Antipyretic, analgesic and anti-oxidative activities of Aquilaria crassna leaves extract in rodents

In Thailand, the leaves of Aquilaria crassna have been used traditionally for the treatments of various disorders, but without any scientific analysis. In this study, the antipyretic, analgesic, anti-inflammatory and anti-oxidative properties of A. crassna leaves extract were investigated at a wide dose range in rodents. Experimental animals were treated orally with an aqueous extract of Aquilaria crassna leaves (ACE). They were tested for antipyretic (Baker′s yeast-induced fever in rats), analgesic (hot plate test in mice) and anti-inflammatory (carrageenan-induced paw edema in rats) activities. An anti-oxidative effect of ACE was evaluated by using the DPPH anti-oxidant assay. The results showed that, after 5 hours of yeast injection, 400 and 800 mg/kg ACE significantly reduced the rectal temperature of rats. Mice were found significantly less sensitive to heat at an oral dose of 800 mg/kg ACE, after 60 and 90 min. No anti-inflammatory activity of ACE at an 800 mg/kg dose could be observed in the rat paw assay. An anti-oxidative activity of ACE was observed with an IC 50 value of 47.18 g/ ml. No behavioral or movement change could be observed in mice after oral administration of ACE (800 or 8,000 mg/kg) for seven consecutive days. Interestingly, from the second day of treatment, animals had a significant lower body weight at the 8,000 mg/kg dose of ACE compared to the control. No toxicity was identified and the results of this study state clearly that Aquilaria crassna leaves extracts possess antipyretic, analgesic and anti-oxidative properties without anti-inflammatory activity.

A kutatási és fejlesztési tevékenység lehetőségei és korlátai a kkv szektorban = Opportunities and constrains in the r&d activities of the smes: description of the research design and the analyzed cases

Ezen kutatási tanulmány módszertani összefoglalója a Kutatási és fejlesztési tevékenység lehetőségei és korlátai a KKV szektorban című kutatási műhely tanulmányainak. A kutatók feltáró, kvalitatív kutatás végeztek, azon belül pontosabban kvalitatív mélyinterjúkon alapuló esettanulmányos kutatást. A kutatók 14 kis- és középvállalkozás vezetőjével készítettek mélyinterjút annak érdekében, hogy feltárják a kis- és középvállalkozások adaptációs és növekedési lehetőségeit és korlátait, valamint az innovációs tevékenységének lehetőségeit és korlátait. Jelen tanulmány röviden bemutatja a vizsgált 14 esetet is. / === / This research paper is the methodological summary of the research working papers entitled Opportunities and constraints in the R&D activities of the SMES. The researchers carried out an explorative, qualitative research, to be more exact a case study research based on qualitative interviews. The researchers conducted interviews with CEOs of 14 SMEs in order to explore the opportunities and constraints in the adaptation and growth potential and in the innovation activities of the SMEs. This paper introduces in brief the analysed 14 case study, too.

A kutatási és fejlesztési tevékenység lehetőségei és korlátai a kkv szektorban A vezető szerepe az innovációban és az innováció értelmezése a kkv szektorban = Opportunities and constrains in the r&d activities of the SMEs: The role of the entrepreneur in the innovation processes and how it is manifasted in their everyday activities

Jelen tanulmány arra keresi a választ, hogy a vállalkozónak milyen szerepe van az innovációban, és az innovációnak milyen különböző értelmezési lehetőségei fedezhetőek fel kis- és középvállalkozási szektorban. Kiindulási pontja a vállalkozó vezető személye és innovatív magatartása, mellyel folyamatosan keresi a fejlődés új lehetőségeit. A vállalkozó az erőforrások kreatív felhasználása és vállalkozói magatartása révén a vállalkozás motorjának tekinthető. A tanulmány alapját kvalitatív mélyinterjúkon alapuló, 14 interjúból álló kutatás képezi, melyek mélyreható elemzése alátámasztotta, hogy az innovációs hajlandóság erősen összefügg a vállalkozói magatartással, és mindkét tényező szorosan köthető a vállalkozás vezetőjéhez. / === / This paper focuses on the entrepreneur’s role in the innovation process and on the way the entrepreneurs interpret the phenomena of innovation and they perceive their role in this process. The paper begins with the presentation of different entrepreneurial models, focusing especially on entrepreneurial management and its linkages to variable forms of innovation. Based on the deep examination of 14 interviews made with Hungarian entrepreneurs, the paper identifies the entrepreneur’s decisive role in the innovation process, furthermore the article confirms the importance of entrepreneurial and risk-taking behavior in innovative organizations.

