Design, synthesis and biological evaluation of dual inhibitors of GSK-3B and Fyn kinases for the study of inflammatory pathways in neurodegenerative diseases

Neuroinflammation represents a key hallmark of neurodegenerative diseases and is the result of a complex network of signaling cascades within microglial cells. A positive feedback loop exists between inflammation, microglia activation and protein misfolding processes, that, together with oxidative stress and excitotoxicity, lead to neuronal degeneration. Therefore, targeting this vicious cycle can be beneficial for mitigating neurodegeneration and cognitive decline in central nervous system disorders. At molecular level, GSK-3B and Fyn kinases play a crucial role in microglia activation and their deregulation has been associated to many neurodegenerative diseases. Thus, we envisioned their combined targeting as an effective approach to disrupt this toxic loop. Specifically in this project, a hit compound, based on a 7-azaindole-3-aminothiazole structure, was first identified in a virtual screening campaign, and displayed a weak dual inhibitory activity on GSK-3B and Fyn, unbalanced towards the former. Then, in a commitment to uncover the structural features required for modulating the activity on the two targets, we systematically manipulated this compound by inserting various substitution patterns in different positions. The most potent compounds obtained were advanced to deeper investigations to test their ability of tackling the inflammatory burden also in cellular systems and to unveil their binding modes within the catalytic pocket. The new class of molecules synthesized emerged as a valuable tool to deepen our understanding of the complex network governing the inflammatory events in neurodegenerative disorders.

Numerical simulation of the flow and performance evaluation of an aerospike engine

The main focus of this work is to define a numerical methodology to simulate an aerospike engine and then to analyse the performance of DemoP1, which is a small aerospike demonstrator built by Pangea Aerospace. The aerospike is a promising solution to build more efficient engine than the actual one. Its main advantage is the expansion adaptation that allows to reach the optimal expansion in a wide range of ambient pressures delivering more thrust than an equivalent bell-shaped nozzle. The main drawbacks are the cooling system design and the spike manufacturing but nowadays, these issues seem to be overcome with the use of the additive manufacturing method. The simulations are performed with dbnsTurbFoam which is a solver of OpenFOAM. It has been designed to simulate a supersonic compressible turbulent flow. This work is divided in four chapters. The first one is a short introduction. The second one shows a brief summary of the theoretical performance of the aerospike. The third one introduces the numerical methodology to simulate a compressible supersonic flow. In the fourth chapter, the solver has been verified with an experiment found in literature. And in the fifth chapter, the simulations on DemoP1 engine are illustrated.

Aplicação para gestão de activos de rede do Aeroporto do Porto

O presente trabalho enquadra-se na área das redes de computadores, fazendo referência aos protocolos e ao conjunto de equipamentos e softwares necessários para a administração, controlo e monitorização desse tipos de infra-estruturas. Para a gestão de uma rede de dados, é essencial dispor de conhecimentos e documentação de nível técnico para representar da forma mais fiel possível a configuração da rede, seguindo passo a passo a interligação entre os equipamentos existentes e oferecendo assim uma visão o mais fidedigna possível das instalações. O protocolo SNMP é utilizado em larga escala sendo praticamente um standard para a administração de redes baseadas na tecnologia TCP/IP. Este protocolo define a comunicação entre um administrador e um agente, estabelecendo o formato e o significado das mensagens trocadas entre ambos. Tem a capacidade de suportar produtos de diferentes fabricantes, permitindo ao administrador manter uma base de dados com informações relevantes da monitorização de vários equipamentos, que pode ser consultada e analisada por softwares NMS concebidos especialmente para a gestão de redes de computadores. O trabalho apresentado nesta dissertação teve como objectivo desenvolver uma ferramenta para apoiar à gestão da infra-estrutura de comunicações do Aeroporto Francisco Sá Carneiro que permitisse conhecer em tempo real o estado dos elementos de rede, ajudar no diagnóstico de possíveis problemas e ainda apoiar a tarefa de planeamento e expansão da rede instalada. A ferramenta desenvolvida utiliza as potencialidades do protocolo SNMP para adquirir dados de monitorização de equipamentos de rede presentes na rede do AFSC, disponibilizando-os numa interface gráfica para facilitar a visualização dos parâmetros e alertas de funcionamento mais importantes na administração da rede.

