1000 resultados para Activites diriges vers la description, la narration et l’argumentation.
Resumo:
Donateur : Lemuet, Léon (1833-19..?)
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On y remarque des lettres autographes du marquis de Vence, 4 février 1688 (fol. 64), — du marquis de Châteauneuf, 1785-1786 (fol. 67-74 et 79), — de M. de Trans de Tourrettes, 10 déc. 1699 (fol. 75) ; — des notes relatives à la baronnie de La Garde (fol. 88) ; — un « Inventaire des papiers concernant Les Granges Gontardes lez La Garde » (fol. 113) ; — et une copie des preuves de noblesse faites, en juin 1716, par Mlle Marguerite de Villeneuve de Trans, pour être reçue à Saint-Cyr (fol. 147).
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Incomplet. — Le volume ne contient plus aujourd'hui que six lettres patentes, délivrées, par Charles V, à l'occasion de cette affaire (14 mai-30 nov. 1370). — Les deux derniers feuillets, en papier, contiennent des notes sur cet échange.
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Original, avec signatures et sceaux plaqués.
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Advanced stage follicular lymphoma is incurable by conventional treatment. Important progress has been observed with the development of new therapies based on monoclonal antibodies and on the use of radioimmunotherapy (RIT) in the treatment of non-Hodgkin lymphomas (NHL). Rituximab in combination with chemotherapy in the upfront setting significantly improved treatment outcome as compared with chemotherapy alone. Different studies also indicate that RIT has an important role in the management of NHL and could be beneficial in combination with chemotherapy. These two new treatment options have clearly distinctive mechanisms of action, rituximab being an exclusively biological treatment and RIT adding targeted systemic radiation therapy. Both RIT and the unlabeled antibody treatments might be further improved by different strategies including repetition of RIT or combination of different antibodies. We present here our experience with RIT using 131I-tositumomab (Bexxar) and discuss different topics regarding RIT, like the use of different antibodies, the best choice of the radioisotope or the place of radio-imaging. From the therapeutic point of view, we argue that the debate should not be as to which one among antibody immunotherapy or RIT should be best added to chemotherapy, but that all three treatments might be optimally combined with the aim to get the highest chance of cure for advanced stage follicular lymphoma.