Avaliação do desempenho econômico-financeiro da produção de soja nos estados do Rio Grande do Sul e de Santa Catarina, para a safra 2011/12.

Procedimentos e cálculos associados às receitas e aos custos da produção de soja. Procedimentos e cálculos associados aos indicadores de viabilidade econômico-financeira da produção de soja. Resultados. Fig 1. Evolução das cotações semanais da soja no Estado do Rio Grande do Sul entre outubro de 2010 e agosto de 2011. Estimativa de custo de produção da soja transgênica, por hectare, na região que abrange os municípios de Cruz Alta, Santa Bárbara do Sul e Ibirubá, RS, safra 2011/12. Estimativa de custo de produção da soja transgênica, por hectare, na região que abrange o município de Passo Fundo, RS, safra 2011/12. Estimativa de custo de produção da soja transgênica, por hectare, na região que abrange o município de Campos Novos, SC, safra 2011/12. Síntese econômica da produção da soja transgênica, por hectare, na região que abrange os municípios de Cruz Alta, Santa Bárbara do Sul e Ibirubá, RS, safra 2011/12. Síntese econômica da produção da soja transgênica, por hectare, na região que abrange o município de Passo Fundo, RS, safra 2011/12. Síntese econômica da produção da soja transgênica, por hectare, na região que abrange o município de Campos Novos, PR, safra 2011/12.

Eficiência de fungicidas para o controle da mancha-alvo, Corynespora cassiicola, na safra 2011/12: resultados sumarizados dos ensaios cooperativos.

No primeiro ano de realização dos ensaios cooperativos para o controle da mancha-alvo observou-se que há necessidade de ajustes na metodologia, como, por exemplo, não iniciar as aplicações no estádio vegetativo nos ensaios cooperativos. Como as aplicações se iniciaram muito cedo nos ensaios, sendo limitadas a três aplicações, a última aplicação foi realizada entre os estádios R3 e R5, comprometendo a proteção das plantas no final do ciclo da cultura e a porcentagem de controle final dos tratamentos. No entanto, pôde-se observar que há diferença entre os produtos, objetivo principal dos ensaios. Os fungicidas do grupo dos benzimidazóis, amplamente utilizados no campo para controle da mancha-alvo, apresentaram eficiência inferior aos outros produtos. Os produtos com maior eficiência nos ensaios não possuem registro no MAPA até o momento. Outra variável que deve ser analisada com maior rigor é o potencial de dano da mancha-alvo. Para os ensaios cooperativos foram utilizadas cultivares relatadas como suscetíveis no campo e, mesmo assim, a média de redução de produtividade para a testemunha sem controle foi baixa, de 10,3%. Conhecer a reação das cultivares pode auxiliar na definição da necessidade de controle químico específico para essa doença.

Learning and Reuse of Experience in Behavior-Based Service Robots

M.H.Lee, Q. Meng and H. Holstein, ?Learning and Reuse of Experience in Behavior-Based Service Robots?, Seventh International Conference on Control, Automation, Robotics and Vision (ICARCV2002), pp1019-24, December 2002, Singapore

Bacteremic pneumonia before and after withdrawal of 13-valent pneumococcal conjugate vaccine from a public vaccination program in Spain: a case-control study

The objective of this study is to compare the incidence and epidemiology of bacteremic community-acquired pneumonia (CAP) in the setting of changes in 13-valent pneumococcal conjugate vaccine (PCV13) coverage. In the region of Madrid, universal immunization with the PCV13 started in May 2010. In July 2012, public funding ceased. Vaccination coverage decreased from >95% to 82% in 2013 and to 67% in 2014. We performed a multicenter surveillance and case-control study from 2009-2014. Cases were hospitalized children with bacteremic CAP. Controls were children selected 1:1 from next-admitted with negative blood cultures and typical, presumed bacterial CAP. Annual incidence of bacteremic CAP declined from 7.9/100 000 children (95% CI 5.1-11.1) in 2009 to 2.1/100 000 children (95% CI 1.1-4.1) in 2012. In 2014, 2 years after PCV13 was withdrawn from the universal vaccination program, the incidence of bacteremic CAP increased to 5.4/100 000 children (95% CI 3.5-8.4). We enrolled 113 cases and 113 controls. Streptococcus pneumoniae caused most of bloodstream infections (78%). Empyema was associated with bacteremia (P = .003, OR 3.6; 95% CI 1.4-8.9). Simple parapneumonic effusion was not associated with bacteremia. Incomplete PCV immunization was not a risk factor for bacteremic pneumonia.