Configuração de sistema de monitorização

O presente trabalho enquadra-se na área das redes de computadores, fazendo referência aos protocolos e ao conjunto de equipamentos e softwares necessários para a administração, controlo e monitorização desse tipo de infra-estruturas. Para a gestão de uma rede de dados, é essencial dispor de conhecimentos e documentação de nível técnico para representar da forma mais fiel possível a configuração da rede, seguindo passo a passo a interligação entre equipamentos existentes e oferecendo assim uma visão o mais fidedigna possível das instalações. O protocolo SNMP é utilizado em larga escala sendo praticamente um standard para a administração de redes baseadas na tecnologia TCP/IP. Este protocolo define a comunicação entre um administrador e um agente, estabelecendo o formato e o significado das mensagens trocadas entre ambos. Tem a capacidade de suportar produtos de diferentes fabricantes, permitindo ao administrador manter uma base de dados com informações relevantes da monitorização de vários equipamentos, que pode ser consultada e analisada por softwares NMS concebidos especialmente para a gestão de redes de computadores. O trabalho apresentado nesta dissertação teve como objectivo utilizar uma ferramenta NMS, para fazer a monitorização e a gestão da infra-estrutura de comunicações de forma que permitisse conhecer em tempo real o estado dos elementos de rede, ajudar no diagnóstico de possíveis problemas, instalados pela Nonius nos diversos navios da frota Douro Azul. O software NMS escolhido utiliza as potencialidades do protocolo SNMP para adquirir dados de monitorização de equipamentos de rede presentes na rede, bem como monitorizar redes remotas.

Avaliação quantitativa da geodiversidade: desenvolvimento de instrumentos metodológicos com aplicação ao ordenamento do território

Tese de Doutoramento em Ciências (Especialidade de Geologia)

Electronic Bulletin Board System, HR-345, 1998

The primary objectives of the Electronic Bulletin Board System (BBS) project were to: (1) Provide an electronic communication tool which would link city and county engineering offices to each other and to other governmental agencies for messaging and data sharing; (2) Provide a dial-up site for reference information or files accessible on-demand; and (3) Provide a "stepping stone" to the world of electronic data transfer, recognizing that most local government employees face a huge complex of technology with limited knowledge of computers and communications tools. The system was designed to be as simple as possible, and to require minimal equipment and software cost to the users. The original system was an Apex 386/25 computer with MS-DOS 5.0 software and the final configuration was an HP Vectra XM Pentium 90 with MS-NT 3.51 and Mustang - Wildcat 5.0 software. The users of the BBS were county engineers and their staff, offices in the central office of the Iowa Department of Transportation (DOT) and Resident Construction Engineers at the Iowa DOT. Much of the activity was between the county engineers, and their staffs, and the Iowa DOT offices with which they have ongoing business activities. The BBS contained files for mapping, Internet e-mail service, Accident Location Analysis System (ALAS) data, Iowa DOT bid lettings, and Autocad and Intergraph maps and standards. The 800 line calls were recorded and gave the best indication of the usage and the trends that were being followed. The usage tended to be higher in the winter months when design activities are occurring and lower in the summer months when the construction is in progress. The project was judged a success. The BBS did provide a "stepping stone" to the world of electronic data transfer.

Intuboidun hengityslaitehoitoa saavan aikuisen tehohoitopotilaan suunhoidon kirjaaminen

