii Lutz and Hg. leucocelaenus (Dyar and Shannon) in Southern Brazil was studied between March 1980 and April 1983. Data were obtained with 25-hour human bait catches in three areas with patchy residual forests, named "Jacaré-Pepira", "Lupo" Farm, and "Sta. Helena" Farm, in the highland region of S. Paulo State (Brazil). Data obtained on Ae. scapularis were compared with those formerly gathered in the "Ribeira'' Valley lowlands, and were similar, except in the "Lupo" Farm study area, where a precrepuscular peak was observed, not recorded at the "Jacaré-Pepira" site or in the "Ribeira" Valley. In all the areas this mosquito showed diurnal and nocturnal activity, but was most active during the evening crepuscular period. These observations support the hypothesis about the successful adaptation of Ae. scapularis to man-made environments and have epidemiological implications that arise from it. As for Haemagogus, results obtained on the "Lupo" and "Sta. Helena" regions agree with previous data obtained in several other regions and show its diurnal activity. The proximity of "Lupo" Farm, where Hg. capricornii and Hg. leucocelaenus showed considerable activity, to "Araraquara" city where Aedes aegypti was recently found, raises some epidemiological considerations about the possibility of urban yellow fever resurgence.

Effects of an exercise training program in physical condition after liver transplantation in familial amyloidotic polyneuropathy: a case report

Introduction: Familial amyloidotic polyneuropathy (FAP) is a neurodegenerative disease that leads to sensory and motor polyneuropathies as well as functional limitations. So far, liver transplantation is the only treatment for FAP because the mutated protein causing the disease is mainly produced in the liver. With the increasing survival of transplant recipients, functional and cardiovascular problems as consequences of immunosuppressant side effects are increasing associated with sedentary lifestyles and/or retransplantation status. We sought to analyze the impact of exercise training programs on 1 FAP patient’s course long-term after liver transplantation. Methodology. A FAP patient (female; 49 years of age; body mass index 18.8 kg/m2) underwent a liver transplantation 133 months before assessment. She was assessed for body composition, isometric quadriceps muscle strength, functional capacity, fatigue, and levels of physical activity before and after a 6-month period of combined exercise training. Results: After the exercise training program, almost all variables were improved, namely, total body skeletal muscle mass, proximal femoral bone mineral density, quadriceps strength, maximal oxygen consumption on 6 minutes walk test (6mwt) or VO2peak, total ventilation on 6mwt, and fatigue. The improvement in distance on 6mwt (69.2 m) was clinically significant. Preintervention the levels of physical activity were below international recommendations for health; after the program they achieved the recommendations. Conclusion: The results showed an improvement in functional capacity with a decrease in future disability risk associated with a better lifestyle with respect to physical activity levels in 1 patient.

Supplementary feeding programs: a critical analysis

A critical analysis of the Supplementary Feeding Programs which have been undertaken around the world is presented. Although only a few programs have been rigorously evaluated it seems that in relation to their main objectives, most of them have not proved to be successful. Some suggestions for improvement are put forward and the particular case of the Brazilian programs is assessed in detail.