Workshop on FAMIX and Moose in Software Reengineering (FAMOOSr 2009)

The increasing amount of data available about software systems poses new challenges for re- and reverse engineering research, as the proposed approaches need to scale. In this context, concerns about meta-modeling and analysis techniques need to be augmented by technical concerns about how to reuse and how to build upon the efforts of previous research. MOOSE is an extensive infrastructure for reverse engineering evolved for over 10 years that promotes the reuse of engineering efforts in research. MOOSE accommodates various types of data modeled in the FAMIX family of meta-models. The goal of this half-day workshop is to strengthen the community of researchers and practitioners who are working in re- and reverse engineering, by providing a forum for building future research starting from MOOSE and FAMIX as shared infrastructure.

The use of mechanisms and modes of toxic action in integrated testing strategies: the report and recommendations of a workshop held as part of the European Union OSIRIS Integrated Project

This report on The Potential of Mode of Action (MoA) Information Derived from Non-testing and Screening Methodologies to Support Informed Hazard Assessment, resulted from a workshop organised within OSIRIS (Optimised Strategies for Risk Assessment of Industrial Chemicals through Integration of Non-test and Test Information), a project partly funded by the EU Commission within the Sixth Framework Programme. The workshop was held in Liverpool, UK, on 30 October 2008, with 35 attendees. The goal of the OSIRIS project is to develop integrated testing strategies (ITS) fit for use in the REACH system, that would enable a significant increase in the use of non-testing information for regulatory decision making, and thus minimise the need for animal testing. One way to improve the evaluation of chemicals may be through categorisation by way of mechanisms or modes of toxic action. Defining such groups can enhance read-across possibilities and priority settings for certain toxic modes or chemical structures responsible for these toxic modes. Overall, this may result in a reduction of in vivo testing on organisms, through combining available data on mode of action and a focus on the potentially most-toxic groups. In this report, the possibilities of a mechanistic approach to assist in and guide ITS are explored, and the differences between human health and environmental areas are summarised.