Tutkimuksen tarkoituksena oli tutkia potilastietojärjestelmien suunhoitosivut kaikilla suomalaisilla teho-osastoilla, joissa oli käytössä Clinisoft® -potilastietojärjestelmä ja, joilla hoidettiin intuboituja, hengityslaitehoitoa saavia aikuisia tehohoitopotilaita. Lisäksi tutkimuksessa analysoitiin yhden yliopistosairaalan teho-osaston hoitajien suunhoidon kirjauksia potilastietojärjestelmän vuorohuomioraporteista. Tutkimusosion 1 aineisto koostui aikuispotilaita hoitavien teho-osastojen (N=15) Clinisoft® -potilastietojärjestelmien suunhoitosivuista. Tutkimusosion 2 aineisto koostui yhden yliopistosairaalan teho-osaston intuboitujen, hengityslaitehoitoa saaneiden aikuisen tehohoitopotilaiden suunhoidon kirjauksista (n=97). Vuonna 2008–2009 hoidetuista intuboiduista, hengityslaitehoitoa saaneista tehohoitopotilaista (N=1180) valittiin satunnaisotannalla 100 potilasta, joiden suunhoitoon liittyvät potilasasiakirjat otettiin mukaan analyysiin. Aineistot analysoitiin sisällön erittelyllä. Suunhoitosivujen aihesisällöistä muodostettiin 14 sisältöluokkaa. Vuorohuomiokirjaukset oli kirjattu yleensä hengitys tai happeutuminen otsakkeiden alle, josta löytyi yhteensä 589 alkuperäislausumaa. Hoitajat kirjasivat ensin potilaan hengityslaitehoidosta ja happeutumisesta. Alkuperäislausumista tehohoitopotilaan suunhoitoon liittyviä lausumia oli 61 % (n=357). Vuorohuomiokirjauksista muodostettiin 11 sisältöluokkaa. Potilastietojärjestelmän suunhoitosivujen rakenne ei ohjannut VAP:a ehkäisevään suunhoitoon ja tehohoitopotilaan suunhoitoa kirjattiin usealle sivulle. Kaikkien tehohoito-osastojen suunhoitosivupohjissa oli kohdat suun kunnon arvioinnille ja suunhoidolle, mutta sivuilta ei aina selvinnyt tehohoito-osaston suunhoitoon käytättämiä välineitä. Sivuissa oli nähtävissä yksittäisiä VAP:n ehkäisyyn liittyviä interventioita. Vuorohuomioraportteihin kirjaaminen oli päällekkäistä suunhoitosivuun kirjattavien tietojen kanssa. Hoitajat kirjasivat tehohoitopotilaan hengityslaitehoidosta ja potilaan happeutumisesta. Suunhoidosta hoitajat kirjasivat eniten eritteiden määrää ja laatua ja vähiten suunhoidossa käytetyistä välineistä sekä suunhoitoon liittyvästä arvioinnista. Tehohoitopotilaan suuta hoidettiin keskimäärin 2.93 kertaa vuorokaudessa, eniten aamuvuoroissa. Suun kuntoa arvioitiin 1.12 kertaa vuorokaudessa. Pro gradu -tutkielma tuo uutta tietoa intuboidun, hengityslaitehoidossa olevan aikuisen tehohoitopotilaan näyttöön perustuvasta suunhoidosta, potilastietojärjestelmien suunhoitosivujen rakenteesta ja tehohoitopotilaan suunhoidon kirjaamisesta Suomessa. Tutkimustulosten ja kansainvälisten suositusten avulla kehitettiin Clinisoft® -potilastietojärjestelmän mallisivu tehohoitopotilaan suunhoidon tarpeen määrittämisen, suunnittelun, toteutuksen ja arvioinnin tueksi.

Usability comparison of open source content management systems

The purpose of this thesis is to study, investigate and compare usability of open source cms. The thesis examines and compares usability aspect of some open source cms. The research is divided into two complementary parts –theoretical part and analytical part. The theoretical part mainly describes open source web content management systems, usability and the evaluation methods. The analytical part is to compare and analyze the results found from the empirical research. Heuristic evaluation method was used to measure usability problems in the interfaces. The study is fairly limited in scope; six tasks were designed and implemented in each interface for discovering defects in the interfaces. Usability problems were rated according to their level of severity. Time it took by each task, level of problem’s severity and type of heuristics violated will be recorded, analyzed and compared. The results of this study indicate that the comparing systems provide usable interfaces, and WordPress is recognized as the most usable system.

Posicionamento por ponto de alta precisão utilizando o GPS: Uma solução para a geodinâmica

Point positioning from GPS data can provide precision varying from 100 meters to a few millimeters at the level of 95% probability. To reach the best level of accuracy, users need proper equipment and software, as well as access capability to GPS products available at the International GPS Geodynamics Service. In this paper, the theory related to point positioning using GPS is presented as well as the results of an experiment conducted using data from the Brazilian Active Control System. The results show repeatability better than 5mm and 10mm for the N and E baseline components respectively, and 6mm + 4ppb (parts per billion) for the vertical. Comparison with SIRGAS campaign showed results at the same level of uncertainty as that of the stations used to tie the SIRGAS frame to ITRF94. Therefore, precise point positioning is a powerful tool to be used in applications requiring high level of precision, such as Geodynamics.

