Retrospective evaluation of the effects of administration of tetrastarch (hydroxyethyl starch 130/0.4) on plasma creatinine concentration in dogs (2010-2013): 201 dogs

OBJECTIVE To determine changes in creatinine concentrations following the administration of 6% tetrastarch (hydroxyethyl starch [HES] 130/0.4) compared to crystalloids (CRYSs) in critically ill dogs. DESIGN Retrospective case series (2010-2013). SETTING University teaching hospital. ANIMALS Two hundred and one dogs admitted to the intensive care unit with initial plasma creatinine concentrations not exceeding laboratory reference intervals (52-117 μmol/L [0.6-1.3 mg/dL]) and receiving either CRYSs alone (CRYS group, n = 115) or HES with or without CRYSs (HES group, n = 86) for at least 24 hours. INTERVENTIONS None. MEASUREMENTS AND MAIN RESULTS Creatinine concentrations at admission to the intensive care unit (T0), and 2-13 days (T1) and 2-12 weeks (T2) after initiation of fluid therapy were analyzed. Creatinine concentrations were analyzed as absolute values and as the maximum percentage change from T0 to T1 (T1max%) and from T0 to T2 (T2max%), respectively. Creatinine concentrations were available for 192 dogs during T1 and 37 dogs during T2. The median cumulative dose of HES was 86 mL/kg (range, 12-336 mL/kg). No difference was detected between the groups for age, gender, body weight, and length of hospitalization. Outcome was significantly different between the HES (66% survived) and the CRYS (87% survived) groups (P = 0.014). No significant difference was detected between groups for creatinine concentrations at T0, T1, T2, T1max%, or T2max%. No significant difference was detected between the groups for T1max% creatinine in dogs subclassified as having systemic inflammatory response syndrome or sepsis. CONCLUSIONS HES administration in this canine population did not result in increased creatinine concentrations compared to administration of CRYSs. Further studies are needed to establish the safety of HES in critically ill dogs.

Historical sketch of Mount Holyoke seminary. Founded at South Hadley, Mass., in 1837. Prepared in compliance with an invitation from the commissioner of education, representing the Department of the interior in matters relating to the national centennial of 1876.

Mode of access: Internet.

An evaluation of the operation of subarea advisory councils /

Mode of access: Internet.

Centennial exposition: Education and science; catalogue of the exhibit in this department from the State of Illinois.

Mode of access: Internet.

Hearing on child care [microform] : hearing before the Subcommittee on Human Resources of the Committee on Education and Labor, House of Representatives, One hundredth Congress, first session, hearing held in Washington, DC, on July 8, 1987.

"Serial no. 100-26."

Reauthorization of the Juvenile Justice and Delinquency Prevention Act [microform] : runaway and homeless youth : hearing before the Subcommittee on Human Resources of the Committee on Education and Labor, House of Representatives, One Hundredth Congress, second session on H.R. 1801, hearing held in Washington, DC, January 29, 1988.

"Serial no. 100-72."

Oversight hearing on access to health insurance [microform] : hearing before the Subcommittee on Labor-Management Relations of the Committee on Education and Labor, House of Representatives, One Hundredth Congress, second session, hearing held in Washington, DC, June 9, 1988.

"Serial no. 100-94."

Defaults in the federal guaranteed student loan programs [microform] : hearings before the Subcommittee on Postsecondary Education of the Committee on Education and Labor, House of Representatives, One Hundredth Congress, second session, hearings held in Washington, DC, June 14 and 16, 1988.

"Serial no. 100-86."

Evaluation of the handling of the Branch Davidian stand-off in Waco, Texas by the United States Department of Justice and the Federal Bureau of Investigation /

"October 8, 1993."

In-service evaluation of the BRAKEMASTER and C-A-T crash cushions. Final report.

Federal Highway Administration, Washington, D.C.

Test and evaluation of the AMF, Inc. and Fairchild Industries experimental safety vehicles. Volume III. ESV program summary. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Performance evaluation of the SA103C three-year old child test dummies with substitute flesh parts and in various restraint seats. Final report.

National Highway Traffic Safety Administration, Washington, D.C.

Evaluation of the Alcohol Use and Traffic Safety Curriculum (K-12). Section II - volume 7a. Final report.

National Highway Traffic Safety Administration, Office of Driver and Pedestrian Programs, Washington, D.C.

An evaluation of the bumper standard - as modified in 1982. Technical report.

Mode of access: Internet.

Evaluation of the organic fouling problem in the OMRE /

"Prepared by the Civilian Reactors, Evaluations and Planning Branch, Division of Reactor Development and Consultants."