A válság hatása a vállalatok marketingtevékenységére = The Impact of Financial Crisis on Marketing Activities of Hungarian Companies

A tanulmányban azt elemeztük, hogy a vizsgált vállalatok a válságra milyen marketingválaszokat gondoltak megfelelőnek. Ennek megválaszolásához a „Versenyben a világgal” kutatási program 2009-ben készült felmérésének 300 vállalatra kiterjedő mintáját elemeztük, amelyet szakértői interjúkkal egészítettünk ki. A tanulmány alapozó részében elemeztük a nemzetközi trendeket és megoldásokat. A marketingben a válaszok helyessége ugyanis annak alapján ítélhető meg, hogy milyen mértékben képes a vállalat a fogyasztók dinamikusan alakuló igényeit formálni vagy azoknak megfelelni oly módon, hogy figyelembe veszi a környezet sajátosságait. A vizsgált vállalatok válságkezelő stratégiája ad-hoc jellegűnek mondható, nem illeszkedik az addigi stratégiai irányokhoz vagy az addig folytatott marketingstratégiához. A legnépszerűbb válságkezelő marketingeszközök az új piacok keresése, az akciózás és a költségcsökkentés. Közepesen népszerű a más média használata, a termékinnováció, az árcsökkentés, valamint a reklámkiadások csökkentése. A legkevésbé kedvelt eszközök pedig a marketingtevékenység kiszervezése, a termékválaszték vagy a termékminőség csökkentése. A választott eszközök típusai alapján három stratégiai irány határozható meg, az alternatív utak keresése, az ármérséklés, valamint a beszűkülés. A megkérdezett vállalatok 39,9%-a beszűkülő stratégiát, 30,4%-a az alternatív és ármérséklő stratégiák kombinációját, míg 29,7% egyik stratégiát sem preferálja. A választás azonban a legtöbb esetben inkább ad-hoc jellegűnek, mint tudatosan átgondolt stratégiának tűnik, mivel a választott irány nem függ a vállalat addigi marketingtevékenységétől vagy az addig hangsúlyosnak vélt jellemzőktől és versenyelőnyöktől. ________ In this study the marketing responses of the companies were analyzed, which were involved in the Competitiveness Research Program survey carried out during 2009 among 300 companies, combined with expert interviews. A literature review proceeded the empirical part. The capability of dynamic adaptation to consumer needs defines the right strategy in marketing. In our analysis we mainly found ad-hoc adaptation to handling the crisis that has little connection to firms’ previous strategic directions or their marketing strategy. The most popular crisis management tools include the search for new markets, promotions, and cost reductions. New media, product innovation, price reductions and lower advertising is less followed by companies. The least frequent reactions include outsourcing and reducing product quality. Based on the above three directions emerge. 39,9 % of the companies contract, 30,4 % use a combination of price reduction and alternative strategies and the remaining subset has formulated no strategy. The strategic directions show little correlation to previous practices or to the core competitive advantages.

A kereskedelmi láncok CSR-tevékenysége – a versenyképességük fokozása (CSR activities of commercial chains – increasing their competitiveness)

A kereskedelmi láncok különböző stratégiákat választhatnak, illetve alkalmazhatnak a társadalmi, gazdasági és környezeti kihívások kezelésére, a társadalmi normákhoz és elvárásokhoz való igazodáshoz. A tanulmányban a szerző azt vizsgálja, hogy milyen összefüggés van a társadalmi felelősségvállalásuk és a versenyképességük között, s a felelős magatartásuk javítja-e versenypozíciójukat. Bemutatja, hogy hazai viszonylatban a nagyobb forgalmat lebonyolító kereskedelmi láncok milyen CSR-tevékenységet végeznek, ez beépült-e hosszabb távú üzleti stratégiájukba, és mennyiben járul/járulhat hozzá versenyképességük fokozásához. Elemzi több kereskedelmi láncnál, hogy miképpen sikerült összeegyeztetni társadalmi felelősségvállalásukat a profitérdekeltségükkel, továbbá megteremthető-e a felelős működésük és a költséghatékony gazdálkodásuk összhangja. Többek között rámutat arra, hogy a gazdasági és külső szociális felelősségvállalásuk, továbbá a versenyképességük közötti pozitív korreláció megkérdőjelezhetetlen, ami win-win szituációt alakít ki. ______ Commercial companies can embark on and apply different strategies to tackle social, economic and environmental challenges and to comply with the standards and expectations of the community. In the study the author analyses the relationship between corporate social responsibility activities and competitiveness, and whether or not the responsible attitude of these companies improves their competitive position. She outlines the CSR activities of high turnover commercial chains in Hungary, examining their incorporation into the company’s longer term business strategy, and how these activities may contribute to their enhanced competitiveness. She will analyse several commercial chains from the point of view of their success in harmonizing their CSR with their profit making, and whether they can create the harmony of an environmentally friendly attitude and cost-effective operations. Among other findings, the author concludes that there is an unquestionable correlation between corporate economic and outside social responsibility and profitability, which creates a definite win-win situation.

