869 resultados para Stubenrauch, Herbert
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We have studied the physical content of the following models: Maxwell, Proca, Self-Dual and Maxwell-Chern-Simons. One method we have used is the decomposition in the so called helicity variables, which can be done in the Lagrangian formalism. It leads to the correct counting of degrees of freedom without choosing a gauge condition. The method separates the propagating modes from the non-propagating ones. The Hamiltonian of the MCS and the AD is calculated. The second method used here is the analysis of the sign of the imaginary part of the residues of the two-point amplitude of the theory, showing that the models analyzed are free of ghosts. We also carry the dimensional reduction of the Maxwell-Chern-Simons and Self-Dual models from D = 2+1 to D = 1 + 1 dimensions. Next, we show that the dimensional reduction of those equivalent models also leads to equivalent models in D=1+1. Even more interesting is the fact, demonstrated here, that those reduced models can also be connected via gauge embedding. So the gauge embedding of the Self-Dual model into the Maxwell-Chern-Simons theory is preserved by the dimensional reduction
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
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Pós-graduação em Educação - FFC
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This work aims to identify the rootmetaphor of John Dewey’s philosophical and educational discourse, by means of rhetorical analyses parameters. This methodology is founded in Aristotle and in the works of Chaïm Perelman and other contemporary authors involved in the revision of Aristotelian philosophy. The article examines the essays “The philosophical work of Herbert Spencer” and “The influence of darwinism on philosophy”, published by John Dewey respectively in 1904 e 1909. They were written in the early years of Dewey in Columbia University, which intellectual environment was not dominated by Pragmatism, and for this reason they can be considered seminal in the structuring of the author’s arguments. The analysis reveals that Dewey is favorable to Darwinian evolutionism thesis and opposite to Spencer’s one. This positioning suggests that Dewey’s discourse is bound to the metaphor “undetermined route” because it situates evolution as a process devoid of previously listed purposes at a pre-determined plan, subject only to the relations that are established, so unpredictable, between organisms and the environmental conditions that surround. Analyzing Dewey’s ideas about education, the article concludes that “undetermined route” is the rootmetaphor of Dewey’s discourse, hypothesis that can contribute to discuss Dewey in the context of contemporary philosophy.
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This article aims to discuss and reflect on the contributions of the Critical Theory of Society called for the field of education in times of increasing technological development. Therefore, we look to the works of three authors exponents of Critical Theory: Walter Benjamin, Theodor W. Adorno and Herbert Marcuse, highlighting the reflections and analyzes of these authors and using them as input in the educational field. The selfreflective and self-education is conceived in its potential to overcome the conditions of domination that remain in our society increasingly technified and supposedly democratic. Thus, the educational praxis think it seems like something urgent and necessary to be broken with certain conditions that keeps our potential to barbarism.
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Alveolar bone loss associated with periodontal diseases is the result of osteoclastogenesis induced by bacterial pathogens. The mitogen-activated protein kinase (MAPK) phosphatase 1 (MKP-1) is a critical negative regulator of immune response as a key phosphatase capable of dephosphorylating activated MAPKs. In this study, rat macrophages transduced with recombinant adenovirus (Ad.)MKP-1 specifically dephosphorylated activated MAPKs induced by lipopolysaccharide (LPS) compared with control cells. Bone marrow macrophages from MKP-1 knockout (KO) mice exhibited higher interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, and select chemokine compared with wild-type (WT) mice when stimulated by LPS. In addition, bone marrow cultures from MKP-1 KO mice exhibited significantly more osteoclastogenesis induced by LPS than when compared with WT mice. Importantly, MKP-1 gene transfer in bone marrow cells of MKP-1 KO mice significantly decreased IL-6, IL-10, TNF-α and chemokine levels, and formed fewer osteoclasts induced by LPS than compared with control group of cells. Furthermore, MKP-1 gene transfer in an experimental periodontal disease model attenuated bone resorption induced by LPS. Histological analysis confirmed that periodontal tissues transduced with Ad. MKP-1 exhibited less infiltrated inflammatory cells, less osteoclasts and less IL-6 than compared with rats of control groups. These studies indicate that MKP-1 is a key therapeutic target to control of inflammation-induced bone loss.
Silencing mitogen-activated protein kinase-activated protein kinase-2 arrests inflammatory bone loss
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p38 mitogen-activated protein kinases (MAPKs) are critical for innate immune signaling and subsequent cytokine expression in periodontal inflammation and bone destruction. In fact, previous studies show that systemic p38 MAPK inhibitors block periodontal disease progression. However, development of p38 MAPK inhibitors with favorable toxicological profiles is difficult. Here, we report our findings regarding the contribution of the downstream p38 MAPK substrate, mitogen-activated protein kinase-activated protein kinase 2 (MK2 or MAPKAPK-2), in immune response modulation in an experimental model of pathogen-derived lipopolysaccharide (LPS)-induced periodontal bone loss. To determine whether small interfering RNA (siRNA) technology has intraoral applications, we initially validated MK2 siRNA specificity. Then, gingival tissue surrounding maxillary molars of rats was injected with MK2 siRNA or scrambled siRNA at the palatal regions of bone loss. Intraoral tissues treated with MK2 siRNA had significantly less MK2 mRNA expression compared with scrambled siRNA-treated tissues. MK2 siRNA delivery arrested LPS-induced inflammatory bone loss, decreased inflammatory infiltrate, and decreased osteoclastogenesis. This proof-of-concept study suggests a novel target using an intraoral RNA interference strategy to control periodontal inflammation.
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
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Brazil is the largest world producer of yellow passion fruit, a fruit crop which is exigent in nutrients, although little studied in relation to phosphorus fertilizing, fundamental on plant establishment. An experiment was carried out during the period of March/2010 to April/2011 in Remigio County, Paraiba State, Brazil, in order to evaluate the vegetative and productive attributes of yellow passion fruit plants under different sources and doses of phosphorus. Treatments were distributed in randomized blocks in tree replications and twelve plants by plot using the factorial design 2 x 5 referring the sources of superphosphate triple and superphosphate simple at levels P2O5 of 0, 12, 18, 24 and 30 g cave(-1). The following variables were recorded: stem diameter, number of productive branches, number of fruits per plant, fruit mass and fruit yield. The sources and doses of phosphorus affected growth and fruit production of yellow passion plants. The triple superphosphate is the most phosphorus efficient source for growth and fruit production of yellow passion fruit. The triple superphosphate dose which promoted the maximum yield of yellow passion fruit is 42.86 g.
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
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The Marion Allan Wright Papers consist of correspondence, a journal, autobiographical writings, bibliographies, biographical data, essays, speeches, book reviews, short stories, poems, letters to the editor, oral history transcripts and other papers. Subjects include the death penalty, the civil rights movement, civil liberties, libraries in South Carolina and politics. Correspondents include R. Beverly Herbert, L. Mendel Rivers, J, William Fulbright, Sam Ervin, Jr., Reverend James P. Dees, Preston Wright (Wright's brother) and other relatives. See Acc 48 for an earlier accession of Wright papers and the oral history collection for recorded interviews with Wright.
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This study documents one of the slowest feeding behaviors ever recorded for a muricid gastropod in one of the most biotically rigorous regions on the planet. In Pacific Panama, Vitularia salebrosa attacks mollusks by drilling through their shells. The duration of attacks estimated by isotope sclerochronology of oyster shells collected during attacks in progress range from 90 to 230 days, while experimental observation of interactions documented one attack greater than 103 days. The prolonged nature of attacks suggests that V. salebrosa is best characterized as an ectoparasite than as a predator, which is the ancestral condition in the Muricidae. An ectoparasitic lifestyle is also evident in the unusual interaction traces of this species, which include foot scars, feeding tunnels and feeding tubes, specialized soft anatomy, and in the formation of male-female Pairs, which is consistent with protandrous hermaphroditism, as is typical in sedentary gastropods. To delay death of its host, V. salebrosa targets renewable resources when feeding, such as blood and digestive glands. A congener, Vitularia miliaris from the Indo-Pacific, has an identical feeding biology The origin and persistence of extremely slow feeding in the tropics challenges our present understanding of selective pressures influencing the evolution of muricid feeding behaviors and morphological adaptations. Previously, it has been suggested that faster feeding is advantageous because it permits predators to spend a greater proportion of time hiding in enemy-free refugia or to take additional prey, the energetic benefits of which could be translated into increased fecundity or defenses. The benefits of exceptionally slow feeding have received little consideration. In the microhabitat preferred by V. salebrosa (beneath boulders), it is possible that prolonged interactions with hosts decrease vulnerability to enemies by reducing the frequency of risky foraging events between feedings . Ectoparasitic feeding through tunnels by V. salebrosa may also reduce competitive interactions with kleptoparasites (e.g., crabs, snails) that steal food through the gaped valves of dead or dying hosts.
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The morphology and anatomy of Vitularia salebrosa, a muricid ectoparasitic on other mollusks, are investigated based on study of specimens from western Panama. Distinctive characters of this species include the small size of the buccal mass and radular apparatus, simplification of the odontophore muscles and diminished lateral teeth of the radula; all elongated, narrow proboscis; narrow digestive tract and a differentiable glandular region at the beginning of the posterior esophagus. These traits are consistent with adaptive specialization for an ectoparasitic life history.