992 resultados para deficiência do fator XI
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Ciências da Motricidade - IBRC
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A presente invenção se refere ao uso de compostos derivados ftalimídicos e/ou sulfonamídicos com propriedades doadoras de óxido nítrico, os quais apresentam importantes atividades no aumento da expressão gênica de gama globina e atividades antiinflamatórias e analgésicas, potenciais ao tratamento de doenças hematológicas em que há a necessidade de diminuição dos níveis do fator TNF-<244> e a necessidade de uma fonte exógena de óxido nítrico. Mais particularmente, a presente invenção descreve o uso de tais derivados ftalimídicos e/ou sulfonamídicos para o tratamento de anemia falciforme. A invenção também apresenta como característica inovadora, a descrição de novos derivados ftalimídicos funcionalizados, desenhados a partir dos protótipos talidomida e hidroxiuréia e planejados racionalmente através da estratégia de hibridação molecular para o tratamento das doenças citadas. A invenção apresenta ainda um novo método de obtenção de um derivado sulfonamídico específico que pode ser utilizado na preparação de um medicamento para tratamento de doenças em que há a necessidade de diminuição dos níveis do fator TNF-<244> e a necessidade de uma fonte exógena de óxido nítrico.
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Preparation and use of phthalimide and/or sulphonamide derivatives with nitric oxide donor properties, having activities in increasing gamma-globin gene expression and anti-inflammatory and analgesic activities, effective in the treatment of hematologic diseases which require reducing the TNF-[alpha] levels and an exogenous source of nitric oxide, such as sickle-cell disease. The functionalized phthalimide derivatives are designed from the prototypes thalidomide and hydroxyurea.
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This article proposes a theoretical reflection on the development of children with intellectual disabilities, regarding the importance and necessity of the process of learning the written language, from a historical-cultural point of view. For this approach, the course of development of a child disabled or not will occur according to cultural and social conditions experimented by him or her. Therefore, concerning the child with intellectual disabilities, his cultural condition, in dynamic relationship with the obstacles placed in its special condition, will be the source of his development. If the development of higher psychological functions is realized through the use of tools and if the people with intellectual disabilities present an inability to use these tools, there will be the need for aids so they can learn to use them in order to train and develop their psychic functions. In this process, education and written language acquisitions are fundamental ways of accessibility to the cultural world, a wider significance of communication in the world and to oneself. In short, the educators' comprehension about the importance of intentional teaching of written language and the historical process that envolves its development represents a fundamental contribution to the process of humanization of children with disabilities.
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Researchers in the field of Augmentative and Alternative Communication point out the lack of instruments for assessing children and young people with a complex communication needs. This study's focus is the selection of words for creating an instrument for the vocabulary range in non-speaking children aged two to eleven years and eleven months. Three studies were performed. The first study identified and described tools available for assessing receptive vocabulary and their respective word lists. The second identified and described research that presented word inventories or word lists. The third study identified the vocabulary reported by parents and teachers. The words that were identified in the three studies were analyzed according to: the number of times they occurred; the Picture Communication Symbols system classification; and a semantic and syntactic classification. Based on these studies the following criteria for vocabulary selection were established for word selection: the 45 words which appeared in all three studies, the words that occurred five times or more, considering the three studies, representing 167 (14.14%) words; the words identified in study one or two, but that had been reported by the families - 183 (19.37% out of 945 words) - or by teachers - 108 (11.43% out of 945 words). The word list was composed of 269 items, classified in 18 semantic and syntactic topics; it represents an initial tool for professionals in the field of health and education to set goals for beginning assessment of children and teenagers who are users of Augmentative and Alternative Communication systems.
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The law that justifies the inclusion of people with disability in schools and companies has been in force since the end of the 1980thies. In view of its coercion, people with disabilities have been enrolled at schools and been employed in companies. This research attempts to analyze the inclusion process according to Axel Honneth's Social Recognition Theory. Backed by his three dimension recognition process, we show firstly that inclusion signifies a process of individuation and social inclusion. Then, we study the law in force, its goals and strategies of achievement. We show that recognition's approach allows interpreting the law of inclusion more generously - in a less positivistic way. Finally, we approach the conditions for schools and companies to accomplish the law of inclusion so conceived.
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The curricula study allows the verification of trends, concepts and the identification of teaching practices, enabling the planning and implementation of changes when necessary. The material presented here is part of the results obtained in a postgraduate research that deals with the training of psychologists to work with people with disabilities, which appealed to the document analysis. To accomplish this task it was used a methodological procedure named searching through radical, which allowed greater agility to the search, enabling the quick identification of the courses containing topics of interest for research, facilitating their selection to study. The use of document analysis as a methodology allowed both the collection and organization of information that were diffused, providing them new configuration as source of information, as the processing and interpretation of the raw data, giving them direction and adding them value. In 36 courses, 35 had at least one subject related to persons with disabilities, and the sum of these resulted in 85 subjects for analysis. The interpretation of data obtained through reading the menus brought information about prevalent intentions on the menus of the subjects, to research in the area, teaching procedures, techniques and possibilities of action and insertion of psychologists in different contexts in which they can deal with disability. In a positive perspective, the results showed that there seems to be a tendency to enhance the interface of psychology with other knowledge areas to understand the issues related to disability.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Música - IA
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Pós-graduação em Biotecnologia - IQ
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Pós-graduação em Agronomia (Agricultura) - FCA
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Pós-graduação em Agronomia (Irrigação e Drenagem) - FCA