Toward a comprehensive care of HIV patients: Finding a strategy to detect depression in a Spanish HIV cohort

Depression is a common but frequently undiagnosed feature in individuals with HIV infection. To find a strategy to detect depression in a non-specialized clinical setting, the overall performance of the Hospital Anxiety and Depression Scale (HADS) and the depression identification questions proposed by the European AIDS Clinical Society (EACS) guidelines were assessed in a descriptive cross-sectional study of 113 patients with HIV infection. The clinician asked the two screening questions that were proposed under the EACS guidelines and requested patients to complete the HADS. A psychiatrist or psychologist administered semi-structured clinical interviews to yield psychiatric diagnoses of depression (gold standard). A receiver operating characteristic (ROC) analysis for the HADS-Depression (HADS-D) subscale indicated that the best sensitivity and specificity were obtained between the cut-off points of 5 and 8, and the ROC curve for the HADS-Total (HADS-T) indicated that the best cut-off points were between 12 and 14. There were no statistically significant differences in the correlations of the EACS (considering positive responses to one [A] or both questions [B]), the HADS-D ≥ 8 or the HADS-T ≥ 12 with the gold standard. The study concludes that both approaches (the two EACS questions and the HADS-D subscale) are appropriate depression-screening methods in HIV population. We believe that using the EACS-B and the HADS-D subscale in a two-step approach allows for rapid, assumable and accurate clinical diagnosis in non-psychiatric hospital settings.

Dedicated global optimization search for ground state silica nanoclusters: (SiO2)(N) (N=6-12)

Flikkema, E., & Bromley, S. T. (2004). Dedicated global optimization search for ground state silica nanoclusters: (SiO2)(N) (N=6-12). Journal of Physical Chemistry B, 108 (28), 9638-9645. RAE2008

Luctus est istic tuus,/ crimen novercae. Boskie i ludzkie szaleństwo Heraklesa na podstawie tragedii Eurypidesa i Seneki

One of the main, initial thesis of the article is that in the tragedies `Hρακλής μαινόμενος by Euripides and Hercules Furens by Seneca the main character falls into the madness twice. The first madness is sent by Hera/ Juno and is here defined, because of its origin, as a divine madness. The second one is so called human madness and Heracles/ Hercules is most probably overcome by it, after he has recognised, that he, driven by the involuntary fury, killed his own wife and sons. This state of the psyche of the hero is already independent from the deity and originates in such deeply human feelings like despair, anger, pain, shame. The strongly stirred hero plans to commit a suicide. According to the contemporary psychology this situation can be, because of some reasons analysed in the article, recognised as a symptom of irrationality. In the drama by Seneca Amfithryon, the father of the hero also defines the state of Hercules, who has become aware of the truth about his deeds, outright as furor. There is in the drama by Euripides, however, no reference to this second madness, which is connected with the somewhat different mentality that the drama originated in (the still kept in memory Homeric ethos and the attitudes towards the issues of honour, suicide etc. determined by it). Seneca as a stoic noticed and emphasized – although he generally also accepted the suicide – that Hercules, because of the anger, acts irrationally and, as a result, is in fact mentally unable to decide about his life and death. In the article is also presented in what an interesting way the above mentioned differences in the mentality of Euripides and Seneca manifest themselves in the case of the divine madness (among other things, the difference between Greek Lyssa and Roman Furor).