"Lájkolom őket, de ennék is náluk?" – Aktivitásra buzdító kis- és középvállalati közösségimédia-tevékenységek fogyasztói fogadtatása magyarországi vendéglátóhelyek példáján keresztül ("I like them, but would I eat at their place?" – Encouraging social media activities of small and medium-sized enterprises and their consumerreactions – the case of Hungarian catering establishments)

A vendéglátóipari egységek kommunikációjában fontos szerepe van a közösségi médiában való jelenlétnek. Hazánkban a leggyakrabban használt felület a Facebook, amely sok ilyen vállalkozás esetében kiemelt fontosságú, vagy akár az egyetlen reálisan elérhető marketingkommunikációs felület. Kutatásunkban azt vizsgáljuk, hogy a felhasználók hogyan érzékelik a feléjük továbbított üzleti célú információkat a közösségi felületen, illetve hogy a fogyasztókra milyen mértékű aktivitás jellemző kedvenc vendéglátóipari egységük oldalán. Ennek céljából szubjektív fogyasztói narratívákat (n=151) elemzünk a kvalitatív tartalomelemzés módszertanával. A válaszadókat arra kértük, hogy írjanak kedvenc vendéglátóhelyükkel való kapcsolatukról az online térben. A "belájkolt" vendéglátóipari egységek felületeinek fogyasztók által észlelt aktivitása segítheti a vállalkozásokat abban, hogy alaptevékenységük elemeinek kommunikálásával, vagy akár ettől teljesen eltérő közösségi stratégiát használva pozicionálják márkájukat. A márkák tudatos tartalommenedzselése hozzájárulhat továbbá a felhasználók virtuális térben való hatékonyabb eléréséhez és bevonásához. ____ Presence in social media is an important element in the communication of catering establishments. The most frequently used platform in Hungary – that is extraordinarily important, or even the only reasonably accessible marketing communications platform for many catering companies – is Facebook. In our research, we analyse how users perceive the business-purposed information forwarded to them on the social media platform, and how intensive are the consumers’ activities on their most preferred catering establishment's site. For this purpose we analyse subjective consumer narratives (N=151) with the methodology of qualitative content analysis. We asked the respondents to write about the relationship with their most preferred catering establishment in the online sphere. Perceived activity of the "liked" catering establishment's platform could help enterprises to position themselves by communicating their core activities, or by using a totally different social strategy. Moreover, conscious content management of brands could contribute to reach and to engage users in the virtual sphere more efficiently.

Biological activities of compounds from Piper species

It is well established that secondary metabolites play an important role in plant chemical defense. In an effort to find natural herbicides research on plant growth regulatory activity of secondary metabolites has received more and more attention recently. The genus Piper has been an important source for useful secondary metabolites.^ Crude extracts from Piper species inhibited gram-positive bacteria and higher plant growth under laboratory conditions. Bioassay-guided isolation and purification lead to the identification of safrole, a phenylpropene, as the responsible agent for the inhibitory activity. Safrole was found to leach from naturally fallen leaves with water. Mechanisms of plant growth inhibition by safrole were investigated. Disassociation of cell membrane from cell walls was determined to be a major cause.^ Phenylpropenes structurally similar to safrole had similar phytogrowth inhibitory activity. It is postulated that phenylpropanoids are an important group of naturally occurring secondary metabolites in plant-plant interactions. ^

Evaluation of the cytotoxic and cytostatic activities of medicinal plants used by Peruvian healers against cancer-related symptoms

Twelve plants used medicinally in Callejon de Huaylas, Department of Ancash, northeastern Peru were selected and screened in vitro for cytotoxic and cytostatic activities. Traditional preparations, aqueous extracts and organic extracts (methanol:dimethyl chloride) were tested against murine leukemia P388 cells using flow cytometry. Seventy-five percent or more of the traditional and aqueous extracts were cytostatic at concentrations of 1mg/ml. For organic extracts, cytostatic activity ranged from 8.3% (at 6.25 μg/ml) to 58.3% (at 100 μg/ml). Quinchamalium procumbens, Ophryosporus chilca and Baccharis genistelloides showed strong activity. Extracts of Brachyotum rostratum, Monnina salicifolia, and Orthrosanthus chimboracensis were particularly interesting, since they were cytostatic but not cytotoxic at concentrations of 0.5 mg/ml. These Andean plants merit further analysis. The high percentage of activity found among the traditional preparations suggests that the traditional medical knowledge of Callejon de Huaylas healers deserves respect and merits further research. ^

