Iowa Lottery Action, Vol. 18, No. 13, June 20-July 10, 2011

Iowa Lottery Retailer Newsletter

Iowa Department of Transportation Major Items - Preliminary Quantity Report, May 20, 2014; With Addendums

Weekly letting report.

Lottery Action Newsletter, Vol. 20, No. 6, April 7-20, 2014

Iowa Lottery Retailer Newsletter

Lottery Action, Vol. 20, No. 7, April 21-May 4, 2014

Iowa Lottery Retailer Newsletter

Induction of CD8 T-cell responses restricted to multiple HLA class I alleles in a cancer patient by immunization with a 20-mer NY-ESO-1f (NY-ESO-1 91-110) peptide.

Immunogenicity of a long 20-mer NY-ESO-1f peptide vaccine was evaluated in a lung cancer patient TK-f01, immunized with the peptide with Picibanil OK-432 and Montanide ISA-51. We showed that internalization of the peptide was necessary to present CD8 T-cell epitopes on APC, contrasting with the direct presentation of the short epitope. CD8 T-cell responses restricted to all five HLA class I alleles were induced in the patient after the peptide vaccination. Clonal analysis showed that B*35:01 and B*52:01-restricted CD8 T-cell responses were the two dominant responses. The minimal epitopes recognized by A*24:02, B*35:01, B*52:01 and C*12:02-restricted CD8 T-cell clones were defined and peptide/HLA tetramers were produced. NY-ESO-1 91-101 on A*24:02, NY-ESO-1 92-102 on B*35:01, NY-ESO-1 96-104 on B*52:01 and NY-ESO-1 96-104 on C*12:02 were new epitopes first defined in this study. Identification of the A*24:02 epitope is highly relevant for studying the Japanese population because of its high expression frequency (60%). High affinity CD8 T-cells recognizing tumor cells naturally expressing the epitopes and matched HLA were induced at a significant level. The findings suggest the usefulness of a long 20-mer NY-ESO-1f peptide harboring multiple CD8 T-cell epitopes as an NY-ESO-1 vaccine. Characterization of CD8 T-cell responses in immunomonitoring using peptide/HLA tetramers revealed that multiple CD8 T-cell responses comprised the dominant response.

Iowa Crop Progress & Condition, April 20, 2014

Report produced by the The Department of Agriculture and Land Stewardship, Climatology Bureau. Iowa Secretary of Agriculture Bill Northey today commented on the Iowa Crops and Weather report released by the USDA National Agricultural Statistical Service. The report is released weekly from April through October.

[20 phot. de France: Doubs, Isère, Drôme, Hautes-Alpes, Basses-Alpes, Var, don A.P. de Montal en 1892]

Donateur : Montal, A.P. de (18..-18..?)

Farm Families Alive and Well, April 2014, Vol. 20, no.2

News from Iowa’s Center for Agricultural Safety and Health (I-CASH)

Iowa Lottery Action, May 5-18, 2014, Vol. 20, No. 8

Iowa Lottery Retailer Newsletter

Iowa Department of Transportation Major Items - Preliminary Quantity Report, May 20, 2014; With Addendums

Weekly letting report.

Lottery Action, May 19-June 1, 2014, Vol. 20, No. 9

Iowa Lottery Retailer Newsletter

List of Bid Proposal Holders, May 20, 2014

List of Bid Proposal Holders

Bridge Deck Expansion Assembly on U.S. 20 in Sioux City, HR-505A, 1990

This project was to determine possible construction problems and evaluate the performance of experimental joint seals. Joints were installed in Woodbury County on US 20 over the Missouri River. ACME-Beta B-520 joints were used. Visual inspections were made yearly. Although the joints performed well for eight years, they deteriorated rapidly and have failed. It was concluded these joints did not perform satisfactorily.