Doce (12) localidades asistidas técnicamente.

300 hojas : ilustraciones.

June 12, 1820 letter to Epaphras "Kibby[sic]" on Circular by Baltimore preachers in the M.E. Church

Handwritten letter from Timothy Merritt to Epaphras "Kibby [sic]" on a Circular published by local preachers of the Baltimore area. Letter dated 6/12/1820, Circular dated 5/20/1820. Both are on the subject of the changed protocols resulting from decisions made at a General Conference held just previous to publication, involving the installment of new preachers

Letter to Rev. Epaphras "Kible". 05/12/1801

Handwritten letter from T. Merritt to Rev. Epaphras "Kible[sic]" regarding the latter's desire for Merritt to take on his preaching circuit citing ailing health. Dated May 12, 1801.

Letter to nephew, 12/11/1868

Letter from Daniel Whedon to nephew, Daneil Avery Whedon. Dated December 11 1868.

Letter to D. A. Whedon. Pittsfield. July 12, 1844.

Letter from Daniel Denison Whedon to Daniel A. Whedon, his nephew.

Sensitivity of HER-2/neu antibodies in archival tissue samples of invasive breast carcinomas. Correlation with oncogene amplification in 160 cases.

Overexpression and amplification of the HER-2 oncogene in patients with breast cancer has correlated with early onset of metastasis, resistance to hormonal therapy and some forms of chemotherapy, and shortened survival. Therefore, evaluation of this putative prognostic or predictive factor seems critical. Because different antibodies are used for the detection of the 185-kd HER-2 oncoprotein, we studied the sensitivity of 3 frequently used antibodies. Immunohistochemistry results were correlated with gene amplification level as assessed by fluorescence in situ hybridization. Protein overexpression was found in 17.2% and 12.5% of cases using antibodies against the external (TAB250) and internal (CB11) domains of the protein, respectively, and in 38.0% of cases using a rabbit polyclonal antibody. Fluorescence in situ hybridization was successful in all 160 tumors, and amplification was found in 37 tumors (23.1%). The monoclonal antibody TAB250 had the lowest misclassification rate, 9.6% (sensitivity, 67%; specificity, 97.5%).

IL-12 inhibits in vitro immunoglobulin production by human lupus peripheral blood mononuclear cells (PBMC).

Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by polyclonal B cell activation and by the production of anti-double-stranded (ds) DNA antibodies. Given the inhibitory effects of IL-12 on humoral immune responses, we investigated whether IL-12 displayed such an activity on in vitro immunoglobulin production by SLE PBMC. Spontaneous IgG, IgG1, IgG2, IgG3 and IgM antibody production was dramatically reduced by addition of IL-12. These results were confirmed by Elispot assays detecting IgG- and anti-dsDNA-secreting cells. While IL-6 and TNF titres measured in PBMC supernatants were not modified by addition of IL-12, interferon-gamma (IFN-gamma) titres were up-regulated and IL-10 production down-regulated. Since addition of IFN-gamma did not down-regulate immunoglobulin production and since the inhibitory activity of IL-12 on immunoglobulin synthesis was not suppressed by anti-IFN-gamma antibody, we concluded that the effect of IL-12 on immunoglobulin production was not mediated through IFN-gamma. Our data also argue against the possibility that down-regulation of endogenous IL-10 production was responsible for the effect of IL-12. Thus, inhibition of IL-10 production by IFN-gamma was not accompanied by inhibition of immunoglobulin production, and conversely, restoration of IL-10 production by anti-IFN-gamma antibody did not suppress the inhibitory activity exerted by IL-12 on immunoglobulin production. Taken together, our data indicate that reduction of excessive immunoglobulin and anti-dsDNA antibody production by lupus PBMC can be achieved in vitro by IL-12, independently of IFN-gamma and IL-10 modulation.