Beyond the Pay: Current Illicit Activities of the Armed Forces in Central America

The growth of criminal gangs and organized crime groups has created unprecedented challenges in Central America. Homicide rates are among the highest in the world, countries spend on average close to 10 percent of GDP to respond to the challenges of public insecurity, and the security forces are frequently overwhelmed and at times coopted by the criminal groups they are increasingly tasked to counter. With some 90 percent of the 700 metric tons of cocaine trafficked from South America to the United States passing through Central America, the lure of aiding illegal traffickers through provision of arms, intelligence, or simply withholding or delaying the use of force is enormous. These conditions raise the question: to what extent are militaries in Central America compromised by illicit ties to criminal groups? The study focuses on three cases: Nicaragua, El Salvador, and Honduras. It finds that: Although illicit ties between the military and criminal groups have grown in the last decade, militaries in these countries are not yet “lost’ to criminal groups. Supplying criminal groups with light arms from military stocks is typical and on the rise, but still not common. In general the less exposed services, the navies and air forces, are the most reliable and effective ones in their roles in interdiction. Of the three countries in the study, the Honduran military is the most worrying because it is embedded in a context where civilian corruption is extremely common, state institutions are notoriously weak, and the political system remains polarized and lacks the popular legitimacy and political will needed to make necessary reforms. Overall, the armed forces in the three countries remain less compromised than civilian peers, particularly the police. However, in the worsening crime and insecurity context, there is a limited window of opportunity in which to introduce measures targeted toward the military, and such efforts can only succeed if opportunities for corruption in other sectors of the state, in particular in law enforcement and the justice system, are also addressed. Measures targeted toward the military should include: Enhanced material benefits and professional education opportunities that open doors for soldiers in promising legitimate careers once they leave military service. A clear system of rewards and punishments specifically designed to deter collusion with criminal groups. More effective securing of military arsenals. Skills and external oversight leveraged through combined operations, to build cooperation among those sectors of the military that have successful and clean records in countering criminal groups, and to expose weaker forces to effective best practices.

Innovating from the War Economy: Formal, Informal, and Illicit Economic Activities of the Military in Colombia

Over the last decade, the Colombian military has successfully rolled back insurgent groups, cleared and secured conflict zones, and enabled the extraction of oil and other key commodity exports. As a result, official policies of both the Uribe and Santos governments have promoted the armed forces to participate to an unprecedented extent in economic activities intended to consolidate the gains of the 2000s. These include formal involvement in the economy, streamlined in a consortium of military enterprises and social foundations that are intended to put the Colombian defense sector “on the map” nationally and internationally, and informal involvement expanded mainly through new civic action development projects intended to consolidate the security gains of the 2000s. However, failure to roll back paramilitary groups other than through the voluntary amnesty program of 2005 has facilitated the persistence of illicit collusion by military forces with reconstituted “neoparamilitary” drug trafficking groups. It is therefore crucially important to enhance oversight mechanisms and create substantial penalties for collusion with illegal armed groups. This is particularly important if Colombia intends to continue its new practice of exporting its security model to other countries in the region. The Santos government has initiated several promising reforms to enhance state capacity, institutional transparence, and accountability of public officials to the rule of law, which are crucial to locking in security gains and revitalizing democratic politics. Efforts to diminish opportunities for illicit association between the armed forces and criminal groups should complement that agenda, including the following: Champion breaking existing ties between the military and paramilitary successor groups through creative policies involving a mixture of punishments and rewards directed at the military; Investigation and extradition proceedings of drug traffickers, probe all possible ties, including as a matter of course the possibility of Colombian military collaboration. Doing so rigorously may have an important effect deterring military collusion with criminal groups. Establish and enforce zero-tolerance policies at all military ranks regarding collusion with criminal groups; Reward military units that are effective and also avoid corruption and criminal ties by providing them with enhanced resources and recognition; Rely on the military for civic action and development assistance as minimally as possible in order to build long-term civilian public sector capacity and to reduce opportunities for routine exposure of military forces to criminal groups circulating in local populations.

