998 resultados para influence maps
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Drying of porous media, pore network, pore structure, capillary forces, viscous forces, drying kinetics
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Bundle of capillaries, drying kinetics, continuous model, relative permeability, capillary pressure, control volume method
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Background: Matrix metalloproteinases (MMPs) are a family of enzymes important for the resorption of extracellular matrices, control of vascular remodeling and repair. Increased activity of MMP2 has been demonstrated in heart failure, and in acutely decompensated heart failure (ADHF) a decrease in circulating MMPs has been demonstrated along with successful treatment. Objective: Our aim was to test the influence of spironolactone in MMP2 levels. Methods: Secondary analysis of a prospective, interventional study including 100 patients with ADHF. Fifty patients were non-randomly assigned to spironolactone (100 mg/day) plus standard ADHF therapy (spironolactone group) or standard ADHF therapy alone (control group). Results: Spironolactone group patients were younger and had lower creatinine and urea levels (all p < 0.05). Baseline MMP2, NT-pro BNP and weight did not differ between spironolactone and control groups. A trend towards a more pronounced decrease in MMP2 from baseline to day 3 was observed in the spironolactone group (-21 [-50 to 19] vs 1.5 [-26 to 38] ng/mL, p = 0.06). NT-pro BNP and weight also had a greater decrease in the spironolactone group. The proportion of patients with a decrease in MMP2 levels from baseline to day 3 was also likely to be greater in the spironolactone group (50% vs 66.7%), but without statistical significance. Correlations between MMP2, NT-pro BNP and weight variation were not statistically significant. Conclusion: MMP2 levels are increased in ADHF. Patients treated with spironolactone may have a greater reduction in MMP2 levels.
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Mo-Si-B alloys, Real microstructures, Voronoi structures, Microstructural characterization, Modelling and finite element simulations, Effective material properties, Damage and Crack growth, tensile strength, fracture toughness
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Magdeburg, Univ., Fak. für Elektrotechnik und Informationstechnik, Diss., 2008
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Abstract Background: Smoking consumption alters cardiac autonomic function. Objective: Assess the influence of the intensity of smoking and the nicotine dependence degree in cardiac autonomic modulation evaluated through index of heart rate variability (HRV). Methods: 83 smokers, of both genders, between 50 and 70 years of age and with normal lung function were divided according to the intensity of smoking consumption (moderate and severe) and the nicotine dependency degree (mild, moderate and severe). The indexes of HRV were analyzed in rest condition, in linear methods in the time domain (TD), the frequency domain (FD) and through the Poincaré plot. For the comparison of smoking consumption, unpaired t test or Mann-Whitney was employed. For the analysis between the nicotine dependency degrees, we used the One-way ANOVA test, followed by Tukey's post test or Kruskal-Wallis followed by Dunn's test. The significance level was p < 0,05. Results: Differences were only found when compared to the different intensities of smoking consumption in the indexes in the FD. LFun (62.89 ± 15.24 vs 75.45 ± 10.28), which corresponds to low frequency spectrum component in normalized units; HFun (37.11 ± 15.24 vs 24.55 ± 10.28), which corresponds to high frequency spectrum component in normalized units and in the LF/HF ratio (2.21 ± 1.47 vs 4.07 ± 2.94). However, in the evaluation of nicotine dependency, significant differences were not observed (p > 0.05). Conclusion: Only the intensity of smoking consumption had an influence over the cardiac autonomic modulation of the assessed tobacco smokers. Tobacco smokers with severe intensity of smoking consumption presented a lower autonomic modulation than those with moderate intensity.
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Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2010
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Magdeburg, Univ., Fak. für Naturwiss., Diss., 2010
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Magdeburg, Univ., Fak. für Naturwiss., Diss., 2012
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Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2012
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Magdeburg, Univ., Fak. für Verfahrens- und Systemtechnik, Diss., 2012
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This paper devotes to evaluation of performance bottlenecks and algorithm deficiencies in the area of contemporary reliable multicast networking. Hereby, the impact of packet delay jitter on the end-to-end performance of multicast IP data transport is investigated. A series of tests with two most significant open-source implementations of reliable multicast is performed and analyzed. These are: UDP-based File Transfer Protocol (UFTP) and NACK-oriented Reliable multicast (NORM). Tests were targeted to simulate scenario of content distribution in WAN – sized Content Delivery Networks (CDN). Then, results were grouped and averaged, by round trip time and packet losses. This enabled us to see jitter influence independently on round trip time(RTT) and packet loss rates. Revealed jitter influence for different network conditions. Confirmed, that appearance of even small jitter causes significant data rate reduction.
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Magdeburg, Univ., Fak. für Naturwiss., Diss., 2014