IL-10 e TNF-α no sangue materno e nas placentas de gestações complicadas por diabete ou hiperglicemia leve: correlação com controle glicêmico e resultados perinatais

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Algumas metodologias de avaliação para pavimentos de baixo volume de trafego

This work has as objective, show and compares some of several evaluation methods of pavements, based in the rules and researches realized by another authors, with focus on low traffic volume pavements, which are generally more economic flexible pavements subjected to low loads. Were addressed structure evaluation methods and superficial evaluation methods applied to that kind of pavement, exposing of clearly the procedures to be performed, the advantages and disadvantages, as well the results obtained in the execution of each one of these. This theme was chosen by the widespread use of this type of pavement in the road network of the country and the fact that there is no still a culture of the practical of evaluation nor technical knowledge on the part of municipal governments that are usually responsible for these roads. This study also aims to guide the process of maintenance preventive or recuperative, as they are often made improvements that do not actually solve the real problem of the roads

Procedura di progettazione di protesi a basso costo per l'arto inferiore

L'attività di ricerca descritta in questa tesi fornisce linee guida per la progettazione di arti protesici inferiori, con particolare riferimento alla progettazione di protesi a basso costo. La necessità di efficienti protesi a basso costo risulta infatti sentita nei Paesi in via di sviluppo ma anche dalle fasce meno abbienti dei paesi occidentali. Al fine di comprendere le strategie adottate dall'apparato locomotorio per muoversi con le protesi sono analizzati il cammino fisiologico, le protesi presenti sul mercato ed infine le modalità con cui le loro prestazioni sono valutate. Con il presente lavoro, dopo aver osservato la presenza di una scarsa strutturazione della metodologia di progettazione che riguarda specialmente il settore del basso costo, si propone una metodologia il più possibile oggettiva e ripetibile tesa ad individuare quali sono gli aspetti essenziali di una protesi per garantire al paziente una buona qualità di vita. Solo questi aspetti dovranno essere selezionati al fine di ottenere la massima semplificazione della protesi e ridurre il più possibile i costi. Per la simulazione delle attività di locomozione, in particolare del cammino, è stato elaborato un apposito modello spaziale del cammino. Il modello proposto ha 7 membri rigidi (corrispondenti a piedi, tibie, femori e bacino) e 24 gradi di libertà. Le articolazioni e l'appoggio dei piedi al suolo sono modellati con giunti sferici. La pianta del piede consente tre possibili punti di appoggio. I criteri di realizzazione delle simulazioni possono comprendere aspetti energetici, cinematici e dinamici considerati come obiettivo dall'apparato locomotorio. In questa tesi vengono trattati in particolare gli aspetti cinematici ed è mostrata un'applicazione della procedura nella quale vengono dapprima identificati i riferimenti fisiologici del cammino e quindi simulato il cammino in presenza di una menomazione al ginocchio (eliminazione della flessione in fase di appoggio). Viene quindi lasciato a sviluppi futuri il completamento della procedura e la sua implementazione in un codice di calcolo.

Fiabilidad de minimodulos de silicio

El objetivo de este Proyecto Final de Carrera es la realización de un ensayo de fiabilidad de componentes electrónicos, más concretamente de Minimódulos de Silicio, con el fin de estudiar su comportamiento a lo largo del tiempo de vida. Debido a la larga duración de los Minimódulos de Silicio , un ensayo de este tipo podría durar años, por lo que es necesario realizar un ensayo acelerado que acorte significativamente el tiempo del experimento, para ello, han de someterse a esfuerzos mayores que en condiciones normales de funcionamiento. A día de hoy, los Minimódulos de silicio, que conocemos como placas solares fotovoltaicas, se usan en infinidad de dispositivos debido a las múltiples ventajas que conllevan. La principal ventaja es poder llevar electricidad a cualquier parte del planeta sin necesidad de tener que hacer unas elevadas inversiones. Esta electricidad proviene de una fuente de energía inagotable y nada contaminante, con lo que ayudamos a mantener el equilibrio del planeta. La mayoría de las veces estas placas solares fotovoltaicas se usan en el exterior, soportando cambios de temperatura y de humedad elevados, de ahí, la importancia de realizar ensayos de fiabilidad, que muestren sus posibles causas de fallo, los efectos que producen estos fallos y los aspectos de diseño, fabricación y mantenimiento que puedan afectarles. Los Minimódulos de silicio utilizados en este proyecto son el modelo MC-SP0.8-NF-GCS de la empresa fabricante Multicomp. Para realizar el Proyecto hubiéramos necesitado una cámara climática que simulara unas condiciones ambientales determinadas, pero debido a la dificultad de iluminar el módulo dentro de la cámara climática hemos desarrollado un nuevo sistema de ensayos acelerados en temperatura. El nuevo sistema de ensayos acelerados consiste en: •Colocar los módulos fotovoltaicos en el laboratorio con un foco de 500W que irradia lo equivalente al sol. •Los tres módulos trabajarán a tres temperaturas diferentes para simular condiciones ambientales distintas, concretamente a 60°C, 72°C y 84°C. •Mediante un sistema automático de medida diseñado en LabVIEW, de manera simultánea tomará medidas de tensión en las tres placas y estudiaremos el grado degradación en cada placa. Se analizaran los resultados obtenido de cada una de las medidas y se realizará un estudio de fiabilidad y del proceso de degradación sufrido por los Minimódulos de silicio. Este PFC se puede dividir en las siguientes fases de trabajo siendo el ensayo la parte más larga en el tiempo: •Búsqueda de bibliografía documentación y normas aplicables. •Familiarización con los equipos y software, estudiando el manejo del software que viene con el Multímetro Keithley 2601 y el programa LabVIEW. •Desarrollo del hardware y sistemas necesarios para la realización del ensayo. •Montaje del ensayo •Realización del ensayo. •Análisis de resultados. ABSTRACT. The objective of this Final Project is conducting a test reliability of electronic components, more specifically Silicon minimodules, in order to study their behavior throughout the life span. Due to the long duration of Silicon minimodules a test like this could take years, so it is necessary to perform an accelerated significantly shorten the time of the experiment, testing for it, should be subjected to greater efforts than in normal operating. Today, the mini-modules, silicon is known as photovoltaic solar panels are used in a multitude of devices due to the many advantages they bring. The main advantage is to bring electricity to anywhere in the world without having to make high investments. This electricity comes from an inexhaustible source of energy and no pollution, thus helping to maintain the balance of the planet. Most of the time these solar photovoltaic panels are used on the outside, enduring changes in temperature and high humidity, hence, the importance of reliability testing, showing the possible causes of failure, the effects produced by these faults and aspects of design, manufacturing and maintenance that may affect them. The silicon mini-modules used in this project are the MC-SP0.8-NF-GCS model Multicomp manufacturing company. To realize the project we would have needed a climatic chamber to simulate specific environmental conditions, but due to the difficulty of illuminating the module in the climate chamber we have developed a new system of accelerated tests in temperature. The new system is accelerated tests: •Place the PV modules in the laboratory with a focus on the equivalent 500W radiating sun. •The three modules work at three different temperatures to simulate different environmental conditions, namely at 60 °C, 72 °C and 84 °C. •Automatic measurement system designed in LabVIEW, simultaneous voltage measurements taken at the three plates and study the degradation degree in each plate. The results obtained from each of the measurements and a feasibility study and degradation suffered by the silicon is performed minimodules were analyzed. This PFC can be divided into the following phases of the test work the longest part being overtime: •Literature search and documentation standards. •Familiarization with equipment and software, studying management software that comes with the Keithley 2601 multimeter and the LabVIEW program. •Development of hardware and systems necessary for the conduct of the trial. •Experiment setup •Carrying out the experiment. •Analysis of results.

Estudio de la fiabilidad de diodos LEDs rojos mediante ensayos acelerados

El objetivo de este Proyecto Final de Carrera es la realización de un ensayo de fiabilidad de componentes electrónicos, más concretamente de diodos LED, con el fin de estudiar su comportamiento a lo largo del tiempo de vida. Debido a la larga duración de los LEDs, un ensayo de este tipo podría durar años, por lo que es necesario realizar un ensayo acelerado que acorte significativamente el tiempo del experimento, para ello, han de someterse a esfuerzos mayores que en condiciones normales de funcionamiento. En la actualidad, los LEDs son usados en infinidad de aplicaciones, debido a sus múltiples ventajas respecto a otros sistemas de iluminación o señalización convencionales. En numerosos casos se utilizan en el exterior, soportando cambios de temperaturas y de humedad elevados, de ahí, la importancia de realizar ensayos de fiabilidad, que muestren sus posibles causas de fallo, los efectos que producen estos fallos y los aspectos de diseño, fabricación y mantenimiento que puedan afectarles. Como consecuencia del envejecimiento de los LEDs, pueden mostrar una reducción en el flujo luminoso y un empeoramiento de las propiedades cromáticas. Los LEDs utilizados en este Proyecto son de AlInGaP, rojos, de alta luminosidad. Para acelerar el ensayo, se utilizará una cámara climática que simule unas condiciones ambientales determinadas, en concreto, 85º C y 85% HR. Además, se realiza una monitorización periódica, siendo necesaria la utilización de un sistema automático de medida diseñado en LabVIEW, el cual, de manera simultánea realizará medidas y gestionará la inyección de corriente a los LEDs mientras se encuentren en el interior de la cámara climática. Se fabrican dos placas con 4 tiras de LEDs para inyectar un nivel de corriente diferente en cada una y así poder comparar la degradación en función de este parámetro. Fuera de la cámara climática se van a medir las curvas características de tensióncorriente de cada LED a una temperatura ambiente constante, fijada por un módulo Peltier. También se realizarán medidas de potencia luminosa y de espectro de emisión. Se analizarán los resultados obtenidos de cada una de las medidas y se realizará un estudio de fiabilidad y del proceso de degradación sufrido por los LEDs. Este PFC se puede dividir en las siguientes fases de trabajo, siendo el ensayo la parte más larga en el tiempo: · Búsqueda de bibliografía, documentación y normas aplicables. · Familiarización con los equipos y software, estudiando el manejo y funcionamiento de la cámara climática temperatura-humedad y el software a aplicar (LabVIEW y software del espectrómetro). · Desarrollo del hardware y sistemas necesarios para la realización del ensayo. · Realización del ensayo. · Análisis de resultados. ABSTRACT. The objective of this end of degree project is conducting an essay reliability of electronic components, more concretely LEDs, in order to study their behavior throughout its lifespan. Due to the long duration of the LEDs, a essay of this type could last for years, so it is necessary to perform an accelerated essay which significantly shorten the time of the experiment, testing should be subjected to greater efforts than in normal operation. Today, LEDs are used in many applications due to its many advantages over other conventional lighting systems or signaling. In numerous cases are used on the outside, enduring high changes in temperature and humidity, hence the importance of reliability essays, showing the possible causes of failure, the effects produced by these failures and aspects of design, manufacturing and maintenance that may affect them. As a result of the ageing of the LEDs, they may show a reduction in light output and a worsening of the chromatic properties. The LEDs used in this project are AlInGaP, red and high brightness. To speed up the essay will be used a climatic chamber to simulate specific environmental conditions, specifically 85 ° C and 85 % RH. In addition, is pe rformed a periodic monitoring using an automatic measurement system designed in LabVIEW , which , simultaneously will performed measurements and will manage the injection current to the LEDs while are inside of the climatic chamber. 4 strips of LEDs are created to inject a different level of current in each, so can compare the degradation in terms of this parameter. Out of the climatic chamber are obtained the characteristic curves of voltage-current of each LED at a constant room temperature, set by a Peltier module. Also, measures light power and the emitted spectrum. The results of each of the measures and a reliability study and degradation suffered by the LEDs will be discussed. This PFC can be divided into the following steps, the essay being the longest part: • Search bibliography, documentation and standards. • Familiarization with equipment and software, studying the management and the operation of the temperature-humidity environmental chamber and applying software (LabVIEW applications and spectrometer software). • Development of hardware and systems necessary for the conduct of the essay. • Carrying out the essay. • Analysis of results.

Asymmetric 3D video coding based on regions of perceptual relevance

This dissertation presents a study and experimental research on asymmetric coding of stereoscopic video. A review on 3D technologies, video formats and coding is rst presented and then particular emphasis is given to asymmetric coding of 3D content and performance evaluation methods, based on subjective measures, of methods using asymmetric coding. The research objective was de ned to be an extension of the current concept of asymmetric coding for stereo video. To achieve this objective the rst step consists in de ning regions in the spatial dimension of auxiliary view with di erent perceptual relevance within the stereo pair, which are identi ed by a binary mask. Then these regions are encoded with better quality (lower quantisation) for the most relevant ones and worse quality (higher quantisation) for the those with lower perceptual relevance. The actual estimation of the relevance of a given region is based on a measure of disparity according to the absolute di erence between views. To allow encoding of a stereo sequence using this method, a reference H.264/MVC encoder (JM) has been modi ed to allow additional con guration parameters and inputs. The nal encoder is still standard compliant. In order to show the viability of the method subjective assessment tests were performed over a wide range of objective qualities of the auxiliary view. The results of these tests allow us to prove 3 main goals. First, it is shown that the proposed method can be more e cient than traditional asymmetric coding when encoding stereo video at higher qualities/rates. The method can also be used to extend the threshold at which uniform asymmetric coding methods start to have an impact on the subjective quality perceived by the observers. Finally the issue of eye dominance is addressed. Results from stereo still images displayed over a short period of time showed it has little or no impact on the proposed method.