The conceptus induces a switch in protein expression and activities of superoxide dismutase 1 and 2 in the sheep endometrium during early pregnancy

Acknowledgements We thank Philippe Bolifraud (INRA, France), Krawiec Angele, Sandra Grange, Laurence Puillet-Anselme (CHU Grenoble, France) and Margaret Fraser (Aberdeen, UK) for their expert technical assistance. The authors also thank the staff of the sheep sheds of Jouy-en-Josas (INRA, France). The authors would also like to thank the anonymous reviewers for their close examination of this article and their useful comments.

Photocatalytic activities of tin(IV) oxide surface-modified titanium(IV) dioxide show a strong sensitivity to the TiO 2 crystal form

Surface modification of rutile TiO2 with extremely small SnO2 clusters gives rise to a great increase in its UV light activity for degradation of model organic water pollutants, while the effect is much smaller for anatase TiO2. This crystal form sensitivity is rationalized in terms of the difference in the electronic modification of TiO2 through the interfacial Sn−O−Ti bonds. The increase in the density of states near the conduction band minimum of rutile by hybridization with the SnO2 cluster levels intensifies the light absorption, but this is not seen with modified anatase. The electronic transition from the valence band to the conduction band causes the bulk-to-surface interfacial electron transfer to enhance charge separation. Further, electrons relaxed to the conduction minimum are smoothly transferred to O2 due to the action of the SnO2 species as an electron transfer promoter.

Beyond the Convent Walls: The Local and Japan-wide Activities of Daihongan’s Nuns in the Early Modern Period (c. 1550–1868)

This dissertation examines the social and financial activities of Buddhist nuns to demonstrate how and why they deployed Buddhist doctrines, rituals, legends, and material culture to interact with society outside the convent. By examining the activities of the nuns of the Daihongan convent (one of the two administrative heads of the popular pilgrimage temple, Zenkōji) in Japan’s early modern period (roughly 1550 to 1868) as documented in the convent’s rich archival sources, I shed further light on the oft-overlooked political and financial activities of nuns, illustrate how Buddhist institutions interacted with the laity, provide further nuance to the discussion of how Buddhist women navigated patriarchal sectarian and secular hierarchies, and, within the field of Japanese history, give voice to women who were active outside of the household unit around which early modern Japanese society was organized.

Zenkōji temple, surrounded by the mountains of Nagano, has been one of Japan’s most popular pilgrimage sites since the medieval period. The abbesses of Daihongan, one Zenkōji’s main sub-temples, traveled widely to maintain connections with elite and common laypeople, participated in frequent country-wide displays of Zenkōji’s icon, and oversaw the creation of branch temples in Edo (now Tokyo), Osaka, Echigo (now Niigata), and Shinano (now Nagano). The abbesses of Daihongan were one of only a few women to hold the imperially sanctioned title of eminent person (shōnin 上人) and to wear purple robes. While this means that this Pure Land convent was in some ways not representative of all convents in early modern Japan, Daihongan’s position is particularly instructive because the existence of nuns and monks in a single temple complex allows us to see in detail how monastics of both genders interacted in close quarters.

This work draws heavily from the convent’s archival materials, which I used as a guide in framing my dissertation chapters. In the Introduction I discuss previous works on women in Buddhism. In Chapter 1, I briefly discuss the convent’s history and its place within the Zenkōji temple complex. In Chapter 2, I examine the convent’s regular economic bases and its expenditures. In Chapter 3, I highlight Daihongan’s branch temples and discuss the ways that they acted as nodes in a network connecting people in various areas to Daihongan and Zenkōji, thus demonstrating how a rural religious center extended its sphere of influence in urban settings. In Chapter 4, I discuss the nuns’ travels throughout the country to generate new and maintain old connections with the imperial court in Kyoto, confraternities in Osaka, influential women in the shogun’s castle, and commoners in Edo. In Chapter 5, I examine the convent’s reliance upon irregular means of income such as patronage, temple lotteries, loans, and displays of treasures, and how these were needed to balance irregular expenditures such as travel and the maintenance or reconstruction of temple buildings. Throughout the dissertation I describe Daihongan’s inner social structure comprised of abbesses, nuns, and administrators, and its local emplacement within Zenkōji and Zenkōji’s temple lands.

Exploring these themes sheds light on the lives of Japanese Buddhist nuns in this period. While the tensions between freedom and agency on the one hand and obligations to patrons, subordination to monks, or gender- and status-based restrictions on the other are important, and I discuss them in my work, my primary focus is on the nuns’ activities and lives. Doing so demonstrates that nuns were central figures in ever-changing economic and social networks as they made and maintained connections with the outside world through Buddhist practices and through precedents set centuries before. This research contributes to our understanding of nuns in Japan’s early modern period and will participate in and shape debates on the roles of women in patriarchal religious hierarchies.