El lenguaje clásico es atemporal. Entrevista a David Watkin

Watkin se ha distinguido como uno de los más certeros y sobrios polemistas y críticos arquitectónicos, como lo demuestra su celebérrimo ensayo Morality and Architecture (1977), una de las pocas obras imprescindibles en el debate arquitectónico del siglo XX, así como el gran numero de actos y campañas desarrolladas por él en defensa de la supervivencia de la tradición arquitectónica clásica y en solidaridad con los arriesgados arquitectos que hoy en día la representan. Esta faceta pública ha llevado a Watkin a las fronteras de la política y lo ha situado en el centro de un convulso debate público que aún se halla en pleno desarrollo, rodeando cada una de las obras de arquitectos estrella que se levantan en Inglaterra.

Distribution and abundance of fishes and invertebrates in Gulf of Mexico estuaries / project team, David M. Nelson (editor) ... [et al.].

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Distribution and abundance of fishes and invertebrates in Gulf of Mexico estuaries / project team, David M. Nelson (editor) ... [et al.].

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1997-2005: Dr. David B. Henson

17th President 1996-2005

Fundamentos da arbitragem no direito brasileiro e estrangeiro / Jorge David Barrientos Parra. --

Inclui notas bibliográficas.

A autoproteção possessória e seus fundamentos / Carlos David Santos Aarão Reis. --

Inclui bibliografia.

A complementariedade dos sistemas jurídicos estatais e de comerciantes em matéria de contratos internacionais / Jorge David Barrientos Parra. --

Inclui bibliografia.

Profilin I is essential for cell survival and cell division in early mouse development

Profilins are thought to play a central role in the regulation of de novo actin assembly by preventing spontaneous actin polymerization through the binding of actin monomers, and the adding of monomeric actin to the barbed actin-filament ends. Other cellular functions of profilin in membrane trafficking and lipid based signaling are also likely. Binding of profilins to signaling molecules such as Arp2/3 complex, Mena, VASP, N-WASP, dynamin I, and others, further implicates profilin and actin as regulators of diverse motile activities. In mouse, two profilins are expressed from two distinct genes. Profilin I is expressed at high levels in all tissues and throughout development, whereas profilin II is expressed in neuronal cells. To examine the function of profilin I in vivo, we generated a null profilin I (pfn1ko) allele in mice. Homozygous pfn1ko/ko mice are not viable. Pfn1ko/ko embryos died as early as the two-cell stage, and no pfn1ko/ko blastocysts were detectable. Adult pfn1ko/wt mice show a 50% reduction in profilin I expression with no apparent impairment of cell function. However, pfn1ko/wt embryos have reduced survival during embryogenesis compared with wild type. Although weakly expressed in early embryos, profilin II cannot compensate for lack of profilin I. Our results indicate that mouse profilin I is an essential protein that has dosage-dependent effects on cell division and survival during embryogenesis.