Statin use and survival in colorectal cancer: Results from a population-based cohort study and an updated systematic review and meta-analysis

BACKGROUND: The aim of this study was to investigate the association between statin use and survival in a population-based colorectal cancer (CRC) cohort and perform an updated meta-analysis to quantify the magnitude of any association.

METHODS: A cohort of 8391 patients with newly diagnosed Dukes' A-C CRC (2009-2012) was identified from the Scottish Cancer Registry. This cohort was linked to the Prescribing Information System and the National Records of Scotland Death Records (until January 2015) to identify 1064 colorectal cancer-specific deaths. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for cancer-specific mortality by statin use were calculated using time dependent Cox regression models. The systematic review included relevant studies published before January 2016. Meta-analysis techniques were used to derive combined HRs for associations between statin use and cancer-specific and overall mortality.

RESULTS: In the Scottish cohort, statin use before diagnosis (HR=0.84, 95% CI 0.75-0.94), but not after (HR=0.90, 95% CI 0.77-1.05), was associated with significantly improved cancer-specific mortality. The systematic review identified 15 relevant studies. In the meta-analysis, there was consistent (I(2)=0%,heterogeneity P=0.57) evidence of a reduction in cancer-specific mortality with statin use before diagnosis in 6 studies (n=86,622, pooled HR=0.82, 95% CI 0.79-0.86) but this association was less apparent and more heterogeneous (I(2)=67%,heterogeneity P=0.03) with statin use after diagnosis in 4 studies (n=19,152, pooled HR=0.84, 95% CI 0.68-1.04).

CONCLUSION: In a Scottish CRC cohort and updated meta-analysis there was some evidence that statin use was associated with improved survival. However, these associations were weak in magnitude and, particularly for post-diagnosis use, varied markedly between studies.

El valor mitográfico del "Anonymi in Statii Achilleida commentum"

El breve commentum in Statii Achilleida resulta muy interesante para el estudio de la transmisión mitográfica de la Antigüedad tardía al Medievo, pues no sólo participa de las características propias de la mitografía (narraciones de mitos, exégesis racionalista y/o alegórica, interpretaciones etimológicas, anonimato, pseudepigrafía,…), sino que también es otro eslabón en la cadena textual de transmisión, simplificación y canonización de los mitos clásicos.

Beiträge zum griechischen Iob

Textkritische Notizen zu den jüngeren griechischen Übersetzungen des Buches lob; Vermeintliche α' -Wiedergaben im Index von Turner; 1. Scholien am Rand der Catenen-Hss. (= C) des Typ I; 2. Scholien am Rand der Catenen-Hss. (= C) des Typ I, die mit ἀντὶ τοῦ o. ä. eingeführt werden; Scholien, die von Field unter Ἄλλος verzeichnet sind; Scholien am Rand des Kodex B; Scholien am Rand der Hs. 248; Interlinearnoten in der Hs. 523; Lesarten, die mit διπλῆ γραφή (δγρ') am Rand der Catenen-Hss. (= C) des Typ I eingeführt werden; Wiedergaben der "Drei" im armenischen lobkommentar des Hesychius von Jerusalem; LXX-Texte, die unrichtig von Klostermann als Wiedergaben der "Drei" verzeichnet sind; Homerische Vokabeln im griechischen lob

INOVAÇÃO ABERTA COMO ESTRATÉGIA PARA CRIAÇÃO DE VALOR EM EMPRESAS DE BASE TECNOLÓGICA

As empresas diante do cenário dinâmico e competitivo em que se encontra, busca estratégias para atender a demanda do mercado de maneira a criar valor e diferenciais perante a concorrência. Nessa perspectiva a inovação é considerada ferramenta para o ganho de vantagem competitiva e tem sido buscada por meio de estímulos à geração de ideias, do desenvolvimento do capital intelectual e da utilização eficiente de recursos. Porém, o que se vê em algumas empresas é a ausência de recursos que permitam seu crescimento, sejam financeiros, pessoais ou tecnológicos. Nesse sentido, a utilização da inovação aberta surge como proposta para criação de valor organizacional e permite que as organizações se apoiem umas às outras, transferindo conhecimento, recursos financeiros e até mesmo, recursos tecnológicos. Nesse sentido, esse projeto tem como objetivo realizar um estudo sobre os fatores advindas da inovação aberta que influenciam as empresas de base tecnológica na criação de valor. Para tal, serão estudados os requisitos desse tipo de empresa e os construtos principais da inovação aberta e da criação de valor. Após esse estudo, por meio de uma análise quantitativa, poderão ser identificados os fatores que influenciem a criação de valor a esse tipo de empresa quando a inovação aberta é aplicada. 

Prognosis following acute coronary syndromes according to prior coronary artery bypass grafting: Meta-analysis

PURPOSE: Conduct a meta-analysis to study the prognostic influence of a previous coronary artery bypass grafting (CABG) in patients admitted for an acute coronary syndrome (ACS). METHODS: A systematic review of the literature was performed using electronic reference databases through January 2013 (MEDLINE, Cochrane Library, Web of Knowledge, Google Scholar and references cited in other studies). Studies in which ACS outcomes with a previous history of CABG were compared with ACS outcomes with no history of previous CABG were considered for inclusion. The main endpoints of interest were mortality and non-fatal acute myocardial infarction. Data was aggregated at three follow-up times using random-effects meta-analysis models. RESULTS: Twenty-four studies were included which provided 387,181 patients for analysis. Previous CABG ACS patients were older, more diabetic and had a more frequent history of a previous myocardial infarction. Pooled in-hospital mortality was higher for the previous CABG ACS patients (OR 1.22 [1.04-1.44], p<0.01, I(2) 88%). The pooled adjusted OR showed no significant differences for the two groups (adjusted OR 1.13 [0.93-1.37], p=0.22, I(2) 92%). Previous CABG ACS patient had a higher pooled 30-day mortality (OR 1.28 [1.05-1.55], p=0.02, I(2) 74%); a higher non-adjusted (OR 1.61 [1.38-1.88], p<0.01, I(2) 70%) and adjusted (adjusted OR 1.37 [1.15-1.65], p<0.01, I(2) 0%) long-term mortality. Both the in-hospital and the long-term re-infarction rates were higher for the previous CABG ACS patients. CONCLUSIONS: According to our data, ACS patients with previous CABG history had a higher risk for short- and long-term adverse events.

CIL 3.566 – Dedication for Q. Minucius Rufus

Squeeze, photograph and notes by A.E. Gordon

CIL 3.14203, 06 – Inscription on a round base for C. Julius Caesar, son of Gaius

Squeeze, photograph and notes by A.E. Gordon

CIL 3.14203, 22 – Dedication of L. Aemilus Paulus

Photographs and notes by A.E. Gordon

CIL 3.314203, 23 – Dedication of M. Minucius Rufus

Squeeze, photograph and notes by A.E. Gordon

CIL 5.7749 – Sententia Minuciorum on a dispute over public land between the Genovana and the Langensian Viturians - Bronze tablet

Photograph + clipping from Oggi, May 10, 1952

CIL 5.8045 – Milestone

Photographs and notes by A.E. Gordon

CIL 5.8270 – Metrical dedication for Gaius Sempronius Tuditanus

Squeeze, photograph, and notes by A.E. Gordon

CIL 6.1284-1285 – Metrical epitaph on a sarcophagus for Lucius Cornelius Scipio Barbatus

Photographs and translation

CIL 6.1286 – Metrical epitaph for Lucius Cornelius Scipio, son of Barbatus

Photograph

CIL 6.1287 – Metrical epitaph for Lucius Cornelius Scipio, son of Barbatus

Photographs, notes by A.E. Gordon, and translation by A.J. Heisserer