Toxina botulínica para além da cosmética

Dissertação de mestrado, Ciências Farmacêuticas, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2015

Locust bean gum-based microparticles for pulmonary delivery of antibiotics

Dissertação de Mestrado, Ciências Biomédicas, Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, 2016

Deciphering the molecular role of DJ-1 in the etiology of Parkinson’s and Huntingtons’s disease

Tese de doutoramento, Ciências Biomédicas (Neurociências), Universidade de Lisboa, Faculdade de Medicina, 2014

How hydrogen peroxide and CXCL8 modulate neutrophil recruitment "in vivo"

Tese de doutoramento, Ciências Biomédicas (Biologia Celular e Molecular), Universidade de Lisboa, Faculdade de Medicina, 2014

Interaction between glucocorticoid and adenosine A2A receptors in the hippocampus : implications for learning and memory

Tese de doutoramento, Ciências Biomédicas (Neurociências), Universidade de Lisboa, Faculdade de Medicina, 2014

Proposta do modelo 6C Loop Back I/D para o ensino da engenharia no ensino politécnico em modalidade elearning : um estudo exploratório

Trabalho de projecto de mestrado, Educação (Especialização em Educação e Tecnologias Digitais), Universidade de Lisboa, Instituto de Educação, 2014

Functional coherence and annotation agreement metrics for enzyme families

Tese de doutoramento, Informática (Bioinformática), Universidade de Lisboa, Faculdade de Ciências, 2015

Case-series Evaluating a Transdiagnostic Cognitive-behavioral Treatment For Co-occurring Anxiety Disorders.

Background. Patients with anxiety disorder diagnoses commonly have more than one anxiety diagnosis. While cognitive-behavioral interventions have proven efficacy in treating single anxiety disorder diagnoses, there has been little investigation of their efficacy in treating cooccurring anxiety disorders. Aims. To evaluate the efficacy of a transdiagnostic cognitive-behavioral intervention for treating co-occurring anxiety disorders. Methods. An A-B single case study design (N = 6) was used to evaluate the efficacy of a 12 to 13 session modular transdiagnostic cognitive-behavioral intervention for treating co-occurring anxiety disorders across patients with at least two of the following diagnoses: GAD, Social Phobia, Panic Disorder and/or OCD. Results. Five of the six participants completed treatment. At post-treatment assessment the five treatment completers achieved diagnostic and symptomatic change with three participants being diagnosis free. All participants who completed treatment no longer met criteria for any DSM-IV-TR Axis-I diagnosis at the three-month follow-up assessment, and demonstrated reliable and clinically-significant improvements in symptoms. Across the participants, statistically significant improvements from pre- to post-intervention were found on measures of anxiety, depression and general well-being, and all improvements were maintained at three-month follow-up. Conclusions. Results suggest that transdiagnostic cognitive behavioral interventions can be of benefit to patients with co-occurring anxiety disorders.

Beacon

Artwork using Internet search engine technology to make people’s online desires, interests and orientations visible, presenting random search term enquiries in a variety of forms including a railway information sign, an art gallery installation and an online website. activity, curiosity and desire. The project sampled and analysed how ‘search terms’ were used by the public as live data. It then re-presented them on a website, in a gallery and latterly on a bespoke mechanical railway flap-sign, thus creating a snapshot of online enquiry at any give time. Beacon’s originality lies in the manner in which it has taken abstract digital data and found different expressions for it. Thus the work extends debates in media arts that focus on purely virtual and online expressions of data, by developing online information into new non-digital material forms and contexts such as railway signs. This research has been developed over a three year period. Initially with software only and then on receipt of AHRC small grant (£5000) with the lauded Italian manufacturer Solari of Udine, Italy and BFI Southbank. It represents the culmination of a body of research that asks whether live data can be used as material to make artworks. Beacon was specially developed for the Tate Britain programme 40 artists 40 days, produced in conjunction with the UK Olympic Games bid and intended to “create a unique countdown calendar that will focus attention on Britain’s exceptional creative talent”. The project is exhibited by the Tate website ‘Tate Online’ presently in perpetuity. The gallery version of this work is currently held in five private collections in the USA and is shown regularly in galleries around the world. The railway flap-sign is owned by BFI Southbank and will eventually be sited there permanently. All work is developed jointly and equally between Craighead and her collaborator, Jon Thomson, (Slade).

Novel therapeutic targets in colon cancer

Tese de doutoramento, Farmácia (Biologia Celular e Molecular), Universidade de Lisboa, Faculdade de Farmácia, 2016

Ocorrência circadiária de crises em doentes com epilepsia

Tese de mestrado, Ciências do Sono, Faculdade de Medicina, Universidade de Lisboa, 2016

Thomson-Craighead at Studion

Moderna Museet invited Mejan Labs to curate two installations by the British artists Thomson & Craighead. This solo exhibition was in Studion at Moderna Museet, Stockholm. Works included: BEACON when it is shown as a data projection in a gallery. As with the online version and railway flap sign, live web searches are continuously relayed as they are being made around the world -in this case onto a gallery wall in series and at regular intervals as an endless concrete poetry. Decorative Newsfeeds use a live feed from the web to present up to the minute headline news from around the world as a series of pleasant animations, allowing viewers to keep informed while contemplating a kind of readymade sculpture or perhaps an automatic drawing.

Horizon & BEACON

Timecode was a group show at Dundee Contemporary Arts in 2009. Others Artists included where Douglas Gordon, Tatsuo Miyajima, On Kawara, Ceal Floyer, Christian Stock. Thomson and Craighead where commissioned to make an new installation,Horizon and accompanying limited edition print for the exhibition. Also included in the exhibition was a Beacon in the form of a railway flapsign. Horizon is a narrative clock made out of images accessed in realtime from webcams found in every time zone around the world. The result is a constantly updating array of images that read like a series of movie storyboards, but also as an idiosynratic global electronic sundial. BEACON as a unique mechanical railway flap sign built by Solari of Udine in Italy. As with the online and projected version of BEACON, this mechanical half-flap sign continuously relays live web searches as they are being made around the world presenting them back in series and at regular intervals as an endless concrete poetry.

IMP: Imperial Metagenomics Pipeline for high-throughput sequence data

We have developed an in-house pipeline for the processing and analyses of sequence data generated during Illumina technology-based metagenomic studies of the human gut microbiota. Each component of the pipeline has been selected following comparative analysis of available tools; however, the modular nature of software facilitates replacement of any individual component with an alternative should a better tool become available in due course. The pipeline consists of quality analysis and trimming followed by taxonomic filtering of sequence data allowing reads associated with samples to be binned according to whether they represent human, prokaryotic (bacterial/archaeal), viral, parasite, fungal or plant DNA. Viral, parasite, fungal and plant DNA can be assigned to species level on a presence/absence basis, allowing – for example – identification of dietary intake of plant-based foodstuffs and their derivatives. Prokaryotic DNA is subject to taxonomic and functional analyses, with assignment to taxonomic hierarchies (kingdom, class, order, family, genus, species, strain/subspecies) and abundance determination. After de novo assembly of sequence reads, genes within samples are predicted and used to build a non-redundant catalogue of genes. From this catalogue, per-sample gene abundance can be determined after normalization of data based on gene length. Functional annotation of genes is achieved through mapping of gene clusters against KEGG proteins, and InterProScan. The pipeline is undergoing validation using the human faecal metagenomic data of Qin et al. (2014, Nature 513, 59–64). Outputs from the pipeline allow development of tools for the integration of metagenomic and metabolomic data, moving metagenomic studies beyond determination of gene richness and representation towards microbial-metabolite mapping. There is scope to improve the outputs from viral, parasite, fungal and plant DNA analyses, depending on the depth of sequencing associated with samples. The pipeline can easily be adapted for the analyses of environmental and non-human animal samples, and for use with data generated via non-Illumina sequencing platforms.

Codeswitching in Igbo-English Bilingualism

This study evaluates the Matrix Language Frame model of codeswitching with Igbo-English data and concludes that the data can indeed be considered a classic case of codeswitching, in that a Matrix Language can be clearly identified in bilingual clauses. It establishes this through both qualitative and quantitative analyses that make use of the typological contrasts between Igbo and English to uncover supportive evidence for the Matrix Language Frame model and its associated three principles: the Matrix Language Principle, the Asymmetry Principle, and the Uniform Structure Principle. The investigation goes one step further by using spectrograms and the analysis of vowel harmony between English free morphemes and Igbo bound affixes to demonstrate that two phonologies can co-exist in codeswitching and that codeswitching forms are essentially pronounced with a phonology that does not entirely resemble that of the Matrix Language variety. Furthermore, the study finds that the same language production mechanisms as detailed under the Matrix Language Frame model and its associated three principles underlie both single word and multi-word codeswitching. That is, the present study, like those before it adopting the Matrix Language framework (see Amuzu 2010: 277), underlines the importance of the assumptions underpinning the Matrix Language Principle: (1) that language production is modular; (2) that lexical structure is both complex and abstract; and (3) that languages in contact divide responsibilities in what they may contribute toward lexical structure during the production of mixed constituents. Moreover, the study finds that Igbo-English bilinguals can always sustain ready access to their mother tongue mental lexicon during online speech production and thus Igbo-English may duly be described as a ‘classic’ case